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The map label for this gene is hoxA [H]

Identifier: 146338767

GI number: 146338767

Start: 1815694

End: 1817151

Strand: Direct

Name: hoxA [H]

Synonym: BRADO1701

Alternate gene names: 146338767

Gene position: 1815694-1817151 (Clockwise)

Preceding gene: 146338766

Following gene: 146338768

Centisome position: 24.35

GC content: 64.81

Gene sequence:

>1458_bases
ATGGGAATCCAGGGAACCATATTGGTCGTGGACGACGAGATCCGGTCGCAGGAGGCGCTGCGCCGCGTCCTTAACCAGGA
CTTCGAGGTTTTGTGCGCCGGTAATACGGCCGATGCCGAGAGGCTGCTCGAAGGCGAGATCGTCCATGCTGTGATCTGCG
ACCAGCGCATGCCGCAGGAATCCGGCGTCAGCTTCCTCAAGCGCGTGCGCGAGCGGTGGCCTGATCCCGTGAGGATGATC
ATCTCGGGCTACTCGGACTCCGAGGACATCATCGCCGGGCTCAACGAAGCCGGCATCTATCAGTACATCACAAAGCCCTG
GCAGCCGGACCGTCTGATCGAGATCGTGCGCGAGGCCGTGCAGCTCTACCGGCTGCAGAAGGAGACGGAGACCGCGGGCG
TCGACGTCAAGGCGACGCCGGCGCACATCAAGCAGGTCGTCTCCGTCAAGCGCGGCGCGGCGAAGAAGCTGTACGATTTC
GACCGCATCGTTCACTCCGCCGCAAGCCCGATGCGCAACGTGATCGAGCTCGGCCGTCGCGCCGCCGACTACGACATCTC
TGTGCTGATCACCGGCGAGTCCGGCACCGGCAAGGAGCTGCTGGCGCGTGCCATTCATTACGGCTCGGGGCGCGCCAACA
AGGCCTTCGTGGTCGAGAACTGCGGCGCGCTGCCTGACGAGCTGCTGGAGAGCGAGCTGTTCGGCTGCAAGAAGGGCGCC
TTCACCGGCGCCTATCAGGACCGGATCGGCCTGTTCGAGGTCGCCGACGGCGGCACCATCTTTCTCGACGAGATCGGCGA
GACGTCGCCGGCGTTCCAGGTCAAGCTGCTGCGCGTTCTGCAGGAGAGCGAGATCCGGCCGCTCGGTGCTCAGCGCGTCC
GCAAGGTCGACGTCCGCGTCGTTGCCGCCACCAACAGGGATCTCGAGGCCGAGGTCGAGGCCGGCCGCTTCCGCCGCGAT
CTCTATTACCGGCTCGCCGCGTTCCCGGTGCACATGCCATCGCTGCGCGAGCGGCCGATGGACATTCCCCTGATCGCCGA
GGGCGTGCTGGCCGCGGTGAAGAGCTCATTCAACCGGCCTCATCTGCGCTTCGTGCCGGCAGCGCTCGACGAATTCTCGA
AATATCATTGGCCGGGCAATGTCCGCGAGCTGCAGAACGAGATCCAGCGCATGGCCGTGCTCGCCGATGCCGACGAGCTG
CGCTGTCCGCCCTTCGCCGGACGCCGCAGCGCGCGCCGCGCGGCCCCCGCCGCCGTCAACGGCAAGCTGAACGGCAGCGG
CAGCCTGAAGGACAGGGTTGAGGATCTCGAAAAGACGATCATTGTCAGCTGCCTCGAAAAATACGAGGGTAACATCAGCC
GCGTGGCCAGCGAGCTTGGCCTGTCCCGGGTCGGACTGCGCAACAAACTATCGAGATACGATCTGAAAAAAAATGGCAAA
GGCCACGCACTCTCCTGA

Upstream 100 bases:

>100_bases
ACGATCATCGCTTCGTCCAGATGGCTACGAGCTTCGGCGGCGGGCGCATCGTCGACTGGCTGTCGGGCGAGCAGTTGCCG
CGGATCTGCTGAGACGGGTG

Downstream 100 bases:

>100_bases
ATCGGGCGCGGACACGCTGCTGAAGCTGATCGCGAGCAGTAGCGCGCTTGAATTCGACAGCGAGCGCGAGGGCGTCTGGA
TCGAAGTCATCCGCAAGATG

Product: two component sigma-54-dependent hydrogenase Fis family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MGIQGTILVVDDEIRSQEALRRVLNQDFEVLCAGNTADAERLLEGEIVHAVICDQRMPQESGVSFLKRVRERWPDPVRMI
ISGYSDSEDIIAGLNEAGIYQYITKPWQPDRLIEIVREAVQLYRLQKETETAGVDVKATPAHIKQVVSVKRGAAKKLYDF
DRIVHSAASPMRNVIELGRRAADYDISVLITGESGTGKELLARAIHYGSGRANKAFVVENCGALPDELLESELFGCKKGA
FTGAYQDRIGLFEVADGGTIFLDEIGETSPAFQVKLLRVLQESEIRPLGAQRVRKVDVRVVAATNRDLEAEVEAGRFRRD
LYYRLAAFPVHMPSLRERPMDIPLIAEGVLAAVKSSFNRPHLRFVPAALDEFSKYHWPGNVRELQNEIQRMAVLADADEL
RCPPFAGRRSARRAAPAAVNGKLNGSGSLKDRVEDLEKTIIVSCLEKYEGNISRVASELGLSRVGLRNKLSRYDLKKNGK
GHALS

Sequences:

>Translated_485_residues
MGIQGTILVVDDEIRSQEALRRVLNQDFEVLCAGNTADAERLLEGEIVHAVICDQRMPQESGVSFLKRVRERWPDPVRMI
ISGYSDSEDIIAGLNEAGIYQYITKPWQPDRLIEIVREAVQLYRLQKETETAGVDVKATPAHIKQVVSVKRGAAKKLYDF
DRIVHSAASPMRNVIELGRRAADYDISVLITGESGTGKELLARAIHYGSGRANKAFVVENCGALPDELLESELFGCKKGA
FTGAYQDRIGLFEVADGGTIFLDEIGETSPAFQVKLLRVLQESEIRPLGAQRVRKVDVRVVAATNRDLEAEVEAGRFRRD
LYYRLAAFPVHMPSLRERPMDIPLIAEGVLAAVKSSFNRPHLRFVPAALDEFSKYHWPGNVRELQNEIQRMAVLADADEL
RCPPFAGRRSARRAAPAAVNGKLNGSGSLKDRVEDLEKTIIVSCLEKYEGNISRVASELGLSRVGLRNKLSRYDLKKNGK
GHALS
>Mature_484_residues
GIQGTILVVDDEIRSQEALRRVLNQDFEVLCAGNTADAERLLEGEIVHAVICDQRMPQESGVSFLKRVRERWPDPVRMII
SGYSDSEDIIAGLNEAGIYQYITKPWQPDRLIEIVREAVQLYRLQKETETAGVDVKATPAHIKQVVSVKRGAAKKLYDFD
RIVHSAASPMRNVIELGRRAADYDISVLITGESGTGKELLARAIHYGSGRANKAFVVENCGALPDELLESELFGCKKGAF
TGAYQDRIGLFEVADGGTIFLDEIGETSPAFQVKLLRVLQESEIRPLGAQRVRKVDVRVVAATNRDLEAEVEAGRFRRDL
YYRLAAFPVHMPSLRERPMDIPLIAEGVLAAVKSSFNRPHLRFVPAALDEFSKYHWPGNVRELQNEIQRMAVLADADELR
CPPFAGRRSARRAAPAAVNGKLNGSGSLKDRVEDLEKTIIVSCLEKYEGNISRVASELGLSRVGLRNKLSRYDLKKNGKG
HALS

Specific function: Probable member of the two-component regulatory system involved in the regulation of the hydrogenase activity. HoxA is probably phosphorylated by a sensory component (which could be hoxX) and then acts in conjunction with sigma-54 as a transcriptional act

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=476, Percent_Identity=38.8655462184874, Blast_Score=293, Evalue=1e-80,
Organism=Escherichia coli, GI1790437, Length=471, Percent_Identity=39.2781316348195, Blast_Score=283, Evalue=2e-77,
Organism=Escherichia coli, GI1788905, Length=478, Percent_Identity=34.7280334728033, Blast_Score=252, Evalue=4e-68,
Organism=Escherichia coli, GI1790299, Length=491, Percent_Identity=31.5682281059063, Blast_Score=235, Evalue=4e-63,
Organism=Escherichia coli, GI1789087, Length=313, Percent_Identity=43.7699680511182, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI87082117, Length=324, Percent_Identity=43.5185185185185, Blast_Score=225, Evalue=4e-60,
Organism=Escherichia coli, GI87082152, Length=216, Percent_Identity=53.2407407407407, Blast_Score=211, Evalue=8e-56,
Organism=Escherichia coli, GI1789233, Length=312, Percent_Identity=38.4615384615385, Blast_Score=209, Evalue=4e-55,
Organism=Escherichia coli, GI1786524, Length=307, Percent_Identity=39.7394136807818, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI1787583, Length=329, Percent_Identity=37.9939209726444, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI87081872, Length=314, Percent_Identity=37.8980891719745, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI87081858, Length=304, Percent_Identity=32.5657894736842, Blast_Score=145, Evalue=7e-36,
Organism=Escherichia coli, GI1789828, Length=223, Percent_Identity=38.5650224215247, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1789809, Length=113, Percent_Identity=36.283185840708, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 53903; Mature: 53772

Theoretical pI: Translated: 8.12; Mature: 8.12

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIQGTILVVDDEIRSQEALRRVLNQDFEVLCAGNTADAERLLEGEIVHAVICDQRMPQE
CCCCEEEEEECCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCHH
SGVSFLKRVRERWPDPVRMIISGYSDSEDIIAGLNEAGIYQYITKPWQPDRLIEIVREAV
HHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHHHH
QLYRLQKETETAGVDVKATPAHIKQVVSVKRGAAKKLYDFDRIVHSAASPMRNVIELGRR
HHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
AADYDISVLITGESGTGKELLARAIHYGSGRANKAFVVENCGALPDELLESELFGCKKGA
CCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCC
FTGAYQDRIGLFEVADGGTIFLDEIGETSPAFQVKLLRVLQESEIRPLGAQRVRKVDVRV
CCCCHHHCCCEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHEEE
VAATNRDLEAEVEAGRFRRDLYYRLAAFPVHMPSLRERPMDIPLIAEGVLAAVKSSFNRP
EEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCHHHHHHHHHHHHHCCCC
HLRFVPAALDEFSKYHWPGNVRELQNEIQRMAVLADADELRCPPFAGRRSARRAAPAAVN
CEEEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHCCCCCCCCCHHHHHCCCCCCC
GKLNGSGSLKDRVEDLEKTIIVSCLEKYEGNISRVASELGLSRVGLRNKLSRYDLKKNGK
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCHHHHHHHHHHHHHHHCCCCC
GHALS
CCCCC
>Mature Secondary Structure 
GIQGTILVVDDEIRSQEALRRVLNQDFEVLCAGNTADAERLLEGEIVHAVICDQRMPQE
CCCEEEEEECCHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCHH
SGVSFLKRVRERWPDPVRMIISGYSDSEDIIAGLNEAGIYQYITKPWQPDRLIEIVREAV
HHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHCCCCCHHHHHHCCCCCCHHHHHHHHHHH
QLYRLQKETETAGVDVKATPAHIKQVVSVKRGAAKKLYDFDRIVHSAASPMRNVIELGRR
HHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
AADYDISVLITGESGTGKELLARAIHYGSGRANKAFVVENCGALPDELLESELFGCKKGA
CCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCC
FTGAYQDRIGLFEVADGGTIFLDEIGETSPAFQVKLLRVLQESEIRPLGAQRVRKVDVRV
CCCCHHHCCCEEEECCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHEEE
VAATNRDLEAEVEAGRFRRDLYYRLAAFPVHMPSLRERPMDIPLIAEGVLAAVKSSFNRP
EEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCHHHHHHHHHHHHHCCCC
HLRFVPAALDEFSKYHWPGNVRELQNEIQRMAVLADADELRCPPFAGRRSARRAAPAAVN
CEEEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCHHCCCCCCCCCHHHHHCCCCCCC
GKLNGSGSLKDRVEDLEKTIIVSCLEKYEGNISRVASELGLSRVGLRNKLSRYDLKKNGK
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCHHHHHHHHHHHHHHHCCCCC
GHALS
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8510650; 12597275 [H]