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The map label for this gene is hssS [H]

Identifier: 146302028

GI number: 146302028

Start: 5184633

End: 5185988

Strand: Direct

Name: hssS [H]

Synonym: Fjoh_4292

Alternate gene names: 146302028

Gene position: 5184633-5185988 (Clockwise)

Preceding gene: 146302027

Following gene: 146302029

Centisome position: 85.04

GC content: 33.26

Gene sequence:

>1356_bases
ATGAAAATTCGTGATCGTTTTACCTTAATTTCTTCTCTGACTTTCAGTGTTGTGTTTGTCATTGCTTCGCTTATTACCTA
TTTTTCTTTCTACAGTTATTCAGAAAAAATTGTTTACAACGAATTGCAGAAAACCTGTTTACTTACGGGAATTTTTTATC
TCGAAAAAGATGAATTACCAGAAAACCAGCATTTAATAATTGGCCAGCAATTCCGAGAAAATTCACTCGAAATTATCACG
CGTGTTTATGATGAGAAAAATCAAATTGTGTATGGCGACAAAACTTTAGATAACAATATCAATCAGTTAAAGCTGGATTA
CGTTCGAAAAAACAGAAAATTAAGTTTCAAGTCCAAGCATCACTTTTACTTTGGGAGTTATTATCATGACAATCAGGGAG
ATTTTGTGGTTTTCGTTAAAAAAAATGATACCGATTTTAAAACCATGACCGATCGACTTTTGATTATTATGATTTTGGTT
TTAGTTTCAGGTTTAATCAGTATTTATATTGTCAGCCGGGTACTTTCTAATCTCGCTTATGCTCCTATTAAAAATATTAT
CAATCAGGTAAACGAAATCCAGGCTACTTCATTAGACAGGCAGATTGTTTCTCCAAATTCAAAAGATGATATTCAGGAAC
TTATAGAAAGTTATAATAACCTGCTGAAACGTCTTTCTGATACTTTTATCATTCAGAAAAACTTCATCAATTATGTTTCG
CATGAGTTTAAAACTCCTTTAACGGCTATTTCGGGAAACCTTGAAGTTTTTGCCCAAAAAGACAGATCAAGTGCCGAGTA
CAAAGAAATGTCTGAAAAAGTATTAGAAAATGTCTATCAAATCGAAGACACAATGAATACTTTAATGATGCTTTCGGGCC
TTCGCGAAAATATGGAACTCAACGAGATTTTTAGAGTCGACGAGTTGGTCTGGGACATTAACGATCAATTATCTGCCAGT
TACCACTTAAAAGGCCAGATTCAAATTGCATTAGAAGTTCTAAATGACAAACTGCTTTCGATAAAAGGAAATTCTAACGA
AATCAAAATTGCGTTGTTTAATATTATCGAAAATGCGGTTAAGTATTCAGCAGGAAATCCAATAAAAATCAGTTTATCAG
AACACAATCAGCAGTTAAAAATTGTCATCGAAGATCAGGGAAAAGGCATTAGCGAAGAAGACCTGCAATTCATAAAACAA
ACTTTTTACAGAGGCAAAAATGTGAGCGATATAAAAGGAAGCGGCATTGGACTTCCGTTGGCAAATGTCATTTTTAAACA
AAATAATATTGAGTTTACGATTGCTTCCAAAAAAGATGCTGGAACTACTGTAACGCTGGTTTTTCCTAAACTCTAA

Upstream 100 bases:

>100_bases
TTGTCGATGTGTATATTTCGTATTTAAGAAACAAAATCGAACACAATCATAAGTTCATTCACACCATAAAAGGAATTGGT
TATATGTTAAAAGAATAAGT

Downstream 100 bases:

>100_bases
TCGTTTTCTAATCTAACTCTTACTGGTTTCTAACAGACATCAAATTACGGTTTAATACGCGGCAGATAGCTTTGCACTTC
ATTAAATCTACTTAATTTGA

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MKIRDRFTLISSLTFSVVFVIASLITYFSFYSYSEKIVYNELQKTCLLTGIFYLEKDELPENQHLIIGQQFRENSLEIIT
RVYDEKNQIVYGDKTLDNNINQLKLDYVRKNRKLSFKSKHHFYFGSYYHDNQGDFVVFVKKNDTDFKTMTDRLLIIMILV
LVSGLISIYIVSRVLSNLAYAPIKNIINQVNEIQATSLDRQIVSPNSKDDIQELIESYNNLLKRLSDTFIIQKNFINYVS
HEFKTPLTAISGNLEVFAQKDRSSAEYKEMSEKVLENVYQIEDTMNTLMMLSGLRENMELNEIFRVDELVWDINDQLSAS
YHLKGQIQIALEVLNDKLLSIKGNSNEIKIALFNIIENAVKYSAGNPIKISLSEHNQQLKIVIEDQGKGISEEDLQFIKQ
TFYRGKNVSDIKGSGIGLPLANVIFKQNNIEFTIASKKDAGTTVTLVFPKL

Sequences:

>Translated_451_residues
MKIRDRFTLISSLTFSVVFVIASLITYFSFYSYSEKIVYNELQKTCLLTGIFYLEKDELPENQHLIIGQQFRENSLEIIT
RVYDEKNQIVYGDKTLDNNINQLKLDYVRKNRKLSFKSKHHFYFGSYYHDNQGDFVVFVKKNDTDFKTMTDRLLIIMILV
LVSGLISIYIVSRVLSNLAYAPIKNIINQVNEIQATSLDRQIVSPNSKDDIQELIESYNNLLKRLSDTFIIQKNFINYVS
HEFKTPLTAISGNLEVFAQKDRSSAEYKEMSEKVLENVYQIEDTMNTLMMLSGLRENMELNEIFRVDELVWDINDQLSAS
YHLKGQIQIALEVLNDKLLSIKGNSNEIKIALFNIIENAVKYSAGNPIKISLSEHNQQLKIVIEDQGKGISEEDLQFIKQ
TFYRGKNVSDIKGSGIGLPLANVIFKQNNIEFTIASKKDAGTTVTLVFPKL
>Mature_451_residues
MKIRDRFTLISSLTFSVVFVIASLITYFSFYSYSEKIVYNELQKTCLLTGIFYLEKDELPENQHLIIGQQFRENSLEIIT
RVYDEKNQIVYGDKTLDNNINQLKLDYVRKNRKLSFKSKHHFYFGSYYHDNQGDFVVFVKKNDTDFKTMTDRLLIIMILV
LVSGLISIYIVSRVLSNLAYAPIKNIINQVNEIQATSLDRQIVSPNSKDDIQELIESYNNLLKRLSDTFIIQKNFINYVS
HEFKTPLTAISGNLEVFAQKDRSSAEYKEMSEKVLENVYQIEDTMNTLMMLSGLRENMELNEIFRVDELVWDINDQLSAS
YHLKGQIQIALEVLNDKLLSIKGNSNEIKIALFNIIENAVKYSAGNPIKISLSEHNQQLKIVIEDQGKGISEEDLQFIKQ
TFYRGKNVSDIKGSGIGLPLANVIFKQNNIEFTIASKKDAGTTVTLVFPKL

Specific function: Member of the two-component regulatory system hssS/hssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=299, Percent_Identity=25.752508361204, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1788393, Length=281, Percent_Identity=22.7758007117438, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1787374, Length=293, Percent_Identity=23.5494880546075, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790346, Length=245, Percent_Identity=26.9387755102041, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1789808, Length=340, Percent_Identity=22.9411764705882, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790551, Length=308, Percent_Identity=24.3506493506494, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1786600, Length=224, Percent_Identity=25.4464285714286, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1789403, Length=297, Percent_Identity=23.9057239057239, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790436, Length=217, Percent_Identity=25.3456221198157, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1786912, Length=278, Percent_Identity=23.3812949640288, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51930; Mature: 51930

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIRDRFTLISSLTFSVVFVIASLITYFSFYSYSEKIVYNELQKTCLLTGIFYLEKDELP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCC
ENQHLIIGQQFRENSLEIITRVYDEKNQIVYGDKTLDNNINQLKLDYVRKNRKLSFKSKH
CCCEEEEECHHCCCHHHHHHHHHCCCCCEEECCCHHCCCCCCEEHHHHHCCCCCCCCCCC
HFYFGSYYHDNQGDFVVFVKKNDTDFKTMTDRLLIIMILVLVSGLISIYIVSRVLSNLAY
CEEEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
APIKNIINQVNEIQATSLDRQIVSPNSKDDIQELIESYNNLLKRLSDTFIIQKNFINYVS
HHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHH
HEFKTPLTAISGNLEVFAQKDRSSAEYKEMSEKVLENVYQIEDTMNTLMMLSGLRENMEL
HHHCCCHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
NEIFRVDELVWDINDQLSASYHLKGQIQIALEVLNDKLLSIKGNSNEIKIALFNIIENAV
HHHHHHHHHHHCCCCCCCCEEEECEEHEEHEEHHCCCEEEEECCCCEEEEEHHHHHHHHH
KYSAGNPIKISLSEHNQQLKIVIEDQGKGISEEDLQFIKQTFYRGKNVSDIKGSGIGLPL
HHCCCCCEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCH
ANVIFKQNNIEFTIASKKDAGTTVTLVFPKL
HHHHEECCCEEEEEECCCCCCCEEEEEECCC
>Mature Secondary Structure
MKIRDRFTLISSLTFSVVFVIASLITYFSFYSYSEKIVYNELQKTCLLTGIFYLEKDELP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCC
ENQHLIIGQQFRENSLEIITRVYDEKNQIVYGDKTLDNNINQLKLDYVRKNRKLSFKSKH
CCCEEEEECHHCCCHHHHHHHHHCCCCCEEECCCHHCCCCCCEEHHHHHCCCCCCCCCCC
HFYFGSYYHDNQGDFVVFVKKNDTDFKTMTDRLLIIMILVLVSGLISIYIVSRVLSNLAY
CEEEEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
APIKNIINQVNEIQATSLDRQIVSPNSKDDIQELIESYNNLLKRLSDTFIIQKNFINYVS
HHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHH
HEFKTPLTAISGNLEVFAQKDRSSAEYKEMSEKVLENVYQIEDTMNTLMMLSGLRENMEL
HHHCCCHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
NEIFRVDELVWDINDQLSASYHLKGQIQIALEVLNDKLLSIKGNSNEIKIALFNIIENAV
HHHHHHHHHHHCCCCCCCCEEEECEEHEEHEEHHCCCEEEEECCCCEEEEEHHHHHHHHH
KYSAGNPIKISLSEHNQQLKIVIEDQGKGISEEDLQFIKQTFYRGKNVSDIKGSGIGLPL
HHCCCCCEEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCH
ANVIFKQNNIEFTIASKKDAGTTVTLVFPKL
HHHHEECCCEEEEEECCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA