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The map label for this gene is nudH [H]

Identifier: 146337567

GI number: 146337567

Start: 433349

End: 433858

Strand: Reverse

Name: nudH [H]

Synonym: BRADO0422

Alternate gene names: 146337567

Gene position: 433858-433349 (Counterclockwise)

Preceding gene: 146337568

Following gene: 146337560

Centisome position: 5.82

GC content: 69.61

Gene sequence:

>510_bases
ATGGATGCGAGCATGACCGAGACCAGACCCTATCGCCCGAATGTCGGCATCGCCTTGTTGAATGCCGACGGCCTCGTCTT
CCTCGGGCGCCGCTTTCGCGACGACGGCCCGGAGATCGTCCTGCCCGGCCTCGAATGGCAGATGCCGCAGGGTGGCGTCG
ACGCGGGCGAGGATCTGCAGGCGGCGGCGCGGCGCGAGCTGTGGGAGGAGACCGGCATCCGCGACGCCGACATTCTCGCC
GAGACCGACTGGTTGACTTACGAGTTTCCGCCGTTCGAAGACCCCAACCACCGCCTCGCCCGCTTCCGCGGGCAGCGCCA
GAAATGGTTCGCGATGCGCTTCACCGGCCGCGAGGCCGACATCGATCCGGTGACGCCGCGCAACGGCCAGCCGGCCGAGT
TCGACGCCTGGCGCTGGGAACGGCTGGCGCGCGTGCCGGACCTGGTGGTGCCGTTCCGGCGCGAGGTGTATCGCGCGGTA
GCAGAGGCGTTCGCGCATCTGGCGGCGTGA

Upstream 100 bases:

>100_bases
CATCGACCGCTCGGCGCGATCTGCACGGCCGTTGCACGGCATCCCTGCAGACCCGCCGCGACACCGCCGTCACGCTGCGC
TGCTATGCGACGCGCAGACC

Downstream 100 bases:

>100_bases
GTGAACCAGTGAAGTGCACTAATAGGTAGTCGGTGCGCAGCCAGATGCAGCGCCCTCTCCCCTTGTGGGAGAGGGCATCA
CCGACCTTCCGCGCATGCGG

Product: dinucleoside polyphosphate hydrolase

Products: NA

Alternate protein names: (Di)nucleoside polyphosphate hydrolase [H]

Number of amino acids: Translated: 169; Mature: 169

Protein sequence:

>169_residues
MDASMTETRPYRPNVGIALLNADGLVFLGRRFRDDGPEIVLPGLEWQMPQGGVDAGEDLQAAARRELWEETGIRDADILA
ETDWLTYEFPPFEDPNHRLARFRGQRQKWFAMRFTGREADIDPVTPRNGQPAEFDAWRWERLARVPDLVVPFRREVYRAV
AEAFAHLAA

Sequences:

>Translated_169_residues
MDASMTETRPYRPNVGIALLNADGLVFLGRRFRDDGPEIVLPGLEWQMPQGGVDAGEDLQAAARRELWEETGIRDADILA
ETDWLTYEFPPFEDPNHRLARFRGQRQKWFAMRFTGREADIDPVTPRNGQPAEFDAWRWERLARVPDLVVPFRREVYRAV
AEAFAHLAA
>Mature_169_residues
MDASMTETRPYRPNVGIALLNADGLVFLGRRFRDDGPEIVLPGLEWQMPQGGVDAGEDLQAAARRELWEETGIRDADILA
ETDWLTYEFPPFEDPNHRLARFRGQRQKWFAMRFTGREADIDPVTPRNGQPAEFDAWRWERLARVPDLVVPFRREVYRAV
AEAFAHLAA

Specific function: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1789194, Length=173, Percent_Identity=38.150289017341, Blast_Score=100, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR022927 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 19453; Mature: 19453

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDASMTETRPYRPNVGIALLNADGLVFLGRRFRDDGPEIVLPGLEWQMPQGGVDAGEDLQ
CCCCCCCCCCCCCCCCEEEECCCCEEEECCHHCCCCCEEEECCCCEECCCCCCCCCHHHH
AAARRELWEETGIRDADILAETDWLTYEFPPFEDPNHRLARFRGQRQKWFAMRFTGREAD
HHHHHHHHHHHCCCCCHHEECCCCEEEECCCCCCCCHHHHHHCCCCCEEEEEEECCCCCC
IDPVTPRNGQPAEFDAWRWERLARVPDLVVPFRREVYRAVAEAFAHLAA
CCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDASMTETRPYRPNVGIALLNADGLVFLGRRFRDDGPEIVLPGLEWQMPQGGVDAGEDLQ
CCCCCCCCCCCCCCCCEEEECCCCEEEECCHHCCCCCEEEECCCCEECCCCCCCCCHHHH
AAARRELWEETGIRDADILAETDWLTYEFPPFEDPNHRLARFRGQRQKWFAMRFTGREAD
HHHHHHHHHHHCCCCCHHEECCCCEEEECCCCCCCCHHHHHHCCCCCEEEEEEECCCCCC
IDPVTPRNGQPAEFDAWRWERLARVPDLVVPFRREVYRAVAEAFAHLAA
CCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA