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The map label for this gene is ziaA [H]

Identifier: 146301088

GI number: 146301088

Start: 3998681

End: 4000672

Strand: Reverse

Name: ziaA [H]

Synonym: Fjoh_3344

Alternate gene names: 146301088

Gene position: 4000672-3998681 (Counterclockwise)

Preceding gene: 146301089

Following gene: 146301087

Centisome position: 65.62

GC content: 37.5

Gene sequence:

>1992_bases
ATGATACATCAAGATAAAGAAATAAAAAATACAAAAACAAAAGCCAAACCTTCCTGCTGCTGTTCGCATGACGAACCTGT
ACATTCAGATAATGACGGACATGATCACGATCATGAACATGGTGCAGAGGGAAGCTTGTTTAAAATGTTCCTGCCTTCTA
TTATATCTTTCATTTTATTACTAATCGGAATTGGTTTAGACAATTATTTTCCGCAGGATTGGTTTACGGGATACGTTAGA
ATCGGCTGGTATGCTATTGCGTATATTCCGGTTGGGCTTCCGGTTTTGAAAGAAGCTTACGAAAGCATTGTAAAAGGCGA
TGTTTTCTCAGAGTTTTTCCTAATGTGTATTGCCACAATAGGAGCATTTGCAATTGGCGAATATCCCGAAGGTGTTGCGG
TTATGCTGTTTTATACTATAGGCGAAACCTTTCAGGGAATGGCGGTTAGCAAAGCAAAATCGAATATTAAAAGTTTACTG
GACCAGCGTCCGGATGAGGTTAATATTGTAGAAAACAATATTGTTACAAAAGTTAAGGCAAAAGACGTTCAGATTGGAGC
CGTTATTCAGCTTAAAGCAGGAGAAAAACTAGGTTTAGACGGCGAATTACTTTCAGATTCCGCTTCGTTTAATACAGCTG
CTTTAACTGGAGAAAGCAAACCCGATACCAAAAAGAAAGGAGATACGGTTCTGGCCGGAATGATAAACGGAAATACAATT
GCACAGGTAAAAGTAACAACCGCTTACAACGACAGTAAGCTGTCTAAAATTTTGGAGCTGGTACAAAATGCAACCACTAA
AAAAGCACCTGCAGAGCTGTTTATCCGCAAATTTGCTAAAATCTATACACCAATTGTAGTATATCTTGCTATTGGAATTT
GTTTACTGCCAATGCTTTTTGTTGATAATTATGTTTTTAGCAACTGGTTGTACAGAGCTTTGGTTTTCTTGGTAATTTCT
TGTCCGTGTGCTTTGGTTATTAGTATTCCGCTGGGGTATTTTGGCGGAATAGGTGCTGCAAGTAAAAACGGAATTTTATT
TAAAGGAAGTAATTTTCTGGACAGTATTTCGACCATTCAGAATGTGGTTATGGACAAAACCGGAACAATGACCGAAGGTG
TTTTTAAAGTGCAGGAAGTCATTATAAAACCTGATTTTGATAAAGAGGAAATTCTGAAATTTGTTAATGCATTAGAAGGA
AAAAGCACGCATCCCGTAGCAACGGCAATTCATAATCATGTTGGAATAATTGATTCATCAATTGAACTGAATAATGTAGA
AGAAATTTCAGGACACGGTTTAAAAGCTGAAATAAACGGAAAAGAGCTTCATGTTGGAAACTTCAAACTTCTTGATAAAT
TTAATATTTCGTATGATGTTGATCCGTCTTCTGTAGTTTATACCACAATTGCCATAGCTTACGACAGAAAGTTTGCCGGC
TATTTAACCATTGCCGATGAAATTAAAGCAGATGCACAAGAAACGGTTTCTAAACTAAAATCTTTAGGTGTTAAAGTTAC
GATGCTGAGCGGCGACAAAACCAATGTGGTTCAGTTTGTAGCCGATAAACTTAAAATTTCAAATGCTTTTGGAGATTTAC
TTCCAGAAGATAAAGTCAATAAAGTAAACGAAATTAAAGCCAAAAACGAAACAGTAGCTTTTGTGGGTGATGGTGTTAAT
GATGCCCCGGTAATTGCTTTAAGTACCGTAGGAATTGCAATGGGAGGTTTAGGAAGCGACGCTGCCATAGAAACCGCCGA
TGTTGTAATTCAGGACGATAAACCAAGTAAAATTGCAATGGCAATAGACATTGGAAAACAAACCAAAAAAATTGTCTGGC
AGAATATTACTCTGGCTTTTGTTGTAAAAGCTTTTGTTTTAATCCTTGGCGCGGGCGGACTTGCCACAATGTGGGAAGCT
GTTTTTGCCGATGTTGGTGTGGCGCTGTTAGCAATTTTAAATGCGGTTAGAATTCAAAGAATGAAGTTTTAA

Upstream 100 bases:

>100_bases
CTTTGCTTATAACATTTGCTGTAAATTGATTAAATTTAGAGCATTATTAAAATAAGTTTTCAGAATCTGAAACTTTAAAC
TTTAAAGATGAAACTTTCTC

Downstream 100 bases:

>100_bases
TTTGATGAGTTTTGTCTTATTTTAATATAATTATAACTAATACTGGGCATTCTTCTTGTTTAATATAGAGTTATTTGTAG
TAACATATTTTAATCAGTTA

Product: heavy metal translocating P-type ATPase

Products: NA

Alternate protein names: Zn(2+)-translocating P-type ATPase [H]

Number of amino acids: Translated: 663; Mature: 663

Protein sequence:

>663_residues
MIHQDKEIKNTKTKAKPSCCCSHDEPVHSDNDGHDHDHEHGAEGSLFKMFLPSIISFILLLIGIGLDNYFPQDWFTGYVR
IGWYAIAYIPVGLPVLKEAYESIVKGDVFSEFFLMCIATIGAFAIGEYPEGVAVMLFYTIGETFQGMAVSKAKSNIKSLL
DQRPDEVNIVENNIVTKVKAKDVQIGAVIQLKAGEKLGLDGELLSDSASFNTAALTGESKPDTKKKGDTVLAGMINGNTI
AQVKVTTAYNDSKLSKILELVQNATTKKAPAELFIRKFAKIYTPIVVYLAIGICLLPMLFVDNYVFSNWLYRALVFLVIS
CPCALVISIPLGYFGGIGAASKNGILFKGSNFLDSISTIQNVVMDKTGTMTEGVFKVQEVIIKPDFDKEEILKFVNALEG
KSTHPVATAIHNHVGIIDSSIELNNVEEISGHGLKAEINGKELHVGNFKLLDKFNISYDVDPSSVVYTTIAIAYDRKFAG
YLTIADEIKADAQETVSKLKSLGVKVTMLSGDKTNVVQFVADKLKISNAFGDLLPEDKVNKVNEIKAKNETVAFVGDGVN
DAPVIALSTVGIAMGGLGSDAAIETADVVIQDDKPSKIAMAIDIGKQTKKIVWQNITLAFVVKAFVLILGAGGLATMWEA
VFADVGVALLAILNAVRIQRMKF

Sequences:

>Translated_663_residues
MIHQDKEIKNTKTKAKPSCCCSHDEPVHSDNDGHDHDHEHGAEGSLFKMFLPSIISFILLLIGIGLDNYFPQDWFTGYVR
IGWYAIAYIPVGLPVLKEAYESIVKGDVFSEFFLMCIATIGAFAIGEYPEGVAVMLFYTIGETFQGMAVSKAKSNIKSLL
DQRPDEVNIVENNIVTKVKAKDVQIGAVIQLKAGEKLGLDGELLSDSASFNTAALTGESKPDTKKKGDTVLAGMINGNTI
AQVKVTTAYNDSKLSKILELVQNATTKKAPAELFIRKFAKIYTPIVVYLAIGICLLPMLFVDNYVFSNWLYRALVFLVIS
CPCALVISIPLGYFGGIGAASKNGILFKGSNFLDSISTIQNVVMDKTGTMTEGVFKVQEVIIKPDFDKEEILKFVNALEG
KSTHPVATAIHNHVGIIDSSIELNNVEEISGHGLKAEINGKELHVGNFKLLDKFNISYDVDPSSVVYTTIAIAYDRKFAG
YLTIADEIKADAQETVSKLKSLGVKVTMLSGDKTNVVQFVADKLKISNAFGDLLPEDKVNKVNEIKAKNETVAFVGDGVN
DAPVIALSTVGIAMGGLGSDAAIETADVVIQDDKPSKIAMAIDIGKQTKKIVWQNITLAFVVKAFVLILGAGGLATMWEA
VFADVGVALLAILNAVRIQRMKF
>Mature_663_residues
MIHQDKEIKNTKTKAKPSCCCSHDEPVHSDNDGHDHDHEHGAEGSLFKMFLPSIISFILLLIGIGLDNYFPQDWFTGYVR
IGWYAIAYIPVGLPVLKEAYESIVKGDVFSEFFLMCIATIGAFAIGEYPEGVAVMLFYTIGETFQGMAVSKAKSNIKSLL
DQRPDEVNIVENNIVTKVKAKDVQIGAVIQLKAGEKLGLDGELLSDSASFNTAALTGESKPDTKKKGDTVLAGMINGNTI
AQVKVTTAYNDSKLSKILELVQNATTKKAPAELFIRKFAKIYTPIVVYLAIGICLLPMLFVDNYVFSNWLYRALVFLVIS
CPCALVISIPLGYFGGIGAASKNGILFKGSNFLDSISTIQNVVMDKTGTMTEGVFKVQEVIIKPDFDKEEILKFVNALEG
KSTHPVATAIHNHVGIIDSSIELNNVEEISGHGLKAEINGKELHVGNFKLLDKFNISYDVDPSSVVYTTIAIAYDRKFAG
YLTIADEIKADAQETVSKLKSLGVKVTMLSGDKTNVVQFVADKLKISNAFGDLLPEDKVNKVNEIKAKNETVAFVGDGVN
DAPVIALSTVGIAMGGLGSDAAIETADVVIQDDKPSKIAMAIDIGKQTKKIVWQNITLAFVVKAFVLILGAGGLATMWEA
VFADVGVALLAILNAVRIQRMKF

Specific function: Involved In Export Of Lead, Cadmium, Zinc And Mercury. [C]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HMA domain [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=600, Percent_Identity=28.6666666666667, Blast_Score=226, Evalue=8e-59,
Organism=Homo sapiens, GI55743073, Length=557, Percent_Identity=28.9048473967684, Blast_Score=206, Evalue=8e-53,
Organism=Homo sapiens, GI115529486, Length=306, Percent_Identity=30.0653594771242, Blast_Score=131, Evalue=2e-30,
Organism=Escherichia coli, GI1789879, Length=658, Percent_Identity=32.2188449848024, Blast_Score=315, Evalue=4e-87,
Organism=Escherichia coli, GI1786691, Length=549, Percent_Identity=29.6903460837887, Blast_Score=221, Evalue=9e-59,
Organism=Escherichia coli, GI1786914, Length=474, Percent_Identity=24.6835443037975, Blast_Score=107, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17556548, Length=586, Percent_Identity=25.938566552901, Blast_Score=178, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI193203356, Length=208, Percent_Identity=29.3269230769231, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI193203354, Length=208, Percent_Identity=29.3269230769231, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71997275, Length=191, Percent_Identity=27.7486910994764, Blast_Score=69, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71997262, Length=167, Percent_Identity=28.7425149700599, Blast_Score=69, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71997269, Length=167, Percent_Identity=28.7425149700599, Blast_Score=69, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17557486, Length=179, Percent_Identity=27.3743016759777, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17557770, Length=241, Percent_Identity=24.896265560166, Blast_Score=67, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI32566766, Length=241, Percent_Identity=24.896265560166, Blast_Score=66, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320475, Length=539, Percent_Identity=29.8701298701299, Blast_Score=206, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6319772, Length=564, Percent_Identity=24.822695035461, Blast_Score=157, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6321271, Length=196, Percent_Identity=29.0816326530612, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320243, Length=197, Percent_Identity=27.4111675126904, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320244, Length=197, Percent_Identity=27.4111675126904, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320245, Length=197, Percent_Identity=26.9035532994924, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI221329854, Length=305, Percent_Identity=29.5081967213115, Blast_Score=120, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR001366
- InterPro:   IPR006404
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: =3.6.3.5 [H]

Molecular weight: Translated: 71869; Mature: 71869

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS00154 ATPASE_E1_E2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHQDKEIKNTKTKAKPSCCCSHDEPVHSDNDGHDHDHEHGAEGSLFKMFLPSIISFILL
CCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
LIGIGLDNYFPQDWFTGYVRIGWYAIAYIPVGLPVLKEAYESIVKGDVFSEFFLMCIATI
HHHHCCCCCCCHHHHHHHHHHHEEEEEHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHH
GAFAIGEYPEGVAVMLFYTIGETFQGMAVSKAKSNIKSLLDQRPDEVNIVENNIVTKVKA
HHHHHCCCCCCCEEEEEEHHCCHHCCHHHHHHHHHHHHHHHCCCCCEEEECCCEEEEEEE
KDVQIGAVIQLKAGEKLGLDGELLSDSASFNTAALTGESKPDTKKKGDTVLAGMINGNTI
CCEEEEEEEEEECCCCCCCCCHHHCCCCCCCEEEECCCCCCCCCCCCCEEEEEEECCCEE
AQVKVTTAYNDSKLSKILELVQNATTKKAPAELFIRKFAKIYTPIVVYLAIGICLLPMLF
EEEEEEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VDNYVFSNWLYRALVFLVISCPCALVISIPLGYFGGIGAASKNGILFKGSNFLDSISTIQ
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHH
NVVMDKTGTMTEGVFKVQEVIIKPDFDKEEILKFVNALEGKSTHPVATAIHNHVGIIDSS
HHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHCEEECC
IELNNVEEISGHGLKAEINGKELHVGNFKLLDKFNISYDVDPSSVVYTTIAIAYDRKFAG
CCCCCHHHHCCCCEEEEECCCEEEECCEEEEEEECCEECCCCCCEEEEEEEEEECCCCCE
YLTIADEIKADAQETVSKLKSLGVKVTMLSGDKTNVVQFVADKLKISNAFGDLLPEDKVN
EEEEHHHHHCCHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCHHCC
KVNEIKAKNETVAFVGDGVNDAPVIALSTVGIAMGGLGSDAAIETADVVIQDDKPSKIAM
HHHHHHCCCCEEEEEECCCCCCCEEEEEHHHHHHCCCCCCCCEEEEEEEEECCCCCEEEE
AIDIGKQTKKIVWQNITLAFVVKAFVLILGAGGLATMWEAVFADVGVALLAILNAVRIQR
EEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKF
CCC
>Mature Secondary Structure
MIHQDKEIKNTKTKAKPSCCCSHDEPVHSDNDGHDHDHEHGAEGSLFKMFLPSIISFILL
CCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
LIGIGLDNYFPQDWFTGYVRIGWYAIAYIPVGLPVLKEAYESIVKGDVFSEFFLMCIATI
HHHHCCCCCCCHHHHHHHHHHHEEEEEHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHH
GAFAIGEYPEGVAVMLFYTIGETFQGMAVSKAKSNIKSLLDQRPDEVNIVENNIVTKVKA
HHHHHCCCCCCCEEEEEEHHCCHHCCHHHHHHHHHHHHHHHCCCCCEEEECCCEEEEEEE
KDVQIGAVIQLKAGEKLGLDGELLSDSASFNTAALTGESKPDTKKKGDTVLAGMINGNTI
CCEEEEEEEEEECCCCCCCCCHHHCCCCCCCEEEECCCCCCCCCCCCCEEEEEEECCCEE
AQVKVTTAYNDSKLSKILELVQNATTKKAPAELFIRKFAKIYTPIVVYLAIGICLLPMLF
EEEEEEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VDNYVFSNWLYRALVFLVISCPCALVISIPLGYFGGIGAASKNGILFKGSNFLDSISTIQ
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHH
NVVMDKTGTMTEGVFKVQEVIIKPDFDKEEILKFVNALEGKSTHPVATAIHNHVGIIDSS
HHHHCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHCEEECC
IELNNVEEISGHGLKAEINGKELHVGNFKLLDKFNISYDVDPSSVVYTTIAIAYDRKFAG
CCCCCHHHHCCCCEEEEECCCEEEECCEEEEEEECCEECCCCCCEEEEEEEEEECCCCCE
YLTIADEIKADAQETVSKLKSLGVKVTMLSGDKTNVVQFVADKLKISNAFGDLLPEDKVN
EEEEHHHHHCCHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCHHCC
KVNEIKAKNETVAFVGDGVNDAPVIALSTVGIAMGGLGSDAAIETADVVIQDDKPSKIAM
HHHHHHCCCCEEEEEECCCCCCCEEEEEHHHHHHCCCCCCCCEEEEEEEEECCCCCEEEE
AIDIGKQTKKIVWQNITLAFVVKAFVLILGAGGLATMWEAVFADVGVALLAILNAVRIQR
EEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKF
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231; 9724772 [H]