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The map label for this gene is fnr [H]

Identifier: 146302179

GI number: 146302179

Start: 5368036

End: 5368719

Strand: Reverse

Name: fnr [H]

Synonym: Fjoh_4447

Alternate gene names: 146302179

Gene position: 5368719-5368036 (Counterclockwise)

Preceding gene: 146302185

Following gene: 146302178

Centisome position: 88.06

GC content: 32.31

Gene sequence:

>684_bases
ATGATTTCAAAATTTATCTTCAATAATCAGTATGTTTTAAACGAGTTGCCTCAATGTGACAAGGATCTGCTTGAAAAGGT
AATGCAAAGTAAAAAATATGTTAAAAACCAGACAATATTTACTGAGGGGACATTGCCTACAGGTATTTTTTATATTCAAA
CCGGTAAAGTCAAAAAATACAAGGTTGATAATGAAGGAAGGGAACAAATTATTTATATCTACAATTCAGGAGAGTTTTTT
GGTTATACAGCCATACTAAGTGAGCAGGCATATGGAGATACCGCCGTGGTTATTGAAAATTCAGTTATTTCATTTATACC
AAAAGACGATTTTTTTAATGTCCTTAATAATTCTGTAGTATTTTCACGATTGCTTTTAAAATGCCTCAGTTATGAGTTTA
GTGTGATGGCAAATTTGATGGCCGTTTTATCGCAGCGAACCGTAAGAGAGCGAGTAGCCCTTAGTTTATTGATTCTACAT
GATAAATATAAAATAAATGATGACCCAAAAGATGTTTTTATTACACTTTCAAGGGGAGATTTAGCCAATATGGTAGGCAC
TGTAAATGAAACCCTGGCAAGGGTACTACATGATTTTAAAAGTGAAAATCTTATTTGGATGGAGGGACGTAAAATTCAAT
TAATGAATTTTCAACAACTAACCCATATAGCCAATTTTTATTGA

Upstream 100 bases:

>100_bases
GATTTGAAATCGATTTAGTTGATTAAAATGGTATTTAAAACTTGATTTAAATCAAGTTTTAAAAAGACATGGAAAAAATA
TTGTAACTTTGAAATTAGCT

Downstream 100 bases:

>100_bases
TGATAATGCTATAAAAATTAAGCAATCTGGCTTGCGAAAAATAAAATTTTATTTGAATTTCGATAGTTATTTGTTTGCAA
GAATAATTAACACCTAAAAA

Product: CRP/FNR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MISKFIFNNQYVLNELPQCDKDLLEKVMQSKKYVKNQTIFTEGTLPTGIFYIQTGKVKKYKVDNEGREQIIYIYNSGEFF
GYTAILSEQAYGDTAVVIENSVISFIPKDDFFNVLNNSVVFSRLLLKCLSYEFSVMANLMAVLSQRTVRERVALSLLILH
DKYKINDDPKDVFITLSRGDLANMVGTVNETLARVLHDFKSENLIWMEGRKIQLMNFQQLTHIANFY

Sequences:

>Translated_227_residues
MISKFIFNNQYVLNELPQCDKDLLEKVMQSKKYVKNQTIFTEGTLPTGIFYIQTGKVKKYKVDNEGREQIIYIYNSGEFF
GYTAILSEQAYGDTAVVIENSVISFIPKDDFFNVLNNSVVFSRLLLKCLSYEFSVMANLMAVLSQRTVRERVALSLLILH
DKYKINDDPKDVFITLSRGDLANMVGTVNETLARVLHDFKSENLIWMEGRKIQLMNFQQLTHIANFY
>Mature_227_residues
MISKFIFNNQYVLNELPQCDKDLLEKVMQSKKYVKNQTIFTEGTLPTGIFYIQTGKVKKYKVDNEGREQIIYIYNSGEFF
GYTAILSEQAYGDTAVVIENSVISFIPKDDFFNVLNNSVVFSRLLLKCLSYEFSVMANLMAVLSQRTVRERVALSLLILH
DKYKINDDPKDVFITLSRGDLANMVGTVNETLARVLHDFKSENLIWMEGRKIQLMNFQQLTHIANFY

Specific function: Global transcription factor that controls the expression of over 100 target genes in response to anoxia. It facilitates the adaptation to anaerobic growth conditions by regulating the expression of gene products that are involved in anaerobic energy metab

COG id: COG0664

COG function: function code T; cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH crp-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787595, Length=217, Percent_Identity=25.3456221198157, Blast_Score=87, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018490
- InterPro:   IPR000595
- InterPro:   IPR001808
- InterPro:   IPR012318
- InterPro:   IPR014710
- InterPro:   IPR018335
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00027 cNMP_binding; PF00325 Crp [H]

EC number: NA

Molecular weight: Translated: 26248; Mature: 26248

Theoretical pI: Translated: 7.49; Mature: 7.49

Prosite motif: PS50042 CNMP_BINDING_3 ; PS51063 HTH_CRP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISKFIFNNQYVLNELPQCDKDLLEKVMQSKKYVKNQTIFTEGTLPTGIFYIQTGKVKKY
CCCCEEECCCHHHHHCCCCCHHHHHHHHHHHHHHHCCEEEECCCCCCEEEEEEECCEEEE
KVDNEGREQIIYIYNSGEFFGYTAILSEQAYGDTAVVIENSVISFIPKDDFFNVLNNSVV
EECCCCCEEEEEEEECCCEEEEHEEECCCCCCCEEEEEECCEEEECCCHHHHHHHHHHHH
FSRLLLKCLSYEFSVMANLMAVLSQRTVRERVALSLLILHDKYKINDDPKDVFITLSRGD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCEECCCCCCEEEEEECCCC
LANMVGTVNETLARVLHDFKSENLIWMEGRKIQLMNFQQLTHIANFY
HHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEECHHHHHHHHHCC
>Mature Secondary Structure
MISKFIFNNQYVLNELPQCDKDLLEKVMQSKKYVKNQTIFTEGTLPTGIFYIQTGKVKKY
CCCCEEECCCHHHHHCCCCCHHHHHHHHHHHHHHHCCEEEECCCCCCEEEEEEECCEEEE
KVDNEGREQIIYIYNSGEFFGYTAILSEQAYGDTAVVIENSVISFIPKDDFFNVLNNSVV
EECCCCCEEEEEEEECCCEEEEHEEECCCCCCCEEEEEECCEEEECCCHHHHHHHHHHHH
FSRLLLKCLSYEFSVMANLMAVLSQRTVRERVALSLLILHDKYKINDDPKDVFITLSRGD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCEECCCCCCEEEEEECCCC
LANMVGTVNETLARVLHDFKSENLIWMEGRKIQLMNFQQLTHIANFY
HHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEECHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA