Click here to switch to the map view.

The map label for this gene is pip [H]

Identifier: 146298452

GI number: 146298452

Start: 755281

End: 756192

Strand: Direct

Name: pip [H]

Synonym: Fjoh_0689

Alternate gene names: 146298452

Gene position: 755281-756192 (Clockwise)

Preceding gene: 146298451

Following gene: 146298455

Centisome position: 12.39

GC content: 33.55

Gene sequence:

>912_bases
ATGAATAATTCACTGATGAAAAAGATTTTTCTCTTTGGCTTTTTATTGTTTCTGGCAAATATTTACGCGCAAACCGAAGG
TTATGCCGTAAATAACGACGGAAGCAAAACATATTACAAAACATTCGGAAAAGGCGAACCGCTTTTAATTATAAACGGCG
GCCCGGGAATGAACAGTAATGGTTTTGAAGATATGGCAAAAACTTTGGGCGAAAATCAGCAAACAATTATTTATGACCAA
AGAGGAACCGGAAAATCGAAACTTTCAAAATTAGACGCTAAGACAATTTCTATGCGTTTAATGATTGATGATATTGAATC
ATTGAGAAAACATCTTAAAATCAAAAAATGGAATATTCTCGGACATTCTTTTGGAGGAATGTTGGGTTCATATTACGCAA
CTATTTATCCCAACAGTATCAACAAGTTGATTTTATCTTCTTCTGGAGGTGTAGATTTATCTTTATTGAAAGGCCCGAAT
TTAATCGAATCGAATCTTTCGAAAGTTGAAATAGATTCTATGAATTACTGGAATGATAAAATCGAAAAAGGCGATACATC
TCACAAAGCAAGACTCGGACGCGGTCGTGCCATGGCTCCGGCTTATGTCTACGATCAAAAATTTATTCCGATTATTGCCG
AAAGATTAACTCAGGGAAATTCGACAATCAATGGTTTGTTATGGTCGGACATGCAGAAAATGAATTTTGACTATAAATCT
AAACTGAAGAATTTCAAAAATCCTGTTTTAATTATTCAGGGAAAAGAAGATATTATCAGCAATGAAATTGGAGAATTGGC
ACATAAGACTTTTCCAAATTCGAAATTGATTTTATTAGAACATTCCAAACATTACGGATGGCTTGATGCCAGAGAAAAGT
ATTTCAACGATATTAATTCATTTTTAAAATAA

Upstream 100 bases:

>100_bases
ATTCGTTTAGAAGATAATGTTGTGGTTCAGGAAAAAGGAGAACCTTTCAACTTGATGCGCAACATTCCTGTTGAAGCTGA
CGAGATTGAAACATTGATGA

Downstream 100 bases:

>100_bases
AATAAAAAGCTGTCTCAAAAGGACAGCTTTTTTGCTTCTCAAATATTTGCAAAATTTATTCTATGTGTAAAAACCCCAGC
GGGGTGAAATTTTTATCTTA

Product: alpha/beta hydrolase fold protein

Products: NA

Alternate protein names: PIP; Prolyl aminopeptidase; PAP [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MNNSLMKKIFLFGFLLFLANIYAQTEGYAVNNDGSKTYYKTFGKGEPLLIINGGPGMNSNGFEDMAKTLGENQQTIIYDQ
RGTGKSKLSKLDAKTISMRLMIDDIESLRKHLKIKKWNILGHSFGGMLGSYYATIYPNSINKLILSSSGGVDLSLLKGPN
LIESNLSKVEIDSMNYWNDKIEKGDTSHKARLGRGRAMAPAYVYDQKFIPIIAERLTQGNSTINGLLWSDMQKMNFDYKS
KLKNFKNPVLIIQGKEDIISNEIGELAHKTFPNSKLILLEHSKHYGWLDAREKYFNDINSFLK

Sequences:

>Translated_303_residues
MNNSLMKKIFLFGFLLFLANIYAQTEGYAVNNDGSKTYYKTFGKGEPLLIINGGPGMNSNGFEDMAKTLGENQQTIIYDQ
RGTGKSKLSKLDAKTISMRLMIDDIESLRKHLKIKKWNILGHSFGGMLGSYYATIYPNSINKLILSSSGGVDLSLLKGPN
LIESNLSKVEIDSMNYWNDKIEKGDTSHKARLGRGRAMAPAYVYDQKFIPIIAERLTQGNSTINGLLWSDMQKMNFDYKS
KLKNFKNPVLIIQGKEDIISNEIGELAHKTFPNSKLILLEHSKHYGWLDAREKYFNDINSFLK
>Mature_303_residues
MNNSLMKKIFLFGFLLFLANIYAQTEGYAVNNDGSKTYYKTFGKGEPLLIINGGPGMNSNGFEDMAKTLGENQQTIIYDQ
RGTGKSKLSKLDAKTISMRLMIDDIESLRKHLKIKKWNILGHSFGGMLGSYYATIYPNSINKLILSSSGGVDLSLLKGPN
LIESNLSKVEIDSMNYWNDKIEKGDTSHKARLGRGRAMAPAYVYDQKFIPIIAERLTQGNSTINGLLWSDMQKMNFDYKS
KLKNFKNPVLIIQGKEDIISNEIGELAHKTFPNSKLILLEHSKHYGWLDAREKYFNDINSFLK

Specific function: Releases the N-terminal proline from the dipeptides, Pro-Pro, Pro-Gln, Pro-Trp and Pro-Tyr. Also from amides (Pro-beta NA) and oligopeptides, Pro-Leu-GlyNH2, Pro-Leu-Gly and Pro-Phe- Gly-Lys. Higher activity toward small peptides (up to three residues), b

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S33 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR005945
- InterPro:   IPR002410 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: =3.4.11.5 [H]

Molecular weight: Translated: 34248; Mature: 34248

Theoretical pI: Translated: 9.90; Mature: 9.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNSLMKKIFLFGFLLFLANIYAQTEGYAVNNDGSKTYYKTFGKGEPLLIINGGPGMNSN
CCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHEECCCCCCEEEEECCCCCCCC
GFEDMAKTLGENQQTIIYDQRGTGKSKLSKLDAKTISMRLMIDDIESLRKHLKIKKWNIL
CHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHEEEEEHHHHHHHHHHHHCEEEEEEC
GHSFGGMLGSYYATIYPNSINKLILSSSGGVDLSLLKGPNLIESNLSKVEIDSMNYWNDK
CHHHHHHHHHHEEEECCCCCCEEEEECCCCCEEEEECCCCHHHCCCCEEEECCCCCCCHH
IEKGDTSHKARLGRGRAMAPAYVYDQKFIPIIAERLTQGNSTINGLLWSDMQKMNFDYKS
HCCCCCHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHH
KLKNFKNPVLIIQGKEDIISNEIGELAHKTFPNSKLILLEHSKHYGWLDAREKYFNDINS
HHHHCCCCEEEEECCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHH
FLK
HCC
>Mature Secondary Structure
MNNSLMKKIFLFGFLLFLANIYAQTEGYAVNNDGSKTYYKTFGKGEPLLIINGGPGMNSN
CCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHHEECCCCCCEEEEECCCCCCCC
GFEDMAKTLGENQQTIIYDQRGTGKSKLSKLDAKTISMRLMIDDIESLRKHLKIKKWNIL
CHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHEEEEEHHHHHHHHHHHHCEEEEEEC
GHSFGGMLGSYYATIYPNSINKLILSSSGGVDLSLLKGPNLIESNLSKVEIDSMNYWNDK
CHHHHHHHHHHEEEECCCCCCEEEEECCCCCEEEEECCCCHHHCCCCEEEECCCCCCCHH
IEKGDTSHKARLGRGRAMAPAYVYDQKFIPIIAERLTQGNSTINGLLWSDMQKMNFDYKS
HCCCCCHHHHHHCCCCCCCCHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHH
KLKNFKNPVLIIQGKEDIISNEIGELAHKTFPNSKLILLEHSKHYGWLDAREKYFNDINS
HHHHCCCCEEEEECCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHH
FLK
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1459939 [H]