Click here to switch to the map view.

The map label for this gene is nhaK [H]

Identifier: 146301798

GI number: 146301798

Start: 4847536

End: 4849137

Strand: Reverse

Name: nhaK [H]

Synonym: Fjoh_4062

Alternate gene names: 146301798

Gene position: 4849137-4847536 (Counterclockwise)

Preceding gene: 146301801

Following gene: 146301790

Centisome position: 79.53

GC content: 36.52

Gene sequence:

>1602_bases
ATGGAAAATATCACAGTAATTATAATGTTACTCTTTGGCGTAGCTTTTCTTAGTTTAATAAGTAAAAGATATAATTTTCC
AATTCCTATTGTTTTGGTAATGTGCGGTGTAATTATCAGCGTTATTCCGGGACTTCCAGTAATAGCACTGAGCCCGGAAA
TTGTTTTTATTATCTTTTTGCCGCCTCTTTTATATCATGCAGCATGGCATACAAGCTGGTCCGATTTTAAACAAACCATA
CGTCCCATAACTTTAGCAGCTGTTGGTTTGGTTTTTTTTACTACAGGTTTGGTCGCTGTTGTGGCGCACTGGCTTATAGA
TGATATTTCCTGGCCGTTAGCTTTTTTACTTGGTGCTATTGTATCGCCTCCAGATGCGGTTTCGGCAACAGCCATTACTA
AAGGTTTAGGGCTGCATCCCAGATTAATTGCCATTCTAGAAGGAGAAAGTCTTGTAAATGACGCCAGTGGTCTTGTTGCT
TACAAATATGCACTTACGGCTATTACAGCAGGAAATTTCGTTTTATGGCAGGCAGGATTAAACTTTGTTTTAATGTCGGT
TCTAGGTATTGCAGTAGGTTTGGCAGTAGGTTTTATCATGTATTACATTCATAAAAAATTTGTCTGCGATGACATTATCG
AAGTAACGCTTACATTACTGACACCCTTTGCATCGTATTTAATTGCAGAACATTTTCATGGTTCAGGAGTTTTAGCGGTA
GTTGCAACAGGTCTTTTTTTAGCGGCAAGAACAGGAGCTATTTTTTCTCATGAAAGCCGAATCATGACCAATACTATATG
GGATGTTTTAAATAACATTCTCAACGGATTAATTTTTATTTTAATTGGTCTTCAGCTGCGCCAGATTATGGATGGAATCA
GCAATTACTCAGGGAATGCTTTATTTATCTGGGGATCAGTAATTAGTATTGTAGTTATTGTTGTTCGTTTTTTATGGGTG
ATTCCTGCTACTGTGATTCCTAGAATGTTAAGTAAAAGAATCCGGGAAAAAGAAGAATTTGATTATCGAAACATGATTGT
TTTTGGCTGGTCTGGTATGCGCGGTGTGGTTTCGATGGCAGCTGCTCTGGCACTTCCGTTAATGTTGAATAAAACAGAAG
AATTTCCGCTTCGTAATTTAATTATATATTTGGTTTTCTGTGTAATATTGTCAACATTGGTTATTCAGGGACTTACACTT
CCGTGGCTTATTAAAAAACTCAAAATAGAACGCTATTCTATTTTAGCAGAAGAATATAATGTCCGCAACGTAATCGTTTC
TGAAACCATTTCGCATATTGAAGATAATTTCTCTTTATTAGATGATGAATTACTGCATAACATTAAGAGCAAATACGAAG
TAAAATTTAACCGTTTGCAAAAAACAGAACTTCCGGCTAACTTTTTTGGAAACGGAAAAGTATTAGACGGCCAGATTTTT
AATGAGTTTACGAGAGTTCAAATCGATCTTTTGAATGTTGAGCGCAGTAAACTTGAGAGCATGCACAAAAAAGGTTCTGT
AAACGAAGAAATTTTCCGTAAAATAGAAAAAGAACTCGATCTGGAAGAAACGCGTCTTTGGATGGAAATGTACGAGGAGT
AG

Upstream 100 bases:

>100_bases
GGATATACTTTTTTAGTGTTATTCTAATTTAATTATCATAAAATCTTAATTTAGTACCCAGAAATTATAATCCTAAACAA
TAAAATACCCGCAGTAAAAA

Downstream 100 bases:

>100_bases
CATTTCTTGGATTCTTATAAATGATAGTAATAATTATGTAATTGTATTGACTGCCAGTTTTTTAAATTTGGAATATTAAG
TTGAATACAAACAGTAAAAA

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 533; Mature: 533

Protein sequence:

>533_residues
MENITVIIMLLFGVAFLSLISKRYNFPIPIVLVMCGVIISVIPGLPVIALSPEIVFIIFLPPLLYHAAWHTSWSDFKQTI
RPITLAAVGLVFFTTGLVAVVAHWLIDDISWPLAFLLGAIVSPPDAVSATAITKGLGLHPRLIAILEGESLVNDASGLVA
YKYALTAITAGNFVLWQAGLNFVLMSVLGIAVGLAVGFIMYYIHKKFVCDDIIEVTLTLLTPFASYLIAEHFHGSGVLAV
VATGLFLAARTGAIFSHESRIMTNTIWDVLNNILNGLIFILIGLQLRQIMDGISNYSGNALFIWGSVISIVVIVVRFLWV
IPATVIPRMLSKRIREKEEFDYRNMIVFGWSGMRGVVSMAAALALPLMLNKTEEFPLRNLIIYLVFCVILSTLVIQGLTL
PWLIKKLKIERYSILAEEYNVRNVIVSETISHIEDNFSLLDDELLHNIKSKYEVKFNRLQKTELPANFFGNGKVLDGQIF
NEFTRVQIDLLNVERSKLESMHKKGSVNEEIFRKIEKELDLEETRLWMEMYEE

Sequences:

>Translated_533_residues
MENITVIIMLLFGVAFLSLISKRYNFPIPIVLVMCGVIISVIPGLPVIALSPEIVFIIFLPPLLYHAAWHTSWSDFKQTI
RPITLAAVGLVFFTTGLVAVVAHWLIDDISWPLAFLLGAIVSPPDAVSATAITKGLGLHPRLIAILEGESLVNDASGLVA
YKYALTAITAGNFVLWQAGLNFVLMSVLGIAVGLAVGFIMYYIHKKFVCDDIIEVTLTLLTPFASYLIAEHFHGSGVLAV
VATGLFLAARTGAIFSHESRIMTNTIWDVLNNILNGLIFILIGLQLRQIMDGISNYSGNALFIWGSVISIVVIVVRFLWV
IPATVIPRMLSKRIREKEEFDYRNMIVFGWSGMRGVVSMAAALALPLMLNKTEEFPLRNLIIYLVFCVILSTLVIQGLTL
PWLIKKLKIERYSILAEEYNVRNVIVSETISHIEDNFSLLDDELLHNIKSKYEVKFNRLQKTELPANFFGNGKVLDGQIF
NEFTRVQIDLLNVERSKLESMHKKGSVNEEIFRKIEKELDLEETRLWMEMYEE
>Mature_533_residues
MENITVIIMLLFGVAFLSLISKRYNFPIPIVLVMCGVIISVIPGLPVIALSPEIVFIIFLPPLLYHAAWHTSWSDFKQTI
RPITLAAVGLVFFTTGLVAVVAHWLIDDISWPLAFLLGAIVSPPDAVSATAITKGLGLHPRLIAILEGESLVNDASGLVA
YKYALTAITAGNFVLWQAGLNFVLMSVLGIAVGLAVGFIMYYIHKKFVCDDIIEVTLTLLTPFASYLIAEHFHGSGVLAV
VATGLFLAARTGAIFSHESRIMTNTIWDVLNNILNGLIFILIGLQLRQIMDGISNYSGNALFIWGSVISIVVIVVRFLWV
IPATVIPRMLSKRIREKEEFDYRNMIVFGWSGMRGVVSMAAALALPLMLNKTEEFPLRNLIIYLVFCVILSTLVIQGLTL
PWLIKKLKIERYSILAEEYNVRNVIVSETISHIEDNFSLLDDELLHNIKSKYEVKFNRLQKTELPANFFGNGKVLDGQIF
NEFTRVQIDLLNVERSKLESMHKKGSVNEEIFRKIEKELDLEETRLWMEMYEE

Specific function: Transporter involved in the efflux of sodium, potassium, lithium and rubidium [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. Nhak (TC 2.A.36.3.2) subfamily [H]

Homologues:

Organism=Homo sapiens, GI27734935, Length=406, Percent_Identity=26.1083743842365, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI15529998, Length=443, Percent_Identity=22.5733634311512, Blast_Score=97, Evalue=6e-20,
Organism=Homo sapiens, GI27777632, Length=515, Percent_Identity=22.7184466019417, Blast_Score=90, Evalue=6e-18,
Organism=Homo sapiens, GI14211919, Length=395, Percent_Identity=25.8227848101266, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI4759144, Length=384, Percent_Identity=27.6041666666667, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI5454070, Length=369, Percent_Identity=27.10027100271, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI294997330, Length=340, Percent_Identity=27.0588235294118, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI110227626, Length=343, Percent_Identity=27.1137026239067, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI148727259, Length=454, Percent_Identity=23.1277533039648, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI194239733, Length=425, Percent_Identity=25.8823529411765, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI41872703, Length=430, Percent_Identity=24.1860465116279, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1790501, Length=556, Percent_Identity=28.4172661870504, Blast_Score=182, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI25147678, Length=497, Percent_Identity=24.5472837022133, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71980847, Length=406, Percent_Identity=23.6453201970443, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71992101, Length=381, Percent_Identity=25.9842519685039, Blast_Score=82, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI71992107, Length=381, Percent_Identity=25.9842519685039, Blast_Score=82, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI71993590, Length=419, Percent_Identity=23.6276849642005, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71993582, Length=419, Percent_Identity=23.6276849642005, Blast_Score=80, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71990924, Length=404, Percent_Identity=23.7623762376238, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71990932, Length=404, Percent_Identity=23.7623762376238, Blast_Score=79, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71987559, Length=406, Percent_Identity=22.4137931034483, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71987545, Length=404, Percent_Identity=22.2772277227723, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI25150332, Length=406, Percent_Identity=22.1674876847291, Blast_Score=76, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320663, Length=357, Percent_Identity=25.4901960784314, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI221473212, Length=414, Percent_Identity=25.3623188405797, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI221473215, Length=403, Percent_Identity=25.3101736972705, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI281364513, Length=377, Percent_Identity=25.9946949602122, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI221473222, Length=377, Percent_Identity=25.9946949602122, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI281360447, Length=438, Percent_Identity=26.027397260274, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI221510734, Length=431, Percent_Identity=23.2018561484919, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221510738, Length=431, Percent_Identity=23.2018561484919, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221510736, Length=431, Percent_Identity=23.2018561484919, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI221510732, Length=431, Percent_Identity=23.2018561484919, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24585580, Length=431, Percent_Identity=23.2018561484919, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI24585578, Length=431, Percent_Identity=23.2018561484919, Blast_Score=69, Evalue=6e-12,
Organism=Drosophila melanogaster, GI221510740, Length=431, Percent_Identity=23.2018561484919, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR018417
- InterPro:   IPR004705
- InterPro:   IPR002014 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 59790; Mature: 59790

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENITVIIMLLFGVAFLSLISKRYNFPIPIVLVMCGVIISVIPGLPVIALSPEIVFIIFL
CCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEECCCEEEEEHH
PPLLYHAAWHTSWSDFKQTIRPITLAAVGLVFFTTGLVAVVAHWLIDDISWPLAFLLGAI
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
VSPPDAVSATAITKGLGLHPRLIAILEGESLVNDASGLVAYKYALTAITAGNFVLWQAGL
CCCCCCHHHHHHHHCCCCCCCEEEEECCCHHHHCCCCHHHHHHHHHHHCCCCEEEEHHHH
NFVLMSVLGIAVGLAVGFIMYYIHKKFVCDDIIEVTLTLLTPFASYLIAEHFHGSGVLAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
VATGLFLAARTGAIFSHESRIMTNTIWDVLNNILNGLIFILIGLQLRQIMDGISNYSGNA
HHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
LFIWGSVISIVVIVVRFLWVIPATVIPRMLSKRIREKEEFDYRNMIVFGWSGMRGVVSMA
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHH
AALALPLMLNKTEEFPLRNLIIYLVFCVILSTLVIQGLTLPWLIKKLKIERYSILAEEYN
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
VRNVIVSETISHIEDNFSLLDDELLHNIKSKYEVKFNRLQKTELPANFFGNGKVLDGQIF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECHHHH
NEFTRVQIDLLNVERSKLESMHKKGSVNEEIFRKIEKELDLEETRLWMEMYEE
HHHHHHHHEEECCCHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHCC
>Mature Secondary Structure
MENITVIIMLLFGVAFLSLISKRYNFPIPIVLVMCGVIISVIPGLPVIALSPEIVFIIFL
CCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEEEECCCEEEEEHH
PPLLYHAAWHTSWSDFKQTIRPITLAAVGLVFFTTGLVAVVAHWLIDDISWPLAFLLGAI
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
VSPPDAVSATAITKGLGLHPRLIAILEGESLVNDASGLVAYKYALTAITAGNFVLWQAGL
CCCCCCHHHHHHHHCCCCCCCEEEEECCCHHHHCCCCHHHHHHHHHHHCCCCEEEEHHHH
NFVLMSVLGIAVGLAVGFIMYYIHKKFVCDDIIEVTLTLLTPFASYLIAEHFHGSGVLAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
VATGLFLAARTGAIFSHESRIMTNTIWDVLNNILNGLIFILIGLQLRQIMDGISNYSGNA
HHHHHHHHHHCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCE
LFIWGSVISIVVIVVRFLWVIPATVIPRMLSKRIREKEEFDYRNMIVFGWSGMRGVVSMA
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHH
AALALPLMLNKTEEFPLRNLIIYLVFCVILSTLVIQGLTLPWLIKKLKIERYSILAEEYN
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHC
VRNVIVSETISHIEDNFSLLDDELLHNIKSKYEVKFNRLQKTELPANFFGNGKVLDGQIF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECHHHH
NEFTRVQIDLLNVERSKLESMHKKGSVNEEIFRKIEKELDLEETRLWMEMYEE
HHHHHHHHEEECCCHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA