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The map label for this gene is recQ [H]

Identifier: 146338225

GI number: 146338225

Start: 1199823

End: 1201697

Strand: Reverse

Name: recQ [H]

Synonym: BRADO1125

Alternate gene names: 146338225

Gene position: 1201697-1199823 (Counterclockwise)

Preceding gene: 146338226

Following gene: 146338224

Centisome position: 16.12

GC content: 68.21

Gene sequence:

>1875_bases
ATGGCCCCATCCTCCACCGCCCCGACCGACACGGCCGATCGCGCGCTGGCGGTGCTGCATTCGGTATTCGGGCTGCCGGG
CTTTCGCGGCGCGCAAGAGAAGGTGGTCCGGCATGTCGCCGAGGGCGGCAACTGCCTGGTGCTGATGCCGACCGGCGGCG
GCAAGTCGCTGTGCTATCAGCTGCCGGCTTTGCTGCGCAAAGGCTGCGGCATCGTGGTGTCGCCGCTGATCGCGCTGATG
CGCGACCAGGTCGCCGGCCTGATCGAGGCCGGCGTCAATGCGGCGGTGCTGAACTCCACACTGTCGCGCGAGGAGGCCGA
CGAGGTCGAGCGGCGGCTCATCGTCGGCGATCTCGACCTGCTCTATGTCGCCCCCGAGCGGCTGGTGACGCCGCGCTGCC
TGTCGCTGCTGGAGCGCGCCGAGATCGCGCTGTTCGCGATCGACGAGGCGCATTGCGTATCGCAATGGGGGCACGACTTC
CGCCCGGAATATATCGGCCTCTCGATCATCGCCGAGCGCTTCCCGGACGTGCCGCGGATCGCGCTGACGGCGACCGCCGA
CGAGCTGACGCGCAAGGAAATCGCCGAGCGGCTCAGCCTGAGCGACGCGCCGCAATTCGTCGCCAGCTTCGACCGTCCCA
ACATCCGCTACGAGATTGTCGACAAGAACAACGGCCCCGCGCAGCTGAAGGCCTTCATCAAGGAGCGCCATCCCGGGGAC
GCCGGTGTCGTCTACTGCCTGTCGCGCGCCAAGGTCGAGGACACCGCGGCGGCGCTGAACGAGGCCGGCATCACCGCGAT
CCCCTATCACGCCGGGCTCGATCCGGCGGTGCGCTCGCGCAACCAGGACCGCTTCATCAACGAGGACGGCGTCGTCGTCG
TGGCCACCGTCGCCTTCGGCATGGGTATCGACAAGCCGGACGTGCGCTTCGTCGCGCATCTCGACCTACCGAAGAGCATC
GAGGCCTACTACCAGGAGACGGGCCGCGCCGGGCGCGACGGCAAGGCCTCGACCGCCTGGATGGCCTATGGCCTCTCGGA
CATCGTGCAGCAGCGCCGCATGATCGACGAGTCCACCGGCGCCGAGGCGTACAAGCGGATGTCGATCCGCAAGCTCGACG
CGCTGGTCGCGCTCGCGGAGACCGCCGGCTGCCGGCGCAAGCTGCTGCTGAGCTATTTCGGCGAGAGCCCGGCGGGCGAG
AACTGCGGCAATTGTGACAACTGCGTGTCGCCGCCGAAGATGCGCGACGGCAAGGTGATCGCGCAGAAGCTGCTGTCCTG
TGCCTATCGCACCGGCCAGCGTTTCGGCGCCATGCACCTGATCGACGTGCTGGTCGGGCGCGCCACCGAGCGTGTCAAGC
AGTTCGGACATGATCAATTGTCAGTGTTCGGCATCGGCCGCGAGATGAATGAGAAGCAGTGGCGCGCCGCGCTGCGCCAG
CTTGTGGCCATGGGCTACCTGGCGCCCGACAGCGAGGCCTATGGCGCGCTGAAGCTGACGGAGACGTCGCGCGGCGTGCT
CAAGGGCGAAACGCCGGTGATGCTGCGCGAGGAGACCGCCAGCACCCGCGCCATCCGCAGCAAATCGCGGCGCGGCGAGC
TGGTGGCGCGGCCGGCCGCGGCTGCCGATGCGCCCTTGCTCGCGAGCCTCAGGGCATGGCGTTCGGAGATCGCGCGCAAG
CGTGGTGTACCAGCCTATGTCGTGCTGCACGACGCCACCATTGACGGCATCGCCAGTGCCCGCCCGACGACGCTCGGCCA
GCTGCGCGATATACCAGGGATCGGCGACAAGAAGCTCGAGCATTATGGCGAGGAGCTGCTTGCGCTGATCAACGCCGCGC
GGTCGGCAGGAGCAGGATCGCCGCCAGACAGTTGA

Upstream 100 bases:

>100_bases
GGGCAGCATTGACTATGATGCCTCCAGACGTGGACAATACGAGAACAGGCGCGGCTTGATGCGCCGGTTTGCCTGACCTT
CCGGAAGCTCCCTTCGCACC

Downstream 100 bases:

>100_bases
GGTTTGCGCGAAAAAGGTCTACCAAAAGGCCCTTATCGTCCGCTCCCGCCCGGCAGAACCGGTCGGCATTAGTTCCAAAA
CCCTCGTGGCGCCCCTGTTA

Product: ATP-dependent DNA helicase RecQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 624; Mature: 623

Protein sequence:

>624_residues
MAPSSTAPTDTADRALAVLHSVFGLPGFRGAQEKVVRHVAEGGNCLVLMPTGGGKSLCYQLPALLRKGCGIVVSPLIALM
RDQVAGLIEAGVNAAVLNSTLSREEADEVERRLIVGDLDLLYVAPERLVTPRCLSLLERAEIALFAIDEAHCVSQWGHDF
RPEYIGLSIIAERFPDVPRIALTATADELTRKEIAERLSLSDAPQFVASFDRPNIRYEIVDKNNGPAQLKAFIKERHPGD
AGVVYCLSRAKVEDTAAALNEAGITAIPYHAGLDPAVRSRNQDRFINEDGVVVVATVAFGMGIDKPDVRFVAHLDLPKSI
EAYYQETGRAGRDGKASTAWMAYGLSDIVQQRRMIDESTGAEAYKRMSIRKLDALVALAETAGCRRKLLLSYFGESPAGE
NCGNCDNCVSPPKMRDGKVIAQKLLSCAYRTGQRFGAMHLIDVLVGRATERVKQFGHDQLSVFGIGREMNEKQWRAALRQ
LVAMGYLAPDSEAYGALKLTETSRGVLKGETPVMLREETASTRAIRSKSRRGELVARPAAAADAPLLASLRAWRSEIARK
RGVPAYVVLHDATIDGIASARPTTLGQLRDIPGIGDKKLEHYGEELLALINAARSAGAGSPPDS

Sequences:

>Translated_624_residues
MAPSSTAPTDTADRALAVLHSVFGLPGFRGAQEKVVRHVAEGGNCLVLMPTGGGKSLCYQLPALLRKGCGIVVSPLIALM
RDQVAGLIEAGVNAAVLNSTLSREEADEVERRLIVGDLDLLYVAPERLVTPRCLSLLERAEIALFAIDEAHCVSQWGHDF
RPEYIGLSIIAERFPDVPRIALTATADELTRKEIAERLSLSDAPQFVASFDRPNIRYEIVDKNNGPAQLKAFIKERHPGD
AGVVYCLSRAKVEDTAAALNEAGITAIPYHAGLDPAVRSRNQDRFINEDGVVVVATVAFGMGIDKPDVRFVAHLDLPKSI
EAYYQETGRAGRDGKASTAWMAYGLSDIVQQRRMIDESTGAEAYKRMSIRKLDALVALAETAGCRRKLLLSYFGESPAGE
NCGNCDNCVSPPKMRDGKVIAQKLLSCAYRTGQRFGAMHLIDVLVGRATERVKQFGHDQLSVFGIGREMNEKQWRAALRQ
LVAMGYLAPDSEAYGALKLTETSRGVLKGETPVMLREETASTRAIRSKSRRGELVARPAAAADAPLLASLRAWRSEIARK
RGVPAYVVLHDATIDGIASARPTTLGQLRDIPGIGDKKLEHYGEELLALINAARSAGAGSPPDS
>Mature_623_residues
APSSTAPTDTADRALAVLHSVFGLPGFRGAQEKVVRHVAEGGNCLVLMPTGGGKSLCYQLPALLRKGCGIVVSPLIALMR
DQVAGLIEAGVNAAVLNSTLSREEADEVERRLIVGDLDLLYVAPERLVTPRCLSLLERAEIALFAIDEAHCVSQWGHDFR
PEYIGLSIIAERFPDVPRIALTATADELTRKEIAERLSLSDAPQFVASFDRPNIRYEIVDKNNGPAQLKAFIKERHPGDA
GVVYCLSRAKVEDTAAALNEAGITAIPYHAGLDPAVRSRNQDRFINEDGVVVVATVAFGMGIDKPDVRFVAHLDLPKSIE
AYYQETGRAGRDGKASTAWMAYGLSDIVQQRRMIDESTGAEAYKRMSIRKLDALVALAETAGCRRKLLLSYFGESPAGEN
CGNCDNCVSPPKMRDGKVIAQKLLSCAYRTGQRFGAMHLIDVLVGRATERVKQFGHDQLSVFGIGREMNEKQWRAALRQL
VAMGYLAPDSEAYGALKLTETSRGVLKGETPVMLREETASTRAIRSKSRRGELVARPAAAADAPLLASLRAWRSEIARKR
GVPAYVVLHDATIDGIASARPTTLGQLRDIPGIGDKKLEHYGEELLALINAARSAGAGSPPDS

Specific function: Involved in the recF recombination pathway; its gene expression is under the regulation of the SOS system. It is a DNA helicase [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4557365, Length=641, Percent_Identity=33.5413416536661, Blast_Score=352, Evalue=7e-97,
Organism=Homo sapiens, GI14591902, Length=460, Percent_Identity=36.5217391304348, Blast_Score=303, Evalue=3e-82,
Organism=Homo sapiens, GI14591904, Length=460, Percent_Identity=36.5217391304348, Blast_Score=303, Evalue=3e-82,
Organism=Homo sapiens, GI148612816, Length=447, Percent_Identity=39.8210290827741, Blast_Score=278, Evalue=1e-74,
Organism=Homo sapiens, GI51242947, Length=413, Percent_Identity=39.9515738498789, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI51242943, Length=413, Percent_Identity=39.9515738498789, Blast_Score=260, Evalue=3e-69,
Organism=Homo sapiens, GI169218196, Length=526, Percent_Identity=32.8897338403042, Blast_Score=260, Evalue=4e-69,
Organism=Homo sapiens, GI110735439, Length=526, Percent_Identity=32.8897338403042, Blast_Score=259, Evalue=4e-69,
Organism=Homo sapiens, GI284005309, Length=389, Percent_Identity=35.9897172236504, Blast_Score=201, Evalue=2e-51,
Organism=Escherichia coli, GI48994977, Length=598, Percent_Identity=46.3210702341137, Blast_Score=532, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI25145561, Length=642, Percent_Identity=34.2679127725857, Blast_Score=334, Evalue=9e-92,
Organism=Caenorhabditis elegans, GI71987993, Length=410, Percent_Identity=41.7073170731707, Blast_Score=308, Evalue=8e-84,
Organism=Caenorhabditis elegans, GI71987997, Length=410, Percent_Identity=41.7073170731707, Blast_Score=307, Evalue=8e-84,
Organism=Caenorhabditis elegans, GI32564293, Length=673, Percent_Identity=31.9465081723626, Blast_Score=295, Evalue=6e-80,
Organism=Caenorhabditis elegans, GI17552866, Length=410, Percent_Identity=37.8048780487805, Blast_Score=244, Evalue=9e-65,
Organism=Saccharomyces cerevisiae, GI6323844, Length=494, Percent_Identity=38.663967611336, Blast_Score=348, Evalue=1e-96,
Organism=Drosophila melanogaster, GI24646066, Length=637, Percent_Identity=34.5368916797488, Blast_Score=345, Evalue=8e-95,
Organism=Drosophila melanogaster, GI24664226, Length=413, Percent_Identity=37.2881355932203, Blast_Score=269, Evalue=4e-72,
Organism=Drosophila melanogaster, GI62472181, Length=410, Percent_Identity=37.5609756097561, Blast_Score=267, Evalue=1e-71,
Organism=Drosophila melanogaster, GI24664230, Length=410, Percent_Identity=37.5609756097561, Blast_Score=267, Evalue=1e-71,
Organism=Drosophila melanogaster, GI21358123, Length=429, Percent_Identity=34.032634032634, Blast_Score=197, Evalue=2e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 67544; Mature: 67413

Theoretical pI: Translated: 7.89; Mature: 7.89

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPSSTAPTDTADRALAVLHSVFGLPGFRGAQEKVVRHVAEGGNCLVLMPTGGGKSLCYQ
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHH
LPALLRKGCGIVVSPLIALMRDQVAGLIEAGVNAAVLNSTLSREEADEVERRLIVGDLDL
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCE
LYVAPERLVTPRCLSLLERAEIALFAIDEAHCVSQWGHDFRPEYIGLSIIAERFPDVPRI
EEECHHHHCCHHHHHHHHHCCEEEEEECHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCE
ALTATADELTRKEIAERLSLSDAPQFVASFDRPNIRYEIVDKNNGPAQLKAFIKERHPGD
EEECCHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHCCCCC
AGVVYCLSRAKVEDTAAALNEAGITAIPYHAGLDPAVRSRNQDRFINEDGVVVVATVAFG
CCCEEEHHHCCHHHHHHHHHHCCCEEECCCCCCCHHHHCCCCCCCCCCCCEEEEEEHHHH
MGIDKPDVRFVAHLDLPKSIEAYYQETGRAGRDGKASTAWMAYGLSDIVQQRRMIDESTG
CCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
AEAYKRMSIRKLDALVALAETAGCRRKLLLSYFGESPAGENCGNCDNCVSPPKMRDGKVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHH
AQKLLSCAYRTGQRFGAMHLIDVLVGRATERVKQFGHDQLSVFGIGREMNEKQWRAALRQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHH
LVAMGYLAPDSEAYGALKLTETSRGVLKGETPVMLREETASTRAIRSKSRRGELVARPAA
HHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCEEECCCC
AADAPLLASLRAWRSEIARKRGVPAYVVLHDATIDGIASARPTTLGQLRDIPGIGDKKLE
CCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHCCCCCCCCHHHHHHCCCCCCHHHHH
HYGEELLALINAARSAGAGSPPDS
HHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
APSSTAPTDTADRALAVLHSVFGLPGFRGAQEKVVRHVAEGGNCLVLMPTGGGKSLCYQ
CCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHH
LPALLRKGCGIVVSPLIALMRDQVAGLIEAGVNAAVLNSTLSREEADEVERRLIVGDLDL
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCE
LYVAPERLVTPRCLSLLERAEIALFAIDEAHCVSQWGHDFRPEYIGLSIIAERFPDVPRI
EEECHHHHCCHHHHHHHHHCCEEEEEECHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCE
ALTATADELTRKEIAERLSLSDAPQFVASFDRPNIRYEIVDKNNGPAQLKAFIKERHPGD
EEECCHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHCCCCC
AGVVYCLSRAKVEDTAAALNEAGITAIPYHAGLDPAVRSRNQDRFINEDGVVVVATVAFG
CCCEEEHHHCCHHHHHHHHHHCCCEEECCCCCCCHHHHCCCCCCCCCCCCEEEEEEHHHH
MGIDKPDVRFVAHLDLPKSIEAYYQETGRAGRDGKASTAWMAYGLSDIVQQRRMIDESTG
CCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
AEAYKRMSIRKLDALVALAETAGCRRKLLLSYFGESPAGENCGNCDNCVSPPKMRDGKVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHH
AQKLLSCAYRTGQRFGAMHLIDVLVGRATERVKQFGHDQLSVFGIGREMNEKQWRAALRQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHH
LVAMGYLAPDSEAYGALKLTETSRGVLKGETPVMLREETASTRAIRSKSRRGELVARPAA
HHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCEEEEHHHHHHHHHHHHHHCCCEEECCCC
AADAPLLASLRAWRSEIARKRGVPAYVVLHDATIDGIASARPTTLGQLRDIPGIGDKKLE
CCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCHHCCCCCCCCHHHHHHCCCCCCHHHHH
HYGEELLALINAARSAGAGSPPDS
HHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3027506; 1379743; 9278503; 2164680 [H]