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The map label for this gene is cynR [H]

Identifier: 146299042

GI number: 146299042

Start: 1465651

End: 1466532

Strand: Direct

Name: cynR [H]

Synonym: Fjoh_1282

Alternate gene names: 146299042

Gene position: 1465651-1466532 (Clockwise)

Preceding gene: 146299040

Following gene: 146299043

Centisome position: 24.04

GC content: 33.9

Gene sequence:

>882_bases
ATGGAAATCTATCAACTCGAATATTTTATTAAAATAGCTGAGGTATTGCATTTTACAAAAGCAGCCGAATTGTGTTTTGT
AACGCAATCCGGACTTTCGCAGCAAATAAAAAAGCTGGAAGAAGAGCTCGGTATGCCTTTGTTTAAGCGAATTGGAAAGA
AAGTGCAGCTTACAGAAGCGGGATCGGTTTTTTTGATTCATGCCAAAAAAGTAGTAGAAAATGTAGAAAATGGAAAACAG
GCAATTGAAGATTTAAACGAAATGATTGGCGGTGAACTTCGAATAGGGGTTACATATATCTTTGGTTTATTAGTTCTCCC
TGTTGTTAATGCATTTGCTAAAAGATATCAGAATTTAAAAATTATAGTAGATTATGGCACAACTGAAGCCTTAGAACAAA
AATTGATTAATAATGAACTAGATTTAGTATTAGTAATTTCATCACATGAAATTGGTCCTCCAATTCAAAAAGTGCCTTTG
TTTACATCAAATATGGTAATGGCGGTTGCCAAAACAAACTCTTTGGCTTCCTTAGAAAAAATGCCATTTAAAAAAATAGA
AGAAGTACCGCTGATTCTTCCCGGAAAAGGATCGAATTCCAGAGAATATGTAGAAATATTGTTTGTAAAACATCATATGA
AACCAAAGATTTCTATAGAGTTAAATTCTATTAATGCTTTATTGCAAATGGTAGAAAACAGCGACTGGGCAACCATTGTG
GCAGAAAAAGCACTAAAAGGCTGGGAACATAGCCTTAAAGCCATTCAAATTACAGGAGTAGTAACCAAACGAGAATCTTT
TATGCTCACGATTGGAAGCTACCAAAAGAAAGCCGTAAAATTGTTTATGGAAGCATTTAGCAAGAGTATAAACGAATCTT
AA

Upstream 100 bases:

>100_bases
TTTAAACATAATCTGAAATATTTTTTTACAAAGTTCGGGATTATGATTTCATTAGAAAAATTAATAATTTTACTGATAAT
AAGTAGTAAAACTTATCAAT

Downstream 100 bases:

>100_bases
AGATTTACGTTGTGAAACTCGATTTTTTTTGTGTTCTTTGCAGACCAAAATAGAGAGGTGTCCGAGTGGTTGAAGGAGCT
AGCCTGGAAAGCTAGTATAT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MEIYQLEYFIKIAEVLHFTKAAELCFVTQSGLSQQIKKLEEELGMPLFKRIGKKVQLTEAGSVFLIHAKKVVENVENGKQ
AIEDLNEMIGGELRIGVTYIFGLLVLPVVNAFAKRYQNLKIIVDYGTTEALEQKLINNELDLVLVISSHEIGPPIQKVPL
FTSNMVMAVAKTNSLASLEKMPFKKIEEVPLILPGKGSNSREYVEILFVKHHMKPKISIELNSINALLQMVENSDWATIV
AEKALKGWEHSLKAIQITGVVTKRESFMLTIGSYQKKAVKLFMEAFSKSINES

Sequences:

>Translated_293_residues
MEIYQLEYFIKIAEVLHFTKAAELCFVTQSGLSQQIKKLEEELGMPLFKRIGKKVQLTEAGSVFLIHAKKVVENVENGKQ
AIEDLNEMIGGELRIGVTYIFGLLVLPVVNAFAKRYQNLKIIVDYGTTEALEQKLINNELDLVLVISSHEIGPPIQKVPL
FTSNMVMAVAKTNSLASLEKMPFKKIEEVPLILPGKGSNSREYVEILFVKHHMKPKISIELNSINALLQMVENSDWATIV
AEKALKGWEHSLKAIQITGVVTKRESFMLTIGSYQKKAVKLFMEAFSKSINES
>Mature_293_residues
MEIYQLEYFIKIAEVLHFTKAAELCFVTQSGLSQQIKKLEEELGMPLFKRIGKKVQLTEAGSVFLIHAKKVVENVENGKQ
AIEDLNEMIGGELRIGVTYIFGLLVLPVVNAFAKRYQNLKIIVDYGTTEALEQKLINNELDLVLVISSHEIGPPIQKVPL
FTSNMVMAVAKTNSLASLEKMPFKKIEEVPLILPGKGSNSREYVEILFVKHHMKPKISIELNSINALLQMVENSDWATIV
AEKALKGWEHSLKAIQITGVVTKRESFMLTIGSYQKKAVKLFMEAFSKSINES

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=282, Percent_Identity=31.2056737588652, Blast_Score=153, Evalue=1e-38,
Organism=Escherichia coli, GI1790399, Length=203, Percent_Identity=31.5270935960591, Blast_Score=97, Evalue=9e-22,
Organism=Escherichia coli, GI1788297, Length=257, Percent_Identity=24.9027237354086, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1787879, Length=245, Percent_Identity=27.7551020408163, Blast_Score=84, Evalue=8e-18,
Organism=Escherichia coli, GI1790208, Length=294, Percent_Identity=24.8299319727891, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1788296, Length=196, Percent_Identity=25.5102040816327, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1788887, Length=180, Percent_Identity=35.5555555555556, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI145693105, Length=234, Percent_Identity=27.3504273504274, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1788481, Length=273, Percent_Identity=25.2747252747253, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1787530, Length=220, Percent_Identity=23.6363636363636, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1787589, Length=213, Percent_Identity=26.2910798122066, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI2367136, Length=240, Percent_Identity=25, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1787601, Length=248, Percent_Identity=21.7741935483871, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87081904, Length=252, Percent_Identity=23.8095238095238, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32923; Mature: 32923

Theoretical pI: Translated: 8.85; Mature: 8.85

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIYQLEYFIKIAEVLHFTKAAELCFVTQSGLSQQIKKLEEELGMPLFKRIGKKVQLTEA
CCEEHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHCCHHHHHCCCEEEEECC
GSVFLIHAKKVVENVENGKQAIEDLNEMIGGELRIGVTYIFGLLVLPVVNAFAKRYQNLK
CCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCEE
IIVDYGTTEALEQKLINNELDLVLVISSHEIGPPIQKVPLFTSNMVMAVAKTNSLASLEK
EEEECCCHHHHHHHHCCCCCCEEEEEECCCCCCCHHHCCCCCCCEEEEEECCCCHHHHHH
MPFKKIEEVPLILPGKGSNSREYVEILFVKHHMKPKISIELNSINALLQMVENSDWATIV
CCHHHHCCCCEEECCCCCCCHHHHHEEEEHHCCCCEEEEEEHHHHHHHHHHHCCCHHHHH
AEKALKGWEHSLKAIQITGVVTKRESFMLTIGSYQKKAVKLFMEAFSKSINES
HHHHHHHHHHCCEEEEEEEEEEECCEEEEEECHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEIYQLEYFIKIAEVLHFTKAAELCFVTQSGLSQQIKKLEEELGMPLFKRIGKKVQLTEA
CCEEHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHCCHHHHHCCCEEEEECC
GSVFLIHAKKVVENVENGKQAIEDLNEMIGGELRIGVTYIFGLLVLPVVNAFAKRYQNLK
CCEEEEEHHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCEE
IIVDYGTTEALEQKLINNELDLVLVISSHEIGPPIQKVPLFTSNMVMAVAKTNSLASLEK
EEEECCCHHHHHHHHCCCCCCEEEEEECCCCCCCHHHCCCCCCCEEEEEECCCCHHHHHH
MPFKKIEEVPLILPGKGSNSREYVEILFVKHHMKPKISIELNSINALLQMVENSDWATIV
CCHHHHCCCCEEECCCCCCCHHHHHEEEEHHCCCCEEEEEEHHHHHHHHHHHCCCHHHHH
AEKALKGWEHSLKAIQITGVVTKRESFMLTIGSYQKKAVKLFMEAFSKSINES
HHHHHHHHHHCCEEEEEEEEEEECCEEEEEECHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]