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The map label for this gene is purE [H]

Identifier: 146338302

GI number: 146338302

Start: 1281936

End: 1282424

Strand: Reverse

Name: purE [H]

Synonym: BRADO1206

Alternate gene names: 146338302

Gene position: 1282424-1281936 (Counterclockwise)

Preceding gene: 146338304

Following gene: 146338301

Centisome position: 17.2

GC content: 69.12

Gene sequence:

>489_bases
ATGACCGCCCCGATCGCCATCATCATGGGAAGCCAGTCGGACTGGGATACCATGCGCCATGCCGCCGAAACACTCGGCGC
GCTGGGCGTGAGCTATGACGCCCGCATCGTCTCGGCCCACCGCACGCCGGACCGGCTGTATGCTTTCGCGAAAGGAGCCA
AGGCGGCCGGATTCCAGGTCGTGATTGCCGGCGCCGGCGGCGCAGCCCACCTTCCCGGCATGACGGCGTCCCTGACCGAG
CTGCCCGTGTTCGGCGTTCCCGTCGAGTCCAAGGCGCTGTCCGGGGTCGATTCGCTGTATTCGATTGTTCAGATGCCCGC
CGGCATTCCGGTCGGCACGCTCGCCATCGGGAAGTCCGGCGCGATCAATGCGGCCCTGCTGGCGGCAAGCGTCCTGGCGC
TGTCGGACCCGGCGCTGGCCGAGCGTCTCTCCGCCTGGCGGCAGTCGCAGACCAACGCCATCGCCGAACGTCCGGAGGGC
GCGGCGTGA

Upstream 100 bases:

>100_bases
CAGGATAGTCCATTCAGACCTCCATGCCATGGCTTGCCGCTGTCGGGACCGATCCTATACTCCGGCCCATGCTGATGGAT
TCCCGAGAAGAATTGAGGTC

Downstream 100 bases:

>100_bases
CCGGCTCCAATCGGGTGAAGCTCAAGCCCGGGGACACCATCGGCATTCTCGGCGGCGGCCAGCTCGGCCGCATGCTGGCG
TTGGCGGCCGCGCGGCTCGG

Product: phosphoribosylaminoimidazole carboxylase catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 162; Mature: 161

Protein sequence:

>162_residues
MTAPIAIIMGSQSDWDTMRHAAETLGALGVSYDARIVSAHRTPDRLYAFAKGAKAAGFQVVIAGAGGAAHLPGMTASLTE
LPVFGVPVESKALSGVDSLYSIVQMPAGIPVGTLAIGKSGAINAALLAASVLALSDPALAERLSAWRQSQTNAIAERPEG
AA

Sequences:

>Translated_162_residues
MTAPIAIIMGSQSDWDTMRHAAETLGALGVSYDARIVSAHRTPDRLYAFAKGAKAAGFQVVIAGAGGAAHLPGMTASLTE
LPVFGVPVESKALSGVDSLYSIVQMPAGIPVGTLAIGKSGAINAALLAASVLALSDPALAERLSAWRQSQTNAIAERPEG
AA
>Mature_161_residues
TAPIAIIMGSQSDWDTMRHAAETLGALGVSYDARIVSAHRTPDRLYAFAKGAKAAGFQVVIAGAGGAAHLPGMTASLTEL
PVFGVPVESKALSGVDSLYSIVQMPAGIPVGTLAIGKSGAINAALLAASVLALSDPALAERLSAWRQSQTNAIAERPEGA
A

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=157, Percent_Identity=63.6942675159236, Blast_Score=175, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6324702, Length=155, Percent_Identity=49.6774193548387, Blast_Score=140, Evalue=7e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 16409; Mature: 16278

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPIAIIMGSQSDWDTMRHAAETLGALGVSYDARIVSAHRTPDRLYAFAKGAKAAGFQV
CCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHCCCCCCCEEE
VIAGAGGAAHLPGMTASLTELPVFGVPVESKALSGVDSLYSIVQMPAGIPVGTLAIGKSG
EEEECCCCCCCCCCCCHHHHCCEECCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCC
AINAALLAASVLALSDPALAERLSAWRQSQTNAIAERPEGAA
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TAPIAIIMGSQSDWDTMRHAAETLGALGVSYDARIVSAHRTPDRLYAFAKGAKAAGFQV
CCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHCCCCCCCEEE
VIAGAGGAAHLPGMTASLTELPVFGVPVESKALSGVDSLYSIVQMPAGIPVGTLAIGKSG
EEEECCCCCCCCCCCCHHHHCCEECCCCCHHHHHHHHHHHHHHHCCCCCCCCEEEECCCC
AINAALLAASVLALSDPALAERLSAWRQSQTNAIAERPEGAA
CHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]