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The map label for this gene is lrp [H]

Identifier: 146299888

GI number: 146299888

Start: 2581767

End: 2582225

Strand: Direct

Name: lrp [H]

Synonym: Fjoh_2132

Alternate gene names: 146299888

Gene position: 2581767-2582225 (Clockwise)

Preceding gene: 146299886

Following gene: 146299889

Centisome position: 42.35

GC content: 32.46

Gene sequence:

>459_bases
ATGACTTTAGACGCCACAGATAAAAAACTTTTGGTTTTACTACAAACCGATAGTAAAAAAACAACCAAGGAATTATCCTT
AAAACTCGATCTTTCTGTTACAGCGGTATATGAAAGAATTAAAAAGTTAGAACGCGAAGGAATAATCAAAAACTACGTCG
CGTTAGTCGATAAATCCAAAATCGAAAAAGGATTTGTCGTTTTCTGTCATTTAAAACTCATTCAGCACACAAAAGAATTC
CTAACCAAATTTGAAAGCGAAGTCATAAAACTTAATGAAGTTTTAGAATGCCATCACGTAAGCGGCGATTATGATTATAT
TTTAAAAGTCTTAGTAAAAGATATGGAAGCGTACAGGGAATTTTTAGTAACAAAACTGACTTCATTACAGCACATTGGAA
GTACACAAAGCATGTTTATGATTAGCGAAGTGAAGAATTCAACGGTGATTTCTTTTTGA

Upstream 100 bases:

>100_bases
TAATGATTTTTAATCTAAATTTGATTCATAAAAAGCATTTAAATAGATTTTCTATCATTTAGAAAAACGATCAACAATCA
ACAAAAAACCATCAACTATA

Downstream 100 bases:

>100_bases
GAGGTTCAAAGGTTCAGAGAGGCAAAGGGGCAGAGGTTTTTTATTCTCATTTTTGTCATTTCGACGAAGGAGAAATCCTC
GCAAGTAACTCCGTAAAGAG

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 152; Mature: 151

Protein sequence:

>152_residues
MTLDATDKKLLVLLQTDSKKTTKELSLKLDLSVTAVYERIKKLEREGIIKNYVALVDKSKIEKGFVVFCHLKLIQHTKEF
LTKFESEVIKLNEVLECHHVSGDYDYILKVLVKDMEAYREFLVTKLTSLQHIGSTQSMFMISEVKNSTVISF

Sequences:

>Translated_152_residues
MTLDATDKKLLVLLQTDSKKTTKELSLKLDLSVTAVYERIKKLEREGIIKNYVALVDKSKIEKGFVVFCHLKLIQHTKEF
LTKFESEVIKLNEVLECHHVSGDYDYILKVLVKDMEAYREFLVTKLTSLQHIGSTQSMFMISEVKNSTVISF
>Mature_151_residues
TLDATDKKLLVLLQTDSKKTTKELSLKLDLSVTAVYERIKKLEREGIIKNYVALVDKSKIEKGFVVFCHLKLIQHTKEFL
TKFESEVIKLNEVLECHHVSGDYDYILKVLVKDMEAYREFLVTKLTSLQHIGSTQSMFMISEVKNSTVISF

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=146, Percent_Identity=38.3561643835616, Blast_Score=112, Evalue=8e-27,
Organism=Escherichia coli, GI87081742, Length=149, Percent_Identity=34.2281879194631, Blast_Score=99, Evalue=1e-22,
Organism=Escherichia coli, GI1790182, Length=143, Percent_Identity=26.5734265734266, Blast_Score=62, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 17533; Mature: 17402

Theoretical pI: Translated: 8.66; Mature: 8.66

Prosite motif: PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLDATDKKLLVLLQTDSKKTTKELSLKLDLSVTAVYERIKKLEREGIIKNYVALVDKSK
CCCCCCCCEEEEEEECCCCHHHHHHEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEKGFVVFCHLKLIQHTKEFLTKFESEVIKLNEVLECHHVSGDYDYILKVLVKDMEAYRE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
FLVTKLTSLQHIGSTQSMFMISEVKNSTVISF
HHHHHHHHHHHCCCCHHHHHHHHHCCCCEECC
>Mature Secondary Structure 
TLDATDKKLLVLLQTDSKKTTKELSLKLDLSVTAVYERIKKLEREGIIKNYVALVDKSK
CCCCCCCEEEEEEECCCCHHHHHHEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEKGFVVFCHLKLIQHTKEFLTKFESEVIKLNEVLECHHVSGDYDYILKVLVKDMEAYRE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
FLVTKLTSLQHIGSTQSMFMISEVKNSTVISF
HHHHHHHHHHHCCCCHHHHHHHHHCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]