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The map label for this gene is hprA [H]

Identifier: 146339544

GI number: 146339544

Start: 2708922

End: 2709806

Strand: Reverse

Name: hprA [H]

Synonym: BRADO2535

Alternate gene names: 146339544

Gene position: 2709806-2708922 (Counterclockwise)

Preceding gene: 146339545

Following gene: 146339542

Centisome position: 36.34

GC content: 68.36

Gene sequence:

>885_bases
TTGTCGCTGGCCGAGATCTTCGAGCGGCAGCGCCAATCTGGCGATCCCGAGATGCGCGTGCATCTCGATCCCGACATCAA
GCCGGAGGACTGGCCGGTCATTCTCGACGGCGCGGAGATCGGCGTGGTCGACCACACCGCGCTGCCGACAGACGTCGCGA
AGCAGTGCAAGGGGCTCAAGCATGTCGTGTTCCTCGGCACCGGCGCGCGCAGCTACATGGATCCCGAAGAGCTGGCCGAG
CTCGGCATCACCGTTCACCTGATCAAGGGCTATGGCGACACGGCGGTGGCGGAAGCTGCCGTCGCCCTGATGTGGGCTTC
GGCGCGCGGCCTCGCGCAGATGGACCGCGAGATGCGCGCCGGCAACTGGCTGCGCGACGACGGCATGCAGCTCACCGGCA
AGACACTCGGCCTGATCGGCTTCGGCGGCATCGCCGCCGAGGTCGCGCGCATCGCGTCGGGCAGCGGCATGAAGGTGATC
GCCTGGAACCGGTCGCCGAAGAGCCATCCGGGCGTGGAGTTCGTGTCGCTCGATCAGCTGCTGGCGACCAGCCACGTGGT
CTCGCTGCATCTCCTGCTCAACGACGACACCCGCGGCTTCCTCTCGCGCGAGCGCATCGCGCAGATGCGCAACGGCGTGC
TCTTCGTCAACACCGCCCGCGCCGCCATCGTCGACGAAGCCGCGATGATCGACGCGCTCCGCTCCGGCCACATCCGCCAC
GCCGGCCTCGACGTCTTCAATACGGAGCCGCTGCCGGCCGGTCACGTGCTGACGACGATCCCCAACGTGACGCTGTCGGC
GCACTCGGCGTTCCGCACCCCCGAGGCGAGCGAGAACCTGATCCACGCCGCCTGGGAGCACTGCCGAAGGGTGGCGAAGA
CGTAG

Upstream 100 bases:

>100_bases
GAGACGCTTCGAGCCAGAACAACAGTCAGTCGCCCTGCCCCATCTGCTCATGGGATCTAATCAGGAGGTATCAGTGCGCG
GAGTTTTCATCGACGCTAAC

Downstream 100 bases:

>100_bases
TTATTTGACGCGTAGGGTGGGCAAAGCGGCCGCCGCAGGCGGCAGCGTGCCCACCATCGATCAGCGCGCACGCGGCAAGA
TGGTGGGCACGGCGCCACTA

Product: putative phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: GDH; Glyoxylate reductase; Hydroxypyruvate dehydrogenase; NADH-dependent hydroxypyruvate reductase; HPR; HPR-A [H]

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MSLAEIFERQRQSGDPEMRVHLDPDIKPEDWPVILDGAEIGVVDHTALPTDVAKQCKGLKHVVFLGTGARSYMDPEELAE
LGITVHLIKGYGDTAVAEAAVALMWASARGLAQMDREMRAGNWLRDDGMQLTGKTLGLIGFGGIAAEVARIASGSGMKVI
AWNRSPKSHPGVEFVSLDQLLATSHVVSLHLLLNDDTRGFLSRERIAQMRNGVLFVNTARAAIVDEAAMIDALRSGHIRH
AGLDVFNTEPLPAGHVLTTIPNVTLSAHSAFRTPEASENLIHAAWEHCRRVAKT

Sequences:

>Translated_294_residues
MSLAEIFERQRQSGDPEMRVHLDPDIKPEDWPVILDGAEIGVVDHTALPTDVAKQCKGLKHVVFLGTGARSYMDPEELAE
LGITVHLIKGYGDTAVAEAAVALMWASARGLAQMDREMRAGNWLRDDGMQLTGKTLGLIGFGGIAAEVARIASGSGMKVI
AWNRSPKSHPGVEFVSLDQLLATSHVVSLHLLLNDDTRGFLSRERIAQMRNGVLFVNTARAAIVDEAAMIDALRSGHIRH
AGLDVFNTEPLPAGHVLTTIPNVTLSAHSAFRTPEASENLIHAAWEHCRRVAKT
>Mature_293_residues
SLAEIFERQRQSGDPEMRVHLDPDIKPEDWPVILDGAEIGVVDHTALPTDVAKQCKGLKHVVFLGTGARSYMDPEELAEL
GITVHLIKGYGDTAVAEAAVALMWASARGLAQMDREMRAGNWLRDDGMQLTGKTLGLIGFGGIAAEVARIASGSGMKVIA
WNRSPKSHPGVEFVSLDQLLATSHVVSLHLLLNDDTRGFLSRERIAQMRNGVLFVNTARAAIVDEAAMIDALRSGHIRHA
GLDVFNTEPLPAGHVLTTIPNVTLSAHSAFRTPEASENLIHAAWEHCRRVAKT

Specific function: Plays a central role in assimilation of carbon. It converts hydroxypyruvate to glycerate as a key step in the serine cycle, and may also play an important role in C2 reactions, by interconverting glyoxylate and glycolate [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=237, Percent_Identity=34.1772151898734, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI145580578, Length=251, Percent_Identity=31.8725099601594, Blast_Score=101, Evalue=7e-22,
Organism=Homo sapiens, GI4557499, Length=251, Percent_Identity=31.8725099601594, Blast_Score=101, Evalue=7e-22,
Organism=Homo sapiens, GI145580575, Length=254, Percent_Identity=31.496062992126, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI6912396, Length=203, Percent_Identity=31.0344827586207, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI61743967, Length=254, Percent_Identity=28.740157480315, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI4557497, Length=254, Percent_Identity=28.740157480315, Blast_Score=93, Evalue=3e-19,
Organism=Escherichia coli, GI1787645, Length=254, Percent_Identity=30.7086614173228, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1789279, Length=256, Percent_Identity=31.25, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI87082289, Length=206, Percent_Identity=33.0097087378641, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI87081824, Length=152, Percent_Identity=34.2105263157895, Blast_Score=74, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=187, Percent_Identity=31.5508021390374, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI25147481, Length=248, Percent_Identity=28.2258064516129, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324055, Length=225, Percent_Identity=34.2222222222222, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6320925, Length=293, Percent_Identity=27.3037542662116, Blast_Score=95, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6322116, Length=271, Percent_Identity=27.3062730627306, Blast_Score=93, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6324964, Length=275, Percent_Identity=26.1818181818182, Blast_Score=69, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24646446, Length=251, Percent_Identity=32.6693227091633, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24646448, Length=251, Percent_Identity=32.6693227091633, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24646452, Length=251, Percent_Identity=32.6693227091633, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24646450, Length=251, Percent_Identity=32.6693227091633, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI62472511, Length=254, Percent_Identity=32.2834645669291, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24585516, Length=213, Percent_Identity=31.924882629108, Blast_Score=98, Evalue=8e-21,
Organism=Drosophila melanogaster, GI19921140, Length=196, Percent_Identity=31.6326530612245, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI28574286, Length=226, Percent_Identity=29.2035398230088, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI45552429, Length=223, Percent_Identity=30.4932735426009, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24585514, Length=223, Percent_Identity=30.9417040358744, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI28574282, Length=223, Percent_Identity=30.9417040358744, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI45551003, Length=223, Percent_Identity=30.9417040358744, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28574284, Length=223, Percent_Identity=30.9417040358744, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28571528, Length=220, Percent_Identity=30.9090909090909, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.29 [H]

Molecular weight: Translated: 31884; Mature: 31753

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLAEIFERQRQSGDPEMRVHLDPDIKPEDWPVILDGAEIGVVDHTALPTDVAKQCKGLK
CCHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEECCCEEEEEECCCCCHHHHHHCCCCE
HVVFLGTGARSYMDPEELAELGITVHLIKGYGDTAVAEAAVALMWASARGLAQMDREMRA
EEEEEECCCCCCCCHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHC
GNWLRDDGMQLTGKTLGLIGFGGIAAEVARIASGSGMKVIAWNRSPKSHPGVEFVSLDQL
CCCCCCCCCEECCCEEEEEECCHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEHHHHH
LATSHVVSLHLLLNDDTRGFLSRERIAQMRNGVLFVNTARAAIVDEAAMIDALRSGHIRH
HHHHHEEEEEEEECCCCCHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHCCCCEE
AGLDVFNTEPLPAGHVLTTIPNVTLSAHSAFRTPEASENLIHAAWEHCRRVAKT
CCCCEECCCCCCCCCCEECCCCCEEECCHHHCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SLAEIFERQRQSGDPEMRVHLDPDIKPEDWPVILDGAEIGVVDHTALPTDVAKQCKGLK
CHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEECCCEEEEEECCCCCHHHHHHCCCCE
HVVFLGTGARSYMDPEELAELGITVHLIKGYGDTAVAEAAVALMWASARGLAQMDREMRA
EEEEEECCCCCCCCHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHHC
GNWLRDDGMQLTGKTLGLIGFGGIAAEVARIASGSGMKVIAWNRSPKSHPGVEFVSLDQL
CCCCCCCCCEECCCEEEEEECCHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEEHHHHH
LATSHVVSLHLLLNDDTRGFLSRERIAQMRNGVLFVNTARAAIVDEAAMIDALRSGHIRH
HHHHHEEEEEEEECCCCCHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHCCCCEE
AGLDVFNTEPLPAGHVLTTIPNVTLSAHSAFRTPEASENLIHAAWEHCRRVAKT
CCCCEECCCCCCCCCCEECCCCCEEECCHHHCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8144463; 1729225; 1657886 [H]