Click here to switch to the map view.

The map label for this gene is fadA [H]

Identifier: 146338036

GI number: 146338036

Start: 992710

End: 993882

Strand: Reverse

Name: fadA [H]

Synonym: BRADO0929

Alternate gene names: 146338036

Gene position: 993882-992710 (Counterclockwise)

Preceding gene: 146338046

Following gene: 146338035

Centisome position: 13.33

GC content: 67.26

Gene sequence:

>1173_bases
ATGGCGGAAGCCTATATCGTCGCGGCTGCGCGCACGGCCGGCGGCCGAAAGGGCGGGCGTCTGGCCGGCTGGCATCCGGC
GGATCTGGCGGCGAAGGTGCTGGACGCGCTGGTCGAGCGCTCCGGCGCCGCGCCGGACCAGGTCGAGGACGTGATCATGG
GCTGCGTCATGCAGACCGGCGAGCAGTCGACCAACATCGCCCGCAACGCGGTACTGGCCTCGAAGCTGCCGGAGAGCGTC
CCGGGCACCTCGATCGACCGCCAGTGCGGGTCGTCGCAGCAGGCGCTGCATTTCGCCGCCCAGGCGGTGATGTCGGGCGC
GATGGACGTGGTGATCGCCGCCGGCGTGGAGTCGATGACCCGGGTGCCGATGGGCCTGTCCTCGACCTTGCCGGCGAAGA
ACGGGTTTGGGCACTACAAGAGCCCGAGCATGGAGAGCCGCTATCCGAACATCCAGTTCAGCCAGTTCACCGGCGCGGAG
ATGATGGCGGAGAAGTACGGGCTCTCCAAGGATGATCTCGACGAATACGCCTATAACAGCCATCAGCGCGCGATCGCGGC
GACGCAGGCCGGGCACTTCAAGGACGAGATCGTCCCGCTGCAGATCACCCGCGCCGACGGTTCGACCGACACCCATCATA
TCGACGAGGGCATCCGCTTCGACGTCAGCCTCGACGGCATCAAGGGCGTCAAGCTGATCGCCGAGAACGGCAAGCTGACC
GCTGCCTCCGCGAGCCAGATCTGCGACGGCGCCTCCGGCGTCATGGTCGTCAACGAGCGCGGCCTGAAGTCGCTCGGCGT
CAAGCCGCTGGCCCGCGTGCACCACATGACCATGATGGGCGGCGATCCCGTCATCATGCTGGAAGCGCCGCTGCCGGCGA
CCCAGCGCGCGCTGCAGAAGGCCGGCATGTCGATCGACGACATCGACCTCTACGAGGTCAACGAGGCCTTCGCCTCGGTG
CCGACCGCCTGGCTCAAGACCACCGGCGCAGATCCGAGCCGTCTCAACGTCAATGGCGGTGCGATTGCGCTCGGCCATCC
GCTCGGCGGCTCCGGCACCAAGCTGATGACGACGCTGCTGCATGCGCTGAAACAGCGCAACAAGCGCTACGGCCTGCAGA
CCATGTGCGAAGGCGGCGGCATGGCGAATGTGACGATCGTCGAGCGGCTCTAG

Upstream 100 bases:

>100_bases
AGCCGGAGTTGATCTCAAGCGTTAATTGATCGATTGACTAAAGCTCAATCGCGCATTTAAATCGGCGCCAATCACGAACC
AAGTCTAGGGAGGAAACCTC

Downstream 100 bases:

>100_bases
CTGTCGCTCCATCAATGGTGTCGTCCCGGCCTTGAGCCGGGACCCATAGCCACCGAATCCAACGTTACGCGAGCTGGAGC
CACAGCTCGCTTTCACCACA

Product: acetyl-CoA acetyltransferase

Products: NA

Alternate protein names: Acetyl-CoA acyltransferase; Beta-ketothiolase; Fatty acid oxidation complex subunit beta [H]

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MAEAYIVAAARTAGGRKGGRLAGWHPADLAAKVLDALVERSGAAPDQVEDVIMGCVMQTGEQSTNIARNAVLASKLPESV
PGTSIDRQCGSSQQALHFAAQAVMSGAMDVVIAAGVESMTRVPMGLSSTLPAKNGFGHYKSPSMESRYPNIQFSQFTGAE
MMAEKYGLSKDDLDEYAYNSHQRAIAATQAGHFKDEIVPLQITRADGSTDTHHIDEGIRFDVSLDGIKGVKLIAENGKLT
AASASQICDGASGVMVVNERGLKSLGVKPLARVHHMTMMGGDPVIMLEAPLPATQRALQKAGMSIDDIDLYEVNEAFASV
PTAWLKTTGADPSRLNVNGGAIALGHPLGGSGTKLMTTLLHALKQRNKRYGLQTMCEGGGMANVTIVERL

Sequences:

>Translated_390_residues
MAEAYIVAAARTAGGRKGGRLAGWHPADLAAKVLDALVERSGAAPDQVEDVIMGCVMQTGEQSTNIARNAVLASKLPESV
PGTSIDRQCGSSQQALHFAAQAVMSGAMDVVIAAGVESMTRVPMGLSSTLPAKNGFGHYKSPSMESRYPNIQFSQFTGAE
MMAEKYGLSKDDLDEYAYNSHQRAIAATQAGHFKDEIVPLQITRADGSTDTHHIDEGIRFDVSLDGIKGVKLIAENGKLT
AASASQICDGASGVMVVNERGLKSLGVKPLARVHHMTMMGGDPVIMLEAPLPATQRALQKAGMSIDDIDLYEVNEAFASV
PTAWLKTTGADPSRLNVNGGAIALGHPLGGSGTKLMTTLLHALKQRNKRYGLQTMCEGGGMANVTIVERL
>Mature_389_residues
AEAYIVAAARTAGGRKGGRLAGWHPADLAAKVLDALVERSGAAPDQVEDVIMGCVMQTGEQSTNIARNAVLASKLPESVP
GTSIDRQCGSSQQALHFAAQAVMSGAMDVVIAAGVESMTRVPMGLSSTLPAKNGFGHYKSPSMESRYPNIQFSQFTGAEM
MAEKYGLSKDDLDEYAYNSHQRAIAATQAGHFKDEIVPLQITRADGSTDTHHIDEGIRFDVSLDGIKGVKLIAENGKLTA
ASASQICDGASGVMVVNERGLKSLGVKPLARVHHMTMMGGDPVIMLEAPLPATQRALQKAGMSIDDIDLYEVNEAFASVP
TAWLKTTGADPSRLNVNGGAIALGHPLGGSGTKLMTTLLHALKQRNKRYGLQTMCEGGGMANVTIVERL

Specific function: Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed [H]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiolase family [H]

Homologues:

Organism=Homo sapiens, GI167614485, Length=388, Percent_Identity=35.3092783505155, Blast_Score=231, Evalue=1e-60,
Organism=Homo sapiens, GI148539872, Length=393, Percent_Identity=35.3689567430025, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI4557237, Length=399, Percent_Identity=34.8370927318296, Blast_Score=215, Evalue=5e-56,
Organism=Homo sapiens, GI4501853, Length=395, Percent_Identity=34.1772151898734, Blast_Score=207, Evalue=9e-54,
Organism=Homo sapiens, GI4504327, Length=423, Percent_Identity=30.0236406619385, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI194353979, Length=389, Percent_Identity=28.2776349614396, Blast_Score=139, Evalue=6e-33,
Organism=Escherichia coli, GI48994986, Length=397, Percent_Identity=39.5465994962217, Blast_Score=262, Evalue=3e-71,
Organism=Escherichia coli, GI1787663, Length=401, Percent_Identity=39.4014962593516, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI87082165, Length=396, Percent_Identity=39.1414141414141, Blast_Score=250, Evalue=1e-67,
Organism=Escherichia coli, GI1788554, Length=398, Percent_Identity=37.9396984924623, Blast_Score=226, Evalue=2e-60,
Organism=Escherichia coli, GI1788683, Length=409, Percent_Identity=29.3398533007335, Blast_Score=148, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI133906874, Length=391, Percent_Identity=35.8056265984655, Blast_Score=228, Evalue=5e-60,
Organism=Caenorhabditis elegans, GI25147385, Length=392, Percent_Identity=31.8877551020408, Blast_Score=197, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI17535921, Length=394, Percent_Identity=31.2182741116751, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17551802, Length=426, Percent_Identity=28.4037558685446, Blast_Score=150, Evalue=7e-37,
Organism=Caenorhabditis elegans, GI17535917, Length=401, Percent_Identity=27.1820448877805, Blast_Score=135, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6325229, Length=402, Percent_Identity=32.3383084577114, Blast_Score=187, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6322031, Length=395, Percent_Identity=32.4050632911392, Blast_Score=178, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24655093, Length=393, Percent_Identity=36.3867684478371, Blast_Score=229, Evalue=2e-60,
Organism=Drosophila melanogaster, GI17648125, Length=391, Percent_Identity=34.5268542199489, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24640423, Length=393, Percent_Identity=33.0788804071247, Blast_Score=203, Evalue=2e-52,
Organism=Drosophila melanogaster, GI17137578, Length=425, Percent_Identity=27.0588235294118, Blast_Score=152, Evalue=5e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012805
- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020615
- InterPro:   IPR020610
- InterPro:   IPR020617
- InterPro:   IPR020613
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: =2.3.1.16 [H]

Molecular weight: Translated: 41147; Mature: 41015

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS00737 THIOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEAYIVAAARTAGGRKGGRLAGWHPADLAAKVLDALVERSGAAPDQVEDVIMGCVMQTG
CCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
EQSTNIARNAVLASKLPESVPGTSIDRQCGSSQQALHFAAQAVMSGAMDVVIAAGVESMT
CCHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHH
RVPMGLSSTLPAKNGFGHYKSPSMESRYPNIQFSQFTGAEMMAEKYGLSKDDLDEYAYNS
HCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHCCCHHHHHHHHHCC
HQRAIAATQAGHFKDEIVPLQITRADGSTDTHHIDEGIRFDVSLDGIKGVKLIAENGKLT
CHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCCCCEEEEEECCCCCEEEEECCCCEE
AASASQICDGASGVMVVNERGLKSLGVKPLARVHHMTMMGGDPVIMLEAPLPATQRALQK
ECCHHHHCCCCCCEEEECCCCCHHHCCCHHHHHHHHHEECCCCEEEEECCCCHHHHHHHH
AGMSIDDIDLYEVNEAFASVPTAWLKTTGADPSRLNVNGGAIALGHPLGGSGTKLMTTLL
CCCCCCCCHHHHHHHHHHHCCHHHHHCCCCCCCEEECCCCEEEECCCCCCCCHHHHHHHH
HALKQRNKRYGLQTMCEGGGMANVTIVERL
HHHHHHHHHCCHHHHHCCCCEEEEEEEECC
>Mature Secondary Structure 
AEAYIVAAARTAGGRKGGRLAGWHPADLAAKVLDALVERSGAAPDQVEDVIMGCVMQTG
CCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
EQSTNIARNAVLASKLPESVPGTSIDRQCGSSQQALHFAAQAVMSGAMDVVIAAGVESMT
CCHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHH
RVPMGLSSTLPAKNGFGHYKSPSMESRYPNIQFSQFTGAEMMAEKYGLSKDDLDEYAYNS
HCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCHHHHHHHHCCCHHHHHHHHHCC
HQRAIAATQAGHFKDEIVPLQITRADGSTDTHHIDEGIRFDVSLDGIKGVKLIAENGKLT
CHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCCCCEEEEEECCCCCEEEEECCCCEE
AASASQICDGASGVMVVNERGLKSLGVKPLARVHHMTMMGGDPVIMLEAPLPATQRALQK
ECCHHHHCCCCCCEEEECCCCCHHHCCCHHHHHHHHHEECCCCEEEEECCCCHHHHHHHH
AGMSIDDIDLYEVNEAFASVPTAWLKTTGADPSRLNVNGGAIALGHPLGGSGTKLMTTLL
CCCCCCCCHHHHHHHHHHHCCHHHHHCCCCCCCEEECCCCEEEECCCCCCCCHHHHHHHH
HALKQRNKRYGLQTMCEGGGMANVTIVERL
HHHHHHHHHCCHHHHHCCCCEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA