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The map label for this gene is 146339725

Identifier: 146339725

GI number: 146339725

Start: 2924179

End: 2925771

Strand: Reverse

Name: 146339725

Synonym: BRADO2723

Alternate gene names: NA

Gene position: 2925771-2924179 (Counterclockwise)

Preceding gene: 146339726

Following gene: 146339724

Centisome position: 39.24

GC content: 69.05

Gene sequence:

>1593_bases
ATGAGTGTGACTCTTCGCTTCTGCGGCGCCGCGCACACCGTGACCGGCTCCTGTTATCTGCTGCGGACCGACCAGGGTCA
GGTCCTGATCGATTGCGGTCTGTTCCAGGGGCAGAAGACGCTCAAGGAGCTCAACTACGGGGACTTCCCGTTCCGCCCCG
CAGAGATCGACGCCGTGCTGCTGACGCATGCGCATATCGACCACAGCGGGCTCTTGCCGAAGCTGGTGCGGCTGGGCTTC
GACGGCAGGATCTTCGCCACGCGCGGCACCATCGATCTGTGCTCGTGGATGCTGCCCGACGCCGGCAACATCCAGGAGCA
GGAGGTGCTGGCGCTGAACCGCCGCAACATCGCGCGTGGCCGCGGCGAGGTCAGTCCGATCTACACGCAGGCCGACGCGA
TCGCCGCGTTGCAATACTTCCAGCCGATCGCCTATGAGACCTGGACCGACGTCATTGCCGGCGTCCGTGCGCGCTACTGG
AACGCCGGACATCTTCTGGGCTCCGCCTCGATCGAGATCGAGCTCGCCGGAAAAGGCACGGGCGGCGCGCCGCTGCGGCT
GCTCGCCTCGGGCGATGTGGGCCCCGATGCCAAGCTGCTGCAGCCCGATCCCAAAGCGCCGGCCGGCTTCGACTACGTGA
TCTCGGAGGCGACCTACGGCGACCGCATCCGCGAGCCGACCACGCCGGAGCTGCGCCGCGAACGTCTCGCCGTCGAGGTG
CGCGACGCCGCGGCCGCCCGCGGCGCGCTCCTGATCCCGGCGTTTGCGGTGGAGCGGACGCAGGAGCTGATCGTCGATCT
CGTCGGGCTGATGGAGCGCGGCGGCATTCCGGCCGCACCGATCTTCCTGGACTCGCCGCTCGCGATCCATGCCACCGAGG
TGTTTCGTGCGCATGCGGGCAGTCTCGATGGCGGCAGCGACGTCGGCCGTCTGCTGTCGTCGCCGCATCTGCGCTTCACC
GAGACCGTGGACGAGAGCAAGGCGATCGCCAAGCTGACCGGCTTCCACATCGTCATCGCCGCCAGCGGCATGTGTGATGC
CGGGCGCATCCGTCATCACCTCAAGCGCTGGCTATGGAATCACCGCGCCACCGTGCTGCTGGTCGGCTATCAGGCCAACG
GCACGCTCGGCCGCTTCCTGCAGGACGGCGTCAAGGCGGTGCGCATCCAGGGCGAGGAGATCAAGGTCGGCGCGCGCATC
CGCATGATCGACGACTACTCCGGCCACGCCGACGGCACCGAGATCGCGCGCTGGATCGCGGCCCGCCGGCCGATCGCGCG
CGGGCTGTTTCTGTCGCATGGCGAGGAGGCGGCGATTGCCGCGCCGTCGGCGCGCGTCGCCGGGCGGATCGTGCCTGCGG
CCAACGTCTTCTCCCCGCTGCTCGACGACATCTACGAACTCACAAGCGCGATGCCGACGCCGCTCGATGTCGCGCGCCGG
CGGCGGCTGGCGCCCGAGGCGGTCACCCGGCTCGACTGGCACAACGACATGTCGGGCCTGCTGCTCGACATTCACGCGCG
TATCGAGCAGGCGGCCGACGACCGCGCGCGCGGTGTCATCATCCGCCGCCTGCGGCGGGCACTCGAGGAATGA

Upstream 100 bases:

>100_bases
AGCGGCCGCGAGCGCCAACAATGGCTATGTCCTCGATGGCCCGAACGGCCCTCACTAACGAGGCAGCGTCGCGCCTCACG
TCATCTCGGGAGACTGCCGC

Downstream 100 bases:

>100_bases
CGCGATCGCCGTCTCGGCCACGAGGGGATGTCGGTCCGTTGTCGTCGAACGGTCACACTTTGATCGCAACCTCGCTCGAT
CGACCGTCGACGGATTGCAA

Product: putative metallo-beta-lactamase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 530; Mature: 529

Protein sequence:

>530_residues
MSVTLRFCGAAHTVTGSCYLLRTDQGQVLIDCGLFQGQKTLKELNYGDFPFRPAEIDAVLLTHAHIDHSGLLPKLVRLGF
DGRIFATRGTIDLCSWMLPDAGNIQEQEVLALNRRNIARGRGEVSPIYTQADAIAALQYFQPIAYETWTDVIAGVRARYW
NAGHLLGSASIEIELAGKGTGGAPLRLLASGDVGPDAKLLQPDPKAPAGFDYVISEATYGDRIREPTTPELRRERLAVEV
RDAAAARGALLIPAFAVERTQELIVDLVGLMERGGIPAAPIFLDSPLAIHATEVFRAHAGSLDGGSDVGRLLSSPHLRFT
ETVDESKAIAKLTGFHIVIAASGMCDAGRIRHHLKRWLWNHRATVLLVGYQANGTLGRFLQDGVKAVRIQGEEIKVGARI
RMIDDYSGHADGTEIARWIAARRPIARGLFLSHGEEAAIAAPSARVAGRIVPAANVFSPLLDDIYELTSAMPTPLDVARR
RRLAPEAVTRLDWHNDMSGLLLDIHARIEQAADDRARGVIIRRLRRALEE

Sequences:

>Translated_530_residues
MSVTLRFCGAAHTVTGSCYLLRTDQGQVLIDCGLFQGQKTLKELNYGDFPFRPAEIDAVLLTHAHIDHSGLLPKLVRLGF
DGRIFATRGTIDLCSWMLPDAGNIQEQEVLALNRRNIARGRGEVSPIYTQADAIAALQYFQPIAYETWTDVIAGVRARYW
NAGHLLGSASIEIELAGKGTGGAPLRLLASGDVGPDAKLLQPDPKAPAGFDYVISEATYGDRIREPTTPELRRERLAVEV
RDAAAARGALLIPAFAVERTQELIVDLVGLMERGGIPAAPIFLDSPLAIHATEVFRAHAGSLDGGSDVGRLLSSPHLRFT
ETVDESKAIAKLTGFHIVIAASGMCDAGRIRHHLKRWLWNHRATVLLVGYQANGTLGRFLQDGVKAVRIQGEEIKVGARI
RMIDDYSGHADGTEIARWIAARRPIARGLFLSHGEEAAIAAPSARVAGRIVPAANVFSPLLDDIYELTSAMPTPLDVARR
RRLAPEAVTRLDWHNDMSGLLLDIHARIEQAADDRARGVIIRRLRRALEE
>Mature_529_residues
SVTLRFCGAAHTVTGSCYLLRTDQGQVLIDCGLFQGQKTLKELNYGDFPFRPAEIDAVLLTHAHIDHSGLLPKLVRLGFD
GRIFATRGTIDLCSWMLPDAGNIQEQEVLALNRRNIARGRGEVSPIYTQADAIAALQYFQPIAYETWTDVIAGVRARYWN
AGHLLGSASIEIELAGKGTGGAPLRLLASGDVGPDAKLLQPDPKAPAGFDYVISEATYGDRIREPTTPELRRERLAVEVR
DAAAARGALLIPAFAVERTQELIVDLVGLMERGGIPAAPIFLDSPLAIHATEVFRAHAGSLDGGSDVGRLLSSPHLRFTE
TVDESKAIAKLTGFHIVIAASGMCDAGRIRHHLKRWLWNHRATVLLVGYQANGTLGRFLQDGVKAVRIQGEEIKVGARIR
MIDDYSGHADGTEIARWIAARRPIARGLFLSHGEEAAIAAPSARVAGRIVPAANVFSPLLDDIYELTSAMPTPLDVARRR
RLAPEAVTRLDWHNDMSGLLLDIHARIEQAADDRARGVIIRRLRRALEE

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI7706427, Length=451, Percent_Identity=28.159645232816, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI33300633, Length=487, Percent_Identity=22.9979466119097, Blast_Score=122, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI32566029, Length=433, Percent_Identity=26.0969976905312, Blast_Score=129, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI32564696, Length=449, Percent_Identity=24.7216035634744, Blast_Score=118, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6323307, Length=466, Percent_Identity=25.9656652360515, Blast_Score=138, Evalue=3e-33,
Organism=Drosophila melanogaster, GI24648013, Length=443, Percent_Identity=27.313769751693, Blast_Score=151, Evalue=9e-37,
Organism=Drosophila melanogaster, GI21358523, Length=443, Percent_Identity=25.7336343115124, Blast_Score=123, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 57818; Mature: 57687

Theoretical pI: Translated: 7.48; Mature: 7.48

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVTLRFCGAAHTVTGSCYLLRTDQGQVLIDCGLFQGQKTLKELNYGDFPFRPAEIDAVL
CEEEEEECCCCEEECCEEEEEEECCCCEEEEECCCCCHHHHHHCCCCCCCCCCCCCCEEE
LTHAHIDHSGLLPKLVRLGFDGRIFATRGTIDLCSWMLPDAGNIQEQEVLALNRRNIARG
EEEECCCCCCHHHHHHHCCCCCEEEEECCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHCC
RGEVSPIYTQADAIAALQYFQPIAYETWTDVIAGVRARYWNAGHLLGSASIEIELAGKGT
CCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCEEEEEEECCCC
GGAPLRLLASGDVGPDAKLLQPDPKAPAGFDYVISEATYGDRIREPTTPELRRERLAVEV
CCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHEEECCCCCCCCCCCCCHHHHHHHHHEEE
RDAAAARGALLIPAFAVERTQELIVDLVGLMERGGIPAAPIFLDSPLAIHATEVFRAHAG
HHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCEEHHHHHHHHHCC
SLDGGSDVGRLLSSPHLRFTETVDESKAIAKLTGFHIVIAASGMCDAGRIRHHLKRWLWN
CCCCCHHHHHHHCCCCCEEEHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHC
HRATVLLVGYQANGTLGRFLQDGVKAVRIQGEEIKVGARIRMIDDYSGHADGTEIARWIA
CCCEEEEEEEECCCCHHHHHHHCHHEEEEECCEEEECEEEEEEECCCCCCCHHHHHHHHH
ARRPIARGLFLSHGEEAAIAAPSARVAGRIVPAANVFSPLLDDIYELTSAMPTPLDVARR
HCCCHHHHHHHCCCCCCEEECCCHHHHCEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHH
RRLAPEAVTRLDWHNDMSGLLLDIHARIEQAADDRARGVIIRRLRRALEE
HCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SVTLRFCGAAHTVTGSCYLLRTDQGQVLIDCGLFQGQKTLKELNYGDFPFRPAEIDAVL
EEEEEECCCCEEECCEEEEEEECCCCEEEEECCCCCHHHHHHCCCCCCCCCCCCCCEEE
LTHAHIDHSGLLPKLVRLGFDGRIFATRGTIDLCSWMLPDAGNIQEQEVLALNRRNIARG
EEEECCCCCCHHHHHHHCCCCCEEEEECCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHCC
RGEVSPIYTQADAIAALQYFQPIAYETWTDVIAGVRARYWNAGHLLGSASIEIELAGKGT
CCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCEEEEEEECCCC
GGAPLRLLASGDVGPDAKLLQPDPKAPAGFDYVISEATYGDRIREPTTPELRRERLAVEV
CCCCEEEEECCCCCCCCCCCCCCCCCCCCCHHEEECCCCCCCCCCCCCHHHHHHHHHEEE
RDAAAARGALLIPAFAVERTQELIVDLVGLMERGGIPAAPIFLDSPLAIHATEVFRAHAG
HHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCEEHHHHHHHHHCC
SLDGGSDVGRLLSSPHLRFTETVDESKAIAKLTGFHIVIAASGMCDAGRIRHHLKRWLWN
CCCCCHHHHHHHCCCCCEEEHHHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHHHHHHC
HRATVLLVGYQANGTLGRFLQDGVKAVRIQGEEIKVGARIRMIDDYSGHADGTEIARWIA
CCCEEEEEEEECCCCHHHHHHHCHHEEEEECCEEEECEEEEEEECCCCCCCHHHHHHHHH
ARRPIARGLFLSHGEEAAIAAPSARVAGRIVPAANVFSPLLDDIYELTSAMPTPLDVARR
HCCCHHHHHHHCCCCCCEEECCCHHHHCEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHH
RRLAPEAVTRLDWHNDMSGLLLDIHARIEQAADDRARGVIIRRLRRALEE
HCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA