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The map label for this gene is nrdZ [H]

Identifier: 146301801

GI number: 146301801

Start: 4850803

End: 4852500

Strand: Reverse

Name: nrdZ [H]

Synonym: Fjoh_4065

Alternate gene names: 146301801

Gene position: 4852500-4850803 (Counterclockwise)

Preceding gene: 146301802

Following gene: 146301798

Centisome position: 79.59

GC content: 37.34

Gene sequence:

>1698_bases
ATGAATACAATAGATCCAAATGAAGTAAATAGTCTTCCGCATAATGAAGCAGGAACCAAAATGTGGTGGAAGAACTCTGA
AAGTGAACAAATTTTAAATCGTGGTTATCTTTTAAAAGGAGAAACAGTAGAAGGTGCAATTGACAGAATTTGTACGGCTG
CTGCCAGAAGATTATACAAACCAGAATTAAAAGAGTCTTTTGTAGAAATGATCGAACGCGGCTGGATGAGTATCAGTTCG
CCGGTCTGGGCTAATATGGGAACCGAAAGAGGTCTGCCTATTTCTTGTTTTAACGTTCACGTTCCGGATAAAATTGAAGG
AATTACACATAAATTAGGCGAAGTAATCATGCAGACTAAAATAGGTGGTGGAACATCTGGTTATTTTGGAGAATTGCGTG
AGCGCGGAAGTGCCGTAACCGATAACGGAAAAAGCAGCGGTGCCGTAAGTTTTATGAAACTTTTTGATACGGCTATGGAT
ACGATTTCGCAAGGCGGAGTACGCCGCGGTGCATTTGCAGCGTATTTGGATATTGACCATCCGGATATCGAGGAGTTTTT
GAAAATTAAAAGTATTGGAAATCCAATTCAGAATTTATTTACCGGAATCTGTGTGCCGGATTACTGGATGCAGGAAATGA
TTGATGGTGATGCTGATAAAAGACAAATTTGGGCAAAAGTATTAGAAAGCCGTCAGCAGAAAGGACTGCCGTATATCTTT
TTCAGCGATAACGTAAATAAAAACAAACCACAGGTTTATAAAGATCAAAACCTAAGAATCAATGCAAGTAATTTATGCAG
TGAGATTATGCTTCCGTCAACTCATGACGAATCATTTATCTGCTGTCTTTCTTCTATGAACTTAGAATTGTATGAAGAAT
GGAAAGATACTGAAGCGGTAAAACTGGCGATCTTTTTCTTAGATGCAGTTTTACAGGAATTCATCGAAAAAACAGAAGGC
AACTATTATCTTTCTGCAGCAAATAAATTTGCTAAAAGACACCGTGCGCTTGGATTAGGTGTTTTAGGATGGCATTCTTA
TCTGCAAAAAAATATGATTCCGTTTGAAGGAATGGAAGCTAAAATGAAAACAACAGAGATTTTCAAACATATAAGTGATA
AAGCGGATAAAGCAAGTCAGGAACTGGCTAGAATTTACGGTGAACCAGAATTGTTAAAAGGTTACGGAAGACGTAATACC
ACTACAATGGCAATTGCTCCAACGACTTCATCTTCTGCTATTTTAGGACAGACTTCACCAGGAATTGAACCTTTCAGCAG
TAATTATTATAAAGCTGGATTAAGCAAAGGTAATTTCATGCGTAAGAATAAATATCTTAAAAAGTTATTAGAAGAAAAAG
GTTTAGACAATGAAGAAGTCTGGAGAGGAATTATGCTAAACGGAGGAAGCGTTCAGCACATGTCACAACTAACACAGCAG
GAAAAAGATGTTTTTAAAACATTTAAAGAAATCAGCCAGTTAGAAATTGTTCAACAGGCAGGAATTCGTCAGAAATTTGT
AGATCAGGGACAAAGTTTAAATCTTAATATTCCGGCTGAATTAGCGATTAAAGATGTAAACCGTTTAATGATCGAAGCCT
GGCAGCAAGGAGTTAAAAGTTTGTACTACCAAAGAAGCCAGAGTGTTTCTAAAGAATTAGTAACGAGTCTTGTTTCTTGC
AGCAGCTGTGAATCATGA

Upstream 100 bases:

>100_bases
TGCCAACAGTCTGGACGATTTCTTTGCAAAACGCCCTGTAGAATACACTAAACACGATAAAAGCATCACGGCAAACGACC
TTTTCTAAAAGCAGCACAAT

Downstream 100 bases:

>100_bases
ATATTAAAAAAGCCGAATCTAAATTAAGATTCGGCTTTTTTATTCATATCGTCATGTCGACGAAGGAGATATCTCCGCAA
GTAACTCTGTAATGATTGTC

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 565; Mature: 565

Protein sequence:

>565_residues
MNTIDPNEVNSLPHNEAGTKMWWKNSESEQILNRGYLLKGETVEGAIDRICTAAARRLYKPELKESFVEMIERGWMSISS
PVWANMGTERGLPISCFNVHVPDKIEGITHKLGEVIMQTKIGGGTSGYFGELRERGSAVTDNGKSSGAVSFMKLFDTAMD
TISQGGVRRGAFAAYLDIDHPDIEEFLKIKSIGNPIQNLFTGICVPDYWMQEMIDGDADKRQIWAKVLESRQQKGLPYIF
FSDNVNKNKPQVYKDQNLRINASNLCSEIMLPSTHDESFICCLSSMNLELYEEWKDTEAVKLAIFFLDAVLQEFIEKTEG
NYYLSAANKFAKRHRALGLGVLGWHSYLQKNMIPFEGMEAKMKTTEIFKHISDKADKASQELARIYGEPELLKGYGRRNT
TTMAIAPTTSSSAILGQTSPGIEPFSSNYYKAGLSKGNFMRKNKYLKKLLEEKGLDNEEVWRGIMLNGGSVQHMSQLTQQ
EKDVFKTFKEISQLEIVQQAGIRQKFVDQGQSLNLNIPAELAIKDVNRLMIEAWQQGVKSLYYQRSQSVSKELVTSLVSC
SSCES

Sequences:

>Translated_565_residues
MNTIDPNEVNSLPHNEAGTKMWWKNSESEQILNRGYLLKGETVEGAIDRICTAAARRLYKPELKESFVEMIERGWMSISS
PVWANMGTERGLPISCFNVHVPDKIEGITHKLGEVIMQTKIGGGTSGYFGELRERGSAVTDNGKSSGAVSFMKLFDTAMD
TISQGGVRRGAFAAYLDIDHPDIEEFLKIKSIGNPIQNLFTGICVPDYWMQEMIDGDADKRQIWAKVLESRQQKGLPYIF
FSDNVNKNKPQVYKDQNLRINASNLCSEIMLPSTHDESFICCLSSMNLELYEEWKDTEAVKLAIFFLDAVLQEFIEKTEG
NYYLSAANKFAKRHRALGLGVLGWHSYLQKNMIPFEGMEAKMKTTEIFKHISDKADKASQELARIYGEPELLKGYGRRNT
TTMAIAPTTSSSAILGQTSPGIEPFSSNYYKAGLSKGNFMRKNKYLKKLLEEKGLDNEEVWRGIMLNGGSVQHMSQLTQQ
EKDVFKTFKEISQLEIVQQAGIRQKFVDQGQSLNLNIPAELAIKDVNRLMIEAWQQGVKSLYYQRSQSVSKELVTSLVSC
SSCES
>Mature_565_residues
MNTIDPNEVNSLPHNEAGTKMWWKNSESEQILNRGYLLKGETVEGAIDRICTAAARRLYKPELKESFVEMIERGWMSISS
PVWANMGTERGLPISCFNVHVPDKIEGITHKLGEVIMQTKIGGGTSGYFGELRERGSAVTDNGKSSGAVSFMKLFDTAMD
TISQGGVRRGAFAAYLDIDHPDIEEFLKIKSIGNPIQNLFTGICVPDYWMQEMIDGDADKRQIWAKVLESRQQKGLPYIF
FSDNVNKNKPQVYKDQNLRINASNLCSEIMLPSTHDESFICCLSSMNLELYEEWKDTEAVKLAIFFLDAVLQEFIEKTEG
NYYLSAANKFAKRHRALGLGVLGWHSYLQKNMIPFEGMEAKMKTTEIFKHISDKADKASQELARIYGEPELLKGYGRRNT
TTMAIAPTTSSSAILGQTSPGIEPFSSNYYKAGLSKGNFMRKNKYLKKLLEEKGLDNEEVWRGIMLNGGSVQHMSQLTQQ
EKDVFKTFKEISQLEIVQQAGIRQKFVDQGQSLNLNIPAELAIKDVNRLMIEAWQQGVKSLYYQRSQSVSKELVTSLVSC
SSCES

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=612, Percent_Identity=29.2483660130719, Blast_Score=217, Evalue=2e-56,
Organism=Escherichia coli, GI1789030, Length=602, Percent_Identity=25.7475083056478, Blast_Score=132, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI17555242, Length=563, Percent_Identity=28.7744227353464, Blast_Score=203, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6320914, Length=612, Percent_Identity=28.2679738562091, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6322123, Length=613, Percent_Identity=26.7536704730832, Blast_Score=193, Evalue=6e-50,
Organism=Drosophila melanogaster, GI17352481, Length=571, Percent_Identity=27.4956217162872, Blast_Score=187, Evalue=1e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013344
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 63657; Mature: 63657

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTIDPNEVNSLPHNEAGTKMWWKNSESEQILNRGYLLKGETVEGAIDRICTAAARRLYK
CCCCCCCHHCCCCCCCCCCCCEECCCCHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHCC
PELKESFVEMIERGWMSISSPVWANMGTERGLPISCFNVHVPDKIEGITHKLGEVIMQTK
HHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHC
IGGGTSGYFGELRERGSAVTDNGKSSGAVSFMKLFDTAMDTISQGGVRRGAFAAYLDIDH
CCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCC
PDIEEFLKIKSIGNPIQNLFTGICVPDYWMQEMIDGDADKRQIWAKVLESRQQKGLPYIF
CCHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEE
FSDNVNKNKPQVYKDQNLRINASNLCSEIMLPSTHDESFICCLSSMNLELYEEWKDTEAV
ECCCCCCCCCCEECCCCCEEEHHHHHHHHCCCCCCCCCCEEEHHHCCHHHHHHHCCHHHH
KLAIFFLDAVLQEFIEKTEGNYYLSAANKFAKRHRALGLGVLGWHSYLQKNMIPFEGMEA
HHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCH
KMKTTEIFKHISDKADKASQELARIYGEPELLKGYGRRNTTTMAIAPTTSSSAILGQTSP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCEEEEEEECCCCCEEECCCCC
GIEPFSSNYYKAGLSKGNFMRKNKYLKKLLEEKGLDNEEVWRGIMLNGGSVQHMSQLTQQ
CCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHH
EKDVFKTFKEISQLEIVQQAGIRQKFVDQGQSLNLNIPAELAIKDVNRLMIEAWQQGVKS
HHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHH
LYYQRSQSVSKELVTSLVSCSSCES
HHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNTIDPNEVNSLPHNEAGTKMWWKNSESEQILNRGYLLKGETVEGAIDRICTAAARRLYK
CCCCCCCHHCCCCCCCCCCCCEECCCCHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHCC
PELKESFVEMIERGWMSISSPVWANMGTERGLPISCFNVHVPDKIEGITHKLGEVIMQTK
HHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHC
IGGGTSGYFGELRERGSAVTDNGKSSGAVSFMKLFDTAMDTISQGGVRRGAFAAYLDIDH
CCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCC
PDIEEFLKIKSIGNPIQNLFTGICVPDYWMQEMIDGDADKRQIWAKVLESRQQKGLPYIF
CCHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEE
FSDNVNKNKPQVYKDQNLRINASNLCSEIMLPSTHDESFICCLSSMNLELYEEWKDTEAV
ECCCCCCCCCCEECCCCCEEEHHHHHHHHCCCCCCCCCCEEEHHHCCHHHHHHHCCHHHH
KLAIFFLDAVLQEFIEKTEGNYYLSAANKFAKRHRALGLGVLGWHSYLQKNMIPFEGMEA
HHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCH
KMKTTEIFKHISDKADKASQELARIYGEPELLKGYGRRNTTTMAIAPTTSSSAILGQTSP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCEEEEEEECCCCCEEECCCCC
GIEPFSSNYYKAGLSKGNFMRKNKYLKKLLEEKGLDNEEVWRGIMLNGGSVQHMSQLTQQ
CCCCCCCCHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHH
EKDVFKTFKEISQLEIVQQAGIRQKFVDQGQSLNLNIPAELAIKDVNRLMIEAWQQGVKS
HHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHH
LYYQRSQSVSKELVTSLVSCSSCES
HHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]