Click here to switch to the map view.

The map label for this gene is iorA [H]

Identifier: 146339157

GI number: 146339157

Start: 2250625

End: 2251107

Strand: Reverse

Name: iorA [H]

Synonym: BRADO2115

Alternate gene names: 146339157

Gene position: 2251107-2250625 (Counterclockwise)

Preceding gene: 146339166

Following gene: 146339156

Centisome position: 30.19

GC content: 66.05

Gene sequence:

>483_bases
ATGACGCCAGCAACGATTCGGCTGACGGTGAACGGGCGGACGCATGACGTCGCCGCCGCGTCCGACACGACCCTGCTCCA
TGTTCTGCGCAACGACTTCGCCCTGAACGGCCCGAAATACGGTTGCGGCCTCGGCGAGTGCGGCGCATGCACCGTGCTGA
TCGACGGCCGCGCCGCCCGCTCCTGCGTCATTCCGATCGAAGGCTGCATTGGCCGCAGCGTGGTCACGCTGGAGGGACTC
GGCTCGCGCGACGCACCTGATCCGGTGCAGCAAGCGTTCATCACCGAGCAGGCCGCGCAATGCGGCTATTGTCTTAACGG
CATGATCATGACGACCAAGGCGCTGCTTACGATGCGGCCAGATCCGTCGCTCGAGGAGATCAAGCAGGCGCTGCGTTACA
ATCTCTGCCGCTGCGGTGCTCACGTCGAGATCCTGCGCGCCGCGATGCGCGCGGCCGGCTACACGCTCGAGGCGCTGGAC
TGA

Upstream 100 bases:

>100_bases
CAGCGCAAAACGTGGCACTTGCATGTTAGTACACAAACGATACGCTCCGGGCGATCGCGATCCGTTTCGTTAACGATAGC
ATAGCAGACGGCAGAAGGGC

Downstream 100 bases:

>100_bases
TGACCGAGAGCGCCACCGTGACGGCAGATCATCTGCGCGGCGTGCTGACCGTCGCGCGCGGCATGTCTGATGGCTGCTCC
GAGACCTTCATCAGAATCAC

Product: putative isoquinoline 1-oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 160; Mature: 159

Protein sequence:

>160_residues
MTPATIRLTVNGRTHDVAAASDTTLLHVLRNDFALNGPKYGCGLGECGACTVLIDGRAARSCVIPIEGCIGRSVVTLEGL
GSRDAPDPVQQAFITEQAAQCGYCLNGMIMTTKALLTMRPDPSLEEIKQALRYNLCRCGAHVEILRAAMRAAGYTLEALD

Sequences:

>Translated_160_residues
MTPATIRLTVNGRTHDVAAASDTTLLHVLRNDFALNGPKYGCGLGECGACTVLIDGRAARSCVIPIEGCIGRSVVTLEGL
GSRDAPDPVQQAFITEQAAQCGYCLNGMIMTTKALLTMRPDPSLEEIKQALRYNLCRCGAHVEILRAAMRAAGYTLEALD
>Mature_159_residues
TPATIRLTVNGRTHDVAAASDTTLLHVLRNDFALNGPKYGCGLGECGACTVLIDGRAARSCVIPIEGCIGRSVVTLEGLG
SRDAPDPVQQAFITEQAAQCGYCLNGMIMTTKALLTMRPDPSLEEIKQALRYNLCRCGAHVEILRAAMRAAGYTLEALD

Specific function: Specific towards N-containing N-heterocyclic substrates, including isoquinoline, isoquinolin-5-ol, phthalazine and quinazoline [H]

COG id: COG2080

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=159, Percent_Identity=37.7358490566038, Blast_Score=81, Evalue=3e-16,
Organism=Homo sapiens, GI71773480, Length=90, Percent_Identity=40, Blast_Score=74, Evalue=6e-14,
Organism=Escherichia coli, GI1786480, Length=163, Percent_Identity=39.2638036809816, Blast_Score=113, Evalue=6e-27,
Organism=Escherichia coli, GI1789232, Length=147, Percent_Identity=40.8163265306122, Blast_Score=96, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17539860, Length=158, Percent_Identity=37.3417721518987, Blast_Score=112, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI32566215, Length=153, Percent_Identity=36.6013071895425, Blast_Score=109, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17540638, Length=149, Percent_Identity=38.255033557047, Blast_Score=106, Evalue=5e-24,
Organism=Drosophila melanogaster, GI17737937, Length=158, Percent_Identity=35.4430379746835, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24647193, Length=156, Percent_Identity=32.6923076923077, Blast_Score=83, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24647195, Length=158, Percent_Identity=34.8101265822785, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24647197, Length=158, Percent_Identity=34.8101265822785, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24647199, Length=152, Percent_Identity=30.2631578947368, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24647201, Length=149, Percent_Identity=29.5302013422819, Blast_Score=70, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.3.99.16 [H]

Molecular weight: Translated: 17039; Mature: 16908

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
8.8 %Cys+Met (Translated Protein)
5.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
8.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPATIRLTVNGRTHDVAAASDTTLLHVLRNDFALNGPKYGCGLGECGACTVLIDGRAAR
CCCEEEEEEECCCCCEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCC
SCVIPIEGCIGRSVVTLEGLGSRDAPDPVQQAFITEQAAQCGYCLNGMIMTTKALLTMRP
EEEEECCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCHHHCCEEEEEEEEEEECC
DPSLEEIKQALRYNLCRCGAHVEILRAAMRAAGYTLEALD
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEECC
>Mature Secondary Structure 
TPATIRLTVNGRTHDVAAASDTTLLHVLRNDFALNGPKYGCGLGECGACTVLIDGRAAR
CCEEEEEEECCCCCEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCC
SCVIPIEGCIGRSVVTLEGLGSRDAPDPVQQAFITEQAAQCGYCLNGMIMTTKALLTMRP
EEEEECCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCHHHCCEEEEEEEEEEECC
DPSLEEIKQALRYNLCRCGAHVEILRAAMRAAGYTLEALD
CCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7782304; 8157655 [H]