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The map label for this gene is adh [H]

Identifier: 146338028

GI number: 146338028

Start: 983456

End: 984544

Strand: Direct

Name: adh [H]

Synonym: BRADO0921

Alternate gene names: 146338028

Gene position: 983456-984544 (Clockwise)

Preceding gene: 146338027

Following gene: 146338032

Centisome position: 13.19

GC content: 65.2

Gene sequence:

>1089_bases
ATGAAAGCCGCCGTGCTGATGGAGGTCAACAAGCCGCTGGTGATCGAGGACATCAGCGTGCCCAAGCCCGGGCCGCGCGA
AGTGCTGATCCGGACGGCCGTCGCCGGCCTCTGTCATTCGGATCTGCACTTCATCGAGGGACTCTATCCGCATCCGCTGC
CGGCGGTGCTCGGCCATGAGTCGGCCGGCATCGTCGAGCAGGTCGGCTCAGACGTCACCTATGTGAAGCCCGGCGATCAT
GTCGTCACCTGTCTTTCGGTGTTCTGCGGCACCTGCGACAACTGCACCACGGGCCGCCCGGTGCTGTGCACCGACACCAC
GGTGAAAATGCCGCCCGGCGCCTCCAACCGGCTGTCATGGGGACGAAGTGAGAAGCTGCATCAGTTTCTCAACCTGTCGT
CCTTCGCCGAGCAGATGCTGGTACACGAGAACGCGATCGTGAAGATCCGCAACGACATGCCGCTCGAGCTCGCCGCGCTG
ATCGGCTGCGGCGTCATCACCGGCTATGGCGCTGTCGTCAACACAGCGCGGGTGACGGCGGGGGAGACGGTCGCCGTGAT
CGGCTGCGGCGGCGTCGGCATGGCCGCGATCAACGGCGCCGAGATCGCGGGCGCCGGCCGCATCATCGCCATCGACACCA
ATCCGGCCAAGCTGCAGCTCGCGACCAAGCTCGGCGCCACCGACATCATTAATCCCCTCGATGGTGATGTCGTGGCGCAG
GTGCGCGAGCTCACCAAGGGCGGCGTCCACCACGCCTTCGAGGTGCTGGGGCGGAAGGAGACGGCCGAGCAGGCGTTCGC
GATGCTCGCGCCGGGCGGCACCGCGACCATCGTCGGCATGATCCCGTTCGGCCAGAAGATCGAGCTGCACGGCTTCGACT
TCCTGCGCGAGCGCCGCATCCAGGGCTCGTCGATGGGCTCCAACCATTTCCGCGTCGACATGCCCCGCCTCGTCGAGTTC
TACCTGCGCGGCAAGCTGCACCTGGAGGACTGGATCTCCGCCAAGCTGAAGCTGTCGGAGATCAACGAGGGTTTTGCCAA
CATGAAGGCGGGCAAGACCTTGCGTAGCGTGATCGTATTTGATGCGTGA

Upstream 100 bases:

>100_bases
GTGTAGTCCTCTCCCACAAGGGGAGAGGGCGCAGTCATGAGCGCCGGAAGGCGATCGGCTACGCCGCTCGCTCAAATCAT
AACAAACAGGGAGAACGTCA

Downstream 100 bases:

>100_bases
GTCGCGCGGGGCAACCCGGTATCGACGATGGTTGCCCGTCATGCCCGGGCTTGACCCGGGCATCCCGTCTCTCCCGAAAG
GATGGATGGCCGGGTCAAGC

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH [H]

Number of amino acids: Translated: 362; Mature: 362

Protein sequence:

>362_residues
MKAAVLMEVNKPLVIEDISVPKPGPREVLIRTAVAGLCHSDLHFIEGLYPHPLPAVLGHESAGIVEQVGSDVTYVKPGDH
VVTCLSVFCGTCDNCTTGRPVLCTDTTVKMPPGASNRLSWGRSEKLHQFLNLSSFAEQMLVHENAIVKIRNDMPLELAAL
IGCGVITGYGAVVNTARVTAGETVAVIGCGGVGMAAINGAEIAGAGRIIAIDTNPAKLQLATKLGATDIINPLDGDVVAQ
VRELTKGGVHHAFEVLGRKETAEQAFAMLAPGGTATIVGMIPFGQKIELHGFDFLRERRIQGSSMGSNHFRVDMPRLVEF
YLRGKLHLEDWISAKLKLSEINEGFANMKAGKTLRSVIVFDA

