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The map label for this gene is deoA [C]

Identifier: 146339726

GI number: 146339726

Start: 2925814

End: 2927265

Strand: Reverse

Name: deoA [C]

Synonym: BRADO2724

Alternate gene names: 146339726

Gene position: 2927265-2925814 (Counterclockwise)

Preceding gene: 146339728

Following gene: 146339725

Centisome position: 39.26

GC content: 68.8

Gene sequence:

>1452_bases
GTGATCTCGCGACGCTCGCGGGCCTTGCGGCCCGAGGTCTTCAGCGGCTTTTCCCGGGTCGAGCTGCGCTGCAATTCGCG
CACCCTGCTCGCCACCCTGCTGATCACCGACGACGACGCCCTGGTGGGGCCTGACGAGATCGGGTTGTCCGAGCCCGCGT
TGCGGCGCTTCGCCGAGCCGGCCGGCATGCTGGCGACGGTATCGCCGGCCACCCCGCCCGAGAGCCTGGAGGCGGTGCGC
GCCAAGATCCGAGGCGAAACTCTCAGCGACGAGGCCATCGCGGCTGTGATCGAGGACCTCGCTCACTACCGCTACTCGGA
CATGGAAATCGCCGCATTCCTGATCGGCTCGGCCAGCTTCATGACGTCCGGCGAGTTGCTGGCGCTGACCCACGCGATGG
CCAATGCGGGCACCCAACTGACATGGCCCGAGCCCGTCGTCGTCGACAAGCATTGCATCGGCGGCATCCCCGGCAACCGT
ACCTCCATGGTGGTTGTGCCGATCGTCGCCGCCCATGGCCTGACCATCCCGAAGACGTCCTCGCGCGCGATCACCTCGCC
GGCCGGCACCGCCGACACGATGGAGGTGCTGGCCCGCGTCAACGTCGGCGCCGAGGAGATGAAGTCGATCGTCGCGGCCT
GCAACGGCTGCGTGATCTGGGGCGGCCACGTCAATCTGTCGCCGGCCGATGACATCCTGATCTCCGTCGAGCGCCCGCTC
AGCCTGGACACCCGAGAGCAGATGGTCGCCTCCATCCTGTCGAAGAAGCTCGCCGCCGGCTCGACGCATCTGCTGCTCGA
CCTGCCGGTCGGCCCGACGGCGAAGCTCACCAGCGGTGCGGAGGCCATGCGGCTGCGCAAGCTGTTCGAATTCGTCGGCG
ACCGCTTCGGCCTGAAGGTCGAGGTGATCACGACCGACGGCCGGCAGCCGATCGGCCACGGCATCGGGCCGGTGCTCGAG
GCGCGCGACGTGATGGCGGTGCTCGGCAACGAGCCGCAGGCACCGGCCGACCTGCGCGAGAAATCGCTGCGCCTCGCGGC
GCATCTGCTCGAATATGATCCGAAACTGCGCGGGGGCGCCGGCTATTCACGCGCGCGCGAGTTGCTCGACAGCGGCGCGG
CGCTGAAGCAGATGCAGAAGATCATCGACGCACAGGGGCCGTCCGCGGGCCGCAGCGAGCTCGGCGATCTCGCTTTCGAC
GTCGGGGCTGCCAGCGACGGCGTCGTCTCGGCGATCGACTGCCTGCGGCTCAACCGCCTGGCACGCACCGCCGGCGCGCC
GGTCAATAAGGGCGCGGGCATCCGGCTGTACAAGAAGATCGGCGACCGTGTCGACCAGGGCGAGCCGCTGTACCGCGTGT
TCACCTGCGATCCGTCCGAGCATGATCTGGCGGCAGCGGCCGCGAGCGCCAACAATGGCTATGTCCTCGATGGCCCGAAC
GGCCCTCACTAA

Upstream 100 bases:

>100_bases
GCTTAAGCTTGGTGCGATCATCATGAGCCCAGCAGATACCGCCCGCCCCCAGCTGAAGATCCGCAGCGTCGCGCTCGATA
CCGGGCGGGAGAATGTGGTC

Downstream 100 bases:

>100_bases
CGAGGCAGCGTCGCGCCTCACGTCATCTCGGGAGACTGCCGCATGAGTGTGACTCTTCGCTTCTGCGGCGCCGCGCACAC
CGTGACCGGCTCCTGTTATC

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase [H]

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MISRRSRALRPEVFSGFSRVELRCNSRTLLATLLITDDDALVGPDEIGLSEPALRRFAEPAGMLATVSPATPPESLEAVR
AKIRGETLSDEAIAAVIEDLAHYRYSDMEIAAFLIGSASFMTSGELLALTHAMANAGTQLTWPEPVVVDKHCIGGIPGNR
TSMVVVPIVAAHGLTIPKTSSRAITSPAGTADTMEVLARVNVGAEEMKSIVAACNGCVIWGGHVNLSPADDILISVERPL
SLDTREQMVASILSKKLAAGSTHLLLDLPVGPTAKLTSGAEAMRLRKLFEFVGDRFGLKVEVITTDGRQPIGHGIGPVLE
ARDVMAVLGNEPQAPADLREKSLRLAAHLLEYDPKLRGGAGYSRARELLDSGAALKQMQKIIDAQGPSAGRSELGDLAFD
VGAASDGVVSAIDCLRLNRLARTAGAPVNKGAGIRLYKKIGDRVDQGEPLYRVFTCDPSEHDLAAAAASANNGYVLDGPN
GPH

Sequences:

>Translated_483_residues
MISRRSRALRPEVFSGFSRVELRCNSRTLLATLLITDDDALVGPDEIGLSEPALRRFAEPAGMLATVSPATPPESLEAVR
AKIRGETLSDEAIAAVIEDLAHYRYSDMEIAAFLIGSASFMTSGELLALTHAMANAGTQLTWPEPVVVDKHCIGGIPGNR
TSMVVVPIVAAHGLTIPKTSSRAITSPAGTADTMEVLARVNVGAEEMKSIVAACNGCVIWGGHVNLSPADDILISVERPL
SLDTREQMVASILSKKLAAGSTHLLLDLPVGPTAKLTSGAEAMRLRKLFEFVGDRFGLKVEVITTDGRQPIGHGIGPVLE
ARDVMAVLGNEPQAPADLREKSLRLAAHLLEYDPKLRGGAGYSRARELLDSGAALKQMQKIIDAQGPSAGRSELGDLAFD
VGAASDGVVSAIDCLRLNRLARTAGAPVNKGAGIRLYKKIGDRVDQGEPLYRVFTCDPSEHDLAAAAASANNGYVLDGPN
GPH
>Mature_483_residues
MISRRSRALRPEVFSGFSRVELRCNSRTLLATLLITDDDALVGPDEIGLSEPALRRFAEPAGMLATVSPATPPESLEAVR
AKIRGETLSDEAIAAVIEDLAHYRYSDMEIAAFLIGSASFMTSGELLALTHAMANAGTQLTWPEPVVVDKHCIGGIPGNR
TSMVVVPIVAAHGLTIPKTSSRAITSPAGTADTMEVLARVNVGAEEMKSIVAACNGCVIWGGHVNLSPADDILISVERPL
SLDTREQMVASILSKKLAAGSTHLLLDLPVGPTAKLTSGAEAMRLRKLFEFVGDRFGLKVEVITTDGRQPIGHGIGPVLE
ARDVMAVLGNEPQAPADLREKSLRLAAHLLEYDPKLRGGAGYSRARELLDSGAALKQMQKIIDAQGPSAGRSELGDLAFD
VGAASDGVVSAIDCLRLNRLARTAGAPVNKGAGIRLYKKIGDRVDQGEPLYRVFTCDPSEHDLAAAAASANNGYVLDGPN
GPH

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=425, Percent_Identity=30.8235294117647, Blast_Score=133, Evalue=5e-31,
Organism=Homo sapiens, GI4503445, Length=425, Percent_Identity=30.8235294117647, Blast_Score=133, Evalue=5e-31,
Organism=Homo sapiens, GI166158922, Length=425, Percent_Identity=30.8235294117647, Blast_Score=133, Evalue=5e-31,
Organism=Escherichia coli, GI1790842, Length=408, Percent_Identity=28.6764705882353, Blast_Score=106, Evalue=4e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR000053
- InterPro:   IPR017872
- InterPro:   IPR013466 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.4 [H]

Molecular weight: Translated: 51024; Mature: 51024

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISRRSRALRPEVFSGFSRVELRCNSRTLLATLLITDDDALVGPDEIGLSEPALRRFAEP
CCCCCCCCCCHHHHCCCEEEEEEECCCEEEEEEEEECCCCEECCHHCCCCCHHHHHHCCC
AGMLATVSPATPPESLEAVRAKIRGETLSDEAIAAVIEDLAHYRYSDMEIAAFLIGSASF
CCCEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHEEHHHHCCHHH
MTSGELLALTHAMANAGTQLTWPEPVVVDKHCIGGIPGNRTSMVVVPIVAAHGLTIPKTS
HCCCCHHHHHHHHHCCCCCCCCCCCEEECHHHHCCCCCCCCCEEEEEEHHHCCCCCCCCC
SRAITSPAGTADTMEVLARVNVGAEEMKSIVAACNGCVIWGGHVNLSPADDILISVERPL
CCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCEEEECCEECCCCCCCEEEEECCCC
SLDTREQMVASILSKKLAAGSTHLLLDLPVGPTAKLTSGAEAMRLRKLFEFVGDRFGLKV
CCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEE
EVITTDGRQPIGHGIGPVLEARDVMAVLGNEPQAPADLREKSLRLAAHLLEYDPKLRGGA
EEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
GYSRARELLDSGAALKQMQKIIDAQGPSAGRSELGDLAFDVGAASDGVVSAIDCLRLNRL
CHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHEECCCCCCCHHHHHHHHHHHHH
ARTAGAPVNKGAGIRLYKKIGDRVDQGEPLYRVFTCDPSEHDLAAAAASANNGYVLDGPN
HHHCCCCCCCCCCEEHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHCCCCCEEECCCC
GPH
CCC
>Mature Secondary Structure
MISRRSRALRPEVFSGFSRVELRCNSRTLLATLLITDDDALVGPDEIGLSEPALRRFAEP
CCCCCCCCCCHHHHCCCEEEEEEECCCEEEEEEEEECCCCEECCHHCCCCCHHHHHHCCC
AGMLATVSPATPPESLEAVRAKIRGETLSDEAIAAVIEDLAHYRYSDMEIAAFLIGSASF
CCCEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHEEHHHHCCHHH
MTSGELLALTHAMANAGTQLTWPEPVVVDKHCIGGIPGNRTSMVVVPIVAAHGLTIPKTS
HCCCCHHHHHHHHHCCCCCCCCCCCEEECHHHHCCCCCCCCCEEEEEEHHHCCCCCCCCC
SRAITSPAGTADTMEVLARVNVGAEEMKSIVAACNGCVIWGGHVNLSPADDILISVERPL
CCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCEEEECCEECCCCCCCEEEEECCCC
SLDTREQMVASILSKKLAAGSTHLLLDLPVGPTAKLTSGAEAMRLRKLFEFVGDRFGLKV
CCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEE
EVITTDGRQPIGHGIGPVLEARDVMAVLGNEPQAPADLREKSLRLAAHLLEYDPKLRGGA
EEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCC
GYSRARELLDSGAALKQMQKIIDAQGPSAGRSELGDLAFDVGAASDGVVSAIDCLRLNRL
CHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHHEECCCCCCCHHHHHHHHHHHHH
ARTAGAPVNKGAGIRLYKKIGDRVDQGEPLYRVFTCDPSEHDLAAAAASANNGYVLDGPN
HHHCCCCCCCCCCEEHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHCCCCCEEECCCC
GPH
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA