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The map label for this gene is hemA1

Identifier: 146298704

GI number: 146298704

Start: 1054769

End: 1056019

Strand: Direct

Name: hemA1

Synonym: Fjoh_0942

Alternate gene names: 146298704

Gene position: 1054769-1056019 (Clockwise)

Preceding gene: 146298695

Following gene: 146298705

Centisome position: 17.3

GC content: 33.49

Gene sequence:

>1251_bases
ATGGAAAACAATAACGTACCGAAACACCTTTATTTTTACTCAGTTGGTCTGAGTTATAAAAAAGCTGATGCTGAGGTTAG
AGGTCAATTTAGTTTGGATGCCGTTGCCAAAACGCGATTGCTGGAACAAGCTAAAAACGATGGAATAGAAAGTTTACTAG
TTACTTCAACTTGCAACAGAACCGAAATCTACGGTTTTGCCGAACATCCATTTCAATTAATAAAACTTATCTGCGATAAT
AGTAACGGATCTGTAGACGCTTTTCAAAAAGTTGGTTTCGTTTACAAAAATCAGGAAGCGATTAATCATATGTTTCGCGT
AGGAACTGGTTTAGACAGTCAGATCTTAGGCGATTTCGAAATTATATCTCAAATAAAAACATCTTTTACGCATTCAAAAT
CAATGGGATTAGCCAATGCTTTTATGGAAAGATTGGTAAATGCGGTAATTCAGGCAAGCAAAAGAATTAAAACGGAAACA
GAAATCAGTTCTGGTGCTACTTCAGTTTCTTTTGCATCTGTACAATATATTTTGAAGAATGTTGAAGATATCAGTAACAA
AAACATTTTACTTTTTGGAACTGGTAAAATCGGAAGAAATACGTGTGAGAATTTAGTAAAACACACTAAAAACGAGCATA
TCACTTTAATCAACCGAACTAAAGATAAAGCAGAGAAATTAGCAGGAAAGTTAAATCTTATTGTTAAAGATTATTCTGAA
TTACACTTAGAACTTCAAAAAGCTGATGTTGTAGTTGTAGCAACCGGCGCGCAAAACCCAACGGTTGACAAAGCAATCTT
AAATCTTAAAAAACCTTTGTTGATCCTGGATTTATCGATTCCGAAAAACGTAAATGAAAACGTTGAGGAATTAGAAGGTG
TAACTTTAATTCACATGGATTATTTGTCTCAATTGACAGATGAAACTTTGGAAAACAGAAAATTACATATTCCCGCTGCT
GAAGCAATCATCGAAGAAATCAAAGAAGAATTTGTTACTTGGATGAAAGGAAGAAAGTTCGCTCCAACAATCAATGCTTT
AAAAGAGAAATTAAACGCTATTAAAGCTTCGGAACTAGATTTTCAAAGCAAAAAAATCGCCGATTTTAATGAAGAGCAAG
CTGAAATTATCAGTAACAGAATCATTCAAAAAATCACTACACATTTTGCAAATCATTTAAAAGACGACGATACTATGGTC
GATGAAAGTATCGAATGGATCGAAAAAGTCTTCAAAATAAAAGCATCTTAG

Upstream 100 bases:

>100_bases
TAGGTTCAAAAAAACATACAGCGACATAAAAAGTACTTTTAGCGTTATTTTTATCAATGCTATAGTAATAATTTTGTTGC
ACTTTTATGAAAGTGAATTT

Downstream 100 bases:

>100_bases
TTTTTAATTTAAACCATTAAGATATTAAGGAAATTAAGACCAAGCTTTGTCAAGAGAATTAAGCAACGCTATAACGCAAA
GCTTAATAATCTTAAATTCA

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR 1

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MENNNVPKHLYFYSVGLSYKKADAEVRGQFSLDAVAKTRLLEQAKNDGIESLLVTSTCNRTEIYGFAEHPFQLIKLICDN
SNGSVDAFQKVGFVYKNQEAINHMFRVGTGLDSQILGDFEIISQIKTSFTHSKSMGLANAFMERLVNAVIQASKRIKTET
EISSGATSVSFASVQYILKNVEDISNKNILLFGTGKIGRNTCENLVKHTKNEHITLINRTKDKAEKLAGKLNLIVKDYSE
LHLELQKADVVVVATGAQNPTVDKAILNLKKPLLILDLSIPKNVNENVEELEGVTLIHMDYLSQLTDETLENRKLHIPAA
EAIIEEIKEEFVTWMKGRKFAPTINALKEKLNAIKASELDFQSKKIADFNEEQAEIISNRIIQKITTHFANHLKDDDTMV
DESIEWIEKVFKIKAS

Sequences:

>Translated_416_residues
MENNNVPKHLYFYSVGLSYKKADAEVRGQFSLDAVAKTRLLEQAKNDGIESLLVTSTCNRTEIYGFAEHPFQLIKLICDN
SNGSVDAFQKVGFVYKNQEAINHMFRVGTGLDSQILGDFEIISQIKTSFTHSKSMGLANAFMERLVNAVIQASKRIKTET
EISSGATSVSFASVQYILKNVEDISNKNILLFGTGKIGRNTCENLVKHTKNEHITLINRTKDKAEKLAGKLNLIVKDYSE
LHLELQKADVVVVATGAQNPTVDKAILNLKKPLLILDLSIPKNVNENVEELEGVTLIHMDYLSQLTDETLENRKLHIPAA
EAIIEEIKEEFVTWMKGRKFAPTINALKEKLNAIKASELDFQSKKIADFNEEQAEIISNRIIQKITTHFANHLKDDDTMV
DESIEWIEKVFKIKAS
>Mature_416_residues
MENNNVPKHLYFYSVGLSYKKADAEVRGQFSLDAVAKTRLLEQAKNDGIESLLVTSTCNRTEIYGFAEHPFQLIKLICDN
SNGSVDAFQKVGFVYKNQEAINHMFRVGTGLDSQILGDFEIISQIKTSFTHSKSMGLANAFMERLVNAVIQASKRIKTET
EISSGATSVSFASVQYILKNVEDISNKNILLFGTGKIGRNTCENLVKHTKNEHITLINRTKDKAEKLAGKLNLIVKDYSE
LHLELQKADVVVVATGAQNPTVDKAILNLKKPLLILDLSIPKNVNENVEELEGVTLIHMDYLSQLTDETLENRKLHIPAA
EAIIEEIKEEFVTWMKGRKFAPTINALKEKLNAIKASELDFQSKKIADFNEEQAEIISNRIIQKITTHFANHLKDDDTMV
DESIEWIEKVFKIKAS

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=410, Percent_Identity=27.0731707317073, Blast_Score=150, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM11_FLAJ1 (A5FLE3)

Other databases:

- EMBL:   CP000685
- RefSeq:   YP_001193295.1
- ProteinModelPortal:   A5FLE3
- SMR:   A5FLE3
- STRING:   A5FLE3
- GeneID:   5091356
- GenomeReviews:   CP000685_GR
- KEGG:   fjo:Fjoh_0942
- eggNOG:   COG0373
- HOGENOM:   HBG479062
- OMA:   VPRNVGP
- ProtClustDB:   CLSK851822
- BioCyc:   FJOH376686:FJOH_0942-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 46757; Mature: 46757

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 58-58 BINDING 113-113 BINDING 124-124

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENNNVPKHLYFYSVGLSYKKADAEVRGQFSLDAVAKTRLLEQAKNDGIESLLVTSTCNR
CCCCCCCCEEEEEEECCCEECCCHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHEECCCCC
TEIYGFAEHPFQLIKLICDNSNGSVDAFQKVGFVYKNQEAINHMFRVGTGLDSQILGDFE
CEECEEHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHH
IISQIKTSFTHSKSMGLANAFMERLVNAVIQASKRIKTETEISSGATSVSFASVQYILKN
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHH
VEDISNKNILLFGTGKIGRNTCENLVKHTKNEHITLINRTKDKAEKLAGKLNLIVKDYSE
HHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHH
LHLELQKADVVVVATGAQNPTVDKAILNLKKPLLILDLSIPKNVNENVEELEGVTLIHMD
HHHEEEECCEEEEEECCCCCCHHHHHHHCCCCEEEEEECCCCCCCCCHHHHCCEEEEHHH
YLSQLTDETLENRKLHIPAAEAIIEEIKEEFVTWMKGRKFAPTINALKEKLNAIKASELD
HHHHHHHHHHHCCEEECCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCC
FQSKKIADFNEEQAEIISNRIIQKITTHFANHLKDDDTMVDESIEWIEKVFKIKAS
CCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MENNNVPKHLYFYSVGLSYKKADAEVRGQFSLDAVAKTRLLEQAKNDGIESLLVTSTCNR
CCCCCCCCEEEEEEECCCEECCCHHHCCCCHHHHHHHHHHHHHHHCCCHHHHHEECCCCC
TEIYGFAEHPFQLIKLICDNSNGSVDAFQKVGFVYKNQEAINHMFRVGTGLDSQILGDFE
CEECEEHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHH
IISQIKTSFTHSKSMGLANAFMERLVNAVIQASKRIKTETEISSGATSVSFASVQYILKN
HHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHH
VEDISNKNILLFGTGKIGRNTCENLVKHTKNEHITLINRTKDKAEKLAGKLNLIVKDYSE
HHHCCCCCEEEEECCCCCHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHH
LHLELQKADVVVVATGAQNPTVDKAILNLKKPLLILDLSIPKNVNENVEELEGVTLIHMD
HHHEEEECCEEEEEECCCCCCHHHHHHHCCCCEEEEEECCCCCCCCCHHHHCCEEEEHHH
YLSQLTDETLENRKLHIPAAEAIIEEIKEEFVTWMKGRKFAPTINALKEKLNAIKASELD
HHHHHHHHHHHCCEEECCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCC
FQSKKIADFNEEQAEIISNRIIQKITTHFANHLKDDDTMVDESIEWIEKVFKIKAS
CCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA