Click here to switch to the map view.

The map label for this gene is coaBC [H]

Identifier: 146337250

GI number: 146337250

Start: 87140

End: 88567

Strand: Direct

Name: coaBC [H]

Synonym: BRADO0077

Alternate gene names: 146337250

Gene position: 87140-88567 (Clockwise)

Preceding gene: 146337249

Following gene: 146337251

Centisome position: 1.17

GC content: 69.19

Gene sequence:

>1428_bases
ATGGCCAGCCTGACCATCCGCAAGCTCGACGACTCGCTGAAGACTTATCTCCGGCTGCGCTCGGCGCAGAACGGCCGCTC
CGTCGAGGAGGAGGTCCGGGTCATTCTCCGGGCGCTGATCGAGCCGGTCGACCCATCCGAGCCGCCGGCGGCAGCGCCAT
CTCCGGCCGCTCTGCCGGATCCCGGCCTGCCCCAGCCCGGCCTCGCCCGCGAGGCACGCGTCACCCTGATCATCGGCGGC
GGCATTGCCGCTTACAAGTCGCTCGACCTGATCCGGCGACTCCGGGAGCGCTATATCCAGGTCCGCTGCGTCATGACGAG
AGCGGCGACGCAGTTCGTCACCGAGCTCGCCGCGTCGGCGCTGTCCGGCGACCGCGTCTTCACCGACCTGTTCGACGCGC
GCAGTGAGTTCGACGTCGGCCATATCCGGCTGGCGCGCGACTGCGATCTCATCGTCGTCGCGCCGGCGACCGCCGACCTG
ATGTCCAAGATGGCGCAAGGTGCCGCCGACGATCTCGCCAGCGCCATCCTGCTCGCCGCCAGCCGGCCGATCCTGCTGGC
GCCGGCGATGAATCCGATGATGTGGAGCAATCCGGCGACCCGCCGGAACGCCGCGACCCTGCAGCGCGACGGCATCCACA
TGATCGGGCCGAACGCCGGCGAGATGGCTGAGAAGGGCGAGGCGGGTGTCGGCCGCATGGCCGAGCCGACCGAGATCGCC
GACGCCGTGGTCGCGATGCTGAAGCCCCCGGCGCCGCGCCCGCTCGCCGGCCGCCGCGTGCTGATCACCGCGGGGCCGAC
GCACGAGCCGATCGACCCCGTCCGCTATATCGCCAACCGCTCCTCCGGCAAACAGGGCTTTGCGATTGCCGCCGCAGCCC
AGGCCGCCGGCGCAGACGTCAGGCTGATCGCGGGACCGGTCGAGCTCGCCGATCCCAAGGGCGTCAAGGTCACGCATGTC
GAGTCGGCGCGGCAGATGCTCGAGGCTGTCGAAGCCGAGCTGCCGGCCGACGTCGCGATCTTCGCCGCAGCGGTGGCGGA
TTGGCGCGTCGCCAGTGAAGGCGGCCAGAAGCTGAAGAAAACCGATCAGGCAATCCCGCCGCTGCAGCTGGTCGAGAACC
CTGACATCCTCGCGACCATCTCCAAGCTGAAAGAGAAGCGCCCCGGCCTGGTCATCGGCTTCGCCGCCGAGACGGAACAT
CTGATCGACAACGCCAAAGCCAAGTTCGCGCGCAAGGGCTGCGACTGGATCGTCGCCAACGACGTCTCGCCCGCCACCGG
CGTGATGGGCGGCGACCGCAACACGGTGCATCTCTTGACGAAGGACGCCGACGGCGTCCATGTCGCGTCGTGGCCGATCA
TGACCAAGGACGAGGTGGCGAACGCGCTCGTCGCCGAGATCGCCCGAACCGTAGGACAATCAGCGTGA

Upstream 100 bases:

>100_bases
TGGGCACGGGCCCGTAGAGCTGCTCTAGCGTCTGAACTGATTGCACTGCGATCAATTTCTGCTAGCATTGCATTCACAAC
GACAATGCTGGGAGGCGGTC

Downstream 100 bases:

>100_bases
CACAGACGATCGCGATCGACGTTCGCATCCTGCCGCATGGCGCGGGCCTGCCGCTGCCGGCCTATCAGACCGCGCATGCC
GCCGGGATGGACCTGCTCGC

Product: bifunctional SbtC-like/phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 475; Mature: 474

Protein sequence:

>475_residues
MASLTIRKLDDSLKTYLRLRSAQNGRSVEEEVRVILRALIEPVDPSEPPAAAPSPAALPDPGLPQPGLAREARVTLIIGG
GIAAYKSLDLIRRLRERYIQVRCVMTRAATQFVTELAASALSGDRVFTDLFDARSEFDVGHIRLARDCDLIVVAPATADL
MSKMAQGAADDLASAILLAASRPILLAPAMNPMMWSNPATRRNAATLQRDGIHMIGPNAGEMAEKGEAGVGRMAEPTEIA
DAVVAMLKPPAPRPLAGRRVLITAGPTHEPIDPVRYIANRSSGKQGFAIAAAAQAAGADVRLIAGPVELADPKGVKVTHV
ESARQMLEAVEAELPADVAIFAAAVADWRVASEGGQKLKKTDQAIPPLQLVENPDILATISKLKEKRPGLVIGFAAETEH
LIDNAKAKFARKGCDWIVANDVSPATGVMGGDRNTVHLLTKDADGVHVASWPIMTKDEVANALVAEIARTVGQSA

Sequences:

>Translated_475_residues
MASLTIRKLDDSLKTYLRLRSAQNGRSVEEEVRVILRALIEPVDPSEPPAAAPSPAALPDPGLPQPGLAREARVTLIIGG
GIAAYKSLDLIRRLRERYIQVRCVMTRAATQFVTELAASALSGDRVFTDLFDARSEFDVGHIRLARDCDLIVVAPATADL
MSKMAQGAADDLASAILLAASRPILLAPAMNPMMWSNPATRRNAATLQRDGIHMIGPNAGEMAEKGEAGVGRMAEPTEIA
DAVVAMLKPPAPRPLAGRRVLITAGPTHEPIDPVRYIANRSSGKQGFAIAAAAQAAGADVRLIAGPVELADPKGVKVTHV
ESARQMLEAVEAELPADVAIFAAAVADWRVASEGGQKLKKTDQAIPPLQLVENPDILATISKLKEKRPGLVIGFAAETEH
LIDNAKAKFARKGCDWIVANDVSPATGVMGGDRNTVHLLTKDADGVHVASWPIMTKDEVANALVAEIARTVGQSA
>Mature_474_residues
ASLTIRKLDDSLKTYLRLRSAQNGRSVEEEVRVILRALIEPVDPSEPPAAAPSPAALPDPGLPQPGLAREARVTLIIGGG
IAAYKSLDLIRRLRERYIQVRCVMTRAATQFVTELAASALSGDRVFTDLFDARSEFDVGHIRLARDCDLIVVAPATADLM
SKMAQGAADDLASAILLAASRPILLAPAMNPMMWSNPATRRNAATLQRDGIHMIGPNAGEMAEKGEAGVGRMAEPTEIAD
AVVAMLKPPAPRPLAGRRVLITAGPTHEPIDPVRYIANRSSGKQGFAIAAAAQAAGADVRLIAGPVELADPKGVKVTHVE
SARQMLEAVEAELPADVAIFAAAVADWRVASEGGQKLKKTDQAIPPLQLVENPDILATISKLKEKRPGLVIGFAAETEHL
IDNAKAKFARKGCDWIVANDVSPATGVMGGDRNTVHLLTKDADGVHVASWPIMTKDEVANALVAEIARTVGQSA

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=205, Percent_Identity=31.7073170731707, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI87082301, Length=398, Percent_Identity=44.2211055276382, Blast_Score=276, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI17560194, Length=185, Percent_Identity=30.8108108108108, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322925, Length=299, Percent_Identity=25.4180602006689, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322762, Length=198, Percent_Identity=27.2727272727273, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24657262, Length=190, Percent_Identity=31.0526315789474, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 50333; Mature: 50201

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASLTIRKLDDSLKTYLRLRSAQNGRSVEEEVRVILRALIEPVDPSEPPAAAPSPAALPD
CCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
PGLPQPGLAREARVTLIIGGGIAAYKSLDLIRRLRERYIQVRCVMTRAATQFVTELAASA
CCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSGDRVFTDLFDARSEFDVGHIRLARDCDLIVVAPATADLMSKMAQGAADDLASAILLAA
HCCCHHHHHHHHHHCCCCCCEEEEECCCCEEEECCCHHHHHHHHHCCHHHHHHHHHHHHC
SRPILLAPAMNPMMWSNPATRRNAATLQRDGIHMIGPNAGEMAEKGEAGVGRMAEPTEIA
CCCEEEECCCCCCCCCCCCCCCCCHHHHHCCEEEECCCHHHHHHCCCCCCCCCCCHHHHH
DAVVAMLKPPAPRPLAGRRVLITAGPTHEPIDPVRYIANRSSGKQGFAIAAAAQAAGADV
HHHHHHHCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHCCCCCCCCEEEEEHHHHCCCCE
RLIAGPVELADPKGVKVTHVESARQMLEAVEAELPADVAIFAAAVADWRVASEGGQKLKK
EEEECCCEECCCCCCEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
TDQAIPPLQLVENPDILATISKLKEKRPGLVIGFAAETEHLIDNAKAKFARKGCDWIVAN
HHCCCCCHHHCCCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCCEEEEC
DVSPATGVMGGDRNTVHLLTKDADGVHVASWPIMTKDEVANALVAEIARTVGQSA
CCCCCCCCCCCCCCEEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ASLTIRKLDDSLKTYLRLRSAQNGRSVEEEVRVILRALIEPVDPSEPPAAAPSPAALPD
CCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
PGLPQPGLAREARVTLIIGGGIAAYKSLDLIRRLRERYIQVRCVMTRAATQFVTELAASA
CCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSGDRVFTDLFDARSEFDVGHIRLARDCDLIVVAPATADLMSKMAQGAADDLASAILLAA
HCCCHHHHHHHHHHCCCCCCEEEEECCCCEEEECCCHHHHHHHHHCCHHHHHHHHHHHHC
SRPILLAPAMNPMMWSNPATRRNAATLQRDGIHMIGPNAGEMAEKGEAGVGRMAEPTEIA
CCCEEEECCCCCCCCCCCCCCCCCHHHHHCCEEEECCCHHHHHHCCCCCCCCCCCHHHHH
DAVVAMLKPPAPRPLAGRRVLITAGPTHEPIDPVRYIANRSSGKQGFAIAAAAQAAGADV
HHHHHHHCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHCCCCCCCCEEEEEHHHHCCCCE
RLIAGPVELADPKGVKVTHVESARQMLEAVEAELPADVAIFAAAVADWRVASEGGQKLKK
EEEECCCEECCCCCCEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
TDQAIPPLQLVENPDILATISKLKEKRPGLVIGFAAETEHLIDNAKAKFARKGCDWIVAN
HHCCCCCHHHCCCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCCCCEEEEC
DVSPATGVMGGDRNTVHLLTKDADGVHVASWPIMTKDEVANALVAEIARTVGQSA
CCCCCCCCCCCCCCEEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA