Click here to switch to the map view.

The map label for this gene is coaBC [H]

Identifier: 146301209

GI number: 146301209

Start: 4134217

End: 4135431

Strand: Reverse

Name: coaBC [H]

Synonym: Fjoh_3467

Alternate gene names: 146301209

Gene position: 4135431-4134217 (Counterclockwise)

Preceding gene: 146301210

Following gene: 146301208

Centisome position: 67.83

GC content: 35.23

Gene sequence:

>1215_bases
ATGTCAGTTTTAAACGGTAAAAAGATTTTACTGGGAGTTTCTGGTGGAATTGCAGCGTATAAAACAGCCTCATTAGTACG
ACTTTTTATAAAAGCAGGTGCACATGTCCAAGTGATAATGACACCTGCTTCTAAGGATTTTGTAACCCCGCTTACATTAT
CTACCCTGTCAAAAAATCCAGTGCATTCCAATTTCTTTAATCAGGATGATGAAGATGCTGTATGGAATAATCACGTCGAA
TTAGGTCTTTGGGCCGATTTGATGCTGATAGCGCCTGCAACAGCAAATACATTATCTAAAATGGCGACAGGCAACAGCGA
TAATCTTTTAATTGCTGCATACTTATCAGCAAAATGTCCAGTTTATTTTGCTCCGGCAATGGATCTGGATATGTACAAAC
ATCCTTCTACAATTTCTAGTTTTAATACCCTGAAACAGTTTGGTAATATTATGATTCCGGCTGAAAGCGGTGAGCTGGCC
AGCGGTTTGTCAGGAGAAGGCCGTATGGCAGAACCAGAAAATATTATTGCTTTTTTAGAAGCTGATTTAGAGAGTAAATT
GCCTTTAAAAGGAAAAAAAATACTAATTACTGCAGGTCCGACATACGAAGCGATAGACCCCGTACGTTTTATAGGAAATC
ATTCTTCAGGAAAAATGGGATTTGATATCGCTAATGAAGCGGCTAATCTTGGAGCAGAAGTTGTTTTGGTTTCAGGTCCA
ACACATTACAAAGCTAAGAATGCATCAATTAAAGTTGTAAATGTAATTTCTGCGCAAGATATGTATGAAGCTTGTCATGA
ATATTTTAATGACGTTGATGCAGCAATCGCCGCCGCTGCCGTTGCAGATTACAGACCGAAAGAAGTCGCTTTGCAGAAAA
TTAAAAAAAATGCAGCCGAATTTTCTATTGAGCTGGAAAAGACAAAAGATATTTTATCTTCATTAGGAGCGATCAAAAAA
AATCAATTTTTAGTTGGTTTTGCTTTAGAAACTGAAAATGAAATTGAAAATGCTAAGTTGAAAATTCAGAAAAAAAACTT
AGATTTGATAGTTCTAAATTCTTTGCAGGATGAAGGCGCAGGTTTTAAAAAAGAAACCAATAAAGTTACTTTTATTGATA
AAGATTTTAAAATTGAGCCAATGGAGTTAAAGGCAAAAGAATTTGTAGCTCAAGATATTTTGAATAAAGTAATTTTACAT
TTTTCAAAATTGTAA

Upstream 100 bases:

>100_bases
ATTTTACGAAAAATTACCAAAACCTCACGCTTTAGCAGTTCAGGAATGGTTAGACGGTAAAACTTACCACAGAAACTCAA
ACAAATAATATATAGTAATA

Downstream 100 bases:

>100_bases
TGTTTAAAATGTAGTCTAAAAGCAAAAAATAGGAATACTATTTATGCTATTAAAAATAATATTTTATTTGTATGAACAGG
ATACTTACTTTCTTAGTTTT

Product: phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MSVLNGKKILLGVSGGIAAYKTASLVRLFIKAGAHVQVIMTPASKDFVTPLTLSTLSKNPVHSNFFNQDDEDAVWNNHVE
LGLWADLMLIAPATANTLSKMATGNSDNLLIAAYLSAKCPVYFAPAMDLDMYKHPSTISSFNTLKQFGNIMIPAESGELA
SGLSGEGRMAEPENIIAFLEADLESKLPLKGKKILITAGPTYEAIDPVRFIGNHSSGKMGFDIANEAANLGAEVVLVSGP
THYKAKNASIKVVNVISAQDMYEACHEYFNDVDAAIAAAAVADYRPKEVALQKIKKNAAEFSIELEKTKDILSSLGAIKK
NQFLVGFALETENEIENAKLKIQKKNLDLIVLNSLQDEGAGFKKETNKVTFIDKDFKIEPMELKAKEFVAQDILNKVILH
FSKL

Sequences:

>Translated_404_residues
MSVLNGKKILLGVSGGIAAYKTASLVRLFIKAGAHVQVIMTPASKDFVTPLTLSTLSKNPVHSNFFNQDDEDAVWNNHVE
LGLWADLMLIAPATANTLSKMATGNSDNLLIAAYLSAKCPVYFAPAMDLDMYKHPSTISSFNTLKQFGNIMIPAESGELA
SGLSGEGRMAEPENIIAFLEADLESKLPLKGKKILITAGPTYEAIDPVRFIGNHSSGKMGFDIANEAANLGAEVVLVSGP
THYKAKNASIKVVNVISAQDMYEACHEYFNDVDAAIAAAAVADYRPKEVALQKIKKNAAEFSIELEKTKDILSSLGAIKK
NQFLVGFALETENEIENAKLKIQKKNLDLIVLNSLQDEGAGFKKETNKVTFIDKDFKIEPMELKAKEFVAQDILNKVILH
FSKL
>Mature_403_residues
SVLNGKKILLGVSGGIAAYKTASLVRLFIKAGAHVQVIMTPASKDFVTPLTLSTLSKNPVHSNFFNQDDEDAVWNNHVEL
GLWADLMLIAPATANTLSKMATGNSDNLLIAAYLSAKCPVYFAPAMDLDMYKHPSTISSFNTLKQFGNIMIPAESGELAS
GLSGEGRMAEPENIIAFLEADLESKLPLKGKKILITAGPTYEAIDPVRFIGNHSSGKMGFDIANEAANLGAEVVLVSGPT
HYKAKNASIKVVNVISAQDMYEACHEYFNDVDAAIAAAAVADYRPKEVALQKIKKNAAEFSIELEKTKDILSSLGAIKKN
QFLVGFALETENEIENAKLKIQKKNLDLIVLNSLQDEGAGFKKETNKVTFIDKDFKIEPMELKAKEFVAQDILNKVILHF
SKL

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=178, Percent_Identity=37.6404494382022, Blast_Score=106, Evalue=4e-23,
Organism=Escherichia coli, GI87082301, Length=405, Percent_Identity=41.4814814814815, Blast_Score=267, Evalue=8e-73,
Organism=Caenorhabditis elegans, GI17560194, Length=186, Percent_Identity=33.3333333333333, Blast_Score=78, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6322762, Length=197, Percent_Identity=32.994923857868, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6324629, Length=76, Percent_Identity=40.7894736842105, Blast_Score=64, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24657262, Length=196, Percent_Identity=34.6938775510204, Blast_Score=108, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 43925; Mature: 43794

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVLNGKKILLGVSGGIAAYKTASLVRLFIKAGAHVQVIMTPASKDFVTPLTLSTLSKNP
CCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEHHHCCCCC
VHSNFFNQDDEDAVWNNHVELGLWADLMLIAPATANTLSKMATGNSDNLLIAAYLSAKCP
CCCCCCCCCCCCCCCCCCEEEEEHEEEEEECCCCHHHHHHHHCCCCCCEEEEEEECCCCC
VYFAPAMDLDMYKHPSTISSFNTLKQFGNIMIPAESGELASGLSGEGRMAEPENIIAFLE
EEEECCCCCCHHCCCCHHHHHHHHHHHCCEEEECCCCCHHCCCCCCCCCCCHHHEEEEEE
ADLESKLPLKGKKILITAGPTYEAIDPVRFIGNHSSGKMGFDIANEAANLGAEVVLVSGP
CCCCCCCCCCCCEEEEEECCCCCCCCCHHHHCCCCCCCCCCEEHHHHHCCCEEEEEEECC
THYKAKNASIKVVNVISAQDMYEACHEYFNDVDAAIAAAAVADYRPKEVALQKIKKNAAE
CCEECCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHH
FSIELEKTKDILSSLGAIKKNQFLVGFALETENEIENAKLKIQKKNLDLIVLNSLQDEGA
EEEEHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCEEEEEECCCCEEEEECCCCCCC
GFKKETNKVTFIDKDFKIEPMELKAKEFVAQDILNKVILHFSKL
CCCCCCCEEEEEECCCEECCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SVLNGKKILLGVSGGIAAYKTASLVRLFIKAGAHVQVIMTPASKDFVTPLTLSTLSKNP
CCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEHHHCCCCC
VHSNFFNQDDEDAVWNNHVELGLWADLMLIAPATANTLSKMATGNSDNLLIAAYLSAKCP
CCCCCCCCCCCCCCCCCCEEEEEHEEEEEECCCCHHHHHHHHCCCCCCEEEEEEECCCCC
VYFAPAMDLDMYKHPSTISSFNTLKQFGNIMIPAESGELASGLSGEGRMAEPENIIAFLE
EEEECCCCCCHHCCCCHHHHHHHHHHHCCEEEECCCCCHHCCCCCCCCCCCHHHEEEEEE
ADLESKLPLKGKKILITAGPTYEAIDPVRFIGNHSSGKMGFDIANEAANLGAEVVLVSGP
CCCCCCCCCCCCEEEEEECCCCCCCCCHHHHCCCCCCCCCCEEHHHHHCCCEEEEEEECC
THYKAKNASIKVVNVISAQDMYEACHEYFNDVDAAIAAAAVADYRPKEVALQKIKKNAAE
CCEECCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHH
FSIELEKTKDILSSLGAIKKNQFLVGFALETENEIENAKLKIQKKNLDLIVLNSLQDEGA
EEEEHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCEEEEEECCCCEEEEECCCCCCC
GFKKETNKVTFIDKDFKIEPMELKAKEFVAQDILNKVILHFSKL
CCCCCCCEEEEEECCCEECCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]