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The map label for this gene is oxyR [H]

Identifier: 146338734

GI number: 146338734

Start: 1786553

End: 1787482

Strand: Direct

Name: oxyR [H]

Synonym: BRADO1667

Alternate gene names: 146338734

Gene position: 1786553-1787482 (Clockwise)

Preceding gene: 146338732

Following gene: 146338735

Centisome position: 23.96

GC content: 69.14

Gene sequence:

>930_bases
ATGATCCACCTGACGATGCGGCAGCTTCGCTATTTCGACGCGCTGGCGCGTCTCGGCCATTTCGGCCGCGCCGCGGAGGC
CTGCGCGATCTCGCAGCCGGCGCTGTCGATGCAGATCAAGGAGATGGAGGACGCGCTCGGCGGCGTTCTCCTGGAGCGCA
ACGCGCGCCAGGTGGTGCTGACGCGGTTCGGCGAGCAGCTCGCCGCGCGCGTCCGCGAGATCCTTCGCTCGGTGGACGAG
CTCGGCGACTTCGCCCGCGCCTCGCGCGACACGCTGACCGGACGGCTGCGGCTCGGCATGATCCCCACGGTCGCGCCGTA
TCTCCTTCCGAAAGTGATCGGCGACCTCACCCGCAAGCATCCCGAGATCGACATCCATGTCCGCGAATCCAAGACGCCGA
AGCTGATCGAGGAGCTGGTCGAGGGCCGGCTGGATGCCGCGATCGTCGCGCTGCCGGTGTCGGAACCGTCGCTGACCGAG
GTCGCGCTGTTCTCGGAAAACTTCCTTCTGGTCCGTCCACCTGAATATGAAGGCGCTGCGGTGCCGAGCAGCGAGAGCCT
GCGCGAGATGCGGCTGCTGCTGCTGGAGGAGGGGCACTGCTTCCGCGACCAGGCGCTGTCGTTCTGCAACATGCAGGCGC
CGCGCGAGATGCTCGATGCCTCCTCGCTGTCGACCCTGGTGCAGATGGTCGGCGCCGGCATGGGGGTGACCCTGATCCCG
GAGATGGCGGTCGCCGTCGAGACGCGCTCGGCGTCGGTGTCGCTGGCGCGCTTCGCCGAGCCGCAGCCCCAGCGCACCAT
CGGCATGGTCTGGCGCAAGACCAGCCCCCTCGCCAAGCAGCTGATGCAGATTTCCGAGATCGTCGGCGGCGCGGCGGAGA
GCCTGCGCAAGCAGGCCGCGGCGGGGCAGGGCAGGAAGCGGCGCGGCTGA

Upstream 100 bases:

>100_bases
ACGCGGGCCCACCGCCGGCAGCAATCACGCGTTGTCGGTACACCCTGAGATTGCGGCGGGTCAAAATTGACTCCATGTCG
ACCAACGATAAGATAATCTG

Downstream 100 bases:

>100_bases
GCAGCCAGGAGCGTCCGGCTGAAGCCCATCATTTCATCCCAGTCGGGCTTCAGGCGCCCGCCGCGACCGCGGTGCGCTCC
CCTCCCCCTTGCGGGGAGGG

Product: oxidative stress transcriptional regulator

Products: NA

Alternate protein names: Morphology and auto-aggregation control protein [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MIHLTMRQLRYFDALARLGHFGRAAEACAISQPALSMQIKEMEDALGGVLLERNARQVVLTRFGEQLAARVREILRSVDE
LGDFARASRDTLTGRLRLGMIPTVAPYLLPKVIGDLTRKHPEIDIHVRESKTPKLIEELVEGRLDAAIVALPVSEPSLTE
VALFSENFLLVRPPEYEGAAVPSSESLREMRLLLLEEGHCFRDQALSFCNMQAPREMLDASSLSTLVQMVGAGMGVTLIP
EMAVAVETRSASVSLARFAEPQPQRTIGMVWRKTSPLAKQLMQISEIVGGAAESLRKQAAAGQGRKRRG

Sequences:

>Translated_309_residues
MIHLTMRQLRYFDALARLGHFGRAAEACAISQPALSMQIKEMEDALGGVLLERNARQVVLTRFGEQLAARVREILRSVDE
LGDFARASRDTLTGRLRLGMIPTVAPYLLPKVIGDLTRKHPEIDIHVRESKTPKLIEELVEGRLDAAIVALPVSEPSLTE
VALFSENFLLVRPPEYEGAAVPSSESLREMRLLLLEEGHCFRDQALSFCNMQAPREMLDASSLSTLVQMVGAGMGVTLIP
EMAVAVETRSASVSLARFAEPQPQRTIGMVWRKTSPLAKQLMQISEIVGGAAESLRKQAAAGQGRKRRG
>Mature_309_residues
MIHLTMRQLRYFDALARLGHFGRAAEACAISQPALSMQIKEMEDALGGVLLERNARQVVLTRFGEQLAARVREILRSVDE
LGDFARASRDTLTGRLRLGMIPTVAPYLLPKVIGDLTRKHPEIDIHVRESKTPKLIEELVEGRLDAAIVALPVSEPSLTE
VALFSENFLLVRPPEYEGAAVPSSESLREMRLLLLEEGHCFRDQALSFCNMQAPREMLDASSLSTLVQMVGAGMGVTLIP
EMAVAVETRSASVSLARFAEPQPQRTIGMVWRKTSPLAKQLMQISEIVGGAAESLRKQAAAGQGRKRRG

Specific function: Hydrogen peroxide sensor. Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS (a regulatory RNA), dps, fur and grxA. OxyR expression is negatively autoregulated by binding to a 43 bp region upstre

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790399, Length=305, Percent_Identity=40.327868852459, Blast_Score=211, Evalue=5e-56,
Organism=Escherichia coli, GI157672245, Length=280, Percent_Identity=31.4285714285714, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI1787879, Length=291, Percent_Identity=28.8659793814433, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI145693105, Length=289, Percent_Identity=28.3737024221453, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788748, Length=301, Percent_Identity=28.5714285714286, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI2367136, Length=243, Percent_Identity=31.6872427983539, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788297, Length=244, Percent_Identity=29.0983606557377, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788887, Length=284, Percent_Identity=27.8169014084507, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1787806, Length=281, Percent_Identity=23.8434163701068, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87081904, Length=173, Percent_Identity=31.7919075144509, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1787601, Length=147, Percent_Identity=30.6122448979592, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1787530, Length=250, Percent_Identity=26, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790208, Length=255, Percent_Identity=26.2745098039216, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786401, Length=173, Percent_Identity=31.7919075144509, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1789173, Length=171, Percent_Identity=30.4093567251462, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788626, Length=242, Percent_Identity=30.1652892561983, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1788481, Length=283, Percent_Identity=20.8480565371025, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI87082132, Length=291, Percent_Identity=21.9931271477663, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788706, Length=171, Percent_Identity=28.6549707602339, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI145693193, Length=128, Percent_Identity=28.90625, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34006; Mature: 34006

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHLTMRQLRYFDALARLGHFGRAAEACAISQPALSMQIKEMEDALGGVLLERNARQVVL
CEEHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHCCHHHHCCCHHHHH
TRFGEQLAARVREILRSVDELGDFARASRDTLTGRLRLGMIPTVAPYLLPKVIGDLTRKH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHCC
PEIDIHVRESKTPKLIEELVEGRLDAAIVALPVSEPSLTEVALFSENFLLVRPPEYEGAA
CCEEEEECCCCCHHHHHHHHHCCCCEEEEEEECCCCCHHHHEEECCCEEEEECCCCCCCC
VPSSESLREMRLLLLEEGHCFRDQALSFCNMQAPREMLDASSLSTLVQMVGAGMGVTLIP
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHH
EMAVAVETRSASVSLARFAEPQPQRTIGMVWRKTSPLAKQLMQISEIVGGAAESLRKQAA
HHHHHEECCCCHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AGQGRKRRG
HCCCCCCCC
>Mature Secondary Structure
MIHLTMRQLRYFDALARLGHFGRAAEACAISQPALSMQIKEMEDALGGVLLERNARQVVL
CEEHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHHCCHHHHCCCHHHHH
TRFGEQLAARVREILRSVDELGDFARASRDTLTGRLRLGMIPTVAPYLLPKVIGDLTRKH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHCC
PEIDIHVRESKTPKLIEELVEGRLDAAIVALPVSEPSLTEVALFSENFLLVRPPEYEGAA
CCEEEEECCCCCHHHHHHHHHCCCCEEEEEEECCCCCHHHHEEECCCEEEEECCCCCCCC
VPSSESLREMRLLLLEEGHCFRDQALSFCNMQAPREMLDASSLSTLVQMVGAGMGVTLIP
CCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHH
EMAVAVETRSASVSLARFAEPQPQRTIGMVWRKTSPLAKQLMQISEIVGGAAESLRKQAA
HHHHHEECCCCHHHHHHHCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AGQGRKRRG
HCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]