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The map label for this gene is degS [H]

Identifier: 146302354

GI number: 146302354

Start: 5592380

End: 5594191

Strand: Direct

Name: degS [H]

Synonym: Fjoh_4627

Alternate gene names: 146302354

Gene position: 5592380-5594191 (Clockwise)

Preceding gene: 146302353

Following gene: 146302355

Centisome position: 91.73

GC content: 34.49

Gene sequence:

>1812_bases
ATGAAAAAAAGCAATCAGGAAGCTGCAGAAAAAATCACATTCAAAAATTTACGCCGTCTGTATTTTTTTGCGCTTCTTAC
TATTGCCTTAACTATAATTATCAGTCAGTTTTTAGTGCAATACAATCTGAATCAGCAGTTAAGCGATTCTAAAATCATCA
ATTTTTCTGGTAAACAAAGAATGCTGAGCCAGAAAATTGTCAAAGAAGTTTTGATCCAGCATTACGTTTCTGATACCGCT
TCTGCAAAGCAAATTTCACATTTAAATGACGTTTTAGCGCTTTGGAAAAAAAACCAAAATGCACTTGAAAACGGCAGTGA
CAGTCTGGCTTTTCCAAAAGAAAAATCAGAAACACTTTCTAAATTATATCTTGAAATCAATCCGATTTTCAATAAAATTG
CACAAACTACAGAAGCTTTTTTATTGAATGTAAAGCAGAAAAAAACAACTGCTGAAAACCAAAAATTCGTAAATACTATT
TTAGAAAACGAAGGCATTTTCCTTTCTAAAATGAATCAAATTGTAACCCAATACGATCTTGAAGCGCACGAAAAAGTAAC
CGAACAGCGCCGAATAGAATATTGGATTTTCGGTTTCACGCTTTTAGTTCTTCTTTTAGAATTCTTCTTTATTTTCAAAC
CAACCAACAAAAAAATCGAAAGGTTAATTGCCAAGCTTTTATCTTCAGAAAAGAAAGCTCTAAAGCTCGCATACGACACA
GAAATATTAAGCGAAATCAAAGAAAACTCGGTAAAAGAATTGAAATCTCTTAATTATGCAATGGAAAATACTTTATTGTA
TTGCCGAATTGCGCCAGATGGTTCGATCATTCATATTGGCGAAAAATTTGCTAAACTGCTTAATTATACCAAGTTTTCAT
CCAACAAAAAATTCTCCGAAGTTTTAACCGTTGACGAAAAAGAACAAACCAATTTCGACCGACTAATTTTCGAAAAACAA
AGAAGTGGCTGGCAAGGCGAAATCAGTATTTTAAACAAAGAAAACGAAACCATTTGGCTTGATTTATCAATGGTTCCGGT
AATGATCAAAAAAGACGAACTTGAACTTTTAATTGTTTGTTTTAACATCACCGAACGCAAAAAAGCACAACGCGAAGTCG
AACGTTTGAACCTTGAAAATACGACCGAAAAAATCAATCAACAAAAGATTATTTCGAGCAAAATTGTTGAAAATCAGGAA
AACGAGCAAAACCGAATCGCAAAAGAAATTCACGACGGAATCGGGCAAATGCTTACAGGTTTAAAATTCAGTTTAGAAAG
CATTAATTTAGATGATAGAGGAAAATCAGAACAAAAAATTGAGTATTTAAAGAAGCTTTCGCTTGACATTATTAAAGGTG
TCCGCACTGCAACTTTCAACCTAATGCCACCAGAATTAAGCGATCACGGAATCGTTTCTTCTTTAGCAAAACTCACGCAA
GAACTTTCGAAACTTACGGGAAAAGAAATTCTCTTCTACAACAAAACCGATTTCGACCGACGTCTAGATTCCCTAATCGA
GATCAACATTTATCGTCTCACGCAAGAAGCCATCAACAACGCCATAAAATATGCAGAATCGTCGCACATTATTGTGCAAC
TTTCTCATAGCGAAACACTTCTAAGCATCATCGTTGATGATAACGGAAAAGGTTTTGATGTTAATTCAGTCGACAAAAAA
CGCAACAGCGAATCCGGAATGGGGCTTTTATTTATGAAAGAAAGAATCCAATACATTAACGGACGCGTTTTCATGAACTC
CATTCCAGGCGAAGGAACAAGAATTACTTTTAATATTCCCATTCTCAAATGA

Upstream 100 bases:

>100_bases
GATAAAATGTCCGACAAAGGACATCAGGAAGCTTTAAAAATCAACTATTCTGAAGAAAATTTAAACCTAATAAAAGCTTC
TTTAGGATTGTAAAAAAGAT

Downstream 100 bases:

>100_bases
GACAATGTGTCAATTAGATAATTAGATAATTAGATAATTTATCTAAACGTCGAATTTCTATTTGTCAGGCTGAGCGATCC
CGAGGCTTCGGGAGAAGTCC

Product: multi-sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 603; Mature: 603

Protein sequence:

>603_residues
MKKSNQEAAEKITFKNLRRLYFFALLTIALTIIISQFLVQYNLNQQLSDSKIINFSGKQRMLSQKIVKEVLIQHYVSDTA
SAKQISHLNDVLALWKKNQNALENGSDSLAFPKEKSETLSKLYLEINPIFNKIAQTTEAFLLNVKQKKTTAENQKFVNTI
LENEGIFLSKMNQIVTQYDLEAHEKVTEQRRIEYWIFGFTLLVLLLEFFFIFKPTNKKIERLIAKLLSSEKKALKLAYDT
EILSEIKENSVKELKSLNYAMENTLLYCRIAPDGSIIHIGEKFAKLLNYTKFSSNKKFSEVLTVDEKEQTNFDRLIFEKQ
RSGWQGEISILNKENETIWLDLSMVPVMIKKDELELLIVCFNITERKKAQREVERLNLENTTEKINQQKIISSKIVENQE
NEQNRIAKEIHDGIGQMLTGLKFSLESINLDDRGKSEQKIEYLKKLSLDIIKGVRTATFNLMPPELSDHGIVSSLAKLTQ
ELSKLTGKEILFYNKTDFDRRLDSLIEINIYRLTQEAINNAIKYAESSHIIVQLSHSETLLSIIVDDNGKGFDVNSVDKK
RNSESGMGLLFMKERIQYINGRVFMNSIPGEGTRITFNIPILK

Sequences:

>Translated_603_residues
MKKSNQEAAEKITFKNLRRLYFFALLTIALTIIISQFLVQYNLNQQLSDSKIINFSGKQRMLSQKIVKEVLIQHYVSDTA
SAKQISHLNDVLALWKKNQNALENGSDSLAFPKEKSETLSKLYLEINPIFNKIAQTTEAFLLNVKQKKTTAENQKFVNTI
LENEGIFLSKMNQIVTQYDLEAHEKVTEQRRIEYWIFGFTLLVLLLEFFFIFKPTNKKIERLIAKLLSSEKKALKLAYDT
EILSEIKENSVKELKSLNYAMENTLLYCRIAPDGSIIHIGEKFAKLLNYTKFSSNKKFSEVLTVDEKEQTNFDRLIFEKQ
RSGWQGEISILNKENETIWLDLSMVPVMIKKDELELLIVCFNITERKKAQREVERLNLENTTEKINQQKIISSKIVENQE
NEQNRIAKEIHDGIGQMLTGLKFSLESINLDDRGKSEQKIEYLKKLSLDIIKGVRTATFNLMPPELSDHGIVSSLAKLTQ
ELSKLTGKEILFYNKTDFDRRLDSLIEINIYRLTQEAINNAIKYAESSHIIVQLSHSETLLSIIVDDNGKGFDVNSVDKK
RNSESGMGLLFMKERIQYINGRVFMNSIPGEGTRITFNIPILK
>Mature_603_residues
MKKSNQEAAEKITFKNLRRLYFFALLTIALTIIISQFLVQYNLNQQLSDSKIINFSGKQRMLSQKIVKEVLIQHYVSDTA
SAKQISHLNDVLALWKKNQNALENGSDSLAFPKEKSETLSKLYLEINPIFNKIAQTTEAFLLNVKQKKTTAENQKFVNTI
LENEGIFLSKMNQIVTQYDLEAHEKVTEQRRIEYWIFGFTLLVLLLEFFFIFKPTNKKIERLIAKLLSSEKKALKLAYDT
EILSEIKENSVKELKSLNYAMENTLLYCRIAPDGSIIHIGEKFAKLLNYTKFSSNKKFSEVLTVDEKEQTNFDRLIFEKQ
RSGWQGEISILNKENETIWLDLSMVPVMIKKDELELLIVCFNITERKKAQREVERLNLENTTEKINQQKIISSKIVENQE
NEQNRIAKEIHDGIGQMLTGLKFSLESINLDDRGKSEQKIEYLKKLSLDIIKGVRTATFNLMPPELSDHGIVSSLAKLTQ
ELSKLTGKEILFYNKTDFDRRLDSLIEINIYRLTQEAINNAIKYAESSHIIVQLSHSETLLSIIVDDNGKGFDVNSVDKK
RNSESGMGLLFMKERIQYINGRVFMNSIPGEGTRITFNIPILK

Specific function: Member of the two-component regulatory system degS/degU. Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082311, Length=217, Percent_Identity=25.3456221198157, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1787474, Length=210, Percent_Identity=27.1428571428571, Blast_Score=67, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 69571; Mature: 69571

Theoretical pI: Translated: 9.35; Mature: 9.35

Prosite motif: PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKSNQEAAEKITFKNLRRLYFFALLTIALTIIISQFLVQYNLNQQLSDSKIINFSGKQR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHH
MLSQKIVKEVLIQHYVSDTASAKQISHLNDVLALWKKNQNALENGSDSLAFPKEKSETLS
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHH
KLYLEINPIFNKIAQTTEAFLLNVKQKKTTAENQKFVNTILENEGIFLSKMNQIVTQYDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
EAHEKVTEQRRIEYWIFGFTLLVLLLEFFFIFKPTNKKIERLIAKLLSSEKKALKLAYDT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHH
EILSEIKENSVKELKSLNYAMENTLLYCRIAPDGSIIHIGEKFAKLLNYTKFSSNKKFSE
HHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEECCHHHHHHHHHHHCCCCCCHHH
VLTVDEKEQTNFDRLIFEKQRSGWQGEISILNKENETIWLDLSMVPVMIKKDELELLIVC
HHCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEEEEEEEEECCCEEEEEEE
FNITERKKAQREVERLNLENTTEKINQQKIISSKIVENQENEQNRIAKEIHDGIGQMLTG
ECCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
LKFSLESINLDDRGKSEQKIEYLKKLSLDIIKGVRTATFNLMPPELSDHGIVSSLAKLTQ
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHEEECCCCCCCCCHHHHHHHHHHH
ELSKLTGKEILFYNKTDFDRRLDSLIEINIYRLTQEAINNAIKYAESSHIIVQLSHSETL
HHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEE
LSIIVDDNGKGFDVNSVDKKRNSESGMGLLFMKERIQYINGRVFMNSIPGEGTRITFNIP
EEEEECCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHCCEEEEECCCCCCCEEEEEEC
ILK
CCC
>Mature Secondary Structure
MKKSNQEAAEKITFKNLRRLYFFALLTIALTIIISQFLVQYNLNQQLSDSKIINFSGKQR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHH
MLSQKIVKEVLIQHYVSDTASAKQISHLNDVLALWKKNQNALENGSDSLAFPKEKSETLS
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCHHHHHHH
KLYLEINPIFNKIAQTTEAFLLNVKQKKTTAENQKFVNTILENEGIFLSKMNQIVTQYDL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
EAHEKVTEQRRIEYWIFGFTLLVLLLEFFFIFKPTNKKIERLIAKLLSSEKKALKLAYDT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHH
EILSEIKENSVKELKSLNYAMENTLLYCRIAPDGSIIHIGEKFAKLLNYTKFSSNKKFSE
HHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEECCHHHHHHHHHHHCCCCCCHHH
VLTVDEKEQTNFDRLIFEKQRSGWQGEISILNKENETIWLDLSMVPVMIKKDELELLIVC
HHCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEEEEEEEEECCCEEEEEEE
FNITERKKAQREVERLNLENTTEKINQQKIISSKIVENQENEQNRIAKEIHDGIGQMLTG
ECCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
LKFSLESINLDDRGKSEQKIEYLKKLSLDIIKGVRTATFNLMPPELSDHGIVSSLAKLTQ
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHEEECCCCCCCCCHHHHHHHHHHH
ELSKLTGKEILFYNKTDFDRRLDSLIEINIYRLTQEAINNAIKYAESSHIIVQLSHSETL
HHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCEE
LSIIVDDNGKGFDVNSVDKKRNSESGMGLLFMKERIQYINGRVFMNSIPGEGTRITFNIP
EEEEECCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHCCEEEEECCCCCCCEEEEEEC
ILK
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3141378; 3141377; 9384377; 3136143 [H]