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The map label for this gene is folE [H]

Identifier: 146339620

GI number: 146339620

Start: 2801417

End: 2802037

Strand: Reverse

Name: folE [H]

Synonym: BRADO2613

Alternate gene names: 146339620

Gene position: 2802037-2801417 (Counterclockwise)

Preceding gene: 146339621

Following gene: 146339619

Centisome position: 37.58

GC content: 65.06

Gene sequence:

>621_bases
GTGCGCAACACAGCCAAGAAACTCCCCTTCGTTTGCGATCCCGTCACGGTCACCCAGGACGACGTCGAGGACGCCATCCG
CACCATCCTGACCTGGATCGGCGAGGATCCCTCGCGCGAGGGCCTCTCGGAGACGCCGGCCCGCGTCGCCCGCGCCTACA
AGAGCTACTTCGCCGGCTACGACCAGAACCCGGAGGACTATCTCCGCAAGACCTTCGAGGAGACCGCCGGCTACGACGAG
ATGGTGCTGCTGCGGAACATCCCCTTCCAGAGCCACTGCGAGCACCACATGGCGCCGATCATCGGCCGCGCTTGGGTCGG
CTACGTGCCGCGCAACCGTGTCGTTGGCATTTCCAAGCTCGCCCGGGTCGTCGAGGCCTACGCGGCCCGGCTGCAGATCC
AGGAGCGCATGACAGCCGAGATCGCCAACATCATCGACGAGGTGCTCCAGCCGGAAGGCGTTGCCGTCGTCATCAAGGCC
GCCCACCACTGCATCAGCTCACGCGGGGTCAAGAAGCATGGCGTCGACCTGACCACCAGCCGCATGCTCGGCTGCTTCCG
CTCTGACCCGATGAGCCGGCAGGAGTTTCTCGCGATGGTTAACTCCGACCTGAAGGATTGA

Upstream 100 bases:

>100_bases
TGGACGCGCTCGACTGAGCGCGGCCGCGCCCGGCCATTTTGCGAGACCGGTGATCCACGGGCACGGGGGTTCCGTTTCCC
TACTTTCGGAGAGCCCCCAC

Downstream 100 bases:

>100_bases
CGACCGCGAAAATTCTCGACCCGCTGTGATCCAGCCCGACATCCAGTGCGTTCCCCGGTATCGAAGAGGCGTGCCGGGGA
TCATGACCACGCGACTGAGA

Product: GTP cyclohydrolase I

Products: NA

Alternate protein names: GTP cyclohydrolase I; GTP-CH-I [H]

Number of amino acids: Translated: 206; Mature: 206

Protein sequence:

>206_residues
MRNTAKKLPFVCDPVTVTQDDVEDAIRTILTWIGEDPSREGLSETPARVARAYKSYFAGYDQNPEDYLRKTFEETAGYDE
MVLLRNIPFQSHCEHHMAPIIGRAWVGYVPRNRVVGISKLARVVEAYAARLQIQERMTAEIANIIDEVLQPEGVAVVIKA
AHHCISSRGVKKHGVDLTTSRMLGCFRSDPMSRQEFLAMVNSDLKD

Sequences:

>Translated_206_residues
MRNTAKKLPFVCDPVTVTQDDVEDAIRTILTWIGEDPSREGLSETPARVARAYKSYFAGYDQNPEDYLRKTFEETAGYDE
MVLLRNIPFQSHCEHHMAPIIGRAWVGYVPRNRVVGISKLARVVEAYAARLQIQERMTAEIANIIDEVLQPEGVAVVIKA
AHHCISSRGVKKHGVDLTTSRMLGCFRSDPMSRQEFLAMVNSDLKD
>Mature_206_residues
MRNTAKKLPFVCDPVTVTQDDVEDAIRTILTWIGEDPSREGLSETPARVARAYKSYFAGYDQNPEDYLRKTFEETAGYDE
MVLLRNIPFQSHCEHHMAPIIGRAWVGYVPRNRVVGISKLARVVEAYAARLQIQERMTAEIANIIDEVLQPEGVAVVIKA
AHHCISSRGVKKHGVDLTTSRMLGCFRSDPMSRQEFLAMVNSDLKD

Specific function: Tetrahydrofolate biosynthesis; first step. [C]

COG id: COG0302

COG function: function code H; GTP cyclohydrolase I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase I family [H]

Homologues:

Organism=Homo sapiens, GI66932968, Length=179, Percent_Identity=46.3687150837989, Blast_Score=171, Evalue=3e-43,
Organism=Homo sapiens, GI4503949, Length=179, Percent_Identity=46.3687150837989, Blast_Score=171, Evalue=3e-43,
Organism=Homo sapiens, GI66932970, Length=147, Percent_Identity=43.5374149659864, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI66932972, Length=137, Percent_Identity=45.985401459854, Blast_Score=127, Evalue=6e-30,
Organism=Escherichia coli, GI1788476, Length=174, Percent_Identity=37.3563218390805, Blast_Score=119, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17560486, Length=179, Percent_Identity=45.8100558659218, Blast_Score=179, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6321706, Length=182, Percent_Identity=47.8021978021978, Blast_Score=173, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24656782, Length=183, Percent_Identity=46.448087431694, Blast_Score=167, Evalue=5e-42,
Organism=Drosophila melanogaster, GI24656796, Length=183, Percent_Identity=46.448087431694, Blast_Score=166, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24656791, Length=183, Percent_Identity=46.448087431694, Blast_Score=166, Evalue=1e-41,

Paralogues:

None

Copy number: 420 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001474
- InterPro:   IPR020602
- InterPro:   IPR018234 [H]

Pfam domain/function: PF01227 GTP_cyclohydroI [H]

EC number: =3.5.4.16 [H]

Molecular weight: Translated: 23238; Mature: 23238

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00859 GTP_CYCLOHYDROL_1_1 ; PS00860 GTP_CYCLOHYDROL_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNTAKKLPFVCDPVTVTQDDVEDAIRTILTWIGEDPSREGLSETPARVARAYKSYFAGY
CCCCHHHCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCC
DQNPEDYLRKTFEETAGYDEMVLLRNIPFQSHCEHHMAPIIGRAWVGYVPRNRVVGISKL
CCCHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEECHHHH
ARVVEAYAARLQIQERMTAEIANIIDEVLQPEGVAVVIKAAHHCISSRGVKKHGVDLTTS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHCCCCHHHH
RMLGCFRSDPMSRQEFLAMVNSDLKD
HHHHHHHCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MRNTAKKLPFVCDPVTVTQDDVEDAIRTILTWIGEDPSREGLSETPARVARAYKSYFAGY
CCCCHHHCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCC
DQNPEDYLRKTFEETAGYDEMVLLRNIPFQSHCEHHMAPIIGRAWVGYVPRNRVVGISKL
CCCHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCEECHHHH
ARVVEAYAARLQIQERMTAEIANIIDEVLQPEGVAVVIKAAHHCISSRGVKKHGVDLTTS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHCCCCHHHH
RMLGCFRSDPMSRQEFLAMVNSDLKD
HHHHHHHCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]