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The map label for this gene is pqqL [C]

Identifier: 146284305

GI number: 146284305

Start: 4330848

End: 4332200

Strand: Direct

Name: pqqL [C]

Synonym: PST_3993

Alternate gene names: 146284305

Gene position: 4330848-4332200 (Clockwise)

Preceding gene: 146284300

Following gene: 146284306

Centisome position: 94.82

GC content: 66.89

Gene sequence:

>1353_bases
ATGCCTCTGACGTTACGCCGCGCCGCCGCCCTGCTGCTCGGAGCGCTCTATCTGCCGCTAGTGGCTGCAGCAGACAACCA
GCCGACCCACGAGTTCTTCCTCGACAATGGCCTGAAGGTGATCGTTCGCGAGGATCACCGCGCCCCGGTGGTGGTTTCCC
AGCTCTGGTACAAGGTCGGCTCCAGCTACGAGACCGCCGGCCAGACAGGCCTGTCCCATGCCCTCGAACACATGATGTTC
AAGGGCAGCCGCAAGCTCGACGCCGGCGAAGCCTCGCGCATCCTGCGTGAGCTGGGCGCCGAGGAAAACGCCTTCACCAG
CGACGACTACACCGCCTACTACCAGGTGCTGGCCCGCGACCGTCTGGCCGTGGCCTTCGAACTCGAAGCCGATCGCCTGG
CCAGCCTCAAGCTGCCGCCAGAAGAGTTCGCCCGCGAGATCGAAGTGATCAAGGAAGAACGCCGCCTGCGCACCGACGAC
AAGCCCAGCTCGCTGGCCTATGAGCGCTTCAAGACCATCGCCTATCCGGCCAGCGGCTACCGCAACCCGACCATCGGCTG
GATGGATGACCTCAATCGCATGCAGGCCGACGAGCTGCGTGCCTGGTACGAGCAATGGTACGCGCCGAACAATGCCACCC
TGGTGGTGGTCGGCGACGTGACAGCCGACGAGGTACGCGGGCTGGCCGAGCGTTTCTTCGGCGGCATCGAACGACGCGAG
GTGCCGACGGCCAAGCGGCCGCTGGAACTGGACGAACCGGGCGAGCGCCGCCTCAGGCTGCACGTGAGGACGCAGTTGCC
GACATTGCTGATGGCGTTCAACGCCCCCAGTCTCGCGACCGAGGAGAATGCCCGCCAGGTGCACGCGCTGCGGTTGATCT
CCGCCCTGCTCGACGGTGGCTACAGCGCGCGTCTGCCGGAGCGGCTGGAACGTGGCGAGGAGCTGGTGACCAGCGCCTCG
GCCTGGTACGACGCCTACGCCCGCGGCGACAGCCTGTTTGTCCTGAGCGCCGCGCCGAACATGCAGAAGGGCCGCACCCT
GGAAGAAGTCGAAGCCGGTCTCTGGCGGGAACTGGACGCGCTCAAGGAGGCGCCACCCTCGGCGGACGAACTCGAGCGGG
TTCGCGCCCAGGTCATCGCCGGGCTGGTGTACGAGCGCGATTCCATCACCCAGCAGGCCGCCACCATCGGCAAGCTGGAA
ACCGTCGGCCTGTCCTGGCGGCTGATGGACGAGGAGCTGGCGGCGCTCGAGGCCGTCACGCCCGAAGACATCCAGCAGGC
TGCGCGCAGCTATTTCACCCGCTCGCGCCTGAGCGTCGCCCATGTTCTGCCCGAGGAAGCCCGAGATGAGTGA

Upstream 100 bases:

>100_bases
TACCCCGGCTTTGCCTGACCCGCGCCGGCCATTACCATGGCTGCCGTGTCGCCGCCCTGCCATCCACCGTGGCGGGCACC
AACCTGGACGAGTCCCGACT

Downstream 100 bases:

>100_bases
TTGCAAAGCCCTGCGCAACGGCCTGCTCGGCCTGCTGCTGGCGGCCAGCTTCGGCCTGGCGGGCTGCGATGAGGGCTCCA
CCGCCCTGCCGCGCCCCGGC

Product: zinc protease, putative

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MPLTLRRAAALLLGALYLPLVAAADNQPTHEFFLDNGLKVIVREDHRAPVVVSQLWYKVGSSYETAGQTGLSHALEHMMF
KGSRKLDAGEASRILRELGAEENAFTSDDYTAYYQVLARDRLAVAFELEADRLASLKLPPEEFAREIEVIKEERRLRTDD
KPSSLAYERFKTIAYPASGYRNPTIGWMDDLNRMQADELRAWYEQWYAPNNATLVVVGDVTADEVRGLAERFFGGIERRE
VPTAKRPLELDEPGERRLRLHVRTQLPTLLMAFNAPSLATEENARQVHALRLISALLDGGYSARLPERLERGEELVTSAS
AWYDAYARGDSLFVLSAAPNMQKGRTLEEVEAGLWRELDALKEAPPSADELERVRAQVIAGLVYERDSITQQAATIGKLE
TVGLSWRLMDEELAALEAVTPEDIQQAARSYFTRSRLSVAHVLPEEARDE

Sequences:

>Translated_450_residues
MPLTLRRAAALLLGALYLPLVAAADNQPTHEFFLDNGLKVIVREDHRAPVVVSQLWYKVGSSYETAGQTGLSHALEHMMF
KGSRKLDAGEASRILRELGAEENAFTSDDYTAYYQVLARDRLAVAFELEADRLASLKLPPEEFAREIEVIKEERRLRTDD
KPSSLAYERFKTIAYPASGYRNPTIGWMDDLNRMQADELRAWYEQWYAPNNATLVVVGDVTADEVRGLAERFFGGIERRE
VPTAKRPLELDEPGERRLRLHVRTQLPTLLMAFNAPSLATEENARQVHALRLISALLDGGYSARLPERLERGEELVTSAS
AWYDAYARGDSLFVLSAAPNMQKGRTLEEVEAGLWRELDALKEAPPSADELERVRAQVIAGLVYERDSITQQAATIGKLE
TVGLSWRLMDEELAALEAVTPEDIQQAARSYFTRSRLSVAHVLPEEARDE
>Mature_449_residues
PLTLRRAAALLLGALYLPLVAAADNQPTHEFFLDNGLKVIVREDHRAPVVVSQLWYKVGSSYETAGQTGLSHALEHMMFK
GSRKLDAGEASRILRELGAEENAFTSDDYTAYYQVLARDRLAVAFELEADRLASLKLPPEEFAREIEVIKEERRLRTDDK
PSSLAYERFKTIAYPASGYRNPTIGWMDDLNRMQADELRAWYEQWYAPNNATLVVVGDVTADEVRGLAERFFGGIERREV
PTAKRPLELDEPGERRLRLHVRTQLPTLLMAFNAPSLATEENARQVHALRLISALLDGGYSARLPERLERGEELVTSASA
WYDAYARGDSLFVLSAAPNMQKGRTLEEVEAGLWRELDALKEAPPSADELERVRAQVIAGLVYERDSITQQAATIGKLET
VGLSWRLMDEELAALEAVTPEDIQQAARSYFTRSRLSVAHVLPEEARDE

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI46593007, Length=209, Percent_Identity=26.3157894736842, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI94538354, Length=212, Percent_Identity=27.8301886792453, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1787770, Length=417, Percent_Identity=24.9400479616307, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI2367164, Length=351, Percent_Identity=25.6410256410256, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71999683, Length=427, Percent_Identity=21.3114754098361, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17553678, Length=214, Percent_Identity=27.1028037383178, Blast_Score=72, Evalue=6e-13,
Organism=Saccharomyces cerevisiae, GI6323192, Length=410, Percent_Identity=22.1951219512195, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323421, Length=255, Percent_Identity=21.9607843137255, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21357875, Length=216, Percent_Identity=29.6296296296296, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24646943, Length=216, Percent_Identity=29.6296296296296, Blast_Score=89, Evalue=5e-18,
Organism=Drosophila melanogaster, GI221513245, Length=224, Percent_Identity=28.125, Blast_Score=75, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 50586; Mature: 50454

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLTLRRAAALLLGALYLPLVAAADNQPTHEFFLDNGLKVIVREDHRAPVVVSQLWYKVG
CCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCEEEEECCCCCCHHHHHHHHHHC
SSYETAGQTGLSHALEHMMFKGSRKLDAGEASRILRELGAEENAFTSDDYTAYYQVLARD
CCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHC
RLAVAFELEADRLASLKLPPEEFAREIEVIKEERRLRTDDKPSSLAYERFKTIAYPASGY
CEEEEEEECHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCC
RNPTIGWMDDLNRMQADELRAWYEQWYAPNNATLVVVGDVTADEVRGLAERFFGGIERRE
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCCHHHC
VPTAKRPLELDEPGERRLRLHVRTQLPTLLMAFNAPSLATEENARQVHALRLISALLDGG
CCCCCCCCCCCCCCCCEEEEEEHHHCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCC
YSARLPERLERGEELVTSASAWYDAYARGDSLFVLSAAPNMQKGRTLEEVEAGLWRELDA
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHH
LKEAPPSADELERVRAQVIAGLVYERDSITQQAATIGKLETVGLSWRLMDEELAALEAVT
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHCCC
PEDIQQAARSYFTRSRLSVAHVLPEEARDE
HHHHHHHHHHHHHHHHHHHHHHCCHHHCCