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The map label for this gene is yngG [H]

Identifier: 146299969

GI number: 146299969

Start: 2666958

End: 2667824

Strand: Direct

Name: yngG [H]

Synonym: Fjoh_2213

Alternate gene names: 146299969

Gene position: 2666958-2667824 (Clockwise)

Preceding gene: 146299966

Following gene: 146299970

Centisome position: 43.74

GC content: 37.72

Gene sequence:

>867_bases
TTGAATAAAGAGATCAAGATTATAGAATGTCCAAGAGATGCCATGCAGGGTATCAAAACTTTTATTCCAACCAAAAATAA
AGTAACTTACATACAAGCGCTGCTTCGTGTAGGTTTTGACACGATCGATTTTGGGAGTTTTGTATCTCCAAAAGCAATTC
CGCAAATGCAGGATACGGCTGAGGTTCTTGCAGAATTAGATTTATCTCAAACAAGCAGTAAGCTTCTTTCGATAATTGCC
AATACACAAGGTGCAGCTCTGGCTTCTGGATATGATGCCATTCAGTATTTAGGGTTTCCTTTTTCGATATCTGAAAATTT
TCAGATGCGTAATACACATAAAACGATCGCCGAATCTTTAATTACTCTTGAAGAAATTCTGGAAATCGCCGATAAAAAAA
ATAAAGAAGTTGTAACCTATCTTTCAATGGGTTTCGGGAATCCGTATGGTGACCCGTGGAATGTTGAAATTGTGGCAGAA
TGGACTGAGAAACTGGCAGGAATGGGCGTGAAAATTTTATCGCTTTCAGATACTGTGGGAAGTTCTACTCCAGATGTTAT
TACGTATTTATTTTCGAATTTGATTCCGAAATATCCCGAAATCGAGTTTGGTGCGCATCTGCATACAACGCCTGACAGCT
GGTTTGAAAAAATCGATGCTGCATCAAAAGCCGGATGTACCCGTTTTGACGGTGCAATTCAGGGGTTTGGAGGCTGTCCT
ATGGCGACAGACAAACTAACAGGAAATATGCCGACTGAAAAATTGGTTTCTTATTTTACTGCAAATAAAAAAATAACAGG
ACTTAATTCTTTAAGTTTTGAAAGTGCTTATAATGAAGCATCTAAATTATTTGGAAAGTTTCATTAA

Upstream 100 bases:

>100_bases
AATTAAAGATTACAATATTGTGTAATAACTTTGATAAGAAAAAATTATCTTTTTTATCTTTAAAAAAGGAACTAACTTAG
CATGTACTAAAGAATAAGCT

Downstream 100 bases:

>100_bases
AAAATAATGCTGACAACTAAATGTTATGAAAGGTTTTAAATTATGGCTGGAATTTGAGGAAGTTAATCCTGATAATTGGA
ATGTAAATGATGATTTTTGT

Product: pyruvate carboxyltransferase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MNKEIKIIECPRDAMQGIKTFIPTKNKVTYIQALLRVGFDTIDFGSFVSPKAIPQMQDTAEVLAELDLSQTSSKLLSIIA
NTQGAALASGYDAIQYLGFPFSISENFQMRNTHKTIAESLITLEEILEIADKKNKEVVTYLSMGFGNPYGDPWNVEIVAE
WTEKLAGMGVKILSLSDTVGSSTPDVITYLFSNLIPKYPEIEFGAHLHTTPDSWFEKIDAASKAGCTRFDGAIQGFGGCP
MATDKLTGNMPTEKLVSYFTANKKITGLNSLSFESAYNEASKLFGKFH

Sequences:

>Translated_288_residues
MNKEIKIIECPRDAMQGIKTFIPTKNKVTYIQALLRVGFDTIDFGSFVSPKAIPQMQDTAEVLAELDLSQTSSKLLSIIA
NTQGAALASGYDAIQYLGFPFSISENFQMRNTHKTIAESLITLEEILEIADKKNKEVVTYLSMGFGNPYGDPWNVEIVAE
WTEKLAGMGVKILSLSDTVGSSTPDVITYLFSNLIPKYPEIEFGAHLHTTPDSWFEKIDAASKAGCTRFDGAIQGFGGCP
MATDKLTGNMPTEKLVSYFTANKKITGLNSLSFESAYNEASKLFGKFH
>Mature_288_residues
MNKEIKIIECPRDAMQGIKTFIPTKNKVTYIQALLRVGFDTIDFGSFVSPKAIPQMQDTAEVLAELDLSQTSSKLLSIIA
NTQGAALASGYDAIQYLGFPFSISENFQMRNTHKTIAESLITLEEILEIADKKNKEVVTYLSMGFGNPYGDPWNVEIVAE
WTEKLAGMGVKILSLSDTVGSSTPDVITYLFSNLIPKYPEIEFGAHLHTTPDSWFEKIDAASKAGCTRFDGAIQGFGGCP
MATDKLTGNMPTEKLVSYFTANKKITGLNSLSFESAYNEASKLFGKFH

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI109150422, Length=268, Percent_Identity=31.7164179104478, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI109150427, Length=268, Percent_Identity=31.7164179104478, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI62198232, Length=271, Percent_Identity=33.210332103321, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17510563, Length=265, Percent_Identity=30.5660377358491, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24582381, Length=270, Percent_Identity=30.3703703703704, Blast_Score=115, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 31645; Mature: 31645

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKEIKIIECPRDAMQGIKTFIPTKNKVTYIQALLRVGFDTIDFGSFVSPKAIPQMQDTA
CCCCEEEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHH
EVLAELDLSQTSSKLLSIIANTQGAALASGYDAIQYLGFPFSISENFQMRNTHKTIAESL
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
ITLEEILEIADKKNKEVVTYLSMGFGNPYGDPWNVEIVAEWTEKLAGMGVKILSLSDTVG
HHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCEEEHHHHHHHHHCCCEEEEEECCCCC
SSTPDVITYLFSNLIPKYPEIEFGAHLHTTPDSWFEKIDAASKAGCTRFDGAIQGFGGCP
CCCHHHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHHHHHCCCCHHCHHHCCCCCCC
MATDKLTGNMPTEKLVSYFTANKKITGLNSLSFESAYNEASKLFGKFH
CCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNKEIKIIECPRDAMQGIKTFIPTKNKVTYIQALLRVGFDTIDFGSFVSPKAIPQMQDTA
CCCCEEEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHH
EVLAELDLSQTSSKLLSIIANTQGAALASGYDAIQYLGFPFSISENFQMRNTHKTIAESL
HHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
ITLEEILEIADKKNKEVVTYLSMGFGNPYGDPWNVEIVAEWTEKLAGMGVKILSLSDTVG
HHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCEEEHHHHHHHHHCCCEEEEEECCCCC
SSTPDVITYLFSNLIPKYPEIEFGAHLHTTPDSWFEKIDAASKAGCTRFDGAIQGFGGCP
CCCHHHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHHHHHCCCCHHCHHHCCCCCCC
MATDKLTGNMPTEKLVSYFTANKKITGLNSLSFESAYNEASKLFGKFH
CCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]