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The map label for this gene is nadC [H]

Identifier: 146301230

GI number: 146301230

Start: 4165388

End: 4166245

Strand: Reverse

Name: nadC [H]

Synonym: Fjoh_3488

Alternate gene names: 146301230

Gene position: 4166245-4165388 (Counterclockwise)

Preceding gene: 146301238

Following gene: 146301229

Centisome position: 68.33

GC content: 35.31

Gene sequence:

>858_bases
ATGATAAGCGAAGCTCAATTTCAAGCAGAATTACAACTTTTAATAAAAAATGCTATTAGAGAAGATGTTGGTCCAGGTGA
TTACAGTTCACTTGCCTGTATTCCAGATACAGCTCACGGTCAGGCGAAACTATTGGTAAAAGATCAGGGAATCATTGCCG
GTGTTGAACTTGCTAAGATGATATTTGAACATGTTGATCCAAAATTAAAAGTAAAAACTTTTATAGAAGACGGAACGCAT
GTAGAATACGGGGAAGTTGTTTTTGAAGTTTCGGGAAGTTCGCAATCTATTTTGAAAGCAGAACGAGTGGTTTTGAACAC
CATGCAGAGAATGTCTGCAATTGCGACAAAAACAAACCATTTAATGGGGCTTTTGGAAGGAACAAACGCAAAAATTTTGG
ATACACGCAAAACGACTCCAAATTTTAGGGTGGCTGAAAAATGGGCTGTAAAAATTGGCGGTGGCGAAAATCATCGTTAT
GCTTTGTATGATATGATTATGCTGAAAGACAATCATATTGATTTTGCCGGCGGCATTACACGTGCTATTTCTAAAGCAAA
AGAATATTTAAAAGAGAATAATCTTGATTTGAAAATTATTGTTGAAGCTCGCAATCTGGATGAAATCAGAGAGATTTTAT
TAAGTAACGGAGTTCATAGAATCCTGATTGATAACTTTAATTATGAAGATACTAAAACGGCAGTGAATTTGATTGGTTCA
AAATGTCAGACAGAATCTTCTGGAAATATCAGCGAAAAAACAGTTCGTGAATATGCTTTATGCGGTGTAAATTATATTTC
GTCTGGTGCTTTGACACATTCTGTATATAATATGGATTTGAGCTTGAAAGCCTTTTAA

Upstream 100 bases:

>100_bases
AAAAAGAGATATTTAATGTTTTGTATAATTTTTCATGTTATCGGAATTTTCAAATCCATAAAATAAGTCCTAATTTAGCA
TTATTATTAAAAATAGAAAA

Downstream 100 bases:

>100_bases
ATTGTTAATTATAAATTATCAGTTATTAATTAAAAATCTAAGAAGTCTAAAAACCTAAGTTTATGTCGAAAGAAATAGAG
GATCGGATTGAAAAACTGCC

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MISEAQFQAELQLLIKNAIREDVGPGDYSSLACIPDTAHGQAKLLVKDQGIIAGVELAKMIFEHVDPKLKVKTFIEDGTH
VEYGEVVFEVSGSSQSILKAERVVLNTMQRMSAIATKTNHLMGLLEGTNAKILDTRKTTPNFRVAEKWAVKIGGGENHRY
ALYDMIMLKDNHIDFAGGITRAISKAKEYLKENNLDLKIIVEARNLDEIREILLSNGVHRILIDNFNYEDTKTAVNLIGS
KCQTESSGNISEKTVREYALCGVNYISSGALTHSVYNMDLSLKAF

Sequences:

>Translated_285_residues
MISEAQFQAELQLLIKNAIREDVGPGDYSSLACIPDTAHGQAKLLVKDQGIIAGVELAKMIFEHVDPKLKVKTFIEDGTH
VEYGEVVFEVSGSSQSILKAERVVLNTMQRMSAIATKTNHLMGLLEGTNAKILDTRKTTPNFRVAEKWAVKIGGGENHRY
ALYDMIMLKDNHIDFAGGITRAISKAKEYLKENNLDLKIIVEARNLDEIREILLSNGVHRILIDNFNYEDTKTAVNLIGS
KCQTESSGNISEKTVREYALCGVNYISSGALTHSVYNMDLSLKAF
>Mature_285_residues
MISEAQFQAELQLLIKNAIREDVGPGDYSSLACIPDTAHGQAKLLVKDQGIIAGVELAKMIFEHVDPKLKVKTFIEDGTH
VEYGEVVFEVSGSSQSILKAERVVLNTMQRMSAIATKTNHLMGLLEGTNAKILDTRKTTPNFRVAEKWAVKIGGGENHRY
ALYDMIMLKDNHIDFAGGITRAISKAKEYLKENNLDLKIIVEARNLDEIREILLSNGVHRILIDNFNYEDTKTAVNLIGS
KCQTESSGNISEKTVREYALCGVNYISSGALTHSVYNMDLSLKAF

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=283, Percent_Identity=32.8621908127208, Blast_Score=138, Evalue=6e-33,
Organism=Escherichia coli, GI1786299, Length=274, Percent_Identity=34.6715328467153, Blast_Score=166, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6321162, Length=283, Percent_Identity=31.4487632508834, Blast_Score=125, Evalue=7e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 31607; Mature: 31607

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISEAQFQAELQLLIKNAIREDVGPGDYSSLACIPDTAHGQAKLLVKDQGIIAGVELAKM
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCEEEEEECCCCCHHHHHHHH
IFEHVDPKLKVKTFIEDGTHVEYGEVVFEVSGSSQSILKAERVVLNTMQRMSAIATKTNH
HHHHCCCCEEEEEEECCCCEEEECEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LMGLLEGTNAKILDTRKTTPNFRVAEKWAVKIGGGENHRYALYDMIMLKDNHIDFAGGIT
HEEEEECCCCEEEECCCCCCCCEEEEEEEEEECCCCCCCEEEEEEEEEECCCCCCHHHHH
RAISKAKEYLKENNLDLKIIVEARNLDEIREILLSNGVHRILIDNFNYEDTKTAVNLIGS
HHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHH
KCQTESSGNISEKTVREYALCGVNYISSGALTHSVYNMDLSLKAF
HCCCCCCCCCHHHHHHHHHHHCCHHHCCCCCEEEEEECCEEEEEC
>Mature Secondary Structure
MISEAQFQAELQLLIKNAIREDVGPGDYSSLACIPDTAHGQAKLLVKDQGIIAGVELAKM
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCEEEEEECCCCCHHHHHHHH
IFEHVDPKLKVKTFIEDGTHVEYGEVVFEVSGSSQSILKAERVVLNTMQRMSAIATKTNH
HHHHCCCCEEEEEEECCCCEEEECEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LMGLLEGTNAKILDTRKTTPNFRVAEKWAVKIGGGENHRYALYDMIMLKDNHIDFAGGIT
HEEEEECCCCEEEECCCCCCCCEEEEEEEEEECCCCCCCEEEEEEEEEECCCCCCHHHHH
RAISKAKEYLKENNLDLKIIVEARNLDEIREILLSNGVHRILIDNFNYEDTKTAVNLIGS
HHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHH
KCQTESSGNISEKTVREYALCGVNYISSGALTHSVYNMDLSLKAF
HCCCCCCCCCHHHHHHHHHHHCCHHHCCCCCEEEEEECCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 2430961; 8419294 [H]