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The map label for this gene is aslA [H]

Identifier: 146298903

GI number: 146298903

Start: 1289658

End: 1291325

Strand: Direct

Name: aslA [H]

Synonym: Fjoh_1142

Alternate gene names: 146298903

Gene position: 1289658-1291325 (Clockwise)

Preceding gene: 146298902

Following gene: 146298904

Centisome position: 21.15

GC content: 37.11

Gene sequence:

>1668_bases
ATGAAACAAAGTAAACTTAGAAATGCCTTAATGCTCTTTGCATTAGTATGCTTCACAATTGTTCAGGTGAAAGCTCAGAA
TAAAAAAATCAACATTTTAGTATTATGGGGTGATGATATTGGAACTACAAATATTAGTGCCTACAGTGACGGACTTATGG
GATATACAACTCCTAATATAGATCGTTTAGCTAATGAGGGATTACGTTTCCTTCATTATTACGGAGAACAAAGCTGTACA
GCCGGGCGCGCTGCTTTTTTAACAGGACAGCACGGTCTTAGAACCGGGCTTACAAAAGTAGGTTTCCCTGGTGCGCCAAT
GGGTATGAGTCAATTAGATCCTTCTATAGGCGGTATCATGAAAAGTTTAGGATATGTAACAGGTCAGTTTGGTAAAAACC
ACGTAGGAGATCGTAATGAAAATTTGCCAACGGTAAATGGTTTTGACGAATTTTTTGGAAATCTGTATCATTTAAATGCT
GAAGAAGAGCCAGAATTACCAGATTATCCTAAAGATCCAGAATACCTGAAAAAATTCGGACCAAGAGGAGTATTAAAATG
TACAGCTACAAATACAGATGATGGTACAGTTGATCCTCGTTTTGGGAAAATTGGAAAACAAAGAATTGAAGATACAGGAC
CTCTTACTAAAAAAAGAATGGAAACAGTAGATGATGAAACATCTGCAGCAGCTATCGATTTTATAAAAAGACAAAACGCA
GCAGGCAAACCATTTTTCTGCTGGTTCAATGCTACACGTATGCACCTGCGTACGCATGTTAGAGCAGAACACAGAGGAAG
ATACACACACGGAGACAGTGAATATATCGACGGTATGATCGAACACGATGAAACAATAGGAAGTATTTTAAAAGCATTAG
ACGATTTAGGAATTGCTGATAATACAATTGTAGTGTATTCTACAGATAACGGACCACACATGAATACATGGCCAGATGGA
GCCATGACACCATTTCGTTCTGAAAAAAACACCAACTGGGATGGAGCTTTCCGTGTACCATGTATTGTACGCTGGCCGGG
TGTAATTAAACCTGGAACTGTTACAACTGAGTTGATGAGTCATAATGACTGGATTCCAACCTTTGCCTCAATTGCAGGAG
AACCTGATATTACAAATAAACTTTTGAAAGGATATAATGCTAATGGAAAAACCTATAAAGTACATTTAGACGGTTTTGAT
CAAAGTAATTTCTTGCGAGGTAAAACGCAAAAAAGTGCCAGAGATAAATTCTTTTACACAGATGATGACGGCCTTTTGGT
TGGTTTAAGAGAAGGAGACTATAAATATGTTTTCGCAGAACAGCGTCTAGGTGGTACAATGGGAGTTTGGGCAGAACCTT
TTACTAAACTGCGTTTGCAAAAAATATTTAATCTATACCAAGATCCTTTTGAAAGAGCAGATATAACTTCAAATACATTT
TGGGACTGGCAGATGAATCATGTACAGTTAATGTATGGAGCTATTCAGGATGTGGTTGTATTTGCAGAAACCTTTAAAGA
ATTTCCTCCAAGATCAATCCCGCCAAGTTTCTCTGCGTATACCATTATGGAAGAAGAGATGAAAGCAATTAAGGCACAAA
AATATATTGAAAAAAATGTGATGCCTAAATTAAAAGAAGAAGAAGCAGAAACGAAAAAGAAAAAATAA

Upstream 100 bases:

>100_bases
TTTTAGTATAGGTTATTTTCTACAAAATGTTAGTAGAAAAAATTAGTTCGATTACATAAAAAACCATTATAGAACGAATT
TATTAACAAATCTTATTACC

Downstream 100 bases:

>100_bases
AGAAATATAAATTTTAATAGAGCTTGAATCTCCCTGTTTCAAGCTCTATAAATTAAAAATCGACACCATGATACATAAAA
AAATATATGTATTAGCACTG

Product: sulfatase

Products: NA

Alternate protein names: AS; Aryl-sulfate sulphohydrolase [H]

Number of amino acids: Translated: 555; Mature: 555

Protein sequence:

>555_residues
MKQSKLRNALMLFALVCFTIVQVKAQNKKINILVLWGDDIGTTNISAYSDGLMGYTTPNIDRLANEGLRFLHYYGEQSCT
AGRAAFLTGQHGLRTGLTKVGFPGAPMGMSQLDPSIGGIMKSLGYVTGQFGKNHVGDRNENLPTVNGFDEFFGNLYHLNA
EEEPELPDYPKDPEYLKKFGPRGVLKCTATNTDDGTVDPRFGKIGKQRIEDTGPLTKKRMETVDDETSAAAIDFIKRQNA
AGKPFFCWFNATRMHLRTHVRAEHRGRYTHGDSEYIDGMIEHDETIGSILKALDDLGIADNTIVVYSTDNGPHMNTWPDG
AMTPFRSEKNTNWDGAFRVPCIVRWPGVIKPGTVTTELMSHNDWIPTFASIAGEPDITNKLLKGYNANGKTYKVHLDGFD
QSNFLRGKTQKSARDKFFYTDDDGLLVGLREGDYKYVFAEQRLGGTMGVWAEPFTKLRLQKIFNLYQDPFERADITSNTF
WDWQMNHVQLMYGAIQDVVVFAETFKEFPPRSIPPSFSAYTIMEEEMKAIKAQKYIEKNVMPKLKEEEAETKKKK

Sequences:

>Translated_555_residues
MKQSKLRNALMLFALVCFTIVQVKAQNKKINILVLWGDDIGTTNISAYSDGLMGYTTPNIDRLANEGLRFLHYYGEQSCT
AGRAAFLTGQHGLRTGLTKVGFPGAPMGMSQLDPSIGGIMKSLGYVTGQFGKNHVGDRNENLPTVNGFDEFFGNLYHLNA
EEEPELPDYPKDPEYLKKFGPRGVLKCTATNTDDGTVDPRFGKIGKQRIEDTGPLTKKRMETVDDETSAAAIDFIKRQNA
AGKPFFCWFNATRMHLRTHVRAEHRGRYTHGDSEYIDGMIEHDETIGSILKALDDLGIADNTIVVYSTDNGPHMNTWPDG
AMTPFRSEKNTNWDGAFRVPCIVRWPGVIKPGTVTTELMSHNDWIPTFASIAGEPDITNKLLKGYNANGKTYKVHLDGFD
QSNFLRGKTQKSARDKFFYTDDDGLLVGLREGDYKYVFAEQRLGGTMGVWAEPFTKLRLQKIFNLYQDPFERADITSNTF
WDWQMNHVQLMYGAIQDVVVFAETFKEFPPRSIPPSFSAYTIMEEEMKAIKAQKYIEKNVMPKLKEEEAETKKKK
>Mature_555_residues
MKQSKLRNALMLFALVCFTIVQVKAQNKKINILVLWGDDIGTTNISAYSDGLMGYTTPNIDRLANEGLRFLHYYGEQSCT
AGRAAFLTGQHGLRTGLTKVGFPGAPMGMSQLDPSIGGIMKSLGYVTGQFGKNHVGDRNENLPTVNGFDEFFGNLYHLNA
EEEPELPDYPKDPEYLKKFGPRGVLKCTATNTDDGTVDPRFGKIGKQRIEDTGPLTKKRMETVDDETSAAAIDFIKRQNA
AGKPFFCWFNATRMHLRTHVRAEHRGRYTHGDSEYIDGMIEHDETIGSILKALDDLGIADNTIVVYSTDNGPHMNTWPDG
AMTPFRSEKNTNWDGAFRVPCIVRWPGVIKPGTVTTELMSHNDWIPTFASIAGEPDITNKLLKGYNANGKTYKVHLDGFD
QSNFLRGKTQKSARDKFFYTDDDGLLVGLREGDYKYVFAEQRLGGTMGVWAEPFTKLRLQKIFNLYQDPFERADITSNTF
WDWQMNHVQLMYGAIQDVVVFAETFKEFPPRSIPPSFSAYTIMEEEMKAIKAQKYIEKNVMPKLKEEEAETKKKK

Specific function: Unknown

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI146229331, Length=430, Percent_Identity=31.6279069767442, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI146229329, Length=430, Percent_Identity=31.6279069767442, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI6005990, Length=430, Percent_Identity=31.6279069767442, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI146229324, Length=430, Percent_Identity=31.6279069767442, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI45430057, Length=491, Percent_Identity=26.8839103869654, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI4503899, Length=469, Percent_Identity=29.637526652452, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI58743319, Length=415, Percent_Identity=27.9518072289157, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI31742482, Length=471, Percent_Identity=25.9023354564756, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI38569405, Length=491, Percent_Identity=24.847250509165, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI38569407, Length=386, Percent_Identity=27.720207253886, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI146229327, Length=341, Percent_Identity=30.2052785923754, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI71852584, Length=445, Percent_Identity=26.5168539325843, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI109389362, Length=347, Percent_Identity=26.8011527377522, Blast_Score=106, Evalue=7e-23,
Organism=Homo sapiens, GI53831991, Length=205, Percent_Identity=28.2926829268293, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI157266309, Length=141, Percent_Identity=37.5886524822695, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI71852586, Length=152, Percent_Identity=34.2105263157895, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1790233, Length=506, Percent_Identity=29.4466403162055, Blast_Score=188, Evalue=9e-49,
Organism=Caenorhabditis elegans, GI115533416, Length=479, Percent_Identity=26.3048016701461, Blast_Score=102, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI115533418, Length=461, Percent_Identity=26.2472885032538, Blast_Score=95, Evalue=8e-20,
Organism=Caenorhabditis elegans, GI17559078, Length=292, Percent_Identity=25.6849315068493, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI281366397, Length=464, Percent_Identity=24.7844827586207, Blast_Score=103, Evalue=4e-22,
Organism=Drosophila melanogaster, GI281366395, Length=464, Percent_Identity=24.7844827586207, Blast_Score=103, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24666163, Length=464, Percent_Identity=24.7844827586207, Blast_Score=103, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24666175, Length=385, Percent_Identity=26.7532467532467, Blast_Score=100, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.1 [H]

Molecular weight: Translated: 62621; Mature: 62621

Theoretical pI: Translated: 7.00; Mature: 7.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQSKLRNALMLFALVCFTIVQVKAQNKKINILVLWGDDIGTTNISAYSDGLMGYTTPNI
CCHHHHHHHHHHHHHHHHHHHHHEECCCEEEEEEEECCCCCCCCCCHHCCCCCCCCCCCH
DRLANEGLRFLHYYGEQSCTAGRAAFLTGQHGLRTGLTKVGFPGAPMGMSQLDPSIGGIM
HHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHCCHHCCCCCCCCCHHHCCCHHHHHH
KSLGYVTGQFGKNHVGDRNENLPTVNGFDEFFGNLYHLNAEEEPELPDYPKDPEYLKKFG
HHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHCCCEEEECCCCCCCCCCCCCCHHHHHHCC
PRGVLKCTATNTDDGTVDPRFGKIGKQRIEDTGPLTKKRMETVDDETSAAAIDFIKRQNA
CCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHCCC
AGKPFFCWFNATRMHLRTHVRAEHRGRYTHGDSEYIDGMIEHDETIGSILKALDDLGIAD
CCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NTIVVYSTDNGPHMNTWPDGAMTPFRSEKNTNWDGAFRVPCIVRWPGVIKPGTVTTELMS
CEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCEEEECCCCCCCCCHHHHHHH
HNDWIPTFASIAGEPDITNKLLKGYNANGKTYKVHLDGFDQSNFLRGKTQKSARDKFFYT
CCCCCCHHHHHCCCCCHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCHHHHCCCCEEE
DDDGLLVGLREGDYKYVFAEQRLGGTMGVWAEPFTKLRLQKIFNLYQDPFERADITSNTF
CCCCEEEEEECCCEEEEEEHHHCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHCCCCCCCE
WDWQMNHVQLMYGAIQDVVVFAETFKEFPPRSIPPSFSAYTIMEEEMKAIKAQKYIEKNV
EEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
MPKLKEEEAETKKKK
CCCHHHHHHHHHCCC
>Mature Secondary Structure
MKQSKLRNALMLFALVCFTIVQVKAQNKKINILVLWGDDIGTTNISAYSDGLMGYTTPNI
CCHHHHHHHHHHHHHHHHHHHHHEECCCEEEEEEEECCCCCCCCCCHHCCCCCCCCCCCH
DRLANEGLRFLHYYGEQSCTAGRAAFLTGQHGLRTGLTKVGFPGAPMGMSQLDPSIGGIM
HHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHCCHHCCCCCCCCCHHHCCCHHHHHH
KSLGYVTGQFGKNHVGDRNENLPTVNGFDEFFGNLYHLNAEEEPELPDYPKDPEYLKKFG
HHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHCCCEEEECCCCCCCCCCCCCCHHHHHHCC
PRGVLKCTATNTDDGTVDPRFGKIGKQRIEDTGPLTKKRMETVDDETSAAAIDFIKRQNA
CCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHCCC
AGKPFFCWFNATRMHLRTHVRAEHRGRYTHGDSEYIDGMIEHDETIGSILKALDDLGIAD
CCCCEEEEECCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
NTIVVYSTDNGPHMNTWPDGAMTPFRSEKNTNWDGAFRVPCIVRWPGVIKPGTVTTELMS
CEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCEEEECCCCCCCCCHHHHHHH
HNDWIPTFASIAGEPDITNKLLKGYNANGKTYKVHLDGFDQSNFLRGKTQKSARDKFFYT
CCCCCCHHHHHCCCCCHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCHHHHCCCCEEE
DDDGLLVGLREGDYKYVFAEQRLGGTMGVWAEPFTKLRLQKIFNLYQDPFERADITSNTF
CCCCEEEEEECCCEEEEEEHHHCCCCCCCCCCHHHHHHHHHHHHHHHCHHHHCCCCCCCE
WDWQMNHVQLMYGAIQDVVVFAETFKEFPPRSIPPSFSAYTIMEEEMKAIKAQKYIEKNV
EEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
MPKLKEEEAETKKKK
CCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1379743; 9278503 [H]