Sequences:

>Translated_362_residues
MKAAVLMEVNKPLVIEDISVPKPGPREVLIRTAVAGLCHSDLHFIEGLYPHPLPAVLGHESAGIVEQVGSDVTYVKPGDH
VVTCLSVFCGTCDNCTTGRPVLCTDTTVKMPPGASNRLSWGRSEKLHQFLNLSSFAEQMLVHENAIVKIRNDMPLELAAL
IGCGVITGYGAVVNTARVTAGETVAVIGCGGVGMAAINGAEIAGAGRIIAIDTNPAKLQLATKLGATDIINPLDGDVVAQ
VRELTKGGVHHAFEVLGRKETAEQAFAMLAPGGTATIVGMIPFGQKIELHGFDFLRERRIQGSSMGSNHFRVDMPRLVEF
YLRGKLHLEDWISAKLKLSEINEGFANMKAGKTLRSVIVFDA
>Mature_362_residues
MKAAVLMEVNKPLVIEDISVPKPGPREVLIRTAVAGLCHSDLHFIEGLYPHPLPAVLGHESAGIVEQVGSDVTYVKPGDH
VVTCLSVFCGTCDNCTTGRPVLCTDTTVKMPPGASNRLSWGRSEKLHQFLNLSSFAEQMLVHENAIVKIRNDMPLELAAL
IGCGVITGYGAVVNTARVTAGETVAVIGCGGVGMAAINGAEIAGAGRIIAIDTNPAKLQLATKLGATDIINPLDGDVVAQ
VRELTKGGVHHAFEVLGRKETAEQAFAMLAPGGTATIVGMIPFGQKIELHGFDFLRERRIQGSSMGSNHFRVDMPRLVEF
YLRGKLHLEDWISAKLKLSEINEGFANMKAGKTLRSVIVFDA

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=365, Percent_Identity=41.6438356164384, Blast_Score=268, Evalue=4e-72,
Organism=Homo sapiens, GI4501929, Length=366, Percent_Identity=40.9836065573771, Blast_Score=263, Evalue=1e-70,
Organism=Homo sapiens, GI4501933, Length=365, Percent_Identity=40.2739726027397, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI156523966, Length=367, Percent_Identity=36.5122615803815, Blast_Score=228, Evalue=9e-60,
Organism=Homo sapiens, GI71743840, Length=365, Percent_Identity=36.4383561643836, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI262073058, Length=365, Percent_Identity=36.4383561643836, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI71565152, Length=370, Percent_Identity=35.6756756756757, Blast_Score=223, Evalue=1e-58,
Organism=Homo sapiens, GI4501939, Length=359, Percent_Identity=37.0473537604457, Blast_Score=223, Evalue=3e-58,
Organism=Homo sapiens, GI71565154, Length=366, Percent_Identity=36.8852459016393, Blast_Score=218, Evalue=5e-57,
Organism=Homo sapiens, GI156627571, Length=364, Percent_Identity=24.4505494505494, Blast_Score=86, Evalue=4e-17,
Organism=Escherichia coli, GI1786552, Length=367, Percent_Identity=39.7820163487738, Blast_Score=232, Evalue=3e-62,
Organism=Escherichia coli, GI87082125, Length=371, Percent_Identity=27.7628032345013, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788073, Length=346, Percent_Identity=26.878612716763, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1788075, Length=352, Percent_Identity=26.1363636363636, Blast_Score=104, Evalue=9e-24,
Organism=Escherichia coli, GI87081918, Length=336, Percent_Identity=30.3571428571429, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1790045, Length=376, Percent_Identity=26.063829787234, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786518, Length=369, Percent_Identity=27.6422764227642, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788407, Length=284, Percent_Identity=29.2253521126761, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI226510992, Length=332, Percent_Identity=27.1084337349398, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786825, Length=393, Percent_Identity=24.6819338422392, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787863, Length=358, Percent_Identity=22.6256983240223, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI87082401, Length=342, Percent_Identity=24.8538011695906, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI25146526, Length=373, Percent_Identity=36.7292225201072, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI71997431, Length=375, Percent_Identity=36.5333333333333, Blast_Score=225, Evalue=3e-59,
Organism=Caenorhabditis elegans, GI17565904, Length=337, Percent_Identity=36.2017804154303, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17562584, Length=362, Percent_Identity=28.7292817679558, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17562876, Length=366, Percent_Identity=27.3224043715847, Blast_Score=118, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI71988145, Length=363, Percent_Identity=27.8236914600551, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17562878, Length=370, Percent_Identity=27.2972972972973, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17562582, Length=367, Percent_Identity=28.6103542234332, Blast_Score=102, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6320033, Length=371, Percent_Identity=38.544474393531, Blast_Score=258, Evalue=1e-69,
Organism=Saccharomyces cerevisiae, GI6323729, Length=368, Percent_Identity=30.1630434782609, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6319621, Length=371, Percent_Identity=30.4582210242588, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6323961, Length=330, Percent_Identity=32.1212121212121, Blast_Score=120, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6324486, Length=368, Percent_Identity=29.3478260869565, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6319258, Length=327, Percent_Identity=27.217125382263, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6322619, Length=384, Percent_Identity=27.34375, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6319955, Length=384, Percent_Identity=27.0833333333333, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17737895, Length=370, Percent_Identity=42.1621621621622, Blast_Score=266, Evalue=1e-71,
Organism=Drosophila melanogaster, GI17137530, Length=348, Percent_Identity=24.4252873563218, Blast_Score=82, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17737897, Length=220, Percent_Identity=28.1818181818182, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284; =1.1.1.1 [H]

Molecular weight: Translated: 38636; Mature: 38636

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAAVLMEVNKPLVIEDISVPKPGPREVLIRTAVAGLCHSDLHFIEGLYPHPLPAVLGHE
CCCEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCC
SAGIVEQVGSDVTYVKPGDHVVTCLSVFCGTCDNCTTGRPVLCTDTTVKMPPGASNRLSW
CCCHHHHHCCCEEEECCCHHHHHHHHHHHCCCCCCCCCCCEEEECCEEECCCCCCCCCCC
GRSEKLHQFLNLSSFAEQMLVHENAIVKIRNDMPLELAALIGCGVITGYGAVVNTARVTA
CHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHCCHHHHEEEEEEC
GETVAVIGCGGVGMAAINGAEIAGAGRIIAIDTNPAKLQLATKLGATDIINPLDGDVVAQ
CCEEEEEECCCCCEEEECCCEEECCCEEEEEECCCCEEEEEECCCCHHCCCCCCHHHHHH
VRELTKGGVHHAFEVLGRKETAEQAFAMLAPGGTATIVGMIPFGQKIELHGFDFLRERRI
HHHHHHCCHHHHHHHHCCHHHHHHHHEEECCCCCEEEEEEECCCCEEEECCHHHHHHHHC
QGSSMGSNHFRVDMPRLVEFYLRGKLHLEDWISAKLKLSEINEGFANMKAGKTLRSVIVF
CCCCCCCCCEEECHHHHHHHHHCCCCCHHHHHHHEEEEHHHHCCHHHHHHCCCEEEEEEE
DA
CC
>Mature Secondary Structure
MKAAVLMEVNKPLVIEDISVPKPGPREVLIRTAVAGLCHSDLHFIEGLYPHPLPAVLGHE
CCCEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCC
SAGIVEQVGSDVTYVKPGDHVVTCLSVFCGTCDNCTTGRPVLCTDTTVKMPPGASNRLSW
CCCHHHHHCCCEEEECCCHHHHHHHHHHHCCCCCCCCCCCEEEECCEEECCCCCCCCCCC
GRSEKLHQFLNLSSFAEQMLVHENAIVKIRNDMPLELAALIGCGVITGYGAVVNTARVTA
CHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHCCHHHHEEEEEEC
GETVAVIGCGGVGMAAINGAEIAGAGRIIAIDTNPAKLQLATKLGATDIINPLDGDVVAQ
CCEEEEEECCCCCEEEECCCEEECCCEEEEEECCCCEEEEEECCCCHHCCCCCCHHHHHH
VRELTKGGVHHAFEVLGRKETAEQAFAMLAPGGTATIVGMIPFGQKIELHGFDFLRERRI
HHHHHHCCHHHHHHHHCCHHHHHHHHEEECCCCCEEEEEEECCCCEEEECCHHHHHHHHC
QGSSMGSNHFRVDMPRLVEFYLRGKLHLEDWISAKLKLSEINEGFANMKAGKTLRSVIVF
CCCCCCCCCEEECHHHHHHHHHCCCCCHHHHHHHEEEEHHHHCCHHHHHHCCCEEEEEEE
DA
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]