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The map label for this gene is cocE [H]

Identifier: 146302329

GI number: 146302329

Start: 5564866

End: 5566614

Strand: Direct

Name: cocE [H]

Synonym: Fjoh_4602

Alternate gene names: 146302329

Gene position: 5564866-5566614 (Clockwise)

Preceding gene: 146302327

Following gene: 146302330

Centisome position: 91.27

GC content: 34.88

Gene sequence:

>1749_bases
ATGATTCATAAAGTAACATTATTATTTCTGAGTTTATTTTTCATGGTAATTTCTGTATCTGCACAGCAGACTAAAGCAGC
AAAACTGGCAGATCAGGAAAACGCTTATGATATTCAGGACAGCATATCTATCAAAACGCGTGACGGAGCAATATTATCTG
CCATGATTGCCCGCAAAAAGAACGATAATGAACCGCAGCCTGTAATTCTCCAATATACAATTTATGTTAGAGATAAAGGC
AGAGACCTAAAATCGATCAAAGAATCTGTAGATAAAGGCTATATCGGGATTATAGTTTATTCGAGAGGAAAACGTTTCAG
CCCAGACGAGATTAATCCGTATGAAGATGAAGCTAATGATGTTTACGACGCCATAGACTGGATCAGCAAACAAAAATGGT
GCAATGGAAAAACGGCTATGTATGGCGGCAGTTATAACGGATTTACGCAATGGGCTGCCTGCAAAAAAATGCATCCGGCA
CTTAAAACAATTGTTCCTTCTGTTGCAAACAGACCCGGAATGGGACTGCCAATGGAAAACAATGTTTTTATAAATCCAAA
TTACGAATGGGCGTTTTATGTAGGAAACAATAAATATCTGGATACAGTAACGAATAATAACAGACCTCGTTTTAGAGCTT
TAAAATTTAGATGGTGGGAATCTGGAACAGCGTACAAAAAACTAGACAGTATAGACGGCGAACCAAACAGATGGTTTCAA
AAATGGATAAGCCATCCTTCATTTGACTCTTACTGGCAGAAAATGGCGCCTTATAAAACTGATTTTTCACAGATTAATAT
TCCTGTTTTAGCATTTGACGGTTATTATAACGATTCTCAAAATTCAAGTTTGTATTATTTAAAAGAACTTCAAAAATACA
GCCCGAAAACCCCTTTTTATCTGGTAATTGGACCTTACGGACATTTTGGAACTCAAATTGGCGGTGAAGCTGTTTTAAAC
GATTACAAAGTCGATCCTGTTTCTTTGTTTGATATCAAAAAAATCACTTACGAATGGTTTGATTATATTTTGAAAAACGG
CGCTAAACCAGAAATTTTAAAAGATAAAATTAATTATGAAGTCATGGGAGCAAATGAATGGAAAAGCGCTCCTTCATTTG
AAAAAATGCATAACAACTATCTAACCTTTTATTTGACTTCTGCCGTTTCACAAGATTTTCGTCTCGCAGATACTAAGAAG
CCCAAAAAGAAAGAATTCTTAACACAAGAAGTTGATTTTGCTAACAGAGAAATCAGCAATAACAATTATTATCCTAGTCC
GATTATTCAAAAAGAAGTCAACAAAAATGACGGTTATTTTTTTATAAGTGAGCCTCTAACTGAACCTTTAATTGTAAACG
GTTCTTTTTTGGGAGAAATTAAACTGAGCATCAATAAAAAAGATTTGGATTTGGGCGTAACCCTGTATGAAGTAACTCCA
AACGGAGAATATTTTCATCTCTCCTACTACATTGGACGCGTCAGTTATGCAAAAGATATTGAAAAAAGACAGCTTTTAGA
ACCTAATAAAATAGAAACAATTGCTTTTTCTAATACGCATTTTGTAAGCCGGCAGCTGAGCAAAGGAAGCCGATTATTGA
TTGCATTAAATGTTAATAAAAATCCTTTTTCGCAATTGAATTACGGAACAGGAAAAGAGGTCAGCGATGAAACAATTCTC
GATGCCAAAGAGCCTTTAAAAATTAAATGGTACAATGACAGCTTTGTAAAAATTCCAGTTTTGAAATAG

Upstream 100 bases:

>100_bases
ATTCTAAAAAAATGTAACATATAGTTATAATTTACGTCTATCATAAAAAGTAAATATAGAAATAATAATTAAATTCGTTT
AACCCAAAAACTTAGTAATT

Downstream 100 bases:

>100_bases
TTCTCTTTTCAGCTAAAAACATATTCTCTAAATAAATTAACTCCCATTTTAACAAACCATAAAATGAAACAAATCCTATT
GGCATTACTTATTCTGATAT

Product: peptidase S15

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 582; Mature: 582

Protein sequence:

>582_residues
MIHKVTLLFLSLFFMVISVSAQQTKAAKLADQENAYDIQDSISIKTRDGAILSAMIARKKNDNEPQPVILQYTIYVRDKG
RDLKSIKESVDKGYIGIIVYSRGKRFSPDEINPYEDEANDVYDAIDWISKQKWCNGKTAMYGGSYNGFTQWAACKKMHPA
LKTIVPSVANRPGMGLPMENNVFINPNYEWAFYVGNNKYLDTVTNNNRPRFRALKFRWWESGTAYKKLDSIDGEPNRWFQ
KWISHPSFDSYWQKMAPYKTDFSQINIPVLAFDGYYNDSQNSSLYYLKELQKYSPKTPFYLVIGPYGHFGTQIGGEAVLN
DYKVDPVSLFDIKKITYEWFDYILKNGAKPEILKDKINYEVMGANEWKSAPSFEKMHNNYLTFYLTSAVSQDFRLADTKK
PKKKEFLTQEVDFANREISNNNYYPSPIIQKEVNKNDGYFFISEPLTEPLIVNGSFLGEIKLSINKKDLDLGVTLYEVTP
NGEYFHLSYYIGRVSYAKDIEKRQLLEPNKIETIAFSNTHFVSRQLSKGSRLLIALNVNKNPFSQLNYGTGKEVSDETIL
DAKEPLKIKWYNDSFVKIPVLK

Sequences:

>Translated_582_residues
MIHKVTLLFLSLFFMVISVSAQQTKAAKLADQENAYDIQDSISIKTRDGAILSAMIARKKNDNEPQPVILQYTIYVRDKG
RDLKSIKESVDKGYIGIIVYSRGKRFSPDEINPYEDEANDVYDAIDWISKQKWCNGKTAMYGGSYNGFTQWAACKKMHPA
LKTIVPSVANRPGMGLPMENNVFINPNYEWAFYVGNNKYLDTVTNNNRPRFRALKFRWWESGTAYKKLDSIDGEPNRWFQ
KWISHPSFDSYWQKMAPYKTDFSQINIPVLAFDGYYNDSQNSSLYYLKELQKYSPKTPFYLVIGPYGHFGTQIGGEAVLN
DYKVDPVSLFDIKKITYEWFDYILKNGAKPEILKDKINYEVMGANEWKSAPSFEKMHNNYLTFYLTSAVSQDFRLADTKK
PKKKEFLTQEVDFANREISNNNYYPSPIIQKEVNKNDGYFFISEPLTEPLIVNGSFLGEIKLSINKKDLDLGVTLYEVTP
NGEYFHLSYYIGRVSYAKDIEKRQLLEPNKIETIAFSNTHFVSRQLSKGSRLLIALNVNKNPFSQLNYGTGKEVSDETIL
DAKEPLKIKWYNDSFVKIPVLK
>Mature_582_residues
MIHKVTLLFLSLFFMVISVSAQQTKAAKLADQENAYDIQDSISIKTRDGAILSAMIARKKNDNEPQPVILQYTIYVRDKG
RDLKSIKESVDKGYIGIIVYSRGKRFSPDEINPYEDEANDVYDAIDWISKQKWCNGKTAMYGGSYNGFTQWAACKKMHPA
LKTIVPSVANRPGMGLPMENNVFINPNYEWAFYVGNNKYLDTVTNNNRPRFRALKFRWWESGTAYKKLDSIDGEPNRWFQ
KWISHPSFDSYWQKMAPYKTDFSQINIPVLAFDGYYNDSQNSSLYYLKELQKYSPKTPFYLVIGPYGHFGTQIGGEAVLN
DYKVDPVSLFDIKKITYEWFDYILKNGAKPEILKDKINYEVMGANEWKSAPSFEKMHNNYLTFYLTSAVSQDFRLADTKK
PKKKEFLTQEVDFANREISNNNYYPSPIIQKEVNKNDGYFFISEPLTEPLIVNGSFLGEIKLSINKKDLDLGVTLYEVTP
NGEYFHLSYYIGRVSYAKDIEKRQLLEPNKIETIAFSNTHFVSRQLSKGSRLLIALNVNKNPFSQLNYGTGKEVSDETIL
DAKEPLKIKWYNDSFVKIPVLK

Specific function: Hydrolyzes cocaine to benzoate and ecgonine methyl ester, endowing the bacteria with the ability to utilize cocaine as a sole source of carbon and energy for growth, as this bacterium lives in the rhizosphere of coca plants [H]

COG id: COG2936

COG function: function code R; Predicted acyl esterases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alpha/beta hydrolase family. Carboxylesterase subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005674
- InterPro:   IPR008979
- InterPro:   IPR013736
- InterPro:   IPR000383 [H]

Pfam domain/function: PF02129 Peptidase_S15; PF08530 PepX_C [H]

EC number: NA

Molecular weight: Translated: 67195; Mature: 67195

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHKVTLLFLSLFFMVISVSAQQTKAAKLADQENAYDIQDSISIKTRDGAILSAMIARKK
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEECCCCEEEEECCCHHHHHHHHHCC
NDNEPQPVILQYTIYVRDKGRDLKSIKESVDKGYIGIIVYSRGKRFSPDEINPYEDEAND
CCCCCCCEEEEEEEEEEECCCCHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCCHHH
VYDAIDWISKQKWCNGKTAMYGGSYNGFTQWAACKKMHPALKTIVPSVANRPGMGLPMEN
HHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
NVFINPNYEWAFYVGNNKYLDTVTNNNRPRFRALKFRWWESGTAYKKLDSIDGEPNRWFQ
CEEECCCCEEEEEECCCEEEEECCCCCCCCEEEEEEEEECCCCHHHHHHCCCCCHHHHHH
KWISHPSFDSYWQKMAPYKTDFSQINIPVLAFDGYYNDSQNSSLYYLKELQKYSPKTPFY
HHHCCCCHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHCCCCCCEE
LVIGPYGHFGTQIGGEAVLNDYKVDPVSLFDIKKITYEWFDYILKNGAKPEILKDKINYE
EEECCCCCCCCCCCCHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCHHHHCCCEE
VMGANEWKSAPSFEKMHNNYLTFYLTSAVSQDFRLADTKKPKKKEFLTQEVDFANREISN
EECCCCCCCCCCHHHHCCCEEEEEEEECCCCCCEECCCCCCHHHHHHHHHHHHCCCCCCC
NNYYPSPIIQKEVNKNDGYFFISEPLTEPLIVNGSFLGEIKLSINKKDLDLGVTLYEVTP
CCCCCCCHHHHHCCCCCCEEEEECCCCCCEEECCCEEEEEEEEEECCCCEEEEEEEEECC
NGEYFHLSYYIGRVSYAKDIEKRQLLEPNKIETIAFSNTHFVSRQLSKGSRLLIALNVNK
CCCEEEEEEEEEHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHCCCCEEEEEEECCC
NPFSQLNYGTGKEVSDETILDAKEPLKIKWYNDSFVKIPVLK
CCHHHCCCCCCCCCCCCHHCCCCCCEEEEEECCCEEEEECCC
>Mature Secondary Structure
MIHKVTLLFLSLFFMVISVSAQQTKAAKLADQENAYDIQDSISIKTRDGAILSAMIARKK
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEECCCCEEEEECCCHHHHHHHHHCC
NDNEPQPVILQYTIYVRDKGRDLKSIKESVDKGYIGIIVYSRGKRFSPDEINPYEDEAND
CCCCCCCEEEEEEEEEEECCCCHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCCCCHHH
VYDAIDWISKQKWCNGKTAMYGGSYNGFTQWAACKKMHPALKTIVPSVANRPGMGLPMEN
HHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
NVFINPNYEWAFYVGNNKYLDTVTNNNRPRFRALKFRWWESGTAYKKLDSIDGEPNRWFQ
CEEECCCCEEEEEECCCEEEEECCCCCCCCEEEEEEEEECCCCHHHHHHCCCCCHHHHHH
KWISHPSFDSYWQKMAPYKTDFSQINIPVLAFDGYYNDSQNSSLYYLKELQKYSPKTPFY
HHHCCCCHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHCCCCCCEE
LVIGPYGHFGTQIGGEAVLNDYKVDPVSLFDIKKITYEWFDYILKNGAKPEILKDKINYE
EEECCCCCCCCCCCCHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCHHHHCCCEE
VMGANEWKSAPSFEKMHNNYLTFYLTSAVSQDFRLADTKKPKKKEFLTQEVDFANREISN
EECCCCCCCCCCHHHHCCCEEEEEEEECCCCCCEECCCCCCHHHHHHHHHHHHCCCCCCC
NNYYPSPIIQKEVNKNDGYFFISEPLTEPLIVNGSFLGEIKLSINKKDLDLGVTLYEVTP
CCCCCCCHHHHHCCCCCCEEEEECCCCCCEEECCCEEEEEEEEEECCCCEEEEEEEEECC
NGEYFHLSYYIGRVSYAKDIEKRQLLEPNKIETIAFSNTHFVSRQLSKGSRLLIALNVNK
CCCEEEEEEEEEHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHCCCCEEEEEEECCC
NPFSQLNYGTGKEVSDETILDAKEPLKIKWYNDSFVKIPVLK
CCHHHCCCCCCCCCCCCHHCCCCCCEEEEEECCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10698749; 11742345; 12369817 [H]