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The map label for this gene is purC2 [H]

Identifier: 146337190

GI number: 146337190

Start: 20610

End: 21524

Strand: Direct

Name: purC2 [H]

Synonym: BRADO0015

Alternate gene names: 146337190

Gene position: 20610-21524 (Clockwise)

Preceding gene: 146337189

Following gene: 146337192

Centisome position: 0.28

GC content: 64.92

Gene sequence:

>915_bases
ATGACCACGCTTCTCGCCAGCAATCTGCCGCTCCCGATAATCGGCCGCGGCAAGGTCCGCGACATCTATGCCGTCGGCGA
CGACCGCGTGCTGCTGCTGACCACCGACCGCATCTCCGCCTTCGACGTCGTGATGAACGAGACCATCCCGATGAAGGGCG
CGGTGCTGACGCAGATCTCGGCCTACTGGTTCAACGCGCTCGAAGGCGTCGTGCATCACCATATGATCTCGGCCGACACG
GATGAGATCATCACAGCCGTCCCCGAGTTGAAGCCGCATCGCGACGAGATCCTCGGCCGTGCGATGCTGTGCAAGCGGAC
CACGGTGTTTCCGATCGAATGCGTGATCCGCGGCTATCTCTCGGGCTCGGCCTGGAAGGAATATGCGGCCCACGGCACGC
TCGCCGGCGAACAGTTGCCTGCAGGTCTTGTCGAGAGCCAGAAGCTCGAGCCCGCGATCTTCAGCCCGGCGACCAAGGCC
GAGACCGGCCATGACGAGAACATCACGATCGCCCGGATGCGCGAGGTGGTCGGCGACGAGACGGCATATACGCTCGAGAG
CATGACGCGCGCGGTCTATACACTGGGTGAAAAGCTCGCGCGCGAGCAGGGCATCATCATCGCCGACACCAAATTCGAGT
TCGGCCGCGACAAGGACGGCCACATCATCCTGATCGACGAGGTGATGACGCCGGATTCGTCGCGCTTCTGGGCGGTCGAC
GCCTACAAGCCGGGCCAGCCGCAGCCGAGCTTCGACAAGCAGCCGCTGCGCGACTATCTCGATGCCGAACGCCGTGCCGG
CCGCTGGAACGGCGACGCCCCGCCGCCGCCGCTGCCGCAGAGCGTAGTGGACGCGACAAGCCAGCGCTATCTCGAGGCGT
TCCGGCGCGTGACGGAACGGGAGCTGAAGGTCTGA

Upstream 100 bases:

>100_bases
GAAAACCGGCCGCTTCGCCGCAGTACCGCACGAGCACGAGTTCATTCCGCTGCCGGAATAGGCTATGGGGAGCGACGCTC
CCTTTCGAAGGCTCGACACG

Downstream 100 bases:

>100_bases
GGATTCTAAGCTCACGCGTTGACGCCTGGATCGGGACTTTTTGTAGTAGCGCGCATTGTCGACAGTGTGCATCGTGGACC
CCCAACCCCGATCCTCCCCG

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase 2 [H]

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MTTLLASNLPLPIIGRGKVRDIYAVGDDRVLLLTTDRISAFDVVMNETIPMKGAVLTQISAYWFNALEGVVHHHMISADT
DEIITAVPELKPHRDEILGRAMLCKRTTVFPIECVIRGYLSGSAWKEYAAHGTLAGEQLPAGLVESQKLEPAIFSPATKA
ETGHDENITIARMREVVGDETAYTLESMTRAVYTLGEKLAREQGIIIADTKFEFGRDKDGHIILIDEVMTPDSSRFWAVD
AYKPGQPQPSFDKQPLRDYLDAERRAGRWNGDAPPPPLPQSVVDATSQRYLEAFRRVTERELKV

Sequences:

>Translated_304_residues
MTTLLASNLPLPIIGRGKVRDIYAVGDDRVLLLTTDRISAFDVVMNETIPMKGAVLTQISAYWFNALEGVVHHHMISADT
DEIITAVPELKPHRDEILGRAMLCKRTTVFPIECVIRGYLSGSAWKEYAAHGTLAGEQLPAGLVESQKLEPAIFSPATKA
ETGHDENITIARMREVVGDETAYTLESMTRAVYTLGEKLAREQGIIIADTKFEFGRDKDGHIILIDEVMTPDSSRFWAVD
AYKPGQPQPSFDKQPLRDYLDAERRAGRWNGDAPPPPLPQSVVDATSQRYLEAFRRVTERELKV
>Mature_303_residues
TTLLASNLPLPIIGRGKVRDIYAVGDDRVLLLTTDRISAFDVVMNETIPMKGAVLTQISAYWFNALEGVVHHHMISADTD
EIITAVPELKPHRDEILGRAMLCKRTTVFPIECVIRGYLSGSAWKEYAAHGTLAGEQLPAGLVESQKLEPAIFSPATKAE
TGHDENITIARMREVVGDETAYTLESMTRAVYTLGEKLAREQGIIIADTKFEFGRDKDGHIILIDEVMTPDSSRFWAVDA
YKPGQPQPSFDKQPLRDYLDAERRAGRWNGDAPPPPLPQSVVDATSQRYLEAFRRVTERELKV

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6319326, Length=294, Percent_Identity=44.8979591836735, Blast_Score=250, Evalue=2e-67,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 33876; Mature: 33745

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS01057 SAICAR_SYNTHETASE_1 ; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLLASNLPLPIIGRGKVRDIYAVGDDRVLLLTTDRISAFDVVMNETIPMKGAVLTQIS
CCCEECCCCCCCEECCCCCEEEEEECCCEEEEEECCCCCHHHHHHCCCCCCCCHHHHHHH
AYWFNALEGVVHHHMISADTDEIITAVPELKPHRDEILGRAMLCKRTTVFPIECVIRGYL
HHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
SGSAWKEYAAHGTLAGEQLPAGLVESQKLEPAIFSPATKAETGHDENITIARMREVVGDE
CCHHHHHHHHCCCCCCCCCCCCHHHHCCCCCHHCCCCCCCCCCCCCCCHHHHHHHHHCCC
TAYTLESMTRAVYTLGEKLAREQGIIIADTKFEFGRDKDGHIILIDEVMTPDSSRFWAVD
HHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCEEEEECCCCCCCCCEEEEE
AYKPGQPQPSFDKQPLRDYLDAERRAGRWNGDAPPPPLPQSVVDATSQRYLEAFRRVTER
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ELKV
HCCC
>Mature Secondary Structure 
TTLLASNLPLPIIGRGKVRDIYAVGDDRVLLLTTDRISAFDVVMNETIPMKGAVLTQIS
CCEECCCCCCCEECCCCCEEEEEECCCEEEEEECCCCCHHHHHHCCCCCCCCHHHHHHH
AYWFNALEGVVHHHMISADTDEIITAVPELKPHRDEILGRAMLCKRTTVFPIECVIRGYL
HHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
SGSAWKEYAAHGTLAGEQLPAGLVESQKLEPAIFSPATKAETGHDENITIARMREVVGDE
CCHHHHHHHHCCCCCCCCCCCCHHHHCCCCCHHCCCCCCCCCCCCCCCHHHHHHHHHCCC
TAYTLESMTRAVYTLGEKLAREQGIIIADTKFEFGRDKDGHIILIDEVMTPDSSRFWAVD
HHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCEEEEECCCCCCCCCEEEEE
AYKPGQPQPSFDKQPLRDYLDAERRAGRWNGDAPPPPLPQSVVDATSQRYLEAFRRVTER
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ELKV
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]