Click here to switch to the map view.

The map label for this gene is silS [H]

Identifier: 146300484

GI number: 146300484

Start: 3258999

End: 3260360

Strand: Reverse

Name: silS [H]

Synonym: Fjoh_2734

Alternate gene names: 146300484

Gene position: 3260360-3258999 (Counterclockwise)

Preceding gene: 146300485

Following gene: 146300483

Centisome position: 53.48

GC content: 28.63

Gene sequence:

>1362_bases
ATGACTTTAAAAAACAGAATATCATTATTAGTAAGTCTTTTGTTTACAATCCTTTTTGGATTGGCATCGACTGTGATATT
TGTTTTATATTCTAATTTTAGAAAAGAAGAATTTCGTGAACGCCTTGAAATTAAAGCTCTTTCAAATATTAAACTTTTGG
TTGATGTAAAAGAAGTTGACGAACAGCTTCTTAAAATGATTGACCAAAATTCAATCAATAAATTATATGATGAGAAAACA
TTAGTTTTTGACTCACATTTTAAACTTATTTACAGCAGTATCGATGATGCAAAAATCAATTGGTCTGTTGAAGATTTAAA
ATATCTTAAAAAACATAAAACCTTTTTCAAACAACAAGGCGATTATGAAGTTTACGGCGTTTTTTATGATACTAAAGACA
AAGACTTTTATGCTTTAATTTCTGCTACGGATGATTATGGGAAAAGAAAACTGCTTTTTTTAAGATATACATTAGTTGTA
TCCTATATATTCTTTACATGTCTCTGCTGGGTTTTAACCTCTTTTATGGTTAGAAAAGCAATGAATCCTCTTGGATTATT
TCATCAAAAAATTAAAAATATCAATGAAAACAATCTTGATACTCGTATTGAATCAAAAAGCAATAAAGACGAAATTGACT
TAATTGCAAACGAGTTTAATTTCATGATGGACCGAATTGAAGTTTCCTATCAAAGACAGAAAGAATTTACGGCTCACGCT
TCGCATGAATTAAGAACTCCTTTATCGAGAATTACTGCACAAATTGAAAATACTATAGCCGATTCGACGACATCTCTTAA
AGGAAAAAACTTTCTAACTGCAATTTTATCCGATGTCAATCATTTAACTGAATTAATCAGCTCATTATTAATATTATCTA
AAATTGATAATAATAAAAATAATGAATACAATGAAATTCACAGAATGGATGAGATTCTTTTCTCGGCTATTGAAGATCTA
AAGAAAAGCTTTCCTGATTTTGTTATTTTATTTGAAATTGAAGAAAGCGAAAATTTAGACACAGCTCTGGAAATAAAAGG
AAATAAAAACCTTTTGGAAATTGCTGTAATTAATGTTTTAAAAAATGCCTGTGTTTATTCAGATAATCAGCAGGCTTTAG
TAAAAATAAGCGCGCCGGAAGATCATCTGATTATTTCTATTTTAAACACTGGAAAAACTTTAAGCGAAAGCGAACAAAAA
AATCTTTTTGAACCTTTTATGAGAGGAGAAAATTCTAAAGGCACATCTGGTTTTGGATTGGGATTACGTATTGTAAACAG
AATCTTAAAACTTCACAAATCTCACATAACTTACACTACACCAGAGGATAATGTAAATTTATTCCAATTATTCTTTCATT
AA

Upstream 100 bases:

>100_bases
AAGTTTATATAAATTTTCTTAGAAAAAAAATCGATAAAGATCACGAAACAAAACTCATAAAAACCAAAATTGGTTACGGA
TATTATTTAAGTAACGAGGA

Downstream 100 bases:

>100_bases
TATTTTATTTTAAGCTAATTTTAAGGTAGATTTTAAGCCCGCTTAAAGTCTGCCGATAGCATATTTGTACAAAATAAAAT
AGATACAATGAGAAAACTAT

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 453; Mature: 452

Protein sequence:

>453_residues
MTLKNRISLLVSLLFTILFGLASTVIFVLYSNFRKEEFRERLEIKALSNIKLLVDVKEVDEQLLKMIDQNSINKLYDEKT
LVFDSHFKLIYSSIDDAKINWSVEDLKYLKKHKTFFKQQGDYEVYGVFYDTKDKDFYALISATDDYGKRKLLFLRYTLVV
SYIFFTCLCWVLTSFMVRKAMNPLGLFHQKIKNINENNLDTRIESKSNKDEIDLIANEFNFMMDRIEVSYQRQKEFTAHA
SHELRTPLSRITAQIENTIADSTTSLKGKNFLTAILSDVNHLTELISSLLILSKIDNNKNNEYNEIHRMDEILFSAIEDL
KKSFPDFVILFEIEESENLDTALEIKGNKNLLEIAVINVLKNACVYSDNQQALVKISAPEDHLIISILNTGKTLSESEQK
NLFEPFMRGENSKGTSGFGLGLRIVNRILKLHKSHITYTTPEDNVNLFQLFFH

Sequences:

>Translated_453_residues
MTLKNRISLLVSLLFTILFGLASTVIFVLYSNFRKEEFRERLEIKALSNIKLLVDVKEVDEQLLKMIDQNSINKLYDEKT
LVFDSHFKLIYSSIDDAKINWSVEDLKYLKKHKTFFKQQGDYEVYGVFYDTKDKDFYALISATDDYGKRKLLFLRYTLVV
SYIFFTCLCWVLTSFMVRKAMNPLGLFHQKIKNINENNLDTRIESKSNKDEIDLIANEFNFMMDRIEVSYQRQKEFTAHA
SHELRTPLSRITAQIENTIADSTTSLKGKNFLTAILSDVNHLTELISSLLILSKIDNNKNNEYNEIHRMDEILFSAIEDL
KKSFPDFVILFEIEESENLDTALEIKGNKNLLEIAVINVLKNACVYSDNQQALVKISAPEDHLIISILNTGKTLSESEQK
NLFEPFMRGENSKGTSGFGLGLRIVNRILKLHKSHITYTTPEDNVNLFQLFFH
>Mature_452_residues
TLKNRISLLVSLLFTILFGLASTVIFVLYSNFRKEEFRERLEIKALSNIKLLVDVKEVDEQLLKMIDQNSINKLYDEKTL
VFDSHFKLIYSSIDDAKINWSVEDLKYLKKHKTFFKQQGDYEVYGVFYDTKDKDFYALISATDDYGKRKLLFLRYTLVVS
YIFFTCLCWVLTSFMVRKAMNPLGLFHQKIKNINENNLDTRIESKSNKDEIDLIANEFNFMMDRIEVSYQRQKEFTAHAS
HELRTPLSRITAQIENTIADSTTSLKGKNFLTAILSDVNHLTELISSLLILSKIDNNKNNEYNEIHRMDEILFSAIEDLK
KSFPDFVILFEIEESENLDTALEIKGNKNLLEIAVINVLKNACVYSDNQQALVKISAPEDHLIISILNTGKTLSESEQKN
LFEPFMRGENSKGTSGFGLGLRIVNRILKLHKSHITYTTPEDNVNLFQLFFH

Specific function: Component of the sil cation-efflux system that confers resistance to silver. Probable member of a two-component regulatory system silS/silR. May activate silR by phosphorylation [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=289, Percent_Identity=26.643598615917, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1790551, Length=283, Percent_Identity=23.321554770318, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1788279, Length=289, Percent_Identity=24.2214532871972, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1790346, Length=266, Percent_Identity=25.9398496240602, Blast_Score=75, Evalue=9e-15,
Organism=Escherichia coli, GI1789403, Length=469, Percent_Identity=21.3219616204691, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1788393, Length=262, Percent_Identity=23.6641221374046, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1786912, Length=213, Percent_Identity=29.1079812206573, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1787894, Length=213, Percent_Identity=26.7605633802817, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI1789808, Length=242, Percent_Identity=24.3801652892562, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52540; Mature: 52409

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLKNRISLLVSLLFTILFGLASTVIFVLYSNFRKEEFRERLEIKALSNIKLLVDVKEVD
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHH
EQLLKMIDQNSINKLYDEKTLVFDSHFKLIYSSIDDAKINWSVEDLKYLKKHKTFFKQQG
HHHHHHHCCCHHHHHHCCCEEEEHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHCCC
DYEVYGVFYDTKDKDFYALISATDDYGKRKLLFLRYTLVVSYIFFTCLCWVLTSFMVRKA
CEEEEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MNPLGLFHQKIKNINENNLDTRIESKSNKDEIDLIANEFNFMMDRIEVSYQRQKEFTAHA
CCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SHELRTPLSRITAQIENTIADSTTSLKGKNFLTAILSDVNHLTELISSLLILSKIDNNKN
HHHHHCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NEYNEIHRMDEILFSAIEDLKKSFPDFVILFEIEESENLDTALEIKGNKNLLEIAVINVL
CHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHH
KNACVYSDNQQALVKISAPEDHLIISILNTGKTLSESEQKNLFEPFMRGENSKGTSGFGL
HHHHEECCCCCEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHH
GLRIVNRILKLHKSHITYTTPEDNVNLFQLFFH
HHHHHHHHHHHHHCCCEEECCCCCCCEEEEEEC
>Mature Secondary Structure 
TLKNRISLLVSLLFTILFGLASTVIFVLYSNFRKEEFRERLEIKALSNIKLLVDVKEVD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHH
EQLLKMIDQNSINKLYDEKTLVFDSHFKLIYSSIDDAKINWSVEDLKYLKKHKTFFKQQG
HHHHHHHCCCHHHHHHCCCEEEEHHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHCCC
DYEVYGVFYDTKDKDFYALISATDDYGKRKLLFLRYTLVVSYIFFTCLCWVLTSFMVRKA
CEEEEEEEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MNPLGLFHQKIKNINENNLDTRIESKSNKDEIDLIANEFNFMMDRIEVSYQRQKEFTAHA
CCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SHELRTPLSRITAQIENTIADSTTSLKGKNFLTAILSDVNHLTELISSLLILSKIDNNKN
HHHHHCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NEYNEIHRMDEILFSAIEDLKKSFPDFVILFEIEESENLDTALEIKGNKNLLEIAVINVL
CHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHH
KNACVYSDNQQALVKISAPEDHLIISILNTGKTLSESEQKNLFEPFMRGENSKGTSGFGL
HHHHEECCCCCEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHH
GLRIVNRILKLHKSHITYTTPEDNVNLFQLFFH
HHHHHHHHHHHHHCCCEEECCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9930866 [H]