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The map label for this gene is pepP [H]

Identifier: 146298451

GI number: 146298451

Start: 753996

End: 755288

Strand: Direct

Name: pepP [H]

Synonym: Fjoh_0688

Alternate gene names: 146298451

Gene position: 753996-755288 (Clockwise)

Preceding gene: 146298449

Following gene: 146298452

Centisome position: 12.37

GC content: 37.12

Gene sequence:

>1293_bases
ATGAAATATCATCAAATAAACAGCGCTCTTTTTGTAAAAAACCGCAGAAAGTTCATGGCTGAAATGAAACCTAATTCTGT
TGCAGTATTCAACTCAAATGACATTTACCCAATTAGTGCCGACAGTACTTTACCATTTGCACAGCACAGAGATATTTTCT
ATCTGAGCGGTGTAGATCAGGAAGAAAGTGTTTTGCTTTTGTTTCCGGATGCGCCTTATGAGCATCAAAGAGAAATTCTT
TTTTTGAGAGAAACCAACGATCATATTGCTGTTTGGGAAGGTGAAAAACTGACTAAAGAACGTGCTTTTCAGGTTTCTGG
AATTAGAACCGTTTATTGGTTACAGGATTTTCATAAAATTTTGAACGAAATGATGACGTATGCCGATACGATGTACATCA
ATACAAACGAACATTACCGCGCAACTGTTGAAACAGAAACCCGCGAAGCTCGTTTTGTAAAATGGTGGAAAGAACGTTAT
CCAGCACACAATGTTGCAAAAAGCAACCCAATTTTACAAAGACTTCGTTCTGTAAAAGAAAGCGAAGAAATCGATTTGAT
TCAGCACGCTTGTGATATTACAGAAAAAGGTTTCCGCAGATTATTAGGATTCGTAAAACCAAATGTTACCGAATATGAAG
TTGAAGCTGAATTAGCACACGAATTCATTCGTAACCGTTCTAAAGGTTTTGCATATACACCAATTATCGCTTCTGGAAAC
AATGCTAATGTTTTACATTATATCGAAAACAACCAGCAATGTAAAGAAGGTGATTTGTTATTATTAGACGTTGCTGCAGA
ATATGCAAACTATTCAAGCGATATGACGAGAACAATTCCGGTTTCGGGACGTTTTACAGAACGTCAAAAAGCGGTTTATA
ATGCTGTTTTGAGAGTTAAAAACGAAGCTACTAAAATGCTTACGCCAGGAACGCTTTGGAAACAATATCATATTGAAGTG
GGTAAAATCATGACTTCTGAATTGCTTGGTTTAGGTTTACTAGACAAAGCCGATGTTCAGAACGAAAATCCAGAATGGCC
TGCTTACAAAAAATATTTCATGCACGGAACTTCTCACCACATGGGACTTGACACGCACGATTACGGATTGCTTCATGAAC
CAATGAAACCAAATATGGTTTTTACAGTTGAACCGGGAATTTATATTCCGGCAGAAAAATTCGGAATTCGTTTAGAAGAT
AATGTTGTGGTTCAGGAAAAAGGAGAACCTTTCAACTTGATGCGCAACATTCCTGTTGAAGCTGACGAGATTGAAACATT
GATGAATGAATAA

Upstream 100 bases:

>100_bases
TGGCAAAAACAATAAATAAGAAAACTTTAATAAATCTGCTATACGCCACTAATTCAAAAATCATTAATTTTGAAATTCAA
AGTTCAAAAACGAAACAATT

Downstream 100 bases:

>100_bases
TTCACTGATGAAAAAGATTTTTCTCTTTGGCTTTTTATTGTTTCTGGCAAATATTTACGCGCAAACCGAAGGTTATGCCG
TAAATAACGACGGAAGCAAA

Product: peptidase M24

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MKYHQINSALFVKNRRKFMAEMKPNSVAVFNSNDIYPISADSTLPFAQHRDIFYLSGVDQEESVLLLFPDAPYEHQREIL
FLRETNDHIAVWEGEKLTKERAFQVSGIRTVYWLQDFHKILNEMMTYADTMYINTNEHYRATVETETREARFVKWWKERY
PAHNVAKSNPILQRLRSVKESEEIDLIQHACDITEKGFRRLLGFVKPNVTEYEVEAELAHEFIRNRSKGFAYTPIIASGN
NANVLHYIENNQQCKEGDLLLLDVAAEYANYSSDMTRTIPVSGRFTERQKAVYNAVLRVKNEATKMLTPGTLWKQYHIEV
GKIMTSELLGLGLLDKADVQNENPEWPAYKKYFMHGTSHHMGLDTHDYGLLHEPMKPNMVFTVEPGIYIPAEKFGIRLED
NVVVQEKGEPFNLMRNIPVEADEIETLMNE

Sequences:

>Translated_430_residues
MKYHQINSALFVKNRRKFMAEMKPNSVAVFNSNDIYPISADSTLPFAQHRDIFYLSGVDQEESVLLLFPDAPYEHQREIL
FLRETNDHIAVWEGEKLTKERAFQVSGIRTVYWLQDFHKILNEMMTYADTMYINTNEHYRATVETETREARFVKWWKERY
PAHNVAKSNPILQRLRSVKESEEIDLIQHACDITEKGFRRLLGFVKPNVTEYEVEAELAHEFIRNRSKGFAYTPIIASGN
NANVLHYIENNQQCKEGDLLLLDVAAEYANYSSDMTRTIPVSGRFTERQKAVYNAVLRVKNEATKMLTPGTLWKQYHIEV
GKIMTSELLGLGLLDKADVQNENPEWPAYKKYFMHGTSHHMGLDTHDYGLLHEPMKPNMVFTVEPGIYIPAEKFGIRLED
NVVVQEKGEPFNLMRNIPVEADEIETLMNE
>Mature_430_residues
MKYHQINSALFVKNRRKFMAEMKPNSVAVFNSNDIYPISADSTLPFAQHRDIFYLSGVDQEESVLLLFPDAPYEHQREIL
FLRETNDHIAVWEGEKLTKERAFQVSGIRTVYWLQDFHKILNEMMTYADTMYINTNEHYRATVETETREARFVKWWKERY
PAHNVAKSNPILQRLRSVKESEEIDLIQHACDITEKGFRRLLGFVKPNVTEYEVEAELAHEFIRNRSKGFAYTPIIASGN
NANVLHYIENNQQCKEGDLLLLDVAAEYANYSSDMTRTIPVSGRFTERQKAVYNAVLRVKNEATKMLTPGTLWKQYHIEV
GKIMTSELLGLGLLDKADVQNENPEWPAYKKYFMHGTSHHMGLDTHDYGLLHEPMKPNMVFTVEPGIYIPAEKFGIRLED
NVVVQEKGEPFNLMRNIPVEADEIETLMNE

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=419, Percent_Identity=30.3102625298329, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI149589008, Length=474, Percent_Identity=26.1603375527426, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI260593665, Length=307, Percent_Identity=30.2931596091205, Blast_Score=135, Evalue=9e-32,
Organism=Homo sapiens, GI260593663, Length=330, Percent_Identity=29.0909090909091, Blast_Score=120, Evalue=3e-27,
Organism=Escherichia coli, GI1789275, Length=437, Percent_Identity=32.2654462242563, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1788728, Length=278, Percent_Identity=27.3381294964029, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1790282, Length=288, Percent_Identity=24.6527777777778, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17508215, Length=484, Percent_Identity=25.6198347107438, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI71989583, Length=282, Percent_Identity=26.9503546099291, Blast_Score=114, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6321118, Length=436, Percent_Identity=26.1467889908257, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6320922, Length=451, Percent_Identity=28.159645232816, Blast_Score=157, Evalue=4e-39,
Organism=Drosophila melanogaster, GI19920384, Length=382, Percent_Identity=29.3193717277487, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI21357079, Length=436, Percent_Identity=27.9816513761468, Blast_Score=152, Evalue=4e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 49978; Mature: 49978

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYHQINSALFVKNRRKFMAEMKPNSVAVFNSNDIYPISADSTLPFAQHRDIFYLSGVDQ
CCCEECCCEEEEHHHHHHHHHCCCCEEEEECCCCEEEECCCCCCCHHHCCCEEEEECCCC
EESVLLLFPDAPYEHQREILFLRETNDHIAVWEGEKLTKERAFQVSGIRTVYWLQDFHKI
CCCEEEEECCCCCCCCCEEEEEEECCCEEEEECCCHHHHHHHEEECCCCHHHHHHHHHHH
LNEMMTYADTMYINTNEHYRATVETETREARFVKWWKERYPAHNVAKSNPILQRLRSVKE
HHHHHHHHCEEEEECCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHC
SEEIDLIQHACDITEKGFRRLLGFVKPNVTEYEVEAELAHEFIRNRSKGFAYTPIIASGN
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHCCCCCEEEEEEEECCC
NANVLHYIENNQQCKEGDLLLLDVAAEYANYSSDMTRTIPVSGRFTERQKAVYNAVLRVK
CCCEEEEECCCCCCCCCCEEEEEEHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHC
NEATKMLTPGTLWKQYHIEVGKIMTSELLGLGLLDKADVQNENPEWPAYKKYFMHGTSHH
CCHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCC
MGLDTHDYGLLHEPMKPNMVFTVEPGIYIPAEKFGIRLEDNVVVQEKGEPFNLMRNIPVE
CCCCCCCCCCCCCCCCCCEEEEECCCEEECHHHHCEEEECCEEEEECCCCHHHHHCCCCC
ADEIETLMNE
HHHHHHHHCC
>Mature Secondary Structure
MKYHQINSALFVKNRRKFMAEMKPNSVAVFNSNDIYPISADSTLPFAQHRDIFYLSGVDQ
CCCEECCCEEEEHHHHHHHHHCCCCEEEEECCCCEEEECCCCCCCHHHCCCEEEEECCCC
EESVLLLFPDAPYEHQREILFLRETNDHIAVWEGEKLTKERAFQVSGIRTVYWLQDFHKI
CCCEEEEECCCCCCCCCEEEEEEECCCEEEEECCCHHHHHHHEEECCCCHHHHHHHHHHH
LNEMMTYADTMYINTNEHYRATVETETREARFVKWWKERYPAHNVAKSNPILQRLRSVKE
HHHHHHHHCEEEEECCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHC
SEEIDLIQHACDITEKGFRRLLGFVKPNVTEYEVEAELAHEFIRNRSKGFAYTPIIASGN
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHCCCCCEEEEEEEECCC
NANVLHYIENNQQCKEGDLLLLDVAAEYANYSSDMTRTIPVSGRFTERQKAVYNAVLRVK
CCCEEEEECCCCCCCCCCEEEEEEHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHC
NEATKMLTPGTLWKQYHIEVGKIMTSELLGLGLLDKADVQNENPEWPAYKKYFMHGTSHH
CCHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHCCCCCC
MGLDTHDYGLLHEPMKPNMVFTVEPGIYIPAEKFGIRLEDNVVVQEKGEPFNLMRNIPVE
CCCCCCCCCCCCCCCCCCEEEEECCCEEECHHHHCEEEECCEEEEECCCCHHHHHCCCCC
ADEIETLMNE
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]