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The map label for this gene is ndk

Identifier: 146302703

GI number: 146302703

Start: 6015716

End: 6016135

Strand: Direct

Name: ndk

Synonym: Fjoh_4976

Alternate gene names: 146302703

Gene position: 6015716-6016135 (Clockwise)

Preceding gene: 146302702

Following gene: 146302706

Centisome position: 98.67

GC content: 39.05

Gene sequence:

>420_bases
ATGGCAACAAATAGAACTTTTACAATGATTAAGCCAGATGCTGTTGCAAACGGACACATCGGAAATATCTTAGCAATGAT
CACTAATGGTGGTTTCAAAATCGTTTCATTAAAATTAACTCAATTAACTGTAGCTGATGCTAAAGCATTCTACGCAGTTC
ACGCAGAAAGACCTTTCTACGGAGAATTAGTTGAATTCATGTCACGCGGACCAATTGTTGCTGCAATTTTAGAAAAAGAC
AACGCAGTAGAAGATTTCAGAACTTTAATTGGAGCTACAAATCCAGCTGAAGCTGCTGAAGGAACTATTCGTAAAGCATA
CGCAACTTCTATTGGAGAAAATGCAGTTCACGGTTCAGACAGCGACGAAAATGCTGCTATCGAAAGTGCATTCCACTTTG
CCGGAAGAGAGCAATTCTAA

Upstream 100 bases:

>100_bases
TTTTGGTTAAAACATCATTCTAACGTGTTTTAATTACGAATTAATTAAAATCAATTCACAAAAAAAGTCTACTTTTGCAC
AAAATTTAATAAAATAGAAA

Downstream 100 bases:

>100_bases
TAATTAGTTTTCAGTCACAGTCACAGAATTCAGTGATTGTAAATCATAAAAAAAATCCTGTTTGTTATACAAACAGGATT
TTTTTTATTCCCTATAATAG

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 139; Mature: 138

Protein sequence:

>139_residues
MATNRTFTMIKPDAVANGHIGNILAMITNGGFKIVSLKLTQLTVADAKAFYAVHAERPFYGELVEFMSRGPIVAAILEKD
NAVEDFRTLIGATNPAEAAEGTIRKAYATSIGENAVHGSDSDENAAIESAFHFAGREQF

Sequences:

>Translated_139_residues
MATNRTFTMIKPDAVANGHIGNILAMITNGGFKIVSLKLTQLTVADAKAFYAVHAERPFYGELVEFMSRGPIVAAILEKD
NAVEDFRTLIGATNPAEAAEGTIRKAYATSIGENAVHGSDSDENAAIESAFHFAGREQF
>Mature_138_residues
ATNRTFTMIKPDAVANGHIGNILAMITNGGFKIVSLKLTQLTVADAKAFYAVHAERPFYGELVEFMSRGPIVAAILEKDN
AVEDFRTLIGATNPAEAAEGTIRKAYATSIGENAVHGSDSDENAAIESAFHFAGREQF

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=136, Percent_Identity=44.8529411764706, Blast_Score=120, Evalue=3e-28,
Organism=Homo sapiens, GI4557797, Length=135, Percent_Identity=40, Blast_Score=110, Evalue=5e-25,
Organism=Homo sapiens, GI38045913, Length=135, Percent_Identity=40, Blast_Score=110, Evalue=5e-25,
Organism=Homo sapiens, GI66392203, Length=133, Percent_Identity=38.3458646616541, Blast_Score=107, Evalue=2e-24,
Organism=Homo sapiens, GI66392227, Length=133, Percent_Identity=38.3458646616541, Blast_Score=107, Evalue=3e-24,
Organism=Homo sapiens, GI66392205, Length=133, Percent_Identity=38.3458646616541, Blast_Score=107, Evalue=3e-24,
Organism=Homo sapiens, GI4505409, Length=133, Percent_Identity=38.3458646616541, Blast_Score=107, Evalue=3e-24,
Organism=Homo sapiens, GI66392192, Length=133, Percent_Identity=38.3458646616541, Blast_Score=107, Evalue=3e-24,
Organism=Homo sapiens, GI4826862, Length=133, Percent_Identity=36.8421052631579, Blast_Score=95, Evalue=2e-20,
Organism=Homo sapiens, GI37574614, Length=132, Percent_Identity=36.3636363636364, Blast_Score=90, Evalue=6e-19,
Organism=Homo sapiens, GI7019465, Length=132, Percent_Identity=36.3636363636364, Blast_Score=90, Evalue=7e-19,
Organism=Homo sapiens, GI5031951, Length=136, Percent_Identity=38.2352941176471, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI30023828, Length=143, Percent_Identity=34.965034965035, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI148839372, Length=119, Percent_Identity=33.6134453781513, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1788866, Length=133, Percent_Identity=55.6390977443609, Blast_Score=144, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=39.2592592592593, Blast_Score=106, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6322783, Length=135, Percent_Identity=39.2592592592593, Blast_Score=109, Evalue=1e-25,
Organism=Drosophila melanogaster, GI45549037, Length=139, Percent_Identity=41.726618705036, Blast_Score=114, Evalue=3e-26,
Organism=Drosophila melanogaster, GI18860097, Length=131, Percent_Identity=32.0610687022901, Blast_Score=73, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_FLAJ1 (A5F9Z6)

Other databases:

- EMBL:   CP000685
- RefSeq:   YP_001197294.1
- ProteinModelPortal:   A5F9Z6
- SMR:   A5F9Z6
- STRING:   A5F9Z6
- GeneID:   5094246
- GenomeReviews:   CP000685_GR
- KEGG:   fjo:Fjoh_4976
- eggNOG:   COG0105
- HOGENOM:   HBG445152
- OMA:   FHFAGRE
- ProtClustDB:   PRK14545
- BioCyc:   FJOH376686:FJOH_4976-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 14906; Mature: 14775

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 117-117 BINDING 11-11 BINDING 59-59 BINDING 87-87 BINDING 93-93 BINDING 104-104 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATNRTFTMIKPDAVANGHIGNILAMITNGGFKIVSLKLTQLTVADAKAFYAVHAERPFY
CCCCCEEEEECCCCCCCCCCHHEEEEEECCCEEEEEEEEEEEEECCCCEEEEEECCCCCH
GELVEFMSRGPIVAAILEKDNAVEDFRTLIGATNPAEAAEGTIRKAYATSIGENAVHGSD
HHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
SDENAAIESAFHFAGREQF
CCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
ATNRTFTMIKPDAVANGHIGNILAMITNGGFKIVSLKLTQLTVADAKAFYAVHAERPFY
CCCCEEEEECCCCCCCCCCHHEEEEEECCCEEEEEEEEEEEEECCCCEEEEEECCCCCH
GELVEFMSRGPIVAAILEKDNAVEDFRTLIGATNPAEAAEGTIRKAYATSIGENAVHGSD
HHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
SDENAAIESAFHFAGREQF
CCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA