Click here to switch to the map view.

The map label for this gene is Hadh2 [H]

Identifier: 146338038

GI number: 146338038

Start: 994744

End: 995502

Strand: Direct

Name: Hadh2 [H]

Synonym: BRADO0931

Alternate gene names: 146338038

Gene position: 994744-995502 (Clockwise)

Preceding gene: 146338037

Following gene: 146338039

Centisome position: 13.34

GC content: 68.51

Gene sequence:

>759_bases
ATGCAACTCAACAACGTCGCCGTTCTGATCACCGGCGGTGGCTCGGGTCTCGGCGCCGCGACGGCGCGCGCCATGGCGGC
CAAGGGCGCCAAGGTCGCCGTGCTCGACCAGAGCCTGGAGAATGCCGAGAAAGTCGCCGCCGAGATCAAGGGCGTCGCCC
TGCATGCCGACGTCACCAACGAGGATCAGGTCAAGGCCGGCATCGCCAAGGCGGAGGCAGCGCACGGCATCGCCCGCGTG
CTGGTCAACTGCGCCGGCATCGGCGGCTCGCAGCGCATCGTCGGCAAGGACGGCGTCTATCCGCTGGCGAAGTTCGCGCG
CATCATCAACGTCAACCTGATCGGCACCTTCAACGTGCTGCGCCTGTTCGCCGAGCGCCTGGTCACCGCGGAAGCGGTCG
GCGAGGAGCGCGGCGTCATCATCAACACCGCCAGCGTCGCGGCCTATGAAGGTCAGATCGGCCAGATCGCCTATTCGGCC
TCGAAGGGCGGTGTCGTCGGCCTCACCCTGCCAGCGGCGCGCGATCTCGCCAGCCAGAAGATCCGCGTCAACACCATCGC
GCCTGGCCTGTTCCTGACGCCGCTGCTGATGGGCCTGAACGAGGAGGCCCGCAAGAGCCTCGGCGCCCAGGTGCCGCATC
CCGCCCGCCTCGGCGACGCCTCGGAGTACGGCAACCTCGCCGTCCACATCGTCGAGAACCCGATGCTCAATGGCGAAACC
ATCCGCCTCGACGGCGCCATCCGCATGGCCCCGCGCTGA

Upstream 100 bases:

>100_bases
TGCGGCGGGATACTGAAGAGGGCGAATGGCGAATAGGGAGTATCTATTCGCTACTCCCTTTTCGCTATTCGCTAAAAATA
AACAAAGGAGGAAACGCACC

Downstream 100 bases:

>100_bases
CGGCGCACTTTACTGTCGTCCCGGCCTTGAGCCGGGACCCAGACTCCGCGGCGCCTGTGAGTGGCAAACTGGCAGACGCC
GCGCTCTAACCAATGAAGCC

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: 3-ketoacyl-acyl carrier protein reductase [H]

Number of amino acids: Translated: 252; Mature: 252

Protein sequence:

>252_residues
MQLNNVAVLITGGGSGLGAATARAMAAKGAKVAVLDQSLENAEKVAAEIKGVALHADVTNEDQVKAGIAKAEAAHGIARV
LVNCAGIGGSQRIVGKDGVYPLAKFARIINVNLIGTFNVLRLFAERLVTAEAVGEERGVIINTASVAAYEGQIGQIAYSA
SKGGVVGLTLPAARDLASQKIRVNTIAPGLFLTPLLMGLNEEARKSLGAQVPHPARLGDASEYGNLAVHIVENPMLNGET
IRLDGAIRMAPR

Sequences:

>Translated_252_residues
MQLNNVAVLITGGGSGLGAATARAMAAKGAKVAVLDQSLENAEKVAAEIKGVALHADVTNEDQVKAGIAKAEAAHGIARV
LVNCAGIGGSQRIVGKDGVYPLAKFARIINVNLIGTFNVLRLFAERLVTAEAVGEERGVIINTASVAAYEGQIGQIAYSA
SKGGVVGLTLPAARDLASQKIRVNTIAPGLFLTPLLMGLNEEARKSLGAQVPHPARLGDASEYGNLAVHIVENPMLNGET
IRLDGAIRMAPR
>Mature_252_residues
MQLNNVAVLITGGGSGLGAATARAMAAKGAKVAVLDQSLENAEKVAAEIKGVALHADVTNEDQVKAGIAKAEAAHGIARV
LVNCAGIGGSQRIVGKDGVYPLAKFARIINVNLIGTFNVLRLFAERLVTAEAVGEERGVIINTASVAAYEGQIGQIAYSA
SKGGVVGLTLPAARDLASQKIRVNTIAPGLFLTPLLMGLNEEARKSLGAQVPHPARLGDASEYGNLAVHIVENPMLNGET
IRLDGAIRMAPR

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=248, Percent_Identity=53.2258064516129, Blast_Score=230, Evalue=8e-61,
Organism=Homo sapiens, GI83715985, Length=248, Percent_Identity=50.4032258064516, Blast_Score=211, Evalue=6e-55,
Organism=Homo sapiens, GI40254992, Length=245, Percent_Identity=31.4285714285714, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI15277342, Length=265, Percent_Identity=28.6792452830189, Blast_Score=98, Evalue=8e-21,
Organism=Homo sapiens, GI31542939, Length=261, Percent_Identity=26.8199233716475, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI10190704, Length=193, Percent_Identity=27.979274611399, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI59889578, Length=222, Percent_Identity=27.4774774774775, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI224922801, Length=188, Percent_Identity=29.2553191489362, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI5031737, Length=256, Percent_Identity=28.125, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI33667109, Length=220, Percent_Identity=30, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI4504505, Length=203, Percent_Identity=34.4827586206897, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1787335, Length=254, Percent_Identity=31.1023622047244, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1790717, Length=251, Percent_Identity=31.4741035856574, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI2367175, Length=247, Percent_Identity=31.5789473684211, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI87082100, Length=262, Percent_Identity=32.4427480916031, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI87082160, Length=245, Percent_Identity=29.7959183673469, Blast_Score=78, Evalue=5e-16,
Organism=Escherichia coli, GI1789057, Length=214, Percent_Identity=34.5794392523364, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1787905, Length=237, Percent_Identity=31.2236286919831, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1789208, Length=244, Percent_Identity=29.9180327868852, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789378, Length=242, Percent_Identity=28.099173553719, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1786812, Length=194, Percent_Identity=31.9587628865979, Blast_Score=65, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17538182, Length=247, Percent_Identity=50.6072874493927, Blast_Score=223, Evalue=8e-59,
Organism=Caenorhabditis elegans, GI25147288, Length=247, Percent_Identity=30.7692307692308, Blast_Score=107, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17555706, Length=252, Percent_Identity=30.1587301587302, Blast_Score=104, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17567345, Length=201, Percent_Identity=28.8557213930348, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322861, Length=201, Percent_Identity=35.8208955223881, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6320089, Length=222, Percent_Identity=26.5765765765766, Blast_Score=66, Evalue=5e-12,
Organism=Drosophila melanogaster, GI17737361, Length=254, Percent_Identity=49.2125984251969, Blast_Score=225, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24639444, Length=249, Percent_Identity=30.1204819277108, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24644339, Length=266, Percent_Identity=30.8270676691729, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI23397609, Length=230, Percent_Identity=30, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI21357041, Length=261, Percent_Identity=30.6513409961686, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI28571526, Length=259, Percent_Identity=27.7992277992278, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24643142, Length=247, Percent_Identity=27.9352226720648, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24649181, Length=195, Percent_Identity=30.7692307692308, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21355319, Length=248, Percent_Identity=27.0161290322581, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011284
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.100 [H]

Molecular weight: Translated: 25985; Mature: 25985

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLNNVAVLITGGGSGLGAATARAMAAKGAKVAVLDQSLENAEKVAAEIKGVALHADVTN
CCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCEEEEECCCC
EDQVKAGIAKAEAAHGIARVLVNCAGIGGSQRIVGKDGVYPLAKFARIINVNLIGTFNVL
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHEEEEEHHHHHH
RLFAERLVTAEAVGEERGVIINTASVAAYEGQIGQIAYSASKGGVVGLTLPAARDLASQK
HHHHHHHHHHHHCCCCCCEEEEECEEEEECCCCCEEEEECCCCCEEEEECCCHHHHHHCC
IRVNTIAPGLFLTPLLMGLNEEARKSLGAQVPHPARLGDASEYGNLAVHIVENPMLNGET
EEEEEECCHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCE
IRLDGAIRMAPR
EEECCEEEECCC
>Mature Secondary Structure
MQLNNVAVLITGGGSGLGAATARAMAAKGAKVAVLDQSLENAEKVAAEIKGVALHADVTN
CCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHCCEEEEECCCC
EDQVKAGIAKAEAAHGIARVLVNCAGIGGSQRIVGKDGVYPLAKFARIINVNLIGTFNVL
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHEEEEEHHHHHH
RLFAERLVTAEAVGEERGVIINTASVAAYEGQIGQIAYSASKGGVVGLTLPAARDLASQK
HHHHHHHHHHHHCCCCCCEEEEECEEEEECCCCCEEEEECCCCCEEEEECCCHHHHHHCC
IRVNTIAPGLFLTPLLMGLNEEARKSLGAQVPHPARLGDASEYGNLAVHIVENPMLNGET
EEEEEECCHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCE
IRLDGAIRMAPR
EEECCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]