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The map label for this gene is kapD [H]

Identifier: 146302457

GI number: 146302457

Start: 5716805

End: 5717350

Strand: Reverse

Name: kapD [H]

Synonym: Fjoh_4730

Alternate gene names: 146302457

Gene position: 5717350-5716805 (Counterclockwise)

Preceding gene: 146302458

Following gene: 146302456

Centisome position: 93.78

GC content: 37.91

Gene sequence:

>546_bases
ATGAAAACAACAGATAAAATTATTATTATCGATTTAGAAGCAACATGCTGGCAGGGCGTGGTCCCGAAAGGCCAGCAAAA
TGAAATTATCGAAATTGGATTAGCGGTTTTAGATTCACAAACAGGTGAAATTACAAAGAACAAGGGAATTTTAATAAAGC
CCCAGCGCTCGACCGTGAGTCCGTTTTGTACAGAATTAACCACCATTACTCAGGATTTATTAGATAAAAACGGTGTTTCT
TTTGAGGAAGCTGTAAATCTCTTAATCGACGAATACAATCCCGATTTATATACTTGGGCAAGTTACGGTCAGTACGACTT
AAATATGCTTACAAAACAATGCAAATCGTTTGGTATTCCATATCCAATGGGAGAGGAACATATTAACGTAAAAGAGCATT
TTGCTGAAAAGTTTGGTCTAAAAAGATCCACCGGAATGAACGGTGCCCTGCAATTATTGAATATTCCGCTTGAAGGAACA
CATCACCGCGGAATTGACGATGCCAAAAACATCGCTAAGATTATGCATTGGTGCCTTAAAAATTAG

Upstream 100 bases:

>100_bases
ATTATAAAGATTAAAAGGATTATAAAAAATCTGCCAGATCTGTGAGAAACTATCTTAGCGTTCCTTGCGGTTAAAAAAAA
CAATTATTAAAAATTTAAAA

Downstream 100 bases:

>100_bases
AATTTAATTTGTTAAGAACAGTTATCAAAAGGATAGCAGATAACTGTGCAATGAAGCTGCAGATAATTTAGTATCTGCAG
TTTTTGTTTTTTATAATAGT

Product: exonuclease, RNase T and DNA polymerase III

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 181; Mature: 181

Protein sequence:

>181_residues
MKTTDKIIIIDLEATCWQGVVPKGQQNEIIEIGLAVLDSQTGEITKNKGILIKPQRSTVSPFCTELTTITQDLLDKNGVS
FEEAVNLLIDEYNPDLYTWASYGQYDLNMLTKQCKSFGIPYPMGEEHINVKEHFAEKFGLKRSTGMNGALQLLNIPLEGT
HHRGIDDAKNIAKIMHWCLKN

Sequences:

>Translated_181_residues
MKTTDKIIIIDLEATCWQGVVPKGQQNEIIEIGLAVLDSQTGEITKNKGILIKPQRSTVSPFCTELTTITQDLLDKNGVS
FEEAVNLLIDEYNPDLYTWASYGQYDLNMLTKQCKSFGIPYPMGEEHINVKEHFAEKFGLKRSTGMNGALQLLNIPLEGT
HHRGIDDAKNIAKIMHWCLKN
>Mature_181_residues
MKTTDKIIIIDLEATCWQGVVPKGQQNEIIEIGLAVLDSQTGEITKNKGILIKPQRSTVSPFCTELTTITQDLLDKNGVS
FEEAVNLLIDEYNPDLYTWASYGQYDLNMLTKQCKSFGIPYPMGEEHINVKEHFAEKFGLKRSTGMNGALQLLNIPLEGT
HHRGIDDAKNIAKIMHWCLKN

Specific function: Specifically inhibits the kinA pathway to sporulation [H]

COG id: COG5018

COG function: function code R; Inhibitor of the KinA pathway to sporulation, predicted exonuclease

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 exonuclease domain [H]

Homologues:

Organism=Homo sapiens, GI31543184, Length=183, Percent_Identity=32.7868852459016, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI74136559, Length=183, Percent_Identity=33.3333333333333, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI25148196, Length=184, Percent_Identity=30.9782608695652, Blast_Score=70, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI25148199, Length=184, Percent_Identity=30.9782608695652, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24657520, Length=199, Percent_Identity=30.1507537688442, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24657528, Length=199, Percent_Identity=30.1507537688442, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI28573607, Length=199, Percent_Identity=30.1507537688442, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221330522, Length=199, Percent_Identity=30.1507537688442, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006055
- InterPro:   IPR013520
- InterPro:   IPR012337 [H]

Pfam domain/function: PF00929 Exonuc_X-T [H]

EC number: NA

Molecular weight: Translated: 20352; Mature: 20352

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTTDKIIIIDLEATCWQGVVPKGQQNEIIEIGLAVLDSQTGEITKNKGILIKPQRSTVS
CCCCCCEEEEEECCHHHCCCCCCCCCCCHHHHHHHHHCCCCCCEECCCCEEEECCCCCCC
PFCTELTTITQDLLDKNGVSFEEAVNLLIDEYNPDLYTWASYGQYDLNMLTKQCKSFGIP
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHCCCC
YPMGEEHINVKEHFAEKFGLKRSTGMNGALQLLNIPLEGTHHRGIDDAKNIAKIMHWCLK
CCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHC
N
C
>Mature Secondary Structure
MKTTDKIIIIDLEATCWQGVVPKGQQNEIIEIGLAVLDSQTGEITKNKGILIKPQRSTVS
CCCCCCEEEEEECCHHHCCCCCCCCCCCHHHHHHHHHCCCCCCEECCCCEEEECCCCCCC
PFCTELTTITQDLLDKNGVSFEEAVNLLIDEYNPDLYTWASYGQYDLNMLTKQCKSFGIP
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHCCCC
YPMGEEHINVKEHFAEKFGLKRSTGMNGALQLLNIPLEGTHHRGIDDAKNIAKIMHWCLK
CCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHC
N
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9274030; 9384377 [H]