Click here to switch to the map view.

The map label for this gene is f1pep1 [H]

Identifier: 146302759

GI number: 146302759

Start: 6070932

End: 6073088

Strand: Direct

Name: f1pep1 [H]

Synonym: Fjoh_5032

Alternate gene names: 146302759

Gene position: 6070932-6073088 (Clockwise)

Preceding gene: 146302758

Following gene: 146302760

Centisome position: 99.57

GC content: 33.7

Gene sequence:

>2157_bases
ATGATCAAAAAAACCGCTTTCGCTCTTTTAGTTTTTATTACAAGTCAAGCTTCACAAGCCCAGTACAAATACCCTGCAAC
TCCTGAACGTCCTGTTGTAGAGGATTATTTTGGAACAAAAATCACAGATTCATACAGATGGCTTGAAGACATGAACAATC
CTGAAGTTCAAAAATGGTTCAAAGACGAATCGGATTATACCAACTCTATTGTGAAAACAATTTCTGGACGTGATGCTCTT
TTTAACAGAATGAAAGAAATTCAAGCTTTGAGTGGAGATCAATACGGAACTATTAGACAAGTTGGAGATATTTATTACTA
TACAAAAAATAAAAAGAAAGAAAACATATATAAATTGTATTTCCGTAAAAATAGAAACGGAGCTGAAATTTTATTATTAG
ATCCCAGCACAATAACTAAAGGTGCCACTATAACCAGTTTTAATATTAGTCCTGACAATAAAAAATTGGCAGTAACTATA
TCTGAAGATGGCGCAGAAGTTTGCGATCTTAAAATTATGGATCTTGAATCAAAAAAATTCCTCTCAGATAAACTTACGCC
TGTTTGGAGCGAATTCCCTTTTGAATTTACTCCAGACAGTAAAGCCATAACCTACACTCAAATGGTCACTAGAAATAATA
CAAGTGACGATTTTTTGAAGAACATGAAATCGCTTATACATGTAATTGGCACTGATCCCAAAACAGATAAAATACTTGCT
TCAAAAGAAAACAATCCTGAGTTAGAAATTTTAGCGGCACAATTTCCTTCTGTTAAGCTTCCTGATGATTATTCGTATGT
CATTTTGGATATTGGATCTACAAAAAATGAAGAATTTTCTTTTTATGCCCCGTTTTCAGAACTGGGAAAATCAAAAATTA
ATTGGAAACCATTAATAAAATATGAAGATGAAATAACTGACAGCCAAATTATTGGCGACAAAATATTTTTCCTTACTCAT
AAAAATACACCTAATTATAAACTAGCATATACAAGTCTAAAAAATCCAGATTTCAACAATCCAACGATTCTTGTTCCTGA
AAGCAATAAAATAGTACGAAGATTAAGAAAGTCTAAAAACTTCATTTACTATAATTTGAGTGACGGAATCAATCAGGAAA
TTTTTCAACTTAATGCCAAAACTTTAGAAATCAAAAAGATTCCAATACCTGCGGGTTCTAATGCCGGATATCCACTAAGT
CCACGTTACAACGATGATCTGATGCTTTTTAACAATGGCTGGGTTACACCATCAACAGATTATGATTATAACGGCTTAAC
AGGTAAATTAGAAAAAAGCAAAGAATTAACATCTAATGGTACATTCCCTGACTTTAGCAAAGATTATGTTGTAAAAGAAA
TAGAAGTACCAAGTCATGATGGAGTAATGGTGCCTTTATCTATAATTTATCCTAAAAACATCAAAATGGATGGTTCTACA
TCTTGCTTTATTACAGGATATGGTGCCTATGGAATTAGCCAATATCCGTATTTTGTCGGCCCTAGTTTAATGACTTTATT
AGAACAGCATACTATTGTAGCTTTTACACACATAAGAGGCGGAGGTGAAAAAGGCAATCAATGGCATGTAGACGGAATGA
AAGCTAAAAAACCAAATACATGGAAAGACTTTATTGCCTGTTCTGAATATTTGATAAAAGAAAAATATACTTCTAAAGAA
AAACTTATTGGAAATGGAGTAAGCATGGGAGGTGTATTGATTGGAAGAGCAATTACCGAACGCCCTGATCTTTACAAAGT
GGCACTTGTAGAAGTAGGCTGCACAAACACCTTAAGAATGGAAACTACTCCTAATGGTCCAAACCAAATACCTGAAATTG
GCTCTCTAAAAAATGAAGAAGATGTAAAACATATATTAGAAATGGATTCGCAAAGCAAGGTAAAGAAAGGAGTAAAATAT
CCTGCGGTTTTAATTCGCACCGGTATTAACGACCCTAGAGTTACCCCTTGGGAGCCTGGTAAATTTGCAGCTATTTTACA
AAATTCCACCAGCTCTGATAATCCGGTTTTACTGCATGTTAATTATGCCAATGGTCATCATTCTAATGATTTGGATGTTA
CCTTTGGAGATGAAGCTGACATGTATGCCTTTGCATTGTGGCAGGTTGGAAATACAAAATTTCAAATTAAACCATAA

Upstream 100 bases:

>100_bases
AAATTGACTCTTCCAATTAAATAAAATGTAACATTTTTCTTAAAATAACGTCTTTTATACCAAAACCAAGAACCAATAAT
TATAAATTTATTTAAAAATA

Downstream 100 bases:

>100_bases
CTTTTAAATTTTTGCTTTTTTATAAGATTCTATAAATGCTTGCGAAGACGTGCTGTAGTGCGTCTTCGCAAAATAATAAA
TAAAAAAATTAAACTTTTTT

Product: prolyl oligopeptidase

Products: NA

Alternate protein names: Post-proline cleaving enzyme; Proline-specific endopeptidase; PE; PSE [H]

Number of amino acids: Translated: 718; Mature: 718

Protein sequence:

>718_residues
MIKKTAFALLVFITSQASQAQYKYPATPERPVVEDYFGTKITDSYRWLEDMNNPEVQKWFKDESDYTNSIVKTISGRDAL
FNRMKEIQALSGDQYGTIRQVGDIYYYTKNKKKENIYKLYFRKNRNGAEILLLDPSTITKGATITSFNISPDNKKLAVTI
SEDGAEVCDLKIMDLESKKFLSDKLTPVWSEFPFEFTPDSKAITYTQMVTRNNTSDDFLKNMKSLIHVIGTDPKTDKILA
SKENNPELEILAAQFPSVKLPDDYSYVILDIGSTKNEEFSFYAPFSELGKSKINWKPLIKYEDEITDSQIIGDKIFFLTH
KNTPNYKLAYTSLKNPDFNNPTILVPESNKIVRRLRKSKNFIYYNLSDGINQEIFQLNAKTLEIKKIPIPAGSNAGYPLS
PRYNDDLMLFNNGWVTPSTDYDYNGLTGKLEKSKELTSNGTFPDFSKDYVVKEIEVPSHDGVMVPLSIIYPKNIKMDGST
SCFITGYGAYGISQYPYFVGPSLMTLLEQHTIVAFTHIRGGGEKGNQWHVDGMKAKKPNTWKDFIACSEYLIKEKYTSKE
KLIGNGVSMGGVLIGRAITERPDLYKVALVEVGCTNTLRMETTPNGPNQIPEIGSLKNEEDVKHILEMDSQSKVKKGVKY
PAVLIRTGINDPRVTPWEPGKFAAILQNSTSSDNPVLLHVNYANGHHSNDLDVTFGDEADMYAFALWQVGNTKFQIKP

Sequences:

>Translated_718_residues
MIKKTAFALLVFITSQASQAQYKYPATPERPVVEDYFGTKITDSYRWLEDMNNPEVQKWFKDESDYTNSIVKTISGRDAL
FNRMKEIQALSGDQYGTIRQVGDIYYYTKNKKKENIYKLYFRKNRNGAEILLLDPSTITKGATITSFNISPDNKKLAVTI
SEDGAEVCDLKIMDLESKKFLSDKLTPVWSEFPFEFTPDSKAITYTQMVTRNNTSDDFLKNMKSLIHVIGTDPKTDKILA
SKENNPELEILAAQFPSVKLPDDYSYVILDIGSTKNEEFSFYAPFSELGKSKINWKPLIKYEDEITDSQIIGDKIFFLTH
KNTPNYKLAYTSLKNPDFNNPTILVPESNKIVRRLRKSKNFIYYNLSDGINQEIFQLNAKTLEIKKIPIPAGSNAGYPLS
PRYNDDLMLFNNGWVTPSTDYDYNGLTGKLEKSKELTSNGTFPDFSKDYVVKEIEVPSHDGVMVPLSIIYPKNIKMDGST
SCFITGYGAYGISQYPYFVGPSLMTLLEQHTIVAFTHIRGGGEKGNQWHVDGMKAKKPNTWKDFIACSEYLIKEKYTSKE
KLIGNGVSMGGVLIGRAITERPDLYKVALVEVGCTNTLRMETTPNGPNQIPEIGSLKNEEDVKHILEMDSQSKVKKGVKY
PAVLIRTGINDPRVTPWEPGKFAAILQNSTSSDNPVLLHVNYANGHHSNDLDVTFGDEADMYAFALWQVGNTKFQIKP
>Mature_718_residues
MIKKTAFALLVFITSQASQAQYKYPATPERPVVEDYFGTKITDSYRWLEDMNNPEVQKWFKDESDYTNSIVKTISGRDAL
FNRMKEIQALSGDQYGTIRQVGDIYYYTKNKKKENIYKLYFRKNRNGAEILLLDPSTITKGATITSFNISPDNKKLAVTI
SEDGAEVCDLKIMDLESKKFLSDKLTPVWSEFPFEFTPDSKAITYTQMVTRNNTSDDFLKNMKSLIHVIGTDPKTDKILA
SKENNPELEILAAQFPSVKLPDDYSYVILDIGSTKNEEFSFYAPFSELGKSKINWKPLIKYEDEITDSQIIGDKIFFLTH
KNTPNYKLAYTSLKNPDFNNPTILVPESNKIVRRLRKSKNFIYYNLSDGINQEIFQLNAKTLEIKKIPIPAGSNAGYPLS
PRYNDDLMLFNNGWVTPSTDYDYNGLTGKLEKSKELTSNGTFPDFSKDYVVKEIEVPSHDGVMVPLSIIYPKNIKMDGST
SCFITGYGAYGISQYPYFVGPSLMTLLEQHTIVAFTHIRGGGEKGNQWHVDGMKAKKPNTWKDFIACSEYLIKEKYTSKE
KLIGNGVSMGGVLIGRAITERPDLYKVALVEVGCTNTLRMETTPNGPNQIPEIGSLKNEEDVKHILEMDSQSKVKKGVKY
PAVLIRTGINDPRVTPWEPGKFAAILQNSTSSDNPVLLHVNYANGHHSNDLDVTFGDEADMYAFALWQVGNTKFQIKP

Specific function: Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Has an absolute requirement for an X-Pro bond in the trans configuration immediately preceding the Pro-Y scissible bond [H]

COG id: COG1505

COG function: function code E; Serine proteases of the peptidase family S9A

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9A family [H]

Homologues:

Organism=Homo sapiens, GI41349456, Length=713, Percent_Identity=28.3309957924264, Blast_Score=244, Evalue=2e-64,
Organism=Homo sapiens, GI108860686, Length=243, Percent_Identity=28.3950617283951, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI284172420, Length=243, Percent_Identity=28.3950617283951, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI284172413, Length=243, Percent_Identity=28.3950617283951, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI70778815, Length=243, Percent_Identity=28.3950617283951, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI284172438, Length=243, Percent_Identity=28.3950617283951, Blast_Score=85, Evalue=3e-16,
Organism=Homo sapiens, GI284172431, Length=243, Percent_Identity=28.3950617283951, Blast_Score=85, Evalue=3e-16,
Organism=Homo sapiens, GI108860692, Length=198, Percent_Identity=29.2929292929293, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1788150, Length=689, Percent_Identity=23.9477503628447, Blast_Score=150, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24583414, Length=699, Percent_Identity=29.6137339055794, Blast_Score=231, Evalue=1e-60,
Organism=Drosophila melanogaster, GI221510989, Length=682, Percent_Identity=27.4193548387097, Blast_Score=213, Evalue=4e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002471
- InterPro:   IPR001375
- InterPro:   IPR002470
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9; PF02897 Peptidase_S9_N [H]

EC number: =3.4.21.26 [H]

Molecular weight: Translated: 81205; Mature: 81205

Theoretical pI: Translated: 7.31; Mature: 7.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKKTAFALLVFITSQASQAQYKYPATPERPVVEDYFGTKITDSYRWLEDMNNPEVQKWF
CCCHHHEEEEEEEECCCCCCEECCCCCCCCCCHHHHCCCEECCCHHHHHHCCCHHHHHHH
KDESDYTNSIVKTISGRDALFNRMKEIQALSGDQYGTIRQVGDIYYYTKNKKKENIYKLY
CCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHCEEEEEECCCCCCCEEEEE
FRKNRNGAEILLLDPSTITKGATITSFNISPDNKKLAVTISEDGAEVCDLKIMDLESKKF
EEECCCCCEEEEECCCCCCCCCEEEEEECCCCCCEEEEEECCCCCCEEEEEEEECCCHHH
LSDKLTPVWSEFPFEFTPDSKAITYTQMVTRNNTSDDFLKNMKSLIHVIGTDPKTDKILA
HHHCCCHHHHCCCCEECCCCCEEEEEEEEECCCCHHHHHHHHHHHHHEECCCCCCCCEEE
SKENNPELEILAAQFPSVKLPDDYSYVILDIGSTKNEEFSFYAPFSELGKSKINWKPLIK
CCCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCCEEEECCHHHHCCCCCCCEEEEE
YEDEITDSQIIGDKIFFLTHKNTPNYKLAYTSLKNPDFNNPTILVPESNKIVRRLRKSKN
ECCCCCCCEEECCEEEEEEECCCCCEEEEEEECCCCCCCCCEEEEECCHHHHHHHHHCCC
FIYYNLSDGINQEIFQLNAKTLEIKKIPIPAGSNAGYPLSPRYNDDLMLFNNGWVTPSTD
EEEEECCCCCCCHHHEECCEEEEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCC
YDYNGLTGKLEKSKELTSNGTFPDFSKDYVVKEIEVPSHDGVMVPLSIIYPKNIKMDGST
CCCCCCCCCCCCCHHHHCCCCCCCCCCCEEEEEEECCCCCCEEEEEEEEECCCEEECCCC
SCFITGYGAYGISQYPYFVGPSLMTLLEQHTIVAFTHIRGGGEKGNQWHVDGMKAKKPNT
EEEEEEECCCCCCCCCEEECHHHHHHHHCCEEEEEEEECCCCCCCCEEEECCEECCCCCC
WKDFIACSEYLIKEKYTSKEKLIGNGVSMGGVLIGRAITERPDLYKVALVEVGCTNTLRM
HHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCEEEEHHHCCCCCEEEEEEEEECCCCEEEE
ETTPNGPNQIPEIGSLKNEEDVKHILEMDSQSKVKKGVKYPAVLIRTGINDPRVTPWEPG
EECCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHCCCCCEEEEEECCCCCCCCCCCCC
KFAAILQNSTSSDNPVLLHVNYANGHHSNDLDVTFGDEADMYAFALWQVGNTKFQIKP
CEEEEEECCCCCCCCEEEEEEECCCCCCCCCEEEECCCCCEEEEEEEEECCEEEEECC
>Mature Secondary Structure
MIKKTAFALLVFITSQASQAQYKYPATPERPVVEDYFGTKITDSYRWLEDMNNPEVQKWF
CCCHHHEEEEEEEECCCCCCEECCCCCCCCCCHHHHCCCEECCCHHHHHHCCCHHHHHHH
KDESDYTNSIVKTISGRDALFNRMKEIQALSGDQYGTIRQVGDIYYYTKNKKKENIYKLY
CCCCHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCHHHHCEEEEEECCCCCCCEEEEE
FRKNRNGAEILLLDPSTITKGATITSFNISPDNKKLAVTISEDGAEVCDLKIMDLESKKF
EEECCCCCEEEEECCCCCCCCCEEEEEECCCCCCEEEEEECCCCCCEEEEEEEECCCHHH
LSDKLTPVWSEFPFEFTPDSKAITYTQMVTRNNTSDDFLKNMKSLIHVIGTDPKTDKILA
HHHCCCHHHHCCCCEECCCCCEEEEEEEEECCCCHHHHHHHHHHHHHEECCCCCCCCEEE
SKENNPELEILAAQFPSVKLPDDYSYVILDIGSTKNEEFSFYAPFSELGKSKINWKPLIK
CCCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCCCCEEEECCHHHHCCCCCCCEEEEE
YEDEITDSQIIGDKIFFLTHKNTPNYKLAYTSLKNPDFNNPTILVPESNKIVRRLRKSKN
ECCCCCCCEEECCEEEEEEECCCCCEEEEEEECCCCCCCCCEEEEECCHHHHHHHHHCCC
FIYYNLSDGINQEIFQLNAKTLEIKKIPIPAGSNAGYPLSPRYNDDLMLFNNGWVTPSTD
EEEEECCCCCCCHHHEECCEEEEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCC
YDYNGLTGKLEKSKELTSNGTFPDFSKDYVVKEIEVPSHDGVMVPLSIIYPKNIKMDGST
CCCCCCCCCCCCCHHHHCCCCCCCCCCCEEEEEEECCCCCCEEEEEEEEECCCEEECCCC
SCFITGYGAYGISQYPYFVGPSLMTLLEQHTIVAFTHIRGGGEKGNQWHVDGMKAKKPNT
EEEEEEECCCCCCCCCEEECHHHHHHHHCCEEEEEEEECCCCCCCCEEEECCEECCCCCC
WKDFIACSEYLIKEKYTSKEKLIGNGVSMGGVLIGRAITERPDLYKVALVEVGCTNTLRM
HHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCEEEEHHHCCCCCEEEEEEEEECCCCEEEE
ETTPNGPNQIPEIGSLKNEEDVKHILEMDSQSKVKKGVKYPAVLIRTGINDPRVTPWEPG
EECCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHCCCCCEEEEEECCCCCCCCCCCCC
KFAAILQNSTSSDNPVLLHVNYANGHHSNDLDVTFGDEADMYAFALWQVGNTKFQIKP
CEEEEEECCCCCCCCEEEEEEECCCCCCCCCEEEECCCCCEEEEEEEEECCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1840588; 7764331 [H]