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The map label for this gene is argH [H]

Identifier: 146301169

GI number: 146301169

Start: 4093846

End: 4095126

Strand: Reverse

Name: argH [H]

Synonym: Fjoh_3427

Alternate gene names: 146301169

Gene position: 4095126-4093846 (Counterclockwise)

Preceding gene: 146301170

Following gene: 146301168

Centisome position: 67.17

GC content: 35.52

Gene sequence:

>1281_bases
ATGAAACTTTGGGAAAAAGGAATACCAACAGATAAACAAATCGAGCAATTTACAGTAGGAAACGATCGTGAATTGGATTT
GGTTCTCGCAAAATACGATGCTTTAGGTTCAATCGCACACGCCAAAATGCTGGGTCAGATAGGTTTGTTAACTGAAGAAG
AAACAACTTCTTTAGTTGATGCATTAAACGAAATTATCGCAGATATTGTAGTTGGAAATTTCGAAATCGAAGACAGTTTT
GAAGATGTACATTCTAAAATAGAATATCTTCTAACCGTAAAACTAGGCGATGCCGGAAAGAAAATCCACACCGCACGTTC
TCGTAACGATCAGGTTTTAGTTGATGTTCATTTGTATTTAAAAGATGAATTAAAAGTAATAAAAGAACAGGTAAAAACTT
TGTTTGATTTGTTGATGGAATCGGCAGAAAAACATCAAAATGTTTTATTGCCAGGATATACACATTTGCAAATTGCAATG
CCATCGTCTTTTGGAATGTGGTTTTCTGCTTATGCAGAAAGCTTGATTGATGATGTTACAATGTTGAACGCTGCTTCAAA
AATTGTAGACCAGAATCCGTTAGGCTCGGCTGCAGGTTATGGAAGTTCGTTTCCAATCAACAGAACCTTTACAACGAAAG
AACTAGGCTTTGAGACTTTAAAATACAATGCTGTTGCCGCACAAATGAGTCGAGGGAAAGCAGAAAAAACGGTTGCTTTT
GCTATGACAAGCGTTGCAGGAACGTTGTCAAAATTTGCAATGGACGTTTGTTTATATATGAGCCAGAACTTTGATTTTAT
AGGTCTTCCGGCGCATCTTACAACAGGTTCAAGCATTATGCCTCATAAAAAGAATCCGGACGTTTTCGAATTAATCAGAG
GAAAATGCAATAAGATTCAGGCACTTCCATACGAAATCACTTTAATTACAAATAATCTTCCAAGCGGTTATCATAGAGAT
TTACAGCTTTTAAAGGAAGGTTTGTTTCCGGCAATTCAAAACCTGAAAGCTTGCTTGGATATTGCAATTTTCTCAATTAA
AGATATTACAGTAAAAGATCATATTTTAGAGGATAAGAAATATGACTACTTGTTTACAGTTGATACTTTAAATGAAATGG
TTGTAGAAGGAATGCCGTTTAGAGATGCTTACAAAGCAGTTGCTGAACAATTGGAAGCAGGAACGTACAAATCTCCAAAA
GCAACAAAACACACACACGAAGGCAGTATAAATAATTTATGTCTTGACGCAATAAAAGATAAAATGAAAGCAGCTTTTTA
A

Upstream 100 bases:

>100_bases
AGGAGTCGACTTGTATATTAAAATACTAACTGATTTCTTTAAATTATAATTAAACCCGACAGGTTTTTAAAACCTGTCGG
GTTTCTAAAAAATAGTACCT

Downstream 100 bases:

>100_bases
AGCTGTATTATTTAAATAATGAAGCCGGTTTGTTACCAATACAAATCGGTTTTTTTATTTCTTCAAATATCTTTTTTGAA
CTAAGAAAATTCGGCTTAAA

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 426; Mature: 426

Protein sequence:

>426_residues
MKLWEKGIPTDKQIEQFTVGNDRELDLVLAKYDALGSIAHAKMLGQIGLLTEEETTSLVDALNEIIADIVVGNFEIEDSF
EDVHSKIEYLLTVKLGDAGKKIHTARSRNDQVLVDVHLYLKDELKVIKEQVKTLFDLLMESAEKHQNVLLPGYTHLQIAM
PSSFGMWFSAYAESLIDDVTMLNAASKIVDQNPLGSAAGYGSSFPINRTFTTKELGFETLKYNAVAAQMSRGKAEKTVAF
AMTSVAGTLSKFAMDVCLYMSQNFDFIGLPAHLTTGSSIMPHKKNPDVFELIRGKCNKIQALPYEITLITNNLPSGYHRD
LQLLKEGLFPAIQNLKACLDIAIFSIKDITVKDHILEDKKYDYLFTVDTLNEMVVEGMPFRDAYKAVAEQLEAGTYKSPK
ATKHTHEGSINNLCLDAIKDKMKAAF

Sequences:

>Translated_426_residues
MKLWEKGIPTDKQIEQFTVGNDRELDLVLAKYDALGSIAHAKMLGQIGLLTEEETTSLVDALNEIIADIVVGNFEIEDSF
EDVHSKIEYLLTVKLGDAGKKIHTARSRNDQVLVDVHLYLKDELKVIKEQVKTLFDLLMESAEKHQNVLLPGYTHLQIAM
PSSFGMWFSAYAESLIDDVTMLNAASKIVDQNPLGSAAGYGSSFPINRTFTTKELGFETLKYNAVAAQMSRGKAEKTVAF
AMTSVAGTLSKFAMDVCLYMSQNFDFIGLPAHLTTGSSIMPHKKNPDVFELIRGKCNKIQALPYEITLITNNLPSGYHRD
LQLLKEGLFPAIQNLKACLDIAIFSIKDITVKDHILEDKKYDYLFTVDTLNEMVVEGMPFRDAYKAVAEQLEAGTYKSPK
ATKHTHEGSINNLCLDAIKDKMKAAF
>Mature_426_residues
MKLWEKGIPTDKQIEQFTVGNDRELDLVLAKYDALGSIAHAKMLGQIGLLTEEETTSLVDALNEIIADIVVGNFEIEDSF
EDVHSKIEYLLTVKLGDAGKKIHTARSRNDQVLVDVHLYLKDELKVIKEQVKTLFDLLMESAEKHQNVLLPGYTHLQIAM
PSSFGMWFSAYAESLIDDVTMLNAASKIVDQNPLGSAAGYGSSFPINRTFTTKELGFETLKYNAVAAQMSRGKAEKTVAF
AMTSVAGTLSKFAMDVCLYMSQNFDFIGLPAHLTTGSSIMPHKKNPDVFELIRGKCNKIQALPYEITLITNNLPSGYHRD
LQLLKEGLFPAIQNLKACLDIAIFSIKDITVKDHILEDKKYDYLFTVDTLNEMVVEGMPFRDAYKAVAEQLEAGTYKSPK
ATKHTHEGSINNLCLDAIKDKMKAAF

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=389, Percent_Identity=31.3624678663239, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI68303542, Length=389, Percent_Identity=31.3624678663239, Blast_Score=200, Evalue=3e-51,
Organism=Homo sapiens, GI68303549, Length=389, Percent_Identity=29.8200514138817, Blast_Score=179, Evalue=5e-45,
Organism=Homo sapiens, GI68303547, Length=389, Percent_Identity=29.8200514138817, Blast_Score=177, Evalue=1e-44,
Organism=Escherichia coli, GI1790398, Length=392, Percent_Identity=36.734693877551, Blast_Score=242, Evalue=4e-65,
Organism=Saccharomyces cerevisiae, GI6321806, Length=366, Percent_Identity=32.7868852459016, Blast_Score=189, Evalue=7e-49,
Organism=Drosophila melanogaster, GI221473854, Length=388, Percent_Identity=31.4432989690722, Blast_Score=189, Evalue=5e-48,
Organism=Drosophila melanogaster, GI78706858, Length=388, Percent_Identity=31.4432989690722, Blast_Score=189, Evalue=5e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 47432; Mature: 47432

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLWEKGIPTDKQIEQFTVGNDRELDLVLAKYDALGSIAHAKMLGQIGLLTEEETTSLVD
CCCCCCCCCCCHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
ALNEIIADIVVGNFEIEDSFEDVHSKIEYLLTVKLGDAGKKIHTARSRNDQVLVDVHLYL
HHHHHHHHHHHCCEEECCCHHHHHHHHHEEEEEEECCCCCHHHHHCCCCCEEEEEEEEEH
KDELKVIKEQVKTLFDLLMESAEKHQNVLLPGYTHLQIAMPSSFGMWFSAYAESLIDDVT
HHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHH
MLNAASKIVDQNPLGSAAGYGSSFPINRTFTTKELGFETLKYNAVAAQMSRGKAEKTVAF
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHCHHHHHHHHHHHHHHCCCHHHHHHH
AMTSVAGTLSKFAMDVCLYMSQNFDFIGLPAHLTTGSSIMPHKKNPDVFELIRGKCNKIQ
HHHHHHHHHHHHHHHHHHHHHCCCCEEECCCEECCCCCCCCCCCCCCHHHHHHCCCCCEE
ALPYEITLITNNLPSGYHRDLQLLKEGLFPAIQNLKACLDIAIFSIKDITVKDHILEDKK
ECCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHCCCC
YDYLFTVDTLNEMVVEGMPFRDAYKAVAEQLEAGTYKSPKATKHTHEGSINNLCLDAIKD
CCEEEEHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHH
KMKAAF
HHHHCC
>Mature Secondary Structure
MKLWEKGIPTDKQIEQFTVGNDRELDLVLAKYDALGSIAHAKMLGQIGLLTEEETTSLVD
CCCCCCCCCCCHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
ALNEIIADIVVGNFEIEDSFEDVHSKIEYLLTVKLGDAGKKIHTARSRNDQVLVDVHLYL
HHHHHHHHHHHCCEEECCCHHHHHHHHHEEEEEEECCCCCHHHHHCCCCCEEEEEEEEEH
KDELKVIKEQVKTLFDLLMESAEKHQNVLLPGYTHLQIAMPSSFGMWFSAYAESLIDDVT
HHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHH
MLNAASKIVDQNPLGSAAGYGSSFPINRTFTTKELGFETLKYNAVAAQMSRGKAEKTVAF
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHCHHHHHHHHHHHHHHCCCHHHHHHH
AMTSVAGTLSKFAMDVCLYMSQNFDFIGLPAHLTTGSSIMPHKKNPDVFELIRGKCNKIQ
HHHHHHHHHHHHHHHHHHHHHCCCCEEECCCEECCCCCCCCCCCCCCHHHHHHCCCCCEE
ALPYEITLITNNLPSGYHRDLQLLKEGLFPAIQNLKACLDIAIFSIKDITVKDHILEDKK
ECCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHCCCC
YDYLFTVDTLNEMVVEGMPFRDAYKAVAEQLEAGTYKSPKATKHTHEGSINNLCLDAIKD
CCEEEEHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHH
KMKAAF
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA