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The map label for this gene is treA [H]

Identifier: 146299022

GI number: 146299022

Start: 1438052

End: 1439917

Strand: Direct

Name: treA [H]

Synonym: Fjoh_1262

Alternate gene names: 146299022

Gene position: 1438052-1439917 (Clockwise)

Preceding gene: 146299021

Following gene: 146299024

Centisome position: 23.59

GC content: 35.21

Gene sequence:

>1866_bases
ATGAAATTTAAACTACATATAACCCAAACCATCGAAAAATTATTGGCTCAGGAAGATACTGACGGCGATAAAAAAATTAC
GATAGATGACAACGGTCCAAAAAGTTTTTTACTTTATGATCAAGATGGAAATCCGGCAGTTATTAAAGGAACTTACCAGC
TCTCGAATTTATTGCAGGAACTGGCCTTGGCTAAGAAAAACAATGTCGAATCAGCGGAGATAGATTTAAACGAAATCACC
GAAGATCCTGTCAAAAGAATTTCAAGAAAAATTAAAGACTTGTATTGGAACGGCCTTACCAGAACAATCGATGCCATTGG
CGTAAAGAAAATTCTGGAAGACGATAAAATCGAAAATGAATTTGCTTATTTATATGTGCCTTTTGGCGACGAAATTGTTT
TTGATTATTTCAAGAAATTAGAAGCCTCAACACCAAAATTAAAAGTGGTGCAGATGCCTAAAAATATTACTCCTGAATAT
GTTTTATCACTGAACAAAAAACCGGGAATTCTGGCTTTGGCACTTCAAATTAAAAACAATGAAGTTTCGGGCGTTCCGTT
TGTGGTTCCCGGCGGAAGATTCAACGAAATGTACGGCTGGGACAGTTATTTTATTGCTAAAGGACTTTTAATTGATGATA
AAATTGACCTTGCTTTGGGTATTGCCGAGAACTTTAAATATCAAATAGATCATTACGGAAAAATTCTAAACGCTAACAGA
AGTTATTATTTAACCAGAACACAGCCTCCGTTGTATACATCGTTGATTATAGATGTTTTAGAAAAGTCAAATCCGGATAT
TTTTTGGATTGAAAGACATTTAAAAACGGCTATAAAAGAATATTTAACCGTTTGGATGGAAGAAGGAAAAAGACTTACAG
CAAATGGTTTAAATCGTTATAAAGCAGAAGGAATCGGGCTTCCGTTTGAGGTAGAAGAAGGGCATTTTGATGATATTCTG
GAACAATATGCGCCAAAATACAACTTGTCTACGCGAGAATTCGAAAAGAAATATCTGGAAAGGGAAGTGGTTGATGAAGA
ACTCGATAAATACTTTATTCACGATCGGAGCATGCGCGAAAGCGGTCATGACACAACCAATAGATTAGTTGGAGTTTGTG
CCAATTTAAATACAGTTGCGATCAATAGTCTGCTTTATAAATACGAAACCGATATTGCTTTTTTGATTCAGAAATACTTT
AAAAATGAATTTCAATATTTTGAAGATAAATCCTTTTCAAGTGAATATTGGCTGTTAAAAGCATCTTCGAGAAAAGAAAA
AATAAACAAATTGTTATGGAGTTCTGAAAATGGAATTTATTTCGATTATGATTTTGTGAATGAAAAACAGCATGTTTTTG
AAGCAGCCACAACTTTTTATCCGCTTTGGGCAAAAATAAGTACTCCGGAACAAGCTGAAATTTTGGTGAAAAAGACACTT
CCAAAGTTTAAAATGAAAGGCGGAATTACGGGAAGTACCAAAGAATCAATTGCCGGCGTTGATGAAAATGCACCAATACG
CCAATGGGATTATCCGTTTGGCTGGGCGCCGCATCAAATGCTTTTATGGGAAGGACTTCTGAATTATAATTTTAATGAAG
AAGCGCAGGAAATGGTCTATCGCTGGCTTTGGCTCATTACCAGAAACGCGGTTGATTACAACGGAACGATTCCGGAAAAG
TTTGATTTATCGATAAGCTCGCATAAAATCTTTGCCGAATACGGAAACGTAGGAACGGAATTTAATTATATAACCGAGGA
AGGTTTTGGATGGATGAATGCTTCGTATCAATTCGGTTTAACGATTTTAAAAGACGATTTAAAACAAAAATTATCAGATT
TAGTTGATCCTGATGAACTTTTTTAA

Upstream 100 bases:

>100_bases
TTTAAAAATGAAGGTCCGGAAAAGGCTTTTTATTTTACCCTCATTCCAATGACTTTGTTACTGATCTCCTTTTTTATTCT
TAAAAAAATAACTGCAAAAG

Downstream 100 bases:

>100_bases
GGTTCATAAAATGAGAAACCCGACAGGTTTTTAAAAACCTGTCGGGTTTCTGTTTCATAAGCCTTCGACTTCGCTCAGGA
TGACACTCATTTTATGACAA

Product: alpha,alpha-trehalase

Products: NA

Alternate protein names: Alpha,alpha-trehalase; Alpha,alpha-trehalose glucohydrolase [H]

Number of amino acids: Translated: 621; Mature: 621

Protein sequence:

>621_residues
MKFKLHITQTIEKLLAQEDTDGDKKITIDDNGPKSFLLYDQDGNPAVIKGTYQLSNLLQELALAKKNNVESAEIDLNEIT
EDPVKRISRKIKDLYWNGLTRTIDAIGVKKILEDDKIENEFAYLYVPFGDEIVFDYFKKLEASTPKLKVVQMPKNITPEY
VLSLNKKPGILALALQIKNNEVSGVPFVVPGGRFNEMYGWDSYFIAKGLLIDDKIDLALGIAENFKYQIDHYGKILNANR
SYYLTRTQPPLYTSLIIDVLEKSNPDIFWIERHLKTAIKEYLTVWMEEGKRLTANGLNRYKAEGIGLPFEVEEGHFDDIL
EQYAPKYNLSTREFEKKYLEREVVDEELDKYFIHDRSMRESGHDTTNRLVGVCANLNTVAINSLLYKYETDIAFLIQKYF
KNEFQYFEDKSFSSEYWLLKASSRKEKINKLLWSSENGIYFDYDFVNEKQHVFEAATTFYPLWAKISTPEQAEILVKKTL
PKFKMKGGITGSTKESIAGVDENAPIRQWDYPFGWAPHQMLLWEGLLNYNFNEEAQEMVYRWLWLITRNAVDYNGTIPEK
FDLSISSHKIFAEYGNVGTEFNYITEEGFGWMNASYQFGLTILKDDLKQKLSDLVDPDELF

Sequences:

>Translated_621_residues
MKFKLHITQTIEKLLAQEDTDGDKKITIDDNGPKSFLLYDQDGNPAVIKGTYQLSNLLQELALAKKNNVESAEIDLNEIT
EDPVKRISRKIKDLYWNGLTRTIDAIGVKKILEDDKIENEFAYLYVPFGDEIVFDYFKKLEASTPKLKVVQMPKNITPEY
VLSLNKKPGILALALQIKNNEVSGVPFVVPGGRFNEMYGWDSYFIAKGLLIDDKIDLALGIAENFKYQIDHYGKILNANR
SYYLTRTQPPLYTSLIIDVLEKSNPDIFWIERHLKTAIKEYLTVWMEEGKRLTANGLNRYKAEGIGLPFEVEEGHFDDIL
EQYAPKYNLSTREFEKKYLEREVVDEELDKYFIHDRSMRESGHDTTNRLVGVCANLNTVAINSLLYKYETDIAFLIQKYF
KNEFQYFEDKSFSSEYWLLKASSRKEKINKLLWSSENGIYFDYDFVNEKQHVFEAATTFYPLWAKISTPEQAEILVKKTL
PKFKMKGGITGSTKESIAGVDENAPIRQWDYPFGWAPHQMLLWEGLLNYNFNEEAQEMVYRWLWLITRNAVDYNGTIPEK
FDLSISSHKIFAEYGNVGTEFNYITEEGFGWMNASYQFGLTILKDDLKQKLSDLVDPDELF
>Mature_621_residues
MKFKLHITQTIEKLLAQEDTDGDKKITIDDNGPKSFLLYDQDGNPAVIKGTYQLSNLLQELALAKKNNVESAEIDLNEIT
EDPVKRISRKIKDLYWNGLTRTIDAIGVKKILEDDKIENEFAYLYVPFGDEIVFDYFKKLEASTPKLKVVQMPKNITPEY
VLSLNKKPGILALALQIKNNEVSGVPFVVPGGRFNEMYGWDSYFIAKGLLIDDKIDLALGIAENFKYQIDHYGKILNANR
SYYLTRTQPPLYTSLIIDVLEKSNPDIFWIERHLKTAIKEYLTVWMEEGKRLTANGLNRYKAEGIGLPFEVEEGHFDDIL
EQYAPKYNLSTREFEKKYLEREVVDEELDKYFIHDRSMRESGHDTTNRLVGVCANLNTVAINSLLYKYETDIAFLIQKYF
KNEFQYFEDKSFSSEYWLLKASSRKEKINKLLWSSENGIYFDYDFVNEKQHVFEAATTFYPLWAKISTPEQAEILVKKTL
PKFKMKGGITGSTKESIAGVDENAPIRQWDYPFGWAPHQMLLWEGLLNYNFNEEAQEMVYRWLWLITRNAVDYNGTIPEK
FDLSISSHKIFAEYGNVGTEFNYITEEGFGWMNASYQFGLTILKDDLKQKLSDLVDPDELF

Specific function: Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system [H]

COG id: COG1626

COG function: function code G; Neutral trehalase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 37 family [H]

Homologues:

Organism=Homo sapiens, GI116284412, Length=428, Percent_Identity=28.7383177570093, Blast_Score=120, Evalue=4e-27,
Organism=Escherichia coli, GI1787447, Length=436, Percent_Identity=27.9816513761468, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1789936, Length=427, Percent_Identity=28.5714285714286, Blast_Score=149, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17542196, Length=441, Percent_Identity=26.530612244898, Blast_Score=116, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI25148109, Length=430, Percent_Identity=25.1162790697674, Blast_Score=108, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17565078, Length=482, Percent_Identity=24.2738589211618, Blast_Score=108, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71987755, Length=443, Percent_Identity=23.4762979683973, Blast_Score=96, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI25141398, Length=430, Percent_Identity=25.1162790697674, Blast_Score=96, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6319473, Length=634, Percent_Identity=44.4794952681388, Blast_Score=546, Evalue=1e-156,
Organism=Saccharomyces cerevisiae, GI6320204, Length=637, Percent_Identity=43.7990580847724, Blast_Score=534, Evalue=1e-152,
Organism=Drosophila melanogaster, GI24656680, Length=430, Percent_Identity=27.4418604651163, Blast_Score=125, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24656675, Length=430, Percent_Identity=27.4418604651163, Blast_Score=125, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24656661, Length=430, Percent_Identity=27.4418604651163, Blast_Score=125, Evalue=1e-28,
Organism=Drosophila melanogaster, GI17933716, Length=430, Percent_Identity=27.4418604651163, Blast_Score=125, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24656670, Length=430, Percent_Identity=27.4418604651163, Blast_Score=125, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24656685, Length=430, Percent_Identity=27.4418604651163, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI22024178, Length=423, Percent_Identity=23.4042553191489, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008928
- InterPro:   IPR001661
- InterPro:   IPR018232 [H]

Pfam domain/function: PF01204 Trehalase [H]

EC number: =3.2.1.28 [H]

Molecular weight: Translated: 72092; Mature: 72092

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00927 TREHALASE_1 ; PS00928 TREHALASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFKLHITQTIEKLLAQEDTDGDKKITIDDNGPKSFLLYDQDGNPAVIKGTYQLSNLLQE
CEEEEEHHHHHHHHHHCCCCCCCCEEEECCCCCCEEEEEECCCCCEEEEEHHHHHHHHHH
LALAKKNNVESAEIDLNEITEDPVKRISRKIKDLYWNGLTRTIDAIGVKKILEDDKIENE
HHHHHCCCCCCCCCCHHHHCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCC
FAYLYVPFGDEIVFDYFKKLEASTPKLKVVQMPKNITPEYVLSLNKKPGILALALQIKNN
EEEEEEECCHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHEEEECCCCCEEEEEEEEECC
EVSGVPFVVPGGRFNEMYGWDSYFIAKGLLIDDKIDLALGIAENFKYQIDHYGKILNANR
CCCCCCEEECCCCCCCCCCCCHHHHHCCCEEECCCCEEEEEHHCCEEEHHHHHHEECCCC
SYYLTRTQPPLYTSLIIDVLEKSNPDIFWIERHLKTAIKEYLTVWMEEGKRLTANGLNRY
CEEEEECCCCHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHCCCEEECCCCCHH
KAEGIGLPFEVEEGHFDDILEQYAPKYNLSTREFEKKYLEREVVDEELDKYFIHDRSMRE
HHCCCCCCEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
SGHDTTNRLVGVCANLNTVAINSLLYKYETDIAFLIQKYFKNEFQYFEDKSFSSEYWLLK
CCCCHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
ASSRKEKINKLLWSSENGIYFDYDFVNEKQHVFEAATTFYPLWAKISTPEQAEILVKKTL
CCCHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHEEEEECCCCHHHHHHHHHCC
PKFKMKGGITGSTKESIAGVDENAPIRQWDYPFGWAPHQMLLWEGLLNYNFNEEAQEMVY
CCHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHH
RWLWLITRNAVDYNGTIPEKFDLSISSHKIFAEYGNVGTEFNYITEEGFGWMNASYQFGL
HHHHHHHCCCCCCCCCCCCCEECEECCCEEEEECCCCCCCEEEEECCCCCEECCCHHCCH
TILKDDLKQKLSDLVDPDELF
HHHHHHHHHHHHHCCCHHHCC
>Mature Secondary Structure
MKFKLHITQTIEKLLAQEDTDGDKKITIDDNGPKSFLLYDQDGNPAVIKGTYQLSNLLQE
CEEEEEHHHHHHHHHHCCCCCCCCEEEECCCCCCEEEEEECCCCCEEEEEHHHHHHHHHH
LALAKKNNVESAEIDLNEITEDPVKRISRKIKDLYWNGLTRTIDAIGVKKILEDDKIENE
HHHHHCCCCCCCCCCHHHHCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCC
FAYLYVPFGDEIVFDYFKKLEASTPKLKVVQMPKNITPEYVLSLNKKPGILALALQIKNN
EEEEEEECCHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHEEEECCCCCEEEEEEEEECC
EVSGVPFVVPGGRFNEMYGWDSYFIAKGLLIDDKIDLALGIAENFKYQIDHYGKILNANR
CCCCCCEEECCCCCCCCCCCCHHHHHCCCEEECCCCEEEEEHHCCEEEHHHHHHEECCCC
SYYLTRTQPPLYTSLIIDVLEKSNPDIFWIERHLKTAIKEYLTVWMEEGKRLTANGLNRY
CEEEEECCCCHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHCCCEEECCCCCHH
KAEGIGLPFEVEEGHFDDILEQYAPKYNLSTREFEKKYLEREVVDEELDKYFIHDRSMRE
HHCCCCCCEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
SGHDTTNRLVGVCANLNTVAINSLLYKYETDIAFLIQKYFKNEFQYFEDKSFSSEYWLLK
CCCCHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEE
ASSRKEKINKLLWSSENGIYFDYDFVNEKQHVFEAATTFYPLWAKISTPEQAEILVKKTL
CCCHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHEEEEECCCCHHHHHHHHHCC
PKFKMKGGITGSTKESIAGVDENAPIRQWDYPFGWAPHQMLLWEGLLNYNFNEEAQEMVY
CCHHHCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHH
RWLWLITRNAVDYNGTIPEKFDLSISSHKIFAEYGNVGTEFNYITEEGFGWMNASYQFGL
HHHHHHHCCCCCCCCCCCCCEECEECCCEEEEECCCCCCCEEEEECCCCCEECCCHHCCH
TILKDDLKQKLSDLVDPDELF
HHHHHHHHHHHHHCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA