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The map label for this gene is ilvG [H]

Identifier: 146338783

GI number: 146338783

Start: 1833954

End: 1835666

Strand: Direct

Name: ilvG [H]

Synonym: BRADO1717

Alternate gene names: 146338783

Gene position: 1833954-1835666 (Clockwise)

Preceding gene: 146338782

Following gene: 146338785

Centisome position: 24.6

GC content: 69.29

Gene sequence:

>1713_bases
ATGAAAGTCTCGCCCGACAGTGCCGCCGACCTGATCGCTCGCCTGCTCAAGCGCCGGGGCGTCAACCGCGTGTTCGCGCT
GTGCGGCGGCCACATCATGCCGATCTGGATGCGGCTCGACGCGGCGGGGATCCAGATCATCGACGTCCGCGACGAACGCG
CCGCGGTCCACATGGCGCAAGCGCATGCAGAGCTGACCGGCGAGCTCGGCGTCGCGCTGGTCACGGCAGGACCCGGCATG
ACCAATGCGATCACCGGCATTGCGAATGCCCACGTCTCGCGCGCGCCGGTGCTGGTGCTGTCCGGCGGCAATCCACGGCC
GCAGGAGAACCGCGGTGGGCTGCAGGACATGGACCACACCCAGCTGGTGCGCTCGATCACGCGCTACGCGCGCACCGTGC
GCGAGCCGTCGCTCGTGCTGCAGGAGCTGGATGAGGCGATCGCACGCGCCTTCGGCGATGGCGGCGAGCCCGGTCCCGTC
TTCATCGACTTCCCGGTCGACACCTTGCGCGGCATCGTTCCGAAGGCGCTGCAGCTCGAGGAGCATCTCGCGCCGAAGCC
GCGTACGGCGACGCGGCCCGATCCGGCCGAGGTCGAGAGGGCGGTCGAGCTCTTGTGGTCGGCGCGCCGCGTACTCGTCA
TCTCCGGCCGCGGCGCGCGCGGCGCAGGGCCCGAGCTGATCGGCCTGCTCGACCGCCTCGGCGCCGTCTATCTCGACACA
GGCGAGAGCAGGGGTCTCGTGCCCGACGATCATCTATCGGTGGTTGGCGCGATGCGCGGCGCCGTGATGGGCGATGCCGA
CGTGGTGCTGACGGTCGGCCGGAAGCTCGACTTCCAGCTCGCCTATGGTTCGCCTGCCGTGTTCAAGGATGCCAAGTTCG
TCCGCATCAGCGACACCGCGAGCGAGCTGCGCGACAACCGCCGCGGCGCGGCCGAGATTCTCGCCGCACCCGCGGAAACG
CTCCGTGCGATCGTCGCGCTGGCTGGCAACCGCGAATCGGCTGTCGACAAATCATGGGCGGCGAAGCTGCGCGCCAGCCA
TCAGGAGCGTGCCGCCAAGCTGAAGCAGAGCATGGCGGCGGCGCCTTCCGGCTCAGACGCAAGGCTGCATCCAAATCGTG
TGCTCTCGGCCATCCAGGACGCGATCGGCAATGATGCCGTCGTCATCACTGACGGCGGCGACTTCCTGTCCTTCGCCCGT
GTCGGCTTGAGCGCGCCCTTGATGCTCGACCCCGGCCCGTTCGGATGCATCGGCGTCGGCGTGCCCTATGGCATCGCCGC
GAGCCTCGCTTATCCCGATAAGCCGGTGGTGGTCGCGACCGGCGACGGCGCGTTCGGCTTCAATGCGATCGAGGTGGATA
CCGCCGTCCGCCACAAGGCGCCGGTGCTGATCGTCGTCGCCAACAACGGCGCCTGGCAGATCGAGGTACACGACCAGACC
GTCACGCACGGCAAGGTGGTCGGCACGAAGCTGCAATTCGCCGATCACGCCGCCATGGCGCGCGCCTTCGGCATGCATGC
CGAGAGGGTCGAGACCGAGGAACAGCTGGGGCCTGCGGTCCAGCGCGCACTGGCCAACCGTCCGGCGCTGCTCGACGTGG
TGGTGACGCCGGAGGCGGTGTCGTCGGATGCCAAGACGGGACTTGCGTGGGTGCCGGACCTGCAGCCGCTGGCGGCGTGG
GACGAGGCGGAGCGGAAGTGGCGCGGCTCGTGA

Upstream 100 bases:

>100_bases
GGCTCGATCCTGGTCTCGCACATCTTCGCCGTCCTCACCGTCTCGCTGCTCGTAGCCTGGCTCGCGCCGGGCTGATCGCG
TTCTCTTCCGGAGTGGTCCG

Downstream 100 bases:

>100_bases
ACCGCTCGCGTCTTTACGTCTGCTCCAACTGCCTTGGTGCACTCAGCCACAGCGCCAGCAACGTGCACACCGCGCCTGAC
AGCAGATAGCCGCCGGCCGA

Product: putative acetolactate synthase

Products: NA

Alternate protein names: ALS; Acetohydroxy-acid synthase [H]

Number of amino acids: Translated: 570; Mature: 570

Protein sequence:

>570_residues
MKVSPDSAADLIARLLKRRGVNRVFALCGGHIMPIWMRLDAAGIQIIDVRDERAAVHMAQAHAELTGELGVALVTAGPGM
TNAITGIANAHVSRAPVLVLSGGNPRPQENRGGLQDMDHTQLVRSITRYARTVREPSLVLQELDEAIARAFGDGGEPGPV
FIDFPVDTLRGIVPKALQLEEHLAPKPRTATRPDPAEVERAVELLWSARRVLVISGRGARGAGPELIGLLDRLGAVYLDT
GESRGLVPDDHLSVVGAMRGAVMGDADVVLTVGRKLDFQLAYGSPAVFKDAKFVRISDTASELRDNRRGAAEILAAPAET
LRAIVALAGNRESAVDKSWAAKLRASHQERAAKLKQSMAAAPSGSDARLHPNRVLSAIQDAIGNDAVVITDGGDFLSFAR
VGLSAPLMLDPGPFGCIGVGVPYGIAASLAYPDKPVVVATGDGAFGFNAIEVDTAVRHKAPVLIVVANNGAWQIEVHDQT
VTHGKVVGTKLQFADHAAMARAFGMHAERVETEEQLGPAVQRALANRPALLDVVVTPEAVSSDAKTGLAWVPDLQPLAAW
DEAERKWRGS

Sequences:

>Translated_570_residues
MKVSPDSAADLIARLLKRRGVNRVFALCGGHIMPIWMRLDAAGIQIIDVRDERAAVHMAQAHAELTGELGVALVTAGPGM
TNAITGIANAHVSRAPVLVLSGGNPRPQENRGGLQDMDHTQLVRSITRYARTVREPSLVLQELDEAIARAFGDGGEPGPV
FIDFPVDTLRGIVPKALQLEEHLAPKPRTATRPDPAEVERAVELLWSARRVLVISGRGARGAGPELIGLLDRLGAVYLDT
GESRGLVPDDHLSVVGAMRGAVMGDADVVLTVGRKLDFQLAYGSPAVFKDAKFVRISDTASELRDNRRGAAEILAAPAET
LRAIVALAGNRESAVDKSWAAKLRASHQERAAKLKQSMAAAPSGSDARLHPNRVLSAIQDAIGNDAVVITDGGDFLSFAR
VGLSAPLMLDPGPFGCIGVGVPYGIAASLAYPDKPVVVATGDGAFGFNAIEVDTAVRHKAPVLIVVANNGAWQIEVHDQT
VTHGKVVGTKLQFADHAAMARAFGMHAERVETEEQLGPAVQRALANRPALLDVVVTPEAVSSDAKTGLAWVPDLQPLAAW
DEAERKWRGS
>Mature_570_residues
MKVSPDSAADLIARLLKRRGVNRVFALCGGHIMPIWMRLDAAGIQIIDVRDERAAVHMAQAHAELTGELGVALVTAGPGM
TNAITGIANAHVSRAPVLVLSGGNPRPQENRGGLQDMDHTQLVRSITRYARTVREPSLVLQELDEAIARAFGDGGEPGPV
FIDFPVDTLRGIVPKALQLEEHLAPKPRTATRPDPAEVERAVELLWSARRVLVISGRGARGAGPELIGLLDRLGAVYLDT
GESRGLVPDDHLSVVGAMRGAVMGDADVVLTVGRKLDFQLAYGSPAVFKDAKFVRISDTASELRDNRRGAAEILAAPAET
LRAIVALAGNRESAVDKSWAAKLRASHQERAAKLKQSMAAAPSGSDARLHPNRVLSAIQDAIGNDAVVITDGGDFLSFAR
VGLSAPLMLDPGPFGCIGVGVPYGIAASLAYPDKPVVVATGDGAFGFNAIEVDTAVRHKAPVLIVVANNGAWQIEVHDQT
VTHGKVVGTKLQFADHAAMARAFGMHAERVETEEQLGPAVQRALANRPALLDVVVTPEAVSSDAKTGLAWVPDLQPLAAW
DEAERKWRGS

Specific function: Oxalic acid catabolism; second step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI21361361, Length=583, Percent_Identity=30.7032590051458, Blast_Score=251, Evalue=1e-66,
Organism=Homo sapiens, GI93004078, Length=565, Percent_Identity=27.6106194690265, Blast_Score=211, Evalue=1e-54,
Organism=Escherichia coli, GI1788716, Length=543, Percent_Identity=27.8084714548803, Blast_Score=178, Evalue=8e-46,
Organism=Escherichia coli, GI87081685, Length=566, Percent_Identity=27.208480565371, Blast_Score=171, Evalue=8e-44,
Organism=Escherichia coli, GI1787096, Length=548, Percent_Identity=25.5474452554745, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1790104, Length=552, Percent_Identity=24.0942028985507, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1786717, Length=555, Percent_Identity=24.5045045045045, Blast_Score=126, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17542570, Length=550, Percent_Identity=31.0909090909091, Blast_Score=253, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI17531299, Length=554, Percent_Identity=28.3393501805054, Blast_Score=192, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI17531301, Length=554, Percent_Identity=28.3393501805054, Blast_Score=192, Evalue=5e-49,
Organism=Saccharomyces cerevisiae, GI6320816, Length=571, Percent_Identity=25.2189141856392, Blast_Score=175, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6323755, Length=574, Percent_Identity=24.7386759581882, Blast_Score=127, Evalue=3e-30,
Organism=Drosophila melanogaster, GI19922626, Length=575, Percent_Identity=30.2608695652174, Blast_Score=221, Evalue=1e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 60407; Mature: 60407

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVSPDSAADLIARLLKRRGVNRVFALCGGHIMPIWMRLDAAGIQIIDVRDERAAVHMAQ
CCCCCCHHHHHHHHHHHHCCHHHHHHHHCCCEEEEEEEECCCCEEEEEECCCHHHHHHHH
AHAELTGELGVALVTAGPGMTNAITGIANAHVSRAPVLVLSGGNPRPQENRGGLQDMDHT
HHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCHHH
QLVRSITRYARTVREPSLVLQELDEAIARAFGDGGEPGPVFIDFPVDTLRGIVPKALQLE
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHCHHHHHHH
EHLAPKPRTATRPDPAEVERAVELLWSARRVLVISGRGARGAGPELIGLLDRLGAVYLDT
HHCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHCCEEEEEC
GESRGLVPDDHLSVVGAMRGAVMGDADVVLTVGRKLDFQLAYGSPAVFKDAKFVRISDTA
CCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCEEEEEECCCCCCCCCCEEEEECCCH
SELRDNRRGAAEILAAPAETLRAIVALAGNRESAVDKSWAAKLRASHQERAAKLKQSMAA
HHHHHCCCCHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
APSGSDARLHPNRVLSAIQDAIGNDAVVITDGGDFLSFARVGLSAPLMLDPGPFGCIGVG
CCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCCCEEECCCCCCEEECC
VPYGIAASLAYPDKPVVVATGDGAFGFNAIEVDTAVRHKAPVLIVVANNGAWQIEVHDQT
CCHHHHEECCCCCCCEEEEECCCCCCCCEEEECHHHHCCCCEEEEEECCCEEEEEECCCE
VTHGKVVGTKLQFADHAAMARAFGMHAERVETEEQLGPAVQRALANRPALLDVVVTPEAV
ECCCEEEEEEEHHHHHHHHHHHHCCHHHHHCCHHHHCHHHHHHHCCCCCEEEEEECCHHH
SSDAKTGLAWVPDLQPLAAWDEAERKWRGS
CCCCCCCEEECCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKVSPDSAADLIARLLKRRGVNRVFALCGGHIMPIWMRLDAAGIQIIDVRDERAAVHMAQ
CCCCCCHHHHHHHHHHHHCCHHHHHHHHCCCEEEEEEEECCCCEEEEEECCCHHHHHHHH
AHAELTGELGVALVTAGPGMTNAITGIANAHVSRAPVLVLSGGNPRPQENRGGLQDMDHT
HHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCHHH
QLVRSITRYARTVREPSLVLQELDEAIARAFGDGGEPGPVFIDFPVDTLRGIVPKALQLE
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHCHHHHHHH
EHLAPKPRTATRPDPAEVERAVELLWSARRVLVISGRGARGAGPELIGLLDRLGAVYLDT
HHCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHCCEEEEEC
GESRGLVPDDHLSVVGAMRGAVMGDADVVLTVGRKLDFQLAYGSPAVFKDAKFVRISDTA
CCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCEEEEEECCCCCCCCCCEEEEECCCH
SELRDNRRGAAEILAAPAETLRAIVALAGNRESAVDKSWAAKLRASHQERAAKLKQSMAA
HHHHHCCCCHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
APSGSDARLHPNRVLSAIQDAIGNDAVVITDGGDFLSFARVGLSAPLMLDPGPFGCIGVG
CCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHCCCCCEEECCCCCCEEECC
VPYGIAASLAYPDKPVVVATGDGAFGFNAIEVDTAVRHKAPVLIVVANNGAWQIEVHDQT
CCHHHHEECCCCCCCEEEEECCCCCCCCEEEECHHHHCCCCEEEEEECCCEEEEEECCCE
VTHGKVVGTKLQFADHAAMARAFGMHAERVETEEQLGPAVQRALANRPALLDVVVTPEAV
ECCCEEEEEEEHHHHHHHHHHHHCCHHHHHCCHHHHCHHHHHHHCCCCCEEEEEECCHHH
SSDAKTGLAWVPDLQPLAAWDEAERKWRGS
CCCCCCCEEECCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]