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The map label for this gene is sdhA [H]

Identifier: 146301069

GI number: 146301069

Start: 3973623

End: 3975533

Strand: Direct

Name: sdhA [H]

Synonym: Fjoh_3325

Alternate gene names: 146301069

Gene position: 3973623-3975533 (Clockwise)

Preceding gene: 146301068

Following gene: 146301070

Centisome position: 65.17

GC content: 41.97

Gene sequence:

>1911_bases
ATGATGGAGTCAAAAATACCCGAAGGCCCGCTTGCCGAAAAATGGAATACTTATAAAGCAAAAGCTAAACTCGTAAATCC
GGCCAACCGAAAAAAATTAAACATAATTGTTGTTGGCACCGGACTTGCGGGAGCTTCCTGCGCAGCCTCTTTGGCCGAAC
AGGGTTACAATATAAAATCATTCTATTTTCAGGATTCAGCCAGAAGAGCCCATTCTGTTGCCGCTCAAGGCGGTGTTAAT
GCTGCCAAAAATTACAAAAACGATGGTGACAGTGTTTTCAGAATGTTTTATGATACCATAAAAGGCGGCGATTTCAGGTC
CCGCGAAGCTAATGTGTACCGCTTAGCCGAATGTTCTGCTGCCTTAATAGATCATGCTGTGGCACAAGGCGTTCCCTTTG
CCAGAGAATATGCCGGATATTTAAACAATCGTTCCTTTGGCGGTGTTCAGGTTTCCAGAACTTTTTATGCACGCGGACAG
ACTGGACAACAGCTTTTATTAGGTGCTTATCAGGCTTTGATGAGACAGGTTTCATTAGAAAAAGTAAGCCTGCATACCCG
TCATGAAATGCTTGATTTAGTTGTAATTGACGGAAAAGCAAAAGGAATTATTGCGCGAAATCTTGAAACCGGAGAACTCG
AACGCCACGCTGCAGATGCTGTTGTCTTAGCATCCGGAGGCTACGGAAAAGTATATTATCTCTCTACATTAGCAATGGGC
TGTAACAGTTCTGCTATTTGGAGAGCTCATAAAAAAGGTGCCTACATGGCTGGTGTAAGCTGGATTCAGTTTCACCCTAC
TTCACTGCCCCAGCACGGAACCAATCAATCGAAACTTACTTTAATGTCAGAATCGCTTCGTAATGACGGACGTATCTGGG
TTCCCAAAACAGCTGCAGATGACCGGCTTCCAAATTCAATTCCCGAAGAAGAACGCGATTATTATCTGGAACGACGTTAT
CCTTCTTTTGGCAATCTTGCTCCCAGAGATATTTCATCGCGTGCCGCAAAAGAAAGAATCGATGCCGGACATGGTGTCGG
CCCAATGAAAAATGCTATTTATCTGGATTTCTCCGATGCTATAAAAGCGCAGGGAAAAGATAAAATAGAAGCCAAATACG
GTAATCTTTTTGCGATGTACGAAAAGATTACCGGAATCAACGCTTACAAAGAACCCATGCTCATTTCTCCTTCGGCTCAT
TTTACTATGGGCGGACTTTGGGTTGATTATGAATTAATGACCACAATTCCAGGTTTATTTGCTCTTGGAGAAGCTAATTT
TTCAGATCATGGTGCCAATCGGCTTGGTGCCAATTCATTACTTCAAGCCTGTGTAGACGGTTATTTTATTGCTCCTTATA
CCATTCCAAATTATTTAGCCGGAGAATTAAATACTCCTAAAGCTGCTATTACACATCCCGCTTTTGATGAAGCGGAAAAC
GCTGTCAGAAAACAATTGGATAAATTTCTAAACAGCAAAGGAACACTTAGTGCTGATTATTTTCATAAAACTATCGGCAG
GCTTTTGTATGAAAAATGCGGTTTATCCAGAAGCCGAAAAAGCCTCGAAGAAGCAATTGAAGGGATTAAAATCTTAAAAA
CTTCTTTTGAGAATGAGCTTTTAATTACCGGAGATGATACTTTAAACAGCGAATTAGAAAAAGCAGGACGAATAGCCGAT
TATCTCGAATTAGCCGAATTAATGTGCTACGATGCCCTGCAGAGAGAAGAATCCTGCGGTGCGCATTTTAGAGAAGAATA
CCAAACCGCCGATGGTGAAGCGGTTCGGAATGACGCTGAGTTCTGCTACGTTTCGGCCTGGGAATGGCAGGGAAAAGATA
AGCCTCAAAAATTACATAAAGAACCTCTTGTGTTTGAAGCTGTTGAACTTACTGTTAGAAGCTATAAATAA

Upstream 100 bases:

>100_bases
AACAATAATTTCATTTTATAAGATTTTTATATTAAATTTAGGGTTCTAAAGTACTGTTACTTTTAAAATTTTGCATGAAT
TCATTTTAAACCGCTGAAAA

Downstream 100 bases:

>100_bases
ATGGTGAATGGTGAATTGTAAATTATTAATTAACAATCCACAAGTTCAATTTAAAACCCACCAGTAATTCATAATTAACA
ATTTATAATTAATAATTAGC

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 636; Mature: 636

Protein sequence:

>636_residues
MMESKIPEGPLAEKWNTYKAKAKLVNPANRKKLNIIVVGTGLAGASCAASLAEQGYNIKSFYFQDSARRAHSVAAQGGVN
AAKNYKNDGDSVFRMFYDTIKGGDFRSREANVYRLAECSAALIDHAVAQGVPFAREYAGYLNNRSFGGVQVSRTFYARGQ
TGQQLLLGAYQALMRQVSLEKVSLHTRHEMLDLVVIDGKAKGIIARNLETGELERHAADAVVLASGGYGKVYYLSTLAMG
CNSSAIWRAHKKGAYMAGVSWIQFHPTSLPQHGTNQSKLTLMSESLRNDGRIWVPKTAADDRLPNSIPEEERDYYLERRY
PSFGNLAPRDISSRAAKERIDAGHGVGPMKNAIYLDFSDAIKAQGKDKIEAKYGNLFAMYEKITGINAYKEPMLISPSAH
FTMGGLWVDYELMTTIPGLFALGEANFSDHGANRLGANSLLQACVDGYFIAPYTIPNYLAGELNTPKAAITHPAFDEAEN
AVRKQLDKFLNSKGTLSADYFHKTIGRLLYEKCGLSRSRKSLEEAIEGIKILKTSFENELLITGDDTLNSELEKAGRIAD
YLELAELMCYDALQREESCGAHFREEYQTADGEAVRNDAEFCYVSAWEWQGKDKPQKLHKEPLVFEAVELTVRSYK

Sequences:

>Translated_636_residues
MMESKIPEGPLAEKWNTYKAKAKLVNPANRKKLNIIVVGTGLAGASCAASLAEQGYNIKSFYFQDSARRAHSVAAQGGVN
AAKNYKNDGDSVFRMFYDTIKGGDFRSREANVYRLAECSAALIDHAVAQGVPFAREYAGYLNNRSFGGVQVSRTFYARGQ
TGQQLLLGAYQALMRQVSLEKVSLHTRHEMLDLVVIDGKAKGIIARNLETGELERHAADAVVLASGGYGKVYYLSTLAMG
CNSSAIWRAHKKGAYMAGVSWIQFHPTSLPQHGTNQSKLTLMSESLRNDGRIWVPKTAADDRLPNSIPEEERDYYLERRY
PSFGNLAPRDISSRAAKERIDAGHGVGPMKNAIYLDFSDAIKAQGKDKIEAKYGNLFAMYEKITGINAYKEPMLISPSAH
FTMGGLWVDYELMTTIPGLFALGEANFSDHGANRLGANSLLQACVDGYFIAPYTIPNYLAGELNTPKAAITHPAFDEAEN
AVRKQLDKFLNSKGTLSADYFHKTIGRLLYEKCGLSRSRKSLEEAIEGIKILKTSFENELLITGDDTLNSELEKAGRIAD
YLELAELMCYDALQREESCGAHFREEYQTADGEAVRNDAEFCYVSAWEWQGKDKPQKLHKEPLVFEAVELTVRSYK
>Mature_636_residues
MMESKIPEGPLAEKWNTYKAKAKLVNPANRKKLNIIVVGTGLAGASCAASLAEQGYNIKSFYFQDSARRAHSVAAQGGVN
AAKNYKNDGDSVFRMFYDTIKGGDFRSREANVYRLAECSAALIDHAVAQGVPFAREYAGYLNNRSFGGVQVSRTFYARGQ
TGQQLLLGAYQALMRQVSLEKVSLHTRHEMLDLVVIDGKAKGIIARNLETGELERHAADAVVLASGGYGKVYYLSTLAMG
CNSSAIWRAHKKGAYMAGVSWIQFHPTSLPQHGTNQSKLTLMSESLRNDGRIWVPKTAADDRLPNSIPEEERDYYLERRY
PSFGNLAPRDISSRAAKERIDAGHGVGPMKNAIYLDFSDAIKAQGKDKIEAKYGNLFAMYEKITGINAYKEPMLISPSAH
FTMGGLWVDYELMTTIPGLFALGEANFSDHGANRLGANSLLQACVDGYFIAPYTIPNYLAGELNTPKAAITHPAFDEAEN
AVRKQLDKFLNSKGTLSADYFHKTIGRLLYEKCGLSRSRKSLEEAIEGIKILKTSFENELLITGDDTLNSELEKAGRIAD
YLELAELMCYDALQREESCGAHFREEYQTADGEAVRNDAEFCYVSAWEWQGKDKPQKLHKEPLVFEAVELTVRSYK

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=589, Percent_Identity=28.5229202037351, Blast_Score=184, Evalue=2e-46,
Organism=Escherichia coli, GI1790597, Length=545, Percent_Identity=29.9082568807339, Blast_Score=218, Evalue=1e-57,
Organism=Escherichia coli, GI1786942, Length=549, Percent_Identity=26.775956284153, Blast_Score=147, Evalue=3e-36,
Organism=Escherichia coli, GI1788928, Length=583, Percent_Identity=26.7581475128645, Blast_Score=134, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17505833, Length=594, Percent_Identity=30.6397306397306, Blast_Score=201, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI17550100, Length=543, Percent_Identity=29.4659300184162, Blast_Score=192, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6322701, Length=583, Percent_Identity=30.3602058319039, Blast_Score=209, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6322416, Length=609, Percent_Identity=29.7208538587849, Blast_Score=204, Evalue=3e-53,
Organism=Drosophila melanogaster, GI17137288, Length=573, Percent_Identity=28.9703315881326, Blast_Score=198, Evalue=9e-51,
Organism=Drosophila melanogaster, GI24655642, Length=573, Percent_Identity=28.9703315881326, Blast_Score=198, Evalue=9e-51,
Organism=Drosophila melanogaster, GI24655647, Length=573, Percent_Identity=28.9703315881326, Blast_Score=198, Evalue=9e-51,
Organism=Drosophila melanogaster, GI24663005, Length=584, Percent_Identity=27.3972602739726, Blast_Score=176, Evalue=5e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011280 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 70515; Mature: 70515

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMESKIPEGPLAEKWNTYKAKAKLVNPANRKKLNIIVVGTGLAGASCAASLAEQGYNIKS
CCCCCCCCCCCCCCCCCHHHHHEECCCCCCCEEEEEEEECCCCCHHHHHHHHHCCCCEEE
FYFQDSARRAHSVAAQGGVNAAKNYKNDGDSVFRMFYDTIKGGDFRSREANVYRLAECSA
EEECHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHH
ALIDHAVAQGVPFAREYAGYLNNRSFGGVQVSRTFYARGQTGQQLLLGAYQALMRQVSLE
HHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHH
KVSLHTRHEMLDLVVIDGKAKGIIARNLETGELERHAADAVVLASGGYGKVYYLSTLAMG
HHHHHHHHCEEEEEEECCCCCCEEEECCCCCHHHHHCCCEEEEECCCCCEEEEEEHHHHC
CNSSAIWRAHKKGAYMAGVSWIQFHPTSLPQHGTNQSKLTLMSESLRNDGRIWVPKTAAD
CCCCHHHHHHHCCCEEECEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCEEECCCCCC
DRLPNSIPEEERDYYLERRYPSFGNLAPRDISSRAAKERIDAGHGVGPMKNAIYLDFSDA
CCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHH
IKAQGKDKIEAKYGNLFAMYEKITGINAYKEPMLISPSAHFTMGGLWVDYELMTTIPGLF
HHCCCCCHHHHHHCCHHHHHHHHHCCCCCCCCEEECCCCCEEECCEEEEHHHHHHCCCCE
ALGEANFSDHGANRLGANSLLQACVDGYFIAPYTIPNYLAGELNTPKAAITHPAFDEAEN
EECCCCCCCCCCCCCCHHHHHHHHHCCEEEECCCCCCHHCCCCCCCCCEECCCCHHHHHH
AVRKQLDKFLNSKGTLSADYFHKTIGRLLYEKCGLSRSRKSLEEAIEGIKILKTSFENEL
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCE
LITGDDTLNSELEKAGRIADYLELAELMCYDALQREESCGAHFREEYQTADGEAVRNDAE
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCC
FCYVSAWEWQGKDKPQKLHKEPLVFEAVELTVRSYK
EEEEEEEECCCCCCHHHHCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MMESKIPEGPLAEKWNTYKAKAKLVNPANRKKLNIIVVGTGLAGASCAASLAEQGYNIKS
CCCCCCCCCCCCCCCCCHHHHHEECCCCCCCEEEEEEEECCCCCHHHHHHHHHCCCCEEE
FYFQDSARRAHSVAAQGGVNAAKNYKNDGDSVFRMFYDTIKGGDFRSREANVYRLAECSA
EEECHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHH
ALIDHAVAQGVPFAREYAGYLNNRSFGGVQVSRTFYARGQTGQQLLLGAYQALMRQVSLE
HHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHH
KVSLHTRHEMLDLVVIDGKAKGIIARNLETGELERHAADAVVLASGGYGKVYYLSTLAMG
HHHHHHHHCEEEEEEECCCCCCEEEECCCCCHHHHHCCCEEEEECCCCCEEEEEEHHHHC
CNSSAIWRAHKKGAYMAGVSWIQFHPTSLPQHGTNQSKLTLMSESLRNDGRIWVPKTAAD
CCCCHHHHHHHCCCEEECEEEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCEEECCCCCC
DRLPNSIPEEERDYYLERRYPSFGNLAPRDISSRAAKERIDAGHGVGPMKNAIYLDFSDA
CCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHH
IKAQGKDKIEAKYGNLFAMYEKITGINAYKEPMLISPSAHFTMGGLWVDYELMTTIPGLF
HHCCCCCHHHHHHCCHHHHHHHHHCCCCCCCCEEECCCCCEEECCEEEEHHHHHHCCCCE
ALGEANFSDHGANRLGANSLLQACVDGYFIAPYTIPNYLAGELNTPKAAITHPAFDEAEN
EECCCCCCCCCCCCCCHHHHHHHHHCCEEEECCCCCCHHCCCCCCCCCEECCCCHHHHHH
AVRKQLDKFLNSKGTLSADYFHKTIGRLLYEKCGLSRSRKSLEEAIEGIKILKTSFENEL
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCE
LITGDDTLNSELEKAGRIADYLELAELMCYDALQREESCGAHFREEYQTADGEAVRNDAE
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCC
FCYVSAWEWQGKDKPQKLHKEPLVFEAVELTVRSYK
EEEEEEEECCCCCCHHHHCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3027051; 8969504; 9384377; 3086287; 3021212 [H]