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The map label for this gene is fucP [H]

Identifier: 146301864

GI number: 146301864

Start: 4960972

End: 4962267

Strand: Direct

Name: fucP [H]

Synonym: Fjoh_4128

Alternate gene names: 146301864

Gene position: 4960972-4962267 (Clockwise)

Preceding gene: 146301863

Following gene: 146301869

Centisome position: 81.37

GC content: 36.5

Gene sequence:

>1296_bases
ATGCAAGTAACAAACCAAACAGGCGATCTTCACGAAGTGCCAAACGAAGGCGGAAAAACCAACTATCTTCTGCCATTTAT
TTTAATTACCAGTTTATTTTTCCTTTGGGGAATGGCGCATAATCTGGATTCTATTTTAATTCCGCATTTAAAAAAGGCGT
GTGAATTAAACAACCGTCAGTCGACATTGATTGATACTTCGGTGTTTTTTGCTTATTTTATAATGGCGATTCCTGCGGGA
ATGCTCATTAAACGATTTGGTTATAAAAACAGTATTATTACCGGATTATTAGTTTTTGCAGCGGGAGCATTTTTATTCGT
TCCAGCAGCCAATACCAGAACCTATGAATTGTTTTTATTCGCTTTATTTGTAATTGGATGCGGCTTAACAATTTTAGAAA
CAAGTGCCAATCCGTATGCAGCAATTTTAGGCCCTGCTGAATCTTCTTCTAAAAGACTGAATTTAGCGGCTTCTTTCAAC
GGATTAGCAGCTATGGTAGCTCCAATTGTGGGTTCTCTATTTATACTTTCCGGAAAAAATCATACTCCGGAGCAAATGGC
AGCAATGCCGGAAGCTGAAAAAGCATCGTATTTATTAGGCGAAGCTGCTGCTGTAAAAATGCCTTATATCATTTTAGGAA
GTGTATTGGTTATAGTGGCGATTATATTCTACTTTATGCATTTACCTTCGATGAAACCACAACATACTGAAGCCGAAGTA
AAACCGGGATTTTTCTCTGTTTTAAAGTTTCGCCATTTAAGCTGGGCAGTTGTAGCACAGTTCTTTTATGTAGGTGCACA
GGTTTGCATTACGAGTTTTTTTATTAGAATTGCACAGCAGGGTGCTCATTTAGACGAAAAAACAGCTGGATATTATCTTG
GTATTTATGGCTTCTTGTTTATGGCAGGACGTTTTATTGGTACTTTCTTCTTGAAGTTTGTAAAAGATTACACATTGCTT
TCTATTTATTGTGCTGCAAGTATCATACTTTGTTTGTTAGCGATTTACGGAACCGGAATTGTAGTTATTTATGCTTTAGG
CGGTATCGGATTTTTTATGTCGATTATGTTTCCAACTATTTTCTCTTTAGGATTGGTTGGTTTAAAATCAAATACTGAAA
CGGGTTCATCATGGCTGGTAATGTCAATTGTGGGCGGAGCAATCCTTCCATACGGAATGGGAACTTTAATTGATATGAAA
CACGACGATATTCAGGCTGGATACATTATTCCGCTTTTGTGTTTTGTGATTATTTTATCGTTTGGTTTATATGGTCATAA
AGTAAAAAATAATTGA

Upstream 100 bases:

>100_bases
TACCTTTAGAAAAGACGCACTACAGTACGTCTCTACAGAAAAAACCTTTGAACCTTTGTACCTCAGAACCTTAGAACCTT
TAAAAAAAACTATCTAACAA

Downstream 100 bases:

>100_bases
ATTGTGAATTGTGAATTGACAATTTAAAAAAATAAAAAACGCCTCGTATTGAGGCGTTTTATTTTTTTATTAATTAGCGG
CGATTCCCTTGTGAATGATC

Product: L-fucose transporter

Products: Proton [Cytoplasm]; L-fucose [Cytoplasm] [C]

Alternate protein names: 6-deoxy-L-galactose permease; L-fucose permease [H]

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MQVTNQTGDLHEVPNEGGKTNYLLPFILITSLFFLWGMAHNLDSILIPHLKKACELNNRQSTLIDTSVFFAYFIMAIPAG
MLIKRFGYKNSIITGLLVFAAGAFLFVPAANTRTYELFLFALFVIGCGLTILETSANPYAAILGPAESSSKRLNLAASFN
GLAAMVAPIVGSLFILSGKNHTPEQMAAMPEAEKASYLLGEAAAVKMPYIILGSVLVIVAIIFYFMHLPSMKPQHTEAEV
KPGFFSVLKFRHLSWAVVAQFFYVGAQVCITSFFIRIAQQGAHLDEKTAGYYLGIYGFLFMAGRFIGTFFLKFVKDYTLL
SIYCAASIILCLLAIYGTGIVVIYALGGIGFFMSIMFPTIFSLGLVGLKSNTETGSSWLVMSIVGGAILPYGMGTLIDMK
HDDIQAGYIIPLLCFVIILSFGLYGHKVKNN

Sequences:

>Translated_431_residues
MQVTNQTGDLHEVPNEGGKTNYLLPFILITSLFFLWGMAHNLDSILIPHLKKACELNNRQSTLIDTSVFFAYFIMAIPAG
MLIKRFGYKNSIITGLLVFAAGAFLFVPAANTRTYELFLFALFVIGCGLTILETSANPYAAILGPAESSSKRLNLAASFN
GLAAMVAPIVGSLFILSGKNHTPEQMAAMPEAEKASYLLGEAAAVKMPYIILGSVLVIVAIIFYFMHLPSMKPQHTEAEV
KPGFFSVLKFRHLSWAVVAQFFYVGAQVCITSFFIRIAQQGAHLDEKTAGYYLGIYGFLFMAGRFIGTFFLKFVKDYTLL
SIYCAASIILCLLAIYGTGIVVIYALGGIGFFMSIMFPTIFSLGLVGLKSNTETGSSWLVMSIVGGAILPYGMGTLIDMK
HDDIQAGYIIPLLCFVIILSFGLYGHKVKNN
>Mature_431_residues
MQVTNQTGDLHEVPNEGGKTNYLLPFILITSLFFLWGMAHNLDSILIPHLKKACELNNRQSTLIDTSVFFAYFIMAIPAG
MLIKRFGYKNSIITGLLVFAAGAFLFVPAANTRTYELFLFALFVIGCGLTILETSANPYAAILGPAESSSKRLNLAASFN
GLAAMVAPIVGSLFILSGKNHTPEQMAAMPEAEKASYLLGEAAAVKMPYIILGSVLVIVAIIFYFMHLPSMKPQHTEAEV
KPGFFSVLKFRHLSWAVVAQFFYVGAQVCITSFFIRIAQQGAHLDEKTAGYYLGIYGFLFMAGRFIGTFFLKFVKDYTLL
SIYCAASIILCLLAIYGTGIVVIYALGGIGFFMSIMFPTIFSLGLVGLKSNTETGSSWLVMSIVGGAILPYGMGTLIDMK
HDDIQAGYIIPLLCFVIILSFGLYGHKVKNN

Specific function: Mediates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell (symport system). Can also transport L-galactose and D-arabinose, but at reduced rates compared with L-fucose. Is not able to transport L-

COG id: COG0738

COG function: function code G; Fucose permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. FHS transporter (TC 2.A.1.7) family [H]

Homologues:

Organism=Escherichia coli, GI1789166, Length=436, Percent_Identity=38.5321100917431, Blast_Score=287, Evalue=9e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005275
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 47079; Mature: 47079

Theoretical pI: Translated: 8.52; Mature: 8.52

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQVTNQTGDLHEVPNEGGKTNYLLPFILITSLFFLWGMAHNLDSILIPHLKKACELNNRQ
CCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCC
STLIDTSVFFAYFIMAIPAGMLIKRFGYKNSIITGLLVFAAGAFLFVPAANTRTYELFLF
HHHHHHHHHHHHHHHHHCHHHHHHHHCCCHHHHHHHHHHHCCHHEEEECCCCCHHHHHHH
ALFVIGCGLTILETSANPYAAILGPAESSSKRLNLAASFNGLAAMVAPIVGSLFILSGKN
HHHHHHCCCEEEECCCCCCEEEECCCCCCCCCEEEEECCCHHHHHHHHHHHHEEEECCCC
HTPEQMAAMPEAEKASYLLGEAAAVKMPYIILGSVLVIVAIIFYFMHLPSMKPQHTEAEV
CCHHHHHCCCCHHHHHHHHCCHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
KPGFFSVLKFRHLSWAVVAQFFYVGAQVCITSFFIRIAQQGAHLDEKTAGYYLGIYGFLF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHH
MAGRFIGTFFLKFVKDYTLLSIYCAASIILCLLAIYGTGIVVIYALGGIGFFMSIMFPTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
FSLGLVGLKSNTETGSSWLVMSIVGGAILPYGMGTLIDMKHDDIQAGYIIPLLCFVIILS
HHHHHHCCCCCCCCCCCEEHHHHHCCHHHHCCCCCEEECCCCCCCCCHHHHHHHHHHHHH
FGLYGHKVKNN
HCCCCCCCCCC
>Mature Secondary Structure
MQVTNQTGDLHEVPNEGGKTNYLLPFILITSLFFLWGMAHNLDSILIPHLKKACELNNRQ
CCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCC
STLIDTSVFFAYFIMAIPAGMLIKRFGYKNSIITGLLVFAAGAFLFVPAANTRTYELFLF
HHHHHHHHHHHHHHHHHCHHHHHHHHCCCHHHHHHHHHHHCCHHEEEECCCCCHHHHHHH
ALFVIGCGLTILETSANPYAAILGPAESSSKRLNLAASFNGLAAMVAPIVGSLFILSGKN
HHHHHHCCCEEEECCCCCCEEEECCCCCCCCCEEEEECCCHHHHHHHHHHHHEEEECCCC
HTPEQMAAMPEAEKASYLLGEAAAVKMPYIILGSVLVIVAIIFYFMHLPSMKPQHTEAEV
CCHHHHHCCCCHHHHHHHHCCHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
KPGFFSVLKFRHLSWAVVAQFFYVGAQVCITSFFIRIAQQGAHLDEKTAGYYLGIYGFLF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHH
MAGRFIGTFFLKFVKDYTLLSIYCAASIILCLLAIYGTGIVVIYALGGIGFFMSIMFPTI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
FSLGLVGLKSNTETGSSWLVMSIVGGAILPYGMGTLIDMKHDDIQAGYIIPLLCFVIILS
HHHHHHCCCCCCCCCCCEEHHHHHCCHHHHCCCCCEEECCCCCCCCCHHHHHHHHHHHHH
FGLYGHKVKNN
HCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-fucose [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-fucose [Periplasm] = Proton [Cytoplasm] + L-fucose [Cytoplasm] [C]

General reaction: Permease [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2664711; 9278503; 2553671; 8052131; 2829831; 7783647 [H]