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The map label for this gene is 146302324

Identifier: 146302324

GI number: 146302324

Start: 5560204

End: 5561160

Strand: Direct

Name: 146302324

Synonym: Fjoh_4597

Alternate gene names: NA

Gene position: 5560204-5561160 (Clockwise)

Preceding gene: 146302323

Following gene: 146302325

Centisome position: 91.2

GC content: 37.2

Gene sequence:

>957_bases
ATGAAAAAACTTATTATTACCGCAATTACAGCATTAGTGCTGTTTTCATGTCAAAATGATCAGGCTGAAGGAACAAATTC
TGAAGCAGCTGCACAGCCAACTCTTCGTACTTGCGCAAGTCAGGATGTTTTAGAAGCTCAATTAAAAGCTGATCCAACAT
TAGCAATCAGAATGAACGAAATTGAAGCTTACACAAACAAAGCTTTACTTACAGGTAAACTTGTAAATGGAAAAATCGAA
ATTCCTGTTGTAGTAAACGTTCTTTATAGAACAACTGCAGAAAATATTTCAGCTGCACAAATTCAATCTCAAATTGATGT
TTTAAACAAAGATTTTAATGCATTAAACTCAGACTACAATAGTGTTCCTGCATTATTTGCTGGTGTAAAAGCAAACGTTG
GAATTACATTTGTATTAGATCAAATTATCAGAAAATCAACAACAAAAACCTCTTGGGGAACAAATGATGCCATGAAAAAA
ACGGCTCAGGGCGGTTTAGCTCCAACTTCTCCAACAACAAAACTTAACTTATGGTCTTGCACAATTGGAGGCGGAATTTT
AGGTTATGCACAATTTCCTGGTGGAGCTTCTGCTACAGATGGAGTTGTAATTGATCCAAAATATTTCGGATTATCAGGTG
CTGCAAATGCTCCATATAACTTAGGAAGAACTGGTACTCACGAAGTGGGACACTGGCTGAATTTACGTCACATTTGGGGA
GATGCAACTTGCGGAAGCGATTTAGTTGCTGATACTCCAACTCATAATGCAGCAAACTATGGTGTACCTGCATATCCACA
CTACAGTACTTGTTCTGGAACTCCTGTAGAAATGACAATGAACTACATGGATTATACGGATGATGCTGGAATGTACATGT
TCTCTAACGGACAAAAAAATAGAATTGCGGCTATTTTTACAAGTGGAGGTGCAAGAAATTCTTTTGCACAACCTTAA

Upstream 100 bases:

>100_bases
AATAAATCTGTATAAAAATTTGGCTACAAATAGTATTTGTTATAAAATTGCGATCTGGTTAACCAAAACTATTATTTTAT
AACAAAAACCCCTAGAATTT

Downstream 100 bases:

>100_bases
TAAAAAAAATCTAATTAAAAGCGGGATGAAATCATCCCGCTTTTTTTTTATTAATTATTTTTAGAACGCCCGAAACACTA
GAATTATAAAAGCTTTTTCC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MKKLIITAITALVLFSCQNDQAEGTNSEAAAQPTLRTCASQDVLEAQLKADPTLAIRMNEIEAYTNKALLTGKLVNGKIE
IPVVVNVLYRTTAENISAAQIQSQIDVLNKDFNALNSDYNSVPALFAGVKANVGITFVLDQIIRKSTTKTSWGTNDAMKK
TAQGGLAPTSPTTKLNLWSCTIGGGILGYAQFPGGASATDGVVIDPKYFGLSGAANAPYNLGRTGTHEVGHWLNLRHIWG
DATCGSDLVADTPTHNAANYGVPAYPHYSTCSGTPVEMTMNYMDYTDDAGMYMFSNGQKNRIAAIFTSGGARNSFAQP

Sequences:

>Translated_318_residues
MKKLIITAITALVLFSCQNDQAEGTNSEAAAQPTLRTCASQDVLEAQLKADPTLAIRMNEIEAYTNKALLTGKLVNGKIE
IPVVVNVLYRTTAENISAAQIQSQIDVLNKDFNALNSDYNSVPALFAGVKANVGITFVLDQIIRKSTTKTSWGTNDAMKK
TAQGGLAPTSPTTKLNLWSCTIGGGILGYAQFPGGASATDGVVIDPKYFGLSGAANAPYNLGRTGTHEVGHWLNLRHIWG
DATCGSDLVADTPTHNAANYGVPAYPHYSTCSGTPVEMTMNYMDYTDDAGMYMFSNGQKNRIAAIFTSGGARNSFAQP
>Mature_318_residues
MKKLIITAITALVLFSCQNDQAEGTNSEAAAQPTLRTCASQDVLEAQLKADPTLAIRMNEIEAYTNKALLTGKLVNGKIE
IPVVVNVLYRTTAENISAAQIQSQIDVLNKDFNALNSDYNSVPALFAGVKANVGITFVLDQIIRKSTTKTSWGTNDAMKK
TAQGGLAPTSPTTKLNLWSCTIGGGILGYAQFPGGASATDGVVIDPKYFGLSGAANAPYNLGRTGTHEVGHWLNLRHIWG
DATCGSDLVADTPTHNAANYGVPAYPHYSTCSGTPVEMTMNYMDYTDDAGMYMFSNGQKNRIAAIFTSGGARNSFAQP

Specific function: Metalloprotease which in vitro specifically cleaves IGFBP-2 to -6, insulin, and extracellular matrix proteins but not IGFBP-1 or IGF-II. Shows a preference for substrates with an arginine in the P1' position, the first position downstream of the scissile

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M43B family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008754 [H]

Pfam domain/function: PF05572 Peptidase_M43 [H]

EC number: NA

Molecular weight: Translated: 33860; Mature: 33860

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLIITAITALVLFSCQNDQAEGTNSEAAAQPTLRTCASQDVLEAQLKADPTLAIRMNE
CCHHHHHHHHHHHHEECCCCCCCCCCCCHHCCCHHHHHCCHHHHHHHHCCCCEEEEEEEH
IEAYTNKALLTGKLVNGKIEIPVVVNVLYRTTAENISAAQIQSQIDVLNKDFNALNSDYN
HHHHHCCEEEEEEEECCEEEEHHEEEEHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
SVPALFAGVKANVGITFVLDQIIRKSTTKTSWGTNDAMKKTAQGGLAPTSPTTKLNLWSC
CCHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCCEEEEEEE
TIGGGILGYAQFPGGASATDGVVIDPKYFGLSGAANAPYNLGRTGTHEVGHWLNLRHIWG
EECCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHEEEEEEEEC
DATCGSDLVADTPTHNAANYGVPAYPHYSTCSGTPVEMTMNYMDYTDDAGMYMFSNGQKN
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCEEEEECCCCC
RIAAIFTSGGARNSFAQP
EEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MKKLIITAITALVLFSCQNDQAEGTNSEAAAQPTLRTCASQDVLEAQLKADPTLAIRMNE
CCHHHHHHHHHHHHEECCCCCCCCCCCCHHCCCHHHHHCCHHHHHHHHCCCCEEEEEEEH
IEAYTNKALLTGKLVNGKIEIPVVVNVLYRTTAENISAAQIQSQIDVLNKDFNALNSDYN
HHHHHCCEEEEEEEECCEEEEHHEEEEHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCC
SVPALFAGVKANVGITFVLDQIIRKSTTKTSWGTNDAMKKTAQGGLAPTSPTTKLNLWSC
CCHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCCEEEEEEE
TIGGGILGYAQFPGGASATDGVVIDPKYFGLSGAANAPYNLGRTGTHEVGHWLNLRHIWG
EECCCEEEEEECCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCHHHHHEEEEEEEEC
DATCGSDLVADTPTHNAANYGVPAYPHYSTCSGTPVEMTMNYMDYTDDAGMYMFSNGQKN
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCEEEEECCCCC
RIAAIFTSGGARNSFAQP
EEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]