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The map label for this gene is hbd [H]

Identifier: 146339334

GI number: 146339334

Start: 2466190

End: 2467134

Strand: Reverse

Name: hbd [H]

Synonym: BRADO2315

Alternate gene names: 146339334

Gene position: 2467134-2466190 (Counterclockwise)

Preceding gene: 146339335

Following gene: 146339327

Centisome position: 33.09

GC content: 67.2

Gene sequence:

>945_bases
ATGGGCCGCGGCATCGCCGTCGCCTTCGCCTATGCCGGTCATCCCGTCACGATGATCGACATCAAGCCGCGTACGGCCGA
GGAGTTCGGCAGGCTGGAGCGCGAGGCGCTCAGCGAGATCAGTGCGACGTTCGCGACGCTGGCGCGGCTCGGAATGCTGC
AAGCCGCCGATGCCGACAGGCTGATGGGAAAGATCGACGTCGCGCCGGCGAGTGCGAGCAACGACGTGCTGGCGCAGACG
ACGCTGGTGTTCGAGGGCGTGCCGGAGATCGTCGATCTCAAGCGCGAGGTGCTCGGCGCGGCCTCGCGCGCCGTGGCGCC
CGACGTGATCATCGCGTCGACGACGTCGACGATCCTGGTCGATGATCTCTCCGGCGCAATCGAGAAGCCCGAGCGCTTCC
TCAATGCGCACTGGCTCAATCCGGCCTATCTGATCCCGCTGGTCGAGATCTCGCCGGGCCAGGCGACCGATCCCGACGTC
ACGGCGCGGCTGAAGGCGCTGCTCGAAGGCATCGGCAAGGTGCCCGTGGTGTGCGCGGCGACGCCGGGCTTCATCGTGCC
GCGCATCCAGGCGCTCGCGATGAACGAGGCCGCGCGCATGGTCGGCGAAGGCGTCGCCAGCGCCGAGGAGATCGACAAGG
CGATCCGCTACGGGTTCGGCTTCCGCTACGCGGTGCTCGGCCTGTTGGAGTTCATCGACTGGGGCGGCGGCGACATTCTG
TACTACGCGAGCCGCTATCTCGAAGGCGCGCTGGGCAGCGATCGCTATCGCGCGCCCGAGGTGATCGAGCGCAACATGGC
CGAGGGCCGCATCGGCCTGCGCACCGGAACGGGATTTCTCAATTATTCGGGAATGGACGTGAGCGCCTATCGCGAGCAAC
GGCTTGGGGCGCTGGTCGAGATGCTCAGGCATTTCAAGCTGGCCAGGCCGCCAGTGGTGGATTGA

Upstream 100 bases:

>100_bases
GCTTTGGCAGTCTCGACCGGACCGCCTTGCAGACTCTGCTGCGCAACGGGTTCGCCGCATGAGCGCGCGCGGTCAAATCG
CCTGTCTCGGCGCCGGCCGC

Downstream 100 bases:

>100_bases
GGGCGGCACCGTAGGGTGGGCAAAGGCGCGGCACATCATCGCCGTTGCGCGACGATGTCTCTCGCGCCGTGCCCACCATC
TCGCTCAACATCCGCAGATG

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 314; Mature: 313

Protein sequence:

>314_residues
MGRGIAVAFAYAGHPVTMIDIKPRTAEEFGRLEREALSEISATFATLARLGMLQAADADRLMGKIDVAPASASNDVLAQT
TLVFEGVPEIVDLKREVLGAASRAVAPDVIIASTTSTILVDDLSGAIEKPERFLNAHWLNPAYLIPLVEISPGQATDPDV
TARLKALLEGIGKVPVVCAATPGFIVPRIQALAMNEAARMVGEGVASAEEIDKAIRYGFGFRYAVLGLLEFIDWGGGDIL
YYASRYLEGALGSDRYRAPEVIERNMAEGRIGLRTGTGFLNYSGMDVSAYREQRLGALVEMLRHFKLARPPVVD

Sequences:

>Translated_314_residues
MGRGIAVAFAYAGHPVTMIDIKPRTAEEFGRLEREALSEISATFATLARLGMLQAADADRLMGKIDVAPASASNDVLAQT
TLVFEGVPEIVDLKREVLGAASRAVAPDVIIASTTSTILVDDLSGAIEKPERFLNAHWLNPAYLIPLVEISPGQATDPDV
TARLKALLEGIGKVPVVCAATPGFIVPRIQALAMNEAARMVGEGVASAEEIDKAIRYGFGFRYAVLGLLEFIDWGGGDIL
YYASRYLEGALGSDRYRAPEVIERNMAEGRIGLRTGTGFLNYSGMDVSAYREQRLGALVEMLRHFKLARPPVVD
>Mature_313_residues
GRGIAVAFAYAGHPVTMIDIKPRTAEEFGRLEREALSEISATFATLARLGMLQAADADRLMGKIDVAPASASNDVLAQTT
LVFEGVPEIVDLKREVLGAASRAVAPDVIIASTTSTILVDDLSGAIEKPERFLNAHWLNPAYLIPLVEISPGQATDPDVT
ARLKALLEGIGKVPVVCAATPGFIVPRIQALAMNEAARMVGEGVASAEEIDKAIRYGFGFRYAVLGLLEFIDWGGGDILY
YASRYLEGALGSDRYRAPEVIERNMAEGRIGLRTGTGFLNYSGMDVSAYREQRLGALVEMLRHFKLARPPVVD

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI115430219, Length=251, Percent_Identity=30.2788844621514, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI296179429, Length=287, Percent_Identity=28.2229965156794, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI296179427, Length=303, Percent_Identity=26.7326732673267, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI261878539, Length=295, Percent_Identity=26.4406779661017, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI68989263, Length=295, Percent_Identity=26.4406779661017, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI20127408, Length=204, Percent_Identity=28.4313725490196, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1787661, Length=283, Percent_Identity=31.8021201413428, Blast_Score=124, Evalue=8e-30,
Organism=Escherichia coli, GI1788682, Length=280, Percent_Identity=30, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI1790281, Length=277, Percent_Identity=27.0758122743682, Blast_Score=96, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17553560, Length=293, Percent_Identity=28.6689419795222, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17563036, Length=298, Percent_Identity=27.1812080536913, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI71985923, Length=313, Percent_Identity=23.6421725239617, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17549919, Length=283, Percent_Identity=26.5017667844523, Blast_Score=94, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI71985930, Length=305, Percent_Identity=23.9344262295082, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17558304, Length=207, Percent_Identity=28.5024154589372, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI193203623, Length=184, Percent_Identity=27.1739130434783, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI115533614, Length=184, Percent_Identity=27.1739130434783, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI25144276, Length=202, Percent_Identity=29.2079207920792, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17508953, Length=207, Percent_Identity=28.5024154589372, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17508951, Length=207, Percent_Identity=28.5024154589372, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI45549573, Length=250, Percent_Identity=31.6, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI20129993, Length=234, Percent_Identity=32.4786324786325, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24583077, Length=287, Percent_Identity=25.7839721254355, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24583079, Length=287, Percent_Identity=25.7839721254355, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19921000, Length=287, Percent_Identity=25.7839721254355, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 33808; Mature: 33677

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRGIAVAFAYAGHPVTMIDIKPRTAEEFGRLEREALSEISATFATLARLGMLQAADADR
CCCCEEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LMGKIDVAPASASNDVLAQTTLVFEGVPEIVDLKREVLGAASRAVAPDVIIASTTSTILV
HHHHEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEE
DDLSGAIEKPERFLNAHWLNPAYLIPLVEISPGQATDPDVTARLKALLEGIGKVPVVCAA
ECHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEC
TPGFIVPRIQALAMNEAARMVGEGVASAEEIDKAIRYGFGFRYAVLGLLEFIDWGGGDIL
CCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHH
YYASRYLEGALGSDRYRAPEVIERNMAEGRIGLRTGTGFLNYSGMDVSAYREQRLGALVE
HHHHHHHHCCCCCCCCCCHHHHHHHHHCCCEEEEECCCEEEECCCCHHHHHHHHHHHHHH
MLRHFKLARPPVVD
HHHHHHCCCCCCCC
>Mature Secondary Structure 
GRGIAVAFAYAGHPVTMIDIKPRTAEEFGRLEREALSEISATFATLARLGMLQAADADR
CCCEEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
LMGKIDVAPASASNDVLAQTTLVFEGVPEIVDLKREVLGAASRAVAPDVIIASTTSTILV
HHHHEECCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEEEECCCCEEEE
DDLSGAIEKPERFLNAHWLNPAYLIPLVEISPGQATDPDVTARLKALLEGIGKVPVVCAA
ECHHHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEC
TPGFIVPRIQALAMNEAARMVGEGVASAEEIDKAIRYGFGFRYAVLGLLEFIDWGGGDIL
CCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHH
YYASRYLEGALGSDRYRAPEVIERNMAEGRIGLRTGTGFLNYSGMDVSAYREQRLGALVE
HHHHHHHHCCCCCCCCCCHHHHHHHHHCCCEEEEECCCEEEECCCCHHHHHHHHHHHHHH
MLRHFKLARPPVVD
HHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]