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The map label for this gene is pphA [C]

Identifier: 146298646

GI number: 146298646

Start: 997551

End: 998285

Strand: Direct

Name: pphA [C]

Synonym: Fjoh_0884

Alternate gene names: 146298646

Gene position: 997551-998285 (Clockwise)

Preceding gene: 146298643

Following gene: 146298647

Centisome position: 16.36

GC content: 37.41

Gene sequence:

>735_bases
ATGCGAACATTTGTTATAGGCGACATACACGGAGGATTACTCGCACTTGAACAAGTATTGAAGAAAGCCGAAGTTACTAC
AAAAGATACTCTTATATTTTTAGGCGATTATGTTGACGGCTGGAGCCAGTCGGCAGAAGTTATTGACTTTTTAATCGACC
TTAAAACCAAACAAAACTGCATTTGCATTAGAGGAAATCATGATCAGCTGGCATTAGACTGGCTGGAAAACAGACATGAG
GATTTTGATGAAGAAATGTGGTACAAACATGGCGGAAAAGCCACTGTTGAAGGATATTCTAAAATATCTCCTGAAAGAAA
AAAAGAACATATAGCGTTTTTTGAATCACTGAAAGATTATTATCTTGATGATGAAAACCGCCTTTTTGTTCATGCCGGAT
TCACTAATTTAAATGGTGTAGTCTGGGAATATTTTCCGAAATTATTTTACTGGGACAGAACACTTTGGGAATCTGCTTTG
GCATTAGACCCAAATTTAAAACCTGACGATTTATATTATCCTAAGCGTTTTACCGTTTATAAAGAAATCTACATTGGTCA
TACTCCTGTTACAAGAATTGGACAAACCGTTCCTGTAAACAAAGCCTGCGTTTGGAATGTTGATACGGGTGCCGCTTTCA
AAGGTCCGTTGACGATTATGGACGTGAATACCAAAGAGTTCTGGCAGAGCGATCCGTTAAATGAATTGTATTCTAACGAA
AAAGGTAGGAATTAA

Upstream 100 bases:

>100_bases
TAATAGTTATAAATAGTATCAATTTTTAAAGATTATCAACTAAATGAATCCAAACAAATCATTTTACTTATTTTTGTAGT
TACACCCGAAATATTTAAAA

Downstream 100 bases:

>100_bases
TCCGTAAAAAACTAAATTTGCACCAGCAAAATAATTAATATTTAAGTTTATGAAAAAAGTTATCATCACATTATTGTTTT
TAGTATCATTTGGATTTATT

Product: metallophosphoesterase

Products: A Protein; Orthophosphate. [C]

Alternate protein names: Serine/Threonine Protein Phosphatase; Bis(5Nucleosyl)-Tetraphosphatase ApaH; Serine/Threonine Protein Phosphatase Family Protein; Calcineurin-Like Phosphoesterase; Metallophosphoesterase Domain-Containing Protein; Phosphatase; Ser/Thr Protein Phosphatase Family Protein; Serinethreonine Protein Phosphatase; Phosphoprotein Phosphatase; Serine/Threonine Specific Protein Phosphatase; Serine/Threonine Specific Protein Phosphatase Protein; Protein Phosphatase

Number of amino acids: Translated: 244; Mature: 244

Protein sequence:

>244_residues
MRTFVIGDIHGGLLALEQVLKKAEVTTKDTLIFLGDYVDGWSQSAEVIDFLIDLKTKQNCICIRGNHDQLALDWLENRHE
DFDEEMWYKHGGKATVEGYSKISPERKKEHIAFFESLKDYYLDDENRLFVHAGFTNLNGVVWEYFPKLFYWDRTLWESAL
ALDPNLKPDDLYYPKRFTVYKEIYIGHTPVTRIGQTVPVNKACVWNVDTGAAFKGPLTIMDVNTKEFWQSDPLNELYSNE
KGRN

Sequences:

>Translated_244_residues
MRTFVIGDIHGGLLALEQVLKKAEVTTKDTLIFLGDYVDGWSQSAEVIDFLIDLKTKQNCICIRGNHDQLALDWLENRHE
DFDEEMWYKHGGKATVEGYSKISPERKKEHIAFFESLKDYYLDDENRLFVHAGFTNLNGVVWEYFPKLFYWDRTLWESAL
ALDPNLKPDDLYYPKRFTVYKEIYIGHTPVTRIGQTVPVNKACVWNVDTGAAFKGPLTIMDVNTKEFWQSDPLNELYSNE
KGRN
>Mature_244_residues
MRTFVIGDIHGGLLALEQVLKKAEVTTKDTLIFLGDYVDGWSQSAEVIDFLIDLKTKQNCICIRGNHDQLALDWLENRHE
DFDEEMWYKHGGKATVEGYSKISPERKKEHIAFFESLKDYYLDDENRLFVHAGFTNLNGVVWEYFPKLFYWDRTLWESAL
ALDPNLKPDDLYYPKRFTVYKEIYIGHTPVTRIGQTVPVNKACVWNVDTGAAFKGPLTIMDVNTKEFWQSDPLNELYSNE
KGRN

Specific function: Plays A Key Role In Signaling Protein Misfolding Via The Cpxr/Cpxa Transducing System. It Also Modulates The Phosphorylated Status Of Many Phosphoproteins In E. coli, Some Of Which Acting As Major Chaperones. Has Been Shown, In Vitro, To Act On Ser, Thr A

COG id: COG0639

COG function: function code T; Diadenosine tetraphosphatase and related serine/threonine protein phosphatases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.1.3.16 [C]

Molecular weight: Translated: 28387; Mature: 28387

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTFVIGDIHGGLLALEQVLKKAEVTTKDTLIFLGDYVDGWSQSAEVIDFLIDLKTKQNC
CCEEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCE
ICIRGNHDQLALDWLENRHEDFDEEMWYKHGGKATVEGYSKISPERKKEHIAFFESLKDY
EEEECCCCCCHHHHHHHHCCCHHHHHHHHCCCCEEECCHHHCCCHHHHHHHHHHHHHHHH
YLDDENRLFVHAGFTNLNGVVWEYFPKLFYWDRTLWESALALDPNLKPDDLYYPKRFTVY
HCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEE
KEIYIGHTPVTRIGQTVPVNKACVWNVDTGAAFKGPLTIMDVNTKEFWQSDPLNELYSNE
EEEEECCCCHHHCCCCCCCCCEEEEECCCCCCCCCCEEEEECCHHHHHCCCCHHHHHCCC
KGRN
CCCC
>Mature Secondary Structure
MRTFVIGDIHGGLLALEQVLKKAEVTTKDTLIFLGDYVDGWSQSAEVIDFLIDLKTKQNC
CCEEEEECCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCCE
ICIRGNHDQLALDWLENRHEDFDEEMWYKHGGKATVEGYSKISPERKKEHIAFFESLKDY
EEEECCCCCCHHHHHHHHCCCHHHHHHHHCCCCEEECCHHHCCCHHHHHHHHHHHHHHHH
YLDDENRLFVHAGFTNLNGVVWEYFPKLFYWDRTLWESALALDPNLKPDDLYYPKRFTVY
HCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEE
KEIYIGHTPVTRIGQTVPVNKACVWNVDTGAAFKGPLTIMDVNTKEFWQSDPLNELYSNE
EEEEECCCCHHHCCCCCCCCCEEEEECCCCCCCCCCEEEEECCHHHHHCCCCHHHHHCCC
KGRN
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe; Mn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Phosphoprotein; H2O [C]

Specific reaction: A Phosphoprotein + H2O = A Protein + Orthophosphate. [C]

General reaction: Phosphoric ester hydrolysis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA