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The map label for this gene is fabF [H]

Identifier: 146298899

GI number: 146298899

Start: 1285116

End: 1286408

Strand: Direct

Name: fabF [H]

Synonym: Fjoh_1138

Alternate gene names: 146298899

Gene position: 1285116-1286408 (Clockwise)

Preceding gene: 146298898

Following gene: 146298900

Centisome position: 21.08

GC content: 38.9

Gene sequence:

>1293_bases
ATGGGTTTTATTTGTTTAAAGACACAAAATACATATTTTATGGCATTAAGGCGAGTTGTTGTAACAGGATTAGGTGCACT
TACTCCTATCGGGAATAATATCCAGGAATATTGGAATGCACTTGTGAATGGGGTAAGCGGAGCCGCTCCTATCACATATT
ATGATACAGAGAAGCATAAAACGAAATTTGCCTGCGAAGTAAAAAACTTCAACATTGAAGATTACATGGATCGCAAGGAA
TCTCGCAGACTAGATAAATTTGCTCAGTATGCAATTGCTGCCAGTGACGAAGCTATTAAAGATGCTGGTCTAACAAATGA
TAATATCGACAAAACTAGAGTAGGTGTTATCTGGGGAGCTGGAATTGGAGGTTTAGAAACTTTCCAGGAAGAAGTAATGT
ATTATGCAAAAGGTGACGGAACTCCAAAATTCAATCCGTTTTTTATACCTAAAATGATTGCCGATATTGCTCCTGCGCAT
ATTTCAATGCGTAACGGGTATATGGGACCAAATTATACTACCGTTTCTGCATGTGCATCTTCTGCAAATGCATTAATCGA
TGCTTTTAACTACATTCGTTTAGGAATGTGTGATGTTATTGTGTCTGGTGGTTCTGAAGCTGCTGTTACCATTGCAGGTA
TGGGTGGTTTTAGTTCAATGCACGCTTTATCTACAAGAAATGAAAGTCCTGAAACAGCTTCAAGACCTTTTGATGCAACC
AGAGATGGTTTCGTTTTAGGAGAAGGAGCAGGAGCTTTAGTTCTTGAAGATTATGAGCACGCAAAAGCAAGAGGCGCAAA
AATTTACTGTGAAATTGGCGGCGGCGGAATGTCATCTGATGCTTACCATTTAACAGCACCGCATCCGGAAGGAATTGGAG
TTATCGCAGTAATGAAAAATACACTAAAAGATGCCGGAATGAACCCGGAAGATGTTGATCATATCAACACTCACGGAACT
TCTACTCCACTTGGAGATGTGGCTGAATTAAAAGCAATCAGTAATGTTTTTGGTGAACACGCTAAAAACATTAACATCAA
TTCAACAAAATCAATGACAGGACACTTACTTGGCGCTGCCGGAGCTATCGAAGCAATTGCTTCTATTTTGGCAATGCAGC
ACGGAATTGTTCCTCCAACGATTAACCATACTGTTGTTGATGAAAATATTGATCCATCATTAAACCTTACTTTAAACAAA
CCTCAAAAAAGAGAAGTGAATGTTGCTATGAGTAACACGTTTGGTTTTGGCGGACACAATGCTTGTGTATTGTTTAAAAA
ATTAGCTGACTAA

Upstream 100 bases:

>100_bases
ATTATTTTTTAAAATTTAAATTTCGATTGATTTTCAATCAAAAAGATATATTTATATTGTAATACCCATGGCTCTTAAGT
AGCAATACAGTTAAGAAAGC

Downstream 100 bases:

>100_bases
TTTTCGGATATGAATATTATCAAAAAAATATTTTCTAAATCCCGTTCTCTAGAAGACGGGATTTTTTTTGACACTATTCA
GAAAATTCTTGGTTTTCAGC

Product: beta-ketoacyl synthase

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 430; Mature: 429

Protein sequence:

>430_residues
MGFICLKTQNTYFMALRRVVVTGLGALTPIGNNIQEYWNALVNGVSGAAPITYYDTEKHKTKFACEVKNFNIEDYMDRKE
SRRLDKFAQYAIAASDEAIKDAGLTNDNIDKTRVGVIWGAGIGGLETFQEEVMYYAKGDGTPKFNPFFIPKMIADIAPAH
ISMRNGYMGPNYTTVSACASSANALIDAFNYIRLGMCDVIVSGGSEAAVTIAGMGGFSSMHALSTRNESPETASRPFDAT
RDGFVLGEGAGALVLEDYEHAKARGAKIYCEIGGGGMSSDAYHLTAPHPEGIGVIAVMKNTLKDAGMNPEDVDHINTHGT
STPLGDVAELKAISNVFGEHAKNININSTKSMTGHLLGAAGAIEAIASILAMQHGIVPPTINHTVVDENIDPSLNLTLNK
PQKREVNVAMSNTFGFGGHNACVLFKKLAD

Sequences:

>Translated_430_residues
MGFICLKTQNTYFMALRRVVVTGLGALTPIGNNIQEYWNALVNGVSGAAPITYYDTEKHKTKFACEVKNFNIEDYMDRKE
SRRLDKFAQYAIAASDEAIKDAGLTNDNIDKTRVGVIWGAGIGGLETFQEEVMYYAKGDGTPKFNPFFIPKMIADIAPAH
ISMRNGYMGPNYTTVSACASSANALIDAFNYIRLGMCDVIVSGGSEAAVTIAGMGGFSSMHALSTRNESPETASRPFDAT
RDGFVLGEGAGALVLEDYEHAKARGAKIYCEIGGGGMSSDAYHLTAPHPEGIGVIAVMKNTLKDAGMNPEDVDHINTHGT
STPLGDVAELKAISNVFGEHAKNININSTKSMTGHLLGAAGAIEAIASILAMQHGIVPPTINHTVVDENIDPSLNLTLNK
PQKREVNVAMSNTFGFGGHNACVLFKKLAD
>Mature_429_residues
GFICLKTQNTYFMALRRVVVTGLGALTPIGNNIQEYWNALVNGVSGAAPITYYDTEKHKTKFACEVKNFNIEDYMDRKES
RRLDKFAQYAIAASDEAIKDAGLTNDNIDKTRVGVIWGAGIGGLETFQEEVMYYAKGDGTPKFNPFFIPKMIADIAPAHI
SMRNGYMGPNYTTVSACASSANALIDAFNYIRLGMCDVIVSGGSEAAVTIAGMGGFSSMHALSTRNESPETASRPFDATR
DGFVLGEGAGALVLEDYEHAKARGAKIYCEIGGGGMSSDAYHLTAPHPEGIGVIAVMKNTLKDAGMNPEDVDHINTHGTS
TPLGDVAELKAISNVFGEHAKNININSTKSMTGHLLGAAGAIEAIASILAMQHGIVPPTINHTVVDENIDPSLNLTLNKP
QKREVNVAMSNTFGFGGHNACVLFKKLAD

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=443, Percent_Identity=39.2776523702032, Blast_Score=306, Evalue=2e-83,
Organism=Homo sapiens, GI223972627, Length=152, Percent_Identity=46.7105263157895, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI41872631, Length=429, Percent_Identity=25.1748251748252, Blast_Score=116, Evalue=4e-26,
Organism=Escherichia coli, GI1787337, Length=418, Percent_Identity=48.3253588516746, Blast_Score=361, Evalue=1e-101,
Organism=Escherichia coli, GI1788663, Length=421, Percent_Identity=39.9049881235154, Blast_Score=254, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI71983541, Length=419, Percent_Identity=34.3675417661098, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI71983535, Length=261, Percent_Identity=39.0804597701149, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI212642053, Length=354, Percent_Identity=24.2937853107345, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17550940, Length=258, Percent_Identity=33.3333333333333, Blast_Score=104, Evalue=9e-23,
Organism=Saccharomyces cerevisiae, GI6320904, Length=444, Percent_Identity=35.1351351351351, Blast_Score=257, Evalue=2e-69,
Organism=Drosophila melanogaster, GI24644341, Length=415, Percent_Identity=40, Blast_Score=300, Evalue=9e-82,
Organism=Drosophila melanogaster, GI24581345, Length=428, Percent_Identity=24.7663551401869, Blast_Score=115, Evalue=5e-26,
Organism=Drosophila melanogaster, GI221330659, Length=422, Percent_Identity=24.6445497630332, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI19920632, Length=422, Percent_Identity=24.6445497630332, Blast_Score=112, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 45970; Mature: 45838

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFICLKTQNTYFMALRRVVVTGLGALTPIGNNIQEYWNALVNGVSGAAPITYYDTEKHK
CCEEEEECCCHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCC
TKFACEVKNFNIEDYMDRKESRRLDKFAQYAIAASDEAIKDAGLTNDNIDKTRVGVIWGA
CEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCEEEEEEEEC
GIGGLETFQEEVMYYAKGDGTPKFNPFFIPKMIADIAPAHISMRNGYMGPNYTTVSACAS
CCCHHHHHHHHHEEEECCCCCCCCCCEEHHHHHHHCCCCCEEECCCCCCCCCHHHHHHHH
SANALIDAFNYIRLGMCDVIVSGGSEAAVTIAGMGGFSSMHALSTRNESPETASRPFDAT
HHHHHHHHHHHHHHHHHHEEEECCCCEEEEEEECCCCHHHHHHHCCCCCCCCCCCCCCCC
RDGFVLGEGAGALVLEDYEHAKARGAKIYCEIGGGGMSSDAYHLTAPHPEGIGVIAVMKN
CCCEEEECCCCEEEEECCHHHHCCCCEEEEEECCCCCCCCCEEEECCCCCCCEEEEHHHH
TLKDAGMNPEDVDHINTHGTSTPLGDVAELKAISNVFGEHAKNININSTKSMTGHLLGAA
HHHHCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
GAIEAIASILAMQHGIVPPTINHTVVDENIDPSLNLTLNKPQKREVNVAMSNTFGFGGHN
HHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCEEEEECCCCCCEEEEEEECCCCCCCCC
ACVLFKKLAD
CEEEEEECCC
>Mature Secondary Structure 
GFICLKTQNTYFMALRRVVVTGLGALTPIGNNIQEYWNALVNGVSGAAPITYYDTEKHK
CEEEEECCCHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCC
TKFACEVKNFNIEDYMDRKESRRLDKFAQYAIAASDEAIKDAGLTNDNIDKTRVGVIWGA
CEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCEEEEEEEEC
GIGGLETFQEEVMYYAKGDGTPKFNPFFIPKMIADIAPAHISMRNGYMGPNYTTVSACAS
CCCHHHHHHHHHEEEECCCCCCCCCCEEHHHHHHHCCCCCEEECCCCCCCCCHHHHHHHH
SANALIDAFNYIRLGMCDVIVSGGSEAAVTIAGMGGFSSMHALSTRNESPETASRPFDAT
HHHHHHHHHHHHHHHHHHEEEECCCCEEEEEEECCCCHHHHHHHCCCCCCCCCCCCCCCC
RDGFVLGEGAGALVLEDYEHAKARGAKIYCEIGGGGMSSDAYHLTAPHPEGIGVIAVMKN
CCCEEEECCCCEEEEECCHHHHCCCCEEEEEECCCCCCCCCEEEECCCCCCCEEEEHHHH
TLKDAGMNPEDVDHINTHGTSTPLGDVAELKAISNVFGEHAKNININSTKSMTGHLLGAA
HHHHCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
GAIEAIASILAMQHGIVPPTINHTVVDENIDPSLNLTLNKPQKREVNVAMSNTFGFGGHN
HHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCEEEEECCCCCCEEEEEEECCCCCCCCC
ACVLFKKLAD
CEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]