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The map label for this gene is aroE [H]

Identifier: 146339365

GI number: 146339365

Start: 2498457

End: 2499299

Strand: Reverse

Name: aroE [H]

Synonym: BRADO2346

Alternate gene names: 146339365

Gene position: 2499299-2498457 (Counterclockwise)

Preceding gene: 146339367

Following gene: 146339364

Centisome position: 33.52

GC content: 67.26

Gene sequence:

>843_bases
ATGTCGCAAGCGAACGGATTTGGACTGGCTGGCGTCATCGGCATGCCCGTCGCCCACTCGCGCTCTCCCACGATTCACAA
TTTCTGGCTGAACGCGCACGGGCTGCGCGGCGTCTATGTCCCGCTGGCGGTGCAGCCGGAGCGGCTCAAGGATGCCCTTG
CGGGGCTGGTGGCGCTCGGCTTTCGCGGCTGCAACGTCACCATGCCGCACAAGCAGACGGCGATGCCCCTGCTGCACCGG
GTCAATGACACCGCGCGGCGCATCGGCGCCGTCAACACCATCGTCGTCGAGCAGGATGGGACGCTGAGCGGCTTCAACAA
TGACGGCAATGGCTTCGTTCAGAGCCTCCGCGACGCCAAGCCGGCTTGGCGCGCCGACGAGGGTCCGATCCTGCTGCTCG
GCGCCGGCGGCGCGGCGCGCGCGGTGGTCGTCGCACTGCTGGAGAACGGCGCCCGCGAGATCCGCATCAGCAACCGTACT
GACGACAAGGCGAAAGCCATCGCCGCGGAGTTTGGCTCCGTCATCAGCACGGTGACTTGGGATCATCGCTCCGGCGCCGT
CGCCGATGTCGCGCTGCTGATCAACAGCACTGATCGCGGCATGATCGGCAAGCCCGCGCTGGAGATCGACCTGACGCGGC
TGTCCGCGAAGACGCTCGTGGCCGACCTGATCTACACGCCGCTGGAGACGCCCTTCCTGGCGGACGCGCGCGCCCGCGGC
TGTACCACCGTCAACGGTCTCGGCCTGCTGCTCAACCAGGCGCGTCTCGCCTTCCAGGCCTGGTTTGGCGTTCTGCCGGA
CGTCACACCGGAGCTGATCAAGGCCATCCAAGCGACGTTCTGA

Upstream 100 bases:

>100_bases
GTGACGGAATGTTTCAATTGCATGGCTGGATCATTGTCCATAAGACGATTTCATATCGGCCGGAACAGGCCGAAATCCCG
ACGGGAGGCCTTGGCGCAGC

Downstream 100 bases:

>100_bases
TGCTCAGACAATAACAACCCCGCCATGGCGCTCCCGACAGGACCACGGATCGACTGCCATATCCACGTCATCGATCCCGC
GCGCTTTCCCTATGCGGCGG

Product: shikimate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 280; Mature: 279

Protein sequence:

>280_residues
MSQANGFGLAGVIGMPVAHSRSPTIHNFWLNAHGLRGVYVPLAVQPERLKDALAGLVALGFRGCNVTMPHKQTAMPLLHR
VNDTARRIGAVNTIVVEQDGTLSGFNNDGNGFVQSLRDAKPAWRADEGPILLLGAGGAARAVVVALLENGAREIRISNRT
DDKAKAIAAEFGSVISTVTWDHRSGAVADVALLINSTDRGMIGKPALEIDLTRLSAKTLVADLIYTPLETPFLADARARG
CTTVNGLGLLLNQARLAFQAWFGVLPDVTPELIKAIQATF

Sequences:

>Translated_280_residues
MSQANGFGLAGVIGMPVAHSRSPTIHNFWLNAHGLRGVYVPLAVQPERLKDALAGLVALGFRGCNVTMPHKQTAMPLLHR
VNDTARRIGAVNTIVVEQDGTLSGFNNDGNGFVQSLRDAKPAWRADEGPILLLGAGGAARAVVVALLENGAREIRISNRT
DDKAKAIAAEFGSVISTVTWDHRSGAVADVALLINSTDRGMIGKPALEIDLTRLSAKTLVADLIYTPLETPFLADARARG
CTTVNGLGLLLNQARLAFQAWFGVLPDVTPELIKAIQATF
>Mature_279_residues
SQANGFGLAGVIGMPVAHSRSPTIHNFWLNAHGLRGVYVPLAVQPERLKDALAGLVALGFRGCNVTMPHKQTAMPLLHRV
NDTARRIGAVNTIVVEQDGTLSGFNNDGNGFVQSLRDAKPAWRADEGPILLLGAGGAARAVVVALLENGAREIRISNRTD
DKAKAIAAEFGSVISTVTWDHRSGAVADVALLINSTDRGMIGKPALEIDLTRLSAKTLVADLIYTPLETPFLADARARGC
TTVNGLGLLLNQARLAFQAWFGVLPDVTPELIKAIQATF

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787983, Length=282, Percent_Identity=34.0425531914894, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1789675, Length=273, Percent_Identity=35.5311355311355, Blast_Score=127, Evalue=9e-31,
Organism=Saccharomyces cerevisiae, GI6320332, Length=267, Percent_Identity=28.0898876404494, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151 [H]

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N [H]

EC number: =1.1.1.25 [H]

Molecular weight: Translated: 29744; Mature: 29612

Theoretical pI: Translated: 9.26; Mature: 9.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQANGFGLAGVIGMPVAHSRSPTIHNFWLNAHGLRGVYVPLAVQPERLKDALAGLVALG
CCCCCCCCCHHHHCCCCCCCCCCCEEEEEEECCCCCEEEEEEEECHHHHHHHHHHHHHHC
FRGCNVTMPHKQTAMPLLHRVNDTARRIGAVNTIVVEQDGTLSGFNNDGNGFVQSLRDAK
CCCCCEECCCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCHHHHHHHHHCC
PAWRADEGPILLLGAGGAARAVVVALLENGAREIRISNRTDDKAKAIAAEFGSVISTVTW
CCCCCCCCCEEEEECCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHEEE
DHRSGAVADVALLINSTDRGMIGKPALEIDLTRLSAKTLVADLIYTPLETPFLADARARG
CCCCCCCEEEEEEEECCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
CTTVNGLGLLLNQARLAFQAWFGVLPDVTPELIKAIQATF
CCEECHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
SQANGFGLAGVIGMPVAHSRSPTIHNFWLNAHGLRGVYVPLAVQPERLKDALAGLVALG
CCCCCCCCHHHHCCCCCCCCCCCEEEEEEECCCCCEEEEEEEECHHHHHHHHHHHHHHC
FRGCNVTMPHKQTAMPLLHRVNDTARRIGAVNTIVVEQDGTLSGFNNDGNGFVQSLRDAK
CCCCCEECCCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCCHHHHHHHHHCC
PAWRADEGPILLLGAGGAARAVVVALLENGAREIRISNRTDDKAKAIAAEFGSVISTVTW
CCCCCCCCCEEEEECCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHEEE
DHRSGAVADVALLINSTDRGMIGKPALEIDLTRLSAKTLVADLIYTPLETPFLADARARG
CCCCCCCEEEEEEEECCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
CTTVNGLGLLLNQARLAFQAWFGVLPDVTPELIKAIQATF
CCEECHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA