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The map label for this gene is tycC [H]

Identifier: 146299848

GI number: 146299848

Start: 2491921

End: 2496627

Strand: Direct

Name: tycC [H]

Synonym: Fjoh_2090

Alternate gene names: 146299848

Gene position: 2491921-2496627 (Clockwise)

Preceding gene: 146299847

Following gene: 146299849

Centisome position: 40.87

GC content: 32.84

Gene sequence:

>4707_bases
ATGGAAATACGTTTATTGATTAAAAGATTAAGAGAAGAAGGCGTAATAGTTAAGATGAAAAACGATCAGCTGGAAATATC
GCTGCTATATAATCATATAGAAGATGAGACCCTTCAATTGTTGAAAACGCATAAACTGGAAATTATAGATTATTTATCGA
CGATTTTATCTAAAAACAAAATTGTAGAAATTCCGCTTGTCAAAAAAGCAGATTCTTATCCTTTGACAGCTTCTCAAAAC
CGCTTTTGGATTGTAAGCCAGTTTGAAGACGCTTCTTTAGCTTACAATATGCCAATTGCTTTAAAGCTAAAAGGACAATT
AGATGTAGTAAAATTTGAACAATCCTTTCTTCATCTTTTAGAAAGACATGAAAGCCTGCGCACTTCTTTCAAAATTAATG
AAGAAGGAGATCTGCGTCAATTTATAACTTCTATGCATGATTTGGATTTTAGCTTAAATTATATTGATTTAAGTTTAAAT
GCCGAAACAGAAAAAGCTGTAGAGGAATACATTACAAACCAAAAAGAAATCGTTTTTAATTTAGAGAAAGCACCTCTTGT
ACGTGTTTCGCTTATTAAATCAGCAGAAAATGAATATGTTTTCTTCATGACTATGCATCATATTATTGGAGACGGCTGGT
CATCAGAGCTTTTGGTGAAAGAAGTTATAACAATTTATAACTGTTTGATAGAATCAAAAGAAATAAGTCTGCCAGAATTA
AAAATTCAGTATAAAGATTATGCATCATGGTTAAACGAAGAATCGCAGCAGCAGCTTTATAAAAAAGCAGAAACTTACTG
GCTGAATCAATTTTCGGGCTCACTTCCTGTGGTTGAATTGCCTAGTTCGAAGAAACGTCCATTGATGAAGACCTATAATG
GTGATTTTGTTAACCACCAGTTTACAGTTACATTTTTAGAAAAACTTACGGCTTTTTCACATAAACACGACGTTACCTTG
TTTATGACTTTAATGGCCGGAATCAACGCACTTTTGAGCAGATATACCGGCCAGCAGGATATTATTATAGGTTCTCCTAT
TGCCGGAAGGGAACATCCTGATTTAGAAAACCAAATAGGACTTTATCTCAATACCCTGGCATTTAGAACGAAGATCGATA
AAGGCTTTAATTTTATTGATTTATTGCGCCATGAAAAAGATGTAATACTAGGCAGTTACGAACATCAGAATTATCCGTTT
GATGAATTGGTTGATAAACTCGAATTAAAACGAGACAACAGCAGATCGGTATTATTTGATGTGATGGTTATACTGCAAAG
CCAGTCTAAACTTAATAATTTTGAAAGTGGTAAATTAGAAAATCTAGAATTTAAAGAGTATAAACTAAATACTAAAACAT
CAAAATTTGATTTTGCTTTTTCTTTTACTGAAAAAACAGATTCTCTTTCGTTAGAAATTAATTACAATACAGATATTTAT
GATGCTTTTTTTGTTGAAAAAATTGCTTCTCATTTTGAACAGCTGATTACAGAAATGATCGATCAGCCGGAAACTAAAAT
TCTGGATATTGATTATTTAAGTAAAAAAGAAAAGCAGCTTATTTTAACGGATTTTAATAATACAGCTGCCTATTATACGG
AAGATAAATCTATTGTACAATTATTTGAACAACAGGCAGCAAAAACACCAGATCATACTGCCGTAATTTTTGAAGATAAA
AAAGTAAGTTACCAGGCTCTAAACGAACAGGCCAATCAGCTGGGCGGTTATTTAAGAAAACATTACAATATTCAGCCGGA
TGATCTTATTGGTATAAAGCTGCAAAGAAACGAACGTATGATAACGGCTATTCTGGGTATATTAAAATCCGGAGCTGCTT
ATGTGCCCATTGATCTCTCTTATCCTCAATCCAGAATTGAATATATAGAAAAAGACAGTAACTGCAGGATTATTATCGAT
GAATCTTTTTTGCAGTCATTTTACGAGGAACAGCATAAGTATTCAGTTGTAAATATTGAAAACAGGAATACTCCAAAAGA
TTTAGCTTATATAATATATACCTCTGGAACTACCGGAAACCCTAAAGGAGTTATGGTAGAGCATAAAAATGCAATAGCAC
TGGTAAACTGGTCAAAAGAAGAATATGCCAAAAGCGCATTCGATATGGTATATGGAGTTACGTCATATTGTTTCGATTTA
TCAGTTTATGAATTTTTCTTCACGCTGGCAATCGGAAAAACATTACGTATTTTAAAAAATGCACTGGACATAGAAAACTA
TATAAATACAGATCAAAATGTCCTGCTTAATACGGTTCCTTCGGTAGTTAGAAAATTATTAGAAGATAAGATTTCATTAG
AAAATATCAAGGTCATTAATATGGCAGGAGAAATTCTGCCGACAGATATTGTGGACCAGCTGCCAATAGAAAAAATGGAA
GTAAGAAATCTTTACGGCCCGTCTGAAGATACCACTTACAGTACAAGTCATCTTGTAATTTCAAAAACAAACAGAACTAT
TTCTATCGGGCGCCCAATGTCAAATACACAAGCCTGGATTTTAAATGAATCTCTTTTACCTGTTCCTGTTGGCATATCGG
GTAAATTATATCTTTCCGGAGAAGGAGTTACAAGAGGTTATTTAAACAAACCAGAGCTTACTGCCGAAAAGTTTGTTACT
AATCCTTTTATTGAGAATGAAAGAATGTATGATACCGGCGATCTTGCTTATTGGCTTCCTGACGGAAACATAGAATTTTT
AGGAAGAAAAGATCATCAGGTTAAAATACGCGGTTTCAGGATAGAATTGGGAGAGATTGAAGCGGCTTTGCTTCAATATT
CAACAGATTTAAAACAGGTGGTTGCAGCCGTAAAAGAAGTCAATGGTGAAAAAATATTAGCAGCCTATTATATAAGCACA
AAAGAACTGGACAAATCTTCCCTTCGTGCTTTTCTTAAGGATAAACTGCCAGAATATATGGTTCCGGGATTTTATGTAAG
GTTAGAAAGTCTGCCATTAACACCTAATGGAAAAATAGATCGTGAGATTCTGCCAGGGATTAATGGAGAAGATCTTATTA
GAAAAGAGTATGAGGCGCCAAAAAATGACATAGAAAAGAAACTAGCTGAAATTTGGCAGGAGATTTTATCTTTAAAAGAA
GTAGGAATTCATGATAACTTTTTTGAATTAGGAGGACATAGTATGAAGGCTATGAAACTGATTTCGAAAATTAAACAAGA
ATTCAATATAAATTTTAAGATAAGTGAAATCTTTATCCATCCTACATTATTATCTCAGGCTGAGCAAATTGTTTCACAAG
AAAAGAATTTTAACGATACCATTCCTTTATTAAAAAAAGAAACAAGTTATCCTGTTTCATTTGCACAAAGACGATTACTG
CCCTTAAGTCAGATAAAAGAAAGTTCTGTTGCTTACAATATGCCAATGAAATTGGTGATAAACGGGTATGATCCTGATCT
TTTTATTGAGGCTTTACATGCTGTTGTAGAAAGACATGAAATTTTAAGAACAGTATTTCAGGAAGATGCAAATGGAAACT
TCAGGCAATTTGTGAAAACTAACGAAGAATTAGGGCTAAAAATAAAGACTTATGATTTTACTAAAAATCAAAATCCTTAT
AAAGAAGTATTTGATTATGTTTCTAAAGATTCGCTTGAACCATTTGATATAAAAAGAGGTCCTCTGGTAAGGTTTGCTTT
GCTGAAAACAGCTGAAAATACATTTGTGTTTTACAGTAATTTTCATCACATCATTTTTGATGGATGGTCTTATAAAGTCC
TTAAAAAAGACATAGAGGTATTTTATAACGCTTTTAAAAACCTTGAAAAGCCATTACTCCCGGATTTGCGTATTCAGTAC
AAAGATTTTACTGCTTGGCAGTTAAAAACAATAGAAGGTGATGAATACAAGAATCAGAAAAATTTTTGGCTTAATCAGTT
TCTGGGAGAAATACCACAGTTAAATCTAAGTTTTGCTGATAAGAGACCTAATTTTAAAACTTACAATGGTTCTATGCTGA
CCTATTTAATTAAAGAAGAGAATTTTGAGAGTTTTGTAAAATTAACCAATACTACCGGAAGTACACCTTTTTTAAATCTG
CTTGGTATTGCAGCTATGGTCTTATACAAAAATTCTCTTCAAAAAGAAATAATAATCGGAAGCCCGGTTTCAGGAAGAGT
TCACCCAGATTTAGACGATCAGGTTGGATTTTATGTAAACACACTTCCGTTGCGAATATTTTTAGAAGAAGACAAAACAT
ATCAGGATTTTATAGAAACTATTAAAGAAACTGTGCTGAGTTGTTTTGATAATCAGTCTTATCCGTTCGATATTTTAACA
GAAGACCTAAATCAGGGCAGGGATTTGTCCAGAAGTCCGCTTTTTGATGTCATGCTTAATCTAAACGAGTACGAAGTAAT
TAACGAAAGTTCTATTAAAGCAGGTCAGTATGCAGAAGAAGAGACAGCCAGTAAGTATGATCTTTTACTTGAATTTGACT
TATTTAAAGATAATCTGCAGTGCCGTTTTACTTACAATACTGATTTATTTGGGAAAAAAGATATTGAAAAATTGATTCAG
GAATTTGAAAAATTACTAGAAACAGTATCTCAAGACCAGCAGTATCCGCTTATAAATTATTTGAATTTGATAATGAGCCA
GGAGGAACTTTTGGAACAGGAAGATTTCTTCAGTGCAATTATTTCTGAAATCAGCGAAGAGTTTTAA

Upstream 100 bases:

>100_bases
TCCAACAATTGAAATTCTGGCCTTAAATATAGAAAACACAAAATGGATAGAAGAAACTGTTTTAGAAGATTCTACTGCAA
AAATATTAATATAAAAGCAT

Downstream 100 bases:

>100_bases
AACATTTACTAAAGAAAAAAATAATAAAATGAAAAACACAAATAGAGTAGGAATAATAACCGGCGCAAGTTCAGGCATAG
GCAGGAATACTGCATTACGT

Product: amino acid adenylation domain-containing protein

Products: pyrophosphate; AMP; enterobactin; pyrophosphate; L-Seryl-AMP [C]

Alternate protein names: Tyrocidine synthase III; ATP-dependent asparagine adenylase; AsnA; Asparagine activase; ATP-dependent glutamine adenylase; GlnA; Glutamine activase; ATP-dependent tyrosine adenylase; TyrA; Tyrosine activase; ATP-dependent valine adenylase; ValA; Valine activase; ATP-dependent ornithine adenylase; OrnA; Ornithine activase; ATP-dependent leucine adenylase; LeuA; Leucine activase [H]

Number of amino acids: Translated: 1568; Mature: 1568

Protein sequence:

>1568_residues
MEIRLLIKRLREEGVIVKMKNDQLEISLLYNHIEDETLQLLKTHKLEIIDYLSTILSKNKIVEIPLVKKADSYPLTASQN
RFWIVSQFEDASLAYNMPIALKLKGQLDVVKFEQSFLHLLERHESLRTSFKINEEGDLRQFITSMHDLDFSLNYIDLSLN
AETEKAVEEYITNQKEIVFNLEKAPLVRVSLIKSAENEYVFFMTMHHIIGDGWSSELLVKEVITIYNCLIESKEISLPEL
KIQYKDYASWLNEESQQQLYKKAETYWLNQFSGSLPVVELPSSKKRPLMKTYNGDFVNHQFTVTFLEKLTAFSHKHDVTL
FMTLMAGINALLSRYTGQQDIIIGSPIAGREHPDLENQIGLYLNTLAFRTKIDKGFNFIDLLRHEKDVILGSYEHQNYPF
DELVDKLELKRDNSRSVLFDVMVILQSQSKLNNFESGKLENLEFKEYKLNTKTSKFDFAFSFTEKTDSLSLEINYNTDIY
DAFFVEKIASHFEQLITEMIDQPETKILDIDYLSKKEKQLILTDFNNTAAYYTEDKSIVQLFEQQAAKTPDHTAVIFEDK
KVSYQALNEQANQLGGYLRKHYNIQPDDLIGIKLQRNERMITAILGILKSGAAYVPIDLSYPQSRIEYIEKDSNCRIIID
ESFLQSFYEEQHKYSVVNIENRNTPKDLAYIIYTSGTTGNPKGVMVEHKNAIALVNWSKEEYAKSAFDMVYGVTSYCFDL
SVYEFFFTLAIGKTLRILKNALDIENYINTDQNVLLNTVPSVVRKLLEDKISLENIKVINMAGEILPTDIVDQLPIEKME
VRNLYGPSEDTTYSTSHLVISKTNRTISIGRPMSNTQAWILNESLLPVPVGISGKLYLSGEGVTRGYLNKPELTAEKFVT
NPFIENERMYDTGDLAYWLPDGNIEFLGRKDHQVKIRGFRIELGEIEAALLQYSTDLKQVVAAVKEVNGEKILAAYYIST
KELDKSSLRAFLKDKLPEYMVPGFYVRLESLPLTPNGKIDREILPGINGEDLIRKEYEAPKNDIEKKLAEIWQEILSLKE
VGIHDNFFELGGHSMKAMKLISKIKQEFNINFKISEIFIHPTLLSQAEQIVSQEKNFNDTIPLLKKETSYPVSFAQRRLL
PLSQIKESSVAYNMPMKLVINGYDPDLFIEALHAVVERHEILRTVFQEDANGNFRQFVKTNEELGLKIKTYDFTKNQNPY
KEVFDYVSKDSLEPFDIKRGPLVRFALLKTAENTFVFYSNFHHIIFDGWSYKVLKKDIEVFYNAFKNLEKPLLPDLRIQY
KDFTAWQLKTIEGDEYKNQKNFWLNQFLGEIPQLNLSFADKRPNFKTYNGSMLTYLIKEENFESFVKLTNTTGSTPFLNL
LGIAAMVLYKNSLQKEIIIGSPVSGRVHPDLDDQVGFYVNTLPLRIFLEEDKTYQDFIETIKETVLSCFDNQSYPFDILT
EDLNQGRDLSRSPLFDVMLNLNEYEVINESSIKAGQYAEEETASKYDLLLEFDLFKDNLQCRFTYNTDLFGKKDIEKLIQ
EFEKLLETVSQDQQYPLINYLNLIMSQEELLEQEDFFSAIISEISEEF

Sequences:

>Translated_1568_residues
MEIRLLIKRLREEGVIVKMKNDQLEISLLYNHIEDETLQLLKTHKLEIIDYLSTILSKNKIVEIPLVKKADSYPLTASQN
RFWIVSQFEDASLAYNMPIALKLKGQLDVVKFEQSFLHLLERHESLRTSFKINEEGDLRQFITSMHDLDFSLNYIDLSLN
AETEKAVEEYITNQKEIVFNLEKAPLVRVSLIKSAENEYVFFMTMHHIIGDGWSSELLVKEVITIYNCLIESKEISLPEL
KIQYKDYASWLNEESQQQLYKKAETYWLNQFSGSLPVVELPSSKKRPLMKTYNGDFVNHQFTVTFLEKLTAFSHKHDVTL
FMTLMAGINALLSRYTGQQDIIIGSPIAGREHPDLENQIGLYLNTLAFRTKIDKGFNFIDLLRHEKDVILGSYEHQNYPF
DELVDKLELKRDNSRSVLFDVMVILQSQSKLNNFESGKLENLEFKEYKLNTKTSKFDFAFSFTEKTDSLSLEINYNTDIY
DAFFVEKIASHFEQLITEMIDQPETKILDIDYLSKKEKQLILTDFNNTAAYYTEDKSIVQLFEQQAAKTPDHTAVIFEDK
KVSYQALNEQANQLGGYLRKHYNIQPDDLIGIKLQRNERMITAILGILKSGAAYVPIDLSYPQSRIEYIEKDSNCRIIID
ESFLQSFYEEQHKYSVVNIENRNTPKDLAYIIYTSGTTGNPKGVMVEHKNAIALVNWSKEEYAKSAFDMVYGVTSYCFDL
SVYEFFFTLAIGKTLRILKNALDIENYINTDQNVLLNTVPSVVRKLLEDKISLENIKVINMAGEILPTDIVDQLPIEKME
VRNLYGPSEDTTYSTSHLVISKTNRTISIGRPMSNTQAWILNESLLPVPVGISGKLYLSGEGVTRGYLNKPELTAEKFVT
NPFIENERMYDTGDLAYWLPDGNIEFLGRKDHQVKIRGFRIELGEIEAALLQYSTDLKQVVAAVKEVNGEKILAAYYIST
KELDKSSLRAFLKDKLPEYMVPGFYVRLESLPLTPNGKIDREILPGINGEDLIRKEYEAPKNDIEKKLAEIWQEILSLKE
VGIHDNFFELGGHSMKAMKLISKIKQEFNINFKISEIFIHPTLLSQAEQIVSQEKNFNDTIPLLKKETSYPVSFAQRRLL
PLSQIKESSVAYNMPMKLVINGYDPDLFIEALHAVVERHEILRTVFQEDANGNFRQFVKTNEELGLKIKTYDFTKNQNPY
KEVFDYVSKDSLEPFDIKRGPLVRFALLKTAENTFVFYSNFHHIIFDGWSYKVLKKDIEVFYNAFKNLEKPLLPDLRIQY
KDFTAWQLKTIEGDEYKNQKNFWLNQFLGEIPQLNLSFADKRPNFKTYNGSMLTYLIKEENFESFVKLTNTTGSTPFLNL
LGIAAMVLYKNSLQKEIIIGSPVSGRVHPDLDDQVGFYVNTLPLRIFLEEDKTYQDFIETIKETVLSCFDNQSYPFDILT
EDLNQGRDLSRSPLFDVMLNLNEYEVINESSIKAGQYAEEETASKYDLLLEFDLFKDNLQCRFTYNTDLFGKKDIEKLIQ
EFEKLLETVSQDQQYPLINYLNLIMSQEELLEQEDFFSAIISEISEEF
>Mature_1568_residues
MEIRLLIKRLREEGVIVKMKNDQLEISLLYNHIEDETLQLLKTHKLEIIDYLSTILSKNKIVEIPLVKKADSYPLTASQN
RFWIVSQFEDASLAYNMPIALKLKGQLDVVKFEQSFLHLLERHESLRTSFKINEEGDLRQFITSMHDLDFSLNYIDLSLN
AETEKAVEEYITNQKEIVFNLEKAPLVRVSLIKSAENEYVFFMTMHHIIGDGWSSELLVKEVITIYNCLIESKEISLPEL
KIQYKDYASWLNEESQQQLYKKAETYWLNQFSGSLPVVELPSSKKRPLMKTYNGDFVNHQFTVTFLEKLTAFSHKHDVTL
FMTLMAGINALLSRYTGQQDIIIGSPIAGREHPDLENQIGLYLNTLAFRTKIDKGFNFIDLLRHEKDVILGSYEHQNYPF
DELVDKLELKRDNSRSVLFDVMVILQSQSKLNNFESGKLENLEFKEYKLNTKTSKFDFAFSFTEKTDSLSLEINYNTDIY
DAFFVEKIASHFEQLITEMIDQPETKILDIDYLSKKEKQLILTDFNNTAAYYTEDKSIVQLFEQQAAKTPDHTAVIFEDK
KVSYQALNEQANQLGGYLRKHYNIQPDDLIGIKLQRNERMITAILGILKSGAAYVPIDLSYPQSRIEYIEKDSNCRIIID
ESFLQSFYEEQHKYSVVNIENRNTPKDLAYIIYTSGTTGNPKGVMVEHKNAIALVNWSKEEYAKSAFDMVYGVTSYCFDL
SVYEFFFTLAIGKTLRILKNALDIENYINTDQNVLLNTVPSVVRKLLEDKISLENIKVINMAGEILPTDIVDQLPIEKME
VRNLYGPSEDTTYSTSHLVISKTNRTISIGRPMSNTQAWILNESLLPVPVGISGKLYLSGEGVTRGYLNKPELTAEKFVT
NPFIENERMYDTGDLAYWLPDGNIEFLGRKDHQVKIRGFRIELGEIEAALLQYSTDLKQVVAAVKEVNGEKILAAYYIST
KELDKSSLRAFLKDKLPEYMVPGFYVRLESLPLTPNGKIDREILPGINGEDLIRKEYEAPKNDIEKKLAEIWQEILSLKE
VGIHDNFFELGGHSMKAMKLISKIKQEFNINFKISEIFIHPTLLSQAEQIVSQEKNFNDTIPLLKKETSYPVSFAQRRLL
PLSQIKESSVAYNMPMKLVINGYDPDLFIEALHAVVERHEILRTVFQEDANGNFRQFVKTNEELGLKIKTYDFTKNQNPY
KEVFDYVSKDSLEPFDIKRGPLVRFALLKTAENTFVFYSNFHHIIFDGWSYKVLKKDIEVFYNAFKNLEKPLLPDLRIQY
KDFTAWQLKTIEGDEYKNQKNFWLNQFLGEIPQLNLSFADKRPNFKTYNGSMLTYLIKEENFESFVKLTNTTGSTPFLNL
LGIAAMVLYKNSLQKEIIIGSPVSGRVHPDLDDQVGFYVNTLPLRIFLEEDKTYQDFIETIKETVLSCFDNQSYPFDILT
EDLNQGRDLSRSPLFDVMLNLNEYEVINESSIKAGQYAEEETASKYDLLLEFDLFKDNLQCRFTYNTDLFGKKDIEKLIQ
EFEKLLETVSQDQQYPLINYLNLIMSQEELLEQEDFFSAIISEISEEF

Specific function: Incorporates six amino acids (for tyrocidine A, Asn, Gln, Tyr, Val, Orn, and Leu) in their L-configuration into the peptide product [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 6 acyl carrier domains [H]

Homologues:

Organism=Homo sapiens, GI45580730, Length=615, Percent_Identity=25.8536585365854, Blast_Score=139, Evalue=3e-32,
Organism=Homo sapiens, GI156151445, Length=578, Percent_Identity=21.4532871972318, Blast_Score=86, Evalue=3e-16,
Organism=Homo sapiens, GI38505220, Length=503, Percent_Identity=22.2664015904573, Blast_Score=74, Evalue=8e-13,
Organism=Escherichia coli, GI1786801, Length=1105, Percent_Identity=26.3348416289593, Blast_Score=324, Evalue=3e-89,
Organism=Escherichia coli, GI1786810, Length=517, Percent_Identity=24.5647969052224, Blast_Score=109, Evalue=1e-24,
Organism=Escherichia coli, GI1788107, Length=545, Percent_Identity=24.0366972477064, Blast_Score=95, Evalue=4e-20,
Organism=Escherichia coli, GI145693145, Length=542, Percent_Identity=21.9557195571956, Blast_Score=86, Evalue=2e-17,
Organism=Escherichia coli, GI1790505, Length=621, Percent_Identity=21.7391304347826, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17550940, Length=1108, Percent_Identity=23.4657039711191, Blast_Score=192, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17556356, Length=719, Percent_Identity=26.7037552155772, Blast_Score=168, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17560308, Length=373, Percent_Identity=24.3967828418231, Blast_Score=85, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI32563687, Length=499, Percent_Identity=21.0420841683367, Blast_Score=82, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17559526, Length=372, Percent_Identity=24.7311827956989, Blast_Score=79, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17538037, Length=514, Percent_Identity=23.1517509727626, Blast_Score=70, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319591, Length=911, Percent_Identity=23.7102085620198, Blast_Score=208, Evalue=7e-54,
Organism=Saccharomyces cerevisiae, GI6319699, Length=355, Percent_Identity=23.943661971831, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24648676, Length=670, Percent_Identity=25.8208955223881, Blast_Score=174, Evalue=6e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010071
- InterPro:   IPR009081
- InterPro:   IPR020845
- InterPro:   IPR000873
- InterPro:   IPR001242
- InterPro:   IPR006163
- InterPro:   IPR020806
- InterPro:   IPR006162
- InterPro:   IPR001031 [H]

Pfam domain/function: PF00501 AMP-binding; PF00668 Condensation; PF00550 PP-binding; PF00975 Thioesterase [H]

EC number: 2.7.7.- [C]

Molecular weight: Translated: 181592; Mature: 181592

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00012 PHOSPHOPANTETHEINE ; PS50075 ACP_DOMAIN ; PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIRLLIKRLREEGVIVKMKNDQLEISLLYNHIEDETLQLLKTHKLEIIDYLSTILSKNK
CHHHHHHHHHHHCCEEEEEECCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
IVEIPLVKKADSYPLTASQNRFWIVSQFEDASLAYNMPIALKLKGQLDVVKFEQSFLHLL
EEEEEEEECCCCCCCCCCCCEEEEEEECCCCCEEECCCEEEEECCCEEEHHHHHHHHHHH
ERHESLRTSFKINEEGDLRQFITSMHDLDFSLNYIDLSLNAETEKAVEEYITNQKEIVFN
HHHHHHHHEEEECCCCCHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHHHHCCCEEEEEE
LEKAPLVRVSLIKSAENEYVFFMTMHHIIGDGWSSELLVKEVITIYNCLIESKEISLPEL
ECCCCEEEEEHHHCCCCCEEEEEEEHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEE
KIQYKDYASWLNEESQQQLYKKAETYWLNQFSGSLPVVELPSSKKRPLMKTYNGDFVNHQ
EEEHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCCE
FTVTFLEKLTAFSHKHDVTLFMTLMAGINALLSRYTGQQDIIIGSPIAGREHPDLENQIG
EHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHHH
LYLNTLAFRTKIDKGFNFIDLLRHEKDVILGSYEHQNYPFDELVDKLELKRDNSRSVLFD
HHHHHHHHHHHHHCCCCHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHH
VMVILQSQSKLNNFESGKLENLEFKEYKLNTKTSKFDFAFSFTEKTDSLSLEINYNTDIY
HHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCEEEEEEEECCCCCCEEEEEECCCCHH
DAFFVEKIASHFEQLITEMIDQPETKILDIDYLSKKEKQLILTDFNNTAAYYTEDKSIVQ
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHCCCCCEEEEEECCCCEEEEECCHHHHH
LFEQQAAKTPDHTAVIFEDKKVSYQALNEQANQLGGYLRKHYNIQPDDLIGIKLQRNERM
HHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCHH
ITAILGILKSGAAYVPIDLSYPQSRIEYIEKDSNCRIIIDESFLQSFYEEQHKYSVVNIE
HHHHHHHHHCCCEEEEEECCCCHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHCEEEEEEC
NRNTPKDLAYIIYTSGTTGNPKGVMVEHKNAIALVNWSKEEYAKSAFDMVYGVTSYCFDL
CCCCCCCEEEEEEECCCCCCCCEEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHH
SVYEFFFTLAIGKTLRILKNALDIENYINTDQNVLLNTVPSVVRKLLEDKISLENIKVIN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEE
MAGEILPTDIVDQLPIEKMEVRNLYGPSEDTTYSTSHLVISKTNRTISIGRPMSNTQAWI
ECCCCCCHHHHHHCCCHHHHHHHCCCCCCCCCCCCCEEEEEECCCEEEECCCCCCCCEEE
LNESLLPVPVGISGKLYLSGEGVTRGYLNKPELTAEKFVTNPFIENERMYDTGDLAYWLP
EECCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHCCCCCCCCCEECCCCEEEEEC
DGNIEFLGRKDHQVKIRGFRIELGEIEAALLQYSTDLKQVVAAVKEVNGEKILAAYYIST
CCCEEEEECCCCEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEH
KELDKSSLRAFLKDKLPEYMVPGFYVRLESLPLTPNGKIDREILPGINGEDLIRKEYEAP
HHCCHHHHHHHHHHCCHHHCCCCEEEEEECCCCCCCCCCCHHHCCCCCHHHHHHHHHCCC
KNDIEKKLAEIWQEILSLKEVGIHDNFFELGGHSMKAMKLISKIKQEFNINFKISEIFIH
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEEEC
PTLLSQAEQIVSQEKNFNDTIPLLKKETSYPVSFAQRRLLPLSQIKESSVAYNMPMKLVI
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHCCEEECCCEEEEE
NGYDPDLFIEALHAVVERHEILRTVFQEDANGNFRQFVKTNEELGLKIKTYDFTKNQNPY
ECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHCEEEEEEECCCCCCHH
KEVFDYVSKDSLEPFDIKRGPLVRFALLKTAENTFVFYSNFHHIIFDGWSYKVLKKDIEV
HHHHHHHHCCCCCCCCCCCCCEEEEHHHHCCCCCEEEEECCCEEEECCCCHHHHHHHHHH
FYNAFKNLEKPLLPDLRIQYKDFTAWQLKTIEGDEYKNQKNFWLNQFLGEIPQLNLSFAD
HHHHHHHCCCCCCCCCEEEEECCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCEEECC
KRPNFKTYNGSMLTYLIKEENFESFVKLTNTTGSTPFLNLLGIAAMVLYKNSLQKEIIIG
CCCCCEEECCCEEEEEEECCCHHHHHEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEC
SPVSGRVHPDLDDQVGFYVNTLPLRIFLEEDKTYQDFIETIKETVLSCFDNQSYPFDILT
CCCCCCCCCCCCCCCCEEEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCHHHHH
EDLNQGRDLSRSPLFDVMLNLNEYEVINESSIKAGQYAEEETASKYDLLLEFDLFKDNLQ
HHHHCCCCCCCCCHHHHHCCCCHHEEECCCCCCCCCCCCHHCCCCEEEEEEEEECCCCCE
CRFTYNTDLFGKKDIEKLIQEFEKLLETVSQDQQYPLINYLNLIMSQEELLEQEDFFSAI
EEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHH
ISEISEEF
HHHHHHCC
>Mature Secondary Structure
MEIRLLIKRLREEGVIVKMKNDQLEISLLYNHIEDETLQLLKTHKLEIIDYLSTILSKNK
CHHHHHHHHHHHCCEEEEEECCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
IVEIPLVKKADSYPLTASQNRFWIVSQFEDASLAYNMPIALKLKGQLDVVKFEQSFLHLL
EEEEEEEECCCCCCCCCCCCEEEEEEECCCCCEEECCCEEEEECCCEEEHHHHHHHHHHH
ERHESLRTSFKINEEGDLRQFITSMHDLDFSLNYIDLSLNAETEKAVEEYITNQKEIVFN
HHHHHHHHEEEECCCCCHHHHHHHHHCCCCEEEEEEEEECCCHHHHHHHHHCCCEEEEEE
LEKAPLVRVSLIKSAENEYVFFMTMHHIIGDGWSSELLVKEVITIYNCLIESKEISLPEL
ECCCCEEEEEHHHCCCCCEEEEEEEHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEE
KIQYKDYASWLNEESQQQLYKKAETYWLNQFSGSLPVVELPSSKKRPLMKTYNGDFVNHQ
EEEHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCCE
FTVTFLEKLTAFSHKHDVTLFMTLMAGINALLSRYTGQQDIIIGSPIAGREHPDLENQIG
EHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCHHHHH
LYLNTLAFRTKIDKGFNFIDLLRHEKDVILGSYEHQNYPFDELVDKLELKRDNSRSVLFD
HHHHHHHHHHHHHCCCCHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHCCCCCCHHHHH
VMVILQSQSKLNNFESGKLENLEFKEYKLNTKTSKFDFAFSFTEKTDSLSLEINYNTDIY
HHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCEEEEEEEECCCCCCEEEEEECCCCHH
DAFFVEKIASHFEQLITEMIDQPETKILDIDYLSKKEKQLILTDFNNTAAYYTEDKSIVQ
HHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHCCCCCEEEEEECCCCEEEEECCHHHHH
LFEQQAAKTPDHTAVIFEDKKVSYQALNEQANQLGGYLRKHYNIQPDDLIGIKLQRNERM
HHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCHH
ITAILGILKSGAAYVPIDLSYPQSRIEYIEKDSNCRIIIDESFLQSFYEEQHKYSVVNIE
HHHHHHHHHCCCEEEEEECCCCHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHCEEEEEEC
NRNTPKDLAYIIYTSGTTGNPKGVMVEHKNAIALVNWSKEEYAKSAFDMVYGVTSYCFDL
CCCCCCCEEEEEEECCCCCCCCEEEEECCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHH
SVYEFFFTLAIGKTLRILKNALDIENYINTDQNVLLNTVPSVVRKLLEDKISLENIKVIN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEE
MAGEILPTDIVDQLPIEKMEVRNLYGPSEDTTYSTSHLVISKTNRTISIGRPMSNTQAWI
ECCCCCCHHHHHHCCCHHHHHHHCCCCCCCCCCCCCEEEEEECCCEEEECCCCCCCCEEE
LNESLLPVPVGISGKLYLSGEGVTRGYLNKPELTAEKFVTNPFIENERMYDTGDLAYWLP
EECCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCHHHHHCCCCCCCCCEECCCCEEEEEC
DGNIEFLGRKDHQVKIRGFRIELGEIEAALLQYSTDLKQVVAAVKEVNGEKILAAYYIST
CCCEEEEECCCCEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEH
KELDKSSLRAFLKDKLPEYMVPGFYVRLESLPLTPNGKIDREILPGINGEDLIRKEYEAP
HHCCHHHHHHHHHHCCHHHCCCCEEEEEECCCCCCCCCCCHHHCCCCCHHHHHHHHHCCC
KNDIEKKLAEIWQEILSLKEVGIHDNFFELGGHSMKAMKLISKIKQEFNINFKISEIFIH
HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEEEC
PTLLSQAEQIVSQEKNFNDTIPLLKKETSYPVSFAQRRLLPLSQIKESSVAYNMPMKLVI
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCHHHHHHCCEEECCCEEEEE
NGYDPDLFIEALHAVVERHEILRTVFQEDANGNFRQFVKTNEELGLKIKTYDFTKNQNPY
ECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHCEEEEEEECCCCCCHH
KEVFDYVSKDSLEPFDIKRGPLVRFALLKTAENTFVFYSNFHHIIFDGWSYKVLKKDIEV
HHHHHHHHCCCCCCCCCCCCCEEEEHHHHCCCCCEEEEECCCEEEECCCCHHHHHHHHHH
FYNAFKNLEKPLLPDLRIQYKDFTAWQLKTIEGDEYKNQKNFWLNQFLGEIPQLNLSFAD
HHHHHHHCCCCCCCCCEEEEECCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCCCEEECC
KRPNFKTYNGSMLTYLIKEENFESFVKLTNTTGSTPFLNLLGIAAMVLYKNSLQKEIIIG
CCCCCEEECCCEEEEEEECCCHHHHHEEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEEC
SPVSGRVHPDLDDQVGFYVNTLPLRIFLEEDKTYQDFIETIKETVLSCFDNQSYPFDILT
CCCCCCCCCCCCCCCCEEEEEEEEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCHHHHH
EDLNQGRDLSRSPLFDVMLNLNEYEVINESSIKAGQYAEEETASKYDLLLEFDLFKDNLQ
HHHHCCCCCCCCCHHHHHCCCCHHEEECCCCCCCCCCCCHHCCCCEEEEEEEEECCCCCE
CRFTYNTDLFGKKDIEKLIQEFEKLLETVSQDQQYPLINYLNLIMSQEELLEQEDFFSAI
EEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHH
ISEISEEF
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Phosphopantetheine. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 6 ATP; L-serine; 2,3-dihydroxybenzoate [C]

Specific reaction: 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Seryl-AMP 6 ATP + 3 L-serine + 3 2,3-dihydroxybenzoate = 6 pyrophosphate + 6 AMP + enterobactin ATP + L-serine = pyrophosphate + L-Ser

General reaction: Transferases; Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9352938; 10801488 [H]