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The map label for this gene is proA [H]

Identifier: 146301174

GI number: 146301174

Start: 4099413

End: 4100606

Strand: Reverse

Name: proA [H]

Synonym: Fjoh_3432

Alternate gene names: 146301174

Gene position: 4100606-4099413 (Counterclockwise)

Preceding gene: 146301175

Following gene: 146301173

Centisome position: 67.26

GC content: 36.18

Gene sequence:

>1194_bases
ATGAAACCATTATCAATTGAAACACGTAATGCGGTTTTGCGGACTATGGCAAAGCTGGTCGAGCAGGAGCGGAATGAGAT
AATCTTGACTAATCAGGAAGATCTTGCCGATTATGACGGCTCAGATTTAGCGATGGAAGAACGCTTAAAAGTAGATGATA
AAAAAGTCAACGAGATGATTTTATCATTAAACCAACTAGCTTCACAGGAAGATCCTGTTGGCGTTGAGCGTTTTCATTTT
ACTCATGATAATGGAATAAAAGTGGTCAATAAGACTGCTGCTTTTGGAACGATTTTAATTATTTATGAATCCCGTCCAGA
TGTTACCATAGAAGCGGGAGGAATTGCCTTTAAATCCGGAAATAAGATCTTATTAAAAGGAGGAAAAGAATCTTTAAAAT
CAAACTTAAAAATCGTAAGTCTTTGGCATAAAGCTTTAGAAGAAAATGGAGTTTCAAAAGACTGGGTGGAATATCTGAAT
TACAATAGAACTGAAACCCAGACATTTTTAGAAAAACCAACTCAAAAAGTCGATTTAATAGTTCCAAGAGGCGGAGAAAA
ACTAATTGAGTTTGTAAAAGCGCACGCCACTTGTCCCGTAATTGTAAGCGGACGCGGCAATAATTTTGTTTACGTTCATG
AAGATGCTGACACAGATTTAGCTTTAAAAGTAATTTTAAATGCTAAAACAGCTAAAATTTCGGCTTGCAATGCTTTAGAT
AAAGTTTTGATAAGTTCTAAGCTTCCAAATTTTGAAGGTTTCGCAGCAATGTTAATTGAAGCTTTAATTGAATCAAAAGT
AGAAGTTATTGTCGATAAATCGTTAGAGTATTTCGAAAATACCAAGACGATCGAAAACGAAGACATTTGGTACGAAGAAT
TTCTGGATTATAAAATCGTAATAGGAACCATCGATTCTCAGGATCATGCTATTGATATGATTAATAAATACTGCGGAGGA
CATTCTGCAGCAATTATTACGAGAGATAATGAAGCTGCACAACAGTTTATGGAATCAATAGACGCTGCAGCAGTTTACCA
AAATGCTTCAACCCGTTTTACAGACGGCGGACAATTTGGTCTTGGCGGAGAATTAGCAATAAGTACTGATAAATTACATC
AACGAGGTCCAATCGGTCTTCAACATCTCGTGACCAATAAATGGTACGTTTACGGAGAAGGACAGATTAGATAA

Upstream 100 bases:

>100_bases
TCTCGTTACGTTAAACCTGACGGGTTTTTAAAACCCGTTAGGTTTAAAATAAAGTTTCCGAAAAAGAAACAACCAAAAAA
CAACCAACCCACTTGAAATT

Downstream 100 bases:

>100_bases
TTTTAGAGTTCAGATTTTAGATTGATGATTAACGATTTTTGATTTCAGATTATTGGAATTTGGAATTTAAAAAATTGATA
TTTATTTAAAGATATAGCTT

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MKPLSIETRNAVLRTMAKLVEQERNEIILTNQEDLADYDGSDLAMEERLKVDDKKVNEMILSLNQLASQEDPVGVERFHF
THDNGIKVVNKTAAFGTILIIYESRPDVTIEAGGIAFKSGNKILLKGGKESLKSNLKIVSLWHKALEENGVSKDWVEYLN
YNRTETQTFLEKPTQKVDLIVPRGGEKLIEFVKAHATCPVIVSGRGNNFVYVHEDADTDLALKVILNAKTAKISACNALD
KVLISSKLPNFEGFAAMLIEALIESKVEVIVDKSLEYFENTKTIENEDIWYEEFLDYKIVIGTIDSQDHAIDMINKYCGG
HSAAIITRDNEAAQQFMESIDAAAVYQNASTRFTDGGQFGLGGELAISTDKLHQRGPIGLQHLVTNKWYVYGEGQIR

Sequences:

>Translated_397_residues
MKPLSIETRNAVLRTMAKLVEQERNEIILTNQEDLADYDGSDLAMEERLKVDDKKVNEMILSLNQLASQEDPVGVERFHF
THDNGIKVVNKTAAFGTILIIYESRPDVTIEAGGIAFKSGNKILLKGGKESLKSNLKIVSLWHKALEENGVSKDWVEYLN
YNRTETQTFLEKPTQKVDLIVPRGGEKLIEFVKAHATCPVIVSGRGNNFVYVHEDADTDLALKVILNAKTAKISACNALD
KVLISSKLPNFEGFAAMLIEALIESKVEVIVDKSLEYFENTKTIENEDIWYEEFLDYKIVIGTIDSQDHAIDMINKYCGG
HSAAIITRDNEAAQQFMESIDAAAVYQNASTRFTDGGQFGLGGELAISTDKLHQRGPIGLQHLVTNKWYVYGEGQIR
>Mature_397_residues
MKPLSIETRNAVLRTMAKLVEQERNEIILTNQEDLADYDGSDLAMEERLKVDDKKVNEMILSLNQLASQEDPVGVERFHF
THDNGIKVVNKTAAFGTILIIYESRPDVTIEAGGIAFKSGNKILLKGGKESLKSNLKIVSLWHKALEENGVSKDWVEYLN
YNRTETQTFLEKPTQKVDLIVPRGGEKLIEFVKAHATCPVIVSGRGNNFVYVHEDADTDLALKVILNAKTAKISACNALD
KVLISSKLPNFEGFAAMLIEALIESKVEVIVDKSLEYFENTKTIENEDIWYEEFLDYKIVIGTIDSQDHAIDMINKYCGG
HSAAIITRDNEAAQQFMESIDAAAVYQNASTRFTDGGQFGLGGELAISTDKLHQRGPIGLQHLVTNKWYVYGEGQIR

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361368, Length=401, Percent_Identity=34.1645885286783, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI62912457, Length=401, Percent_Identity=34.1645885286783, Blast_Score=216, Evalue=2e-56,
Organism=Escherichia coli, GI1786438, Length=402, Percent_Identity=34.8258706467662, Blast_Score=234, Evalue=9e-63,
Organism=Caenorhabditis elegans, GI17569967, Length=400, Percent_Identity=32, Blast_Score=201, Evalue=6e-52,
Organism=Caenorhabditis elegans, GI17569969, Length=400, Percent_Identity=32, Blast_Score=201, Evalue=6e-52,
Organism=Saccharomyces cerevisiae, GI6324899, Length=419, Percent_Identity=31.7422434367542, Blast_Score=196, Evalue=4e-51,
Organism=Drosophila melanogaster, GI21357643, Length=402, Percent_Identity=31.8407960199005, Blast_Score=189, Evalue=3e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 44333; Mature: 44333

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPLSIETRNAVLRTMAKLVEQERNEIILTNQEDLADYDGSDLAMEERLKVDDKKVNEMI
CCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCHHHHCCCCCCCCHHHHHCCCHHHHHHHH
LSLNQLASQEDPVGVERFHFTHDNGIKVVNKTAAFGTILIIYESRPDVTIEAGGIAFKSG
HHHHHHCCCCCCCCCEEEEEECCCCCEEEEECCCEEEEEEEEECCCCEEEEECCEEEECC
NKILLKGGKESLKSNLKIVSLWHKALEENGVSKDWVEYLNYNRTETQTFLEKPTQKVDLI
CEEEEECCHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHCCCCEEEEE
VPRGGEKLIEFVKAHATCPVIVSGRGNNFVYVHEDADTDLALKVILNAKTAKISACNALD
ECCCCHHHHHHHHHCCCCCEEEECCCCEEEEEECCCCCCEEEEEEEECCCHHHHHHHHHH
KVLISSKLPNFEGFAAMLIEALIESKVEVIVDKSLEYFENTKTIENEDIWYEEFLDYKIV
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCHHHHHCCEEEE
IGTIDSQDHAIDMINKYCGGHSAAIITRDNEAAQQFMESIDAAAVYQNASTRFTDGGQFG
EEEECCCCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
LGGELAISTDKLHQRGPIGLQHLVTNKWYVYGEGQIR
CCCEEEEEHHHHHCCCCCCHHHHHCCCEEEEECCEEC
>Mature Secondary Structure
MKPLSIETRNAVLRTMAKLVEQERNEIILTNQEDLADYDGSDLAMEERLKVDDKKVNEMI
CCCCCCCHHHHHHHHHHHHHHHCCCCEEEECCHHHHCCCCCCCCHHHHHCCCHHHHHHHH
LSLNQLASQEDPVGVERFHFTHDNGIKVVNKTAAFGTILIIYESRPDVTIEAGGIAFKSG
HHHHHHCCCCCCCCCEEEEEECCCCCEEEEECCCEEEEEEEEECCCCEEEEECCEEEECC
NKILLKGGKESLKSNLKIVSLWHKALEENGVSKDWVEYLNYNRTETQTFLEKPTQKVDLI
CEEEEECCHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHCCCCEEEEE
VPRGGEKLIEFVKAHATCPVIVSGRGNNFVYVHEDADTDLALKVILNAKTAKISACNALD
ECCCCHHHHHHHHHCCCCCEEEECCCCEEEEEECCCCCCEEEEEEEECCCHHHHHHHHHH
KVLISSKLPNFEGFAAMLIEALIESKVEVIVDKSLEYFENTKTIENEDIWYEEFLDYKIV
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCHHHHHCCEEEE
IGTIDSQDHAIDMINKYCGGHSAAIITRDNEAAQQFMESIDAAAVYQNASTRFTDGGQFG
EEEECCCCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
LGGELAISTDKLHQRGPIGLQHLVTNKWYVYGEGQIR
CCCEEEEEHHHHHCCCCCCHHHHHCCCEEEEECCEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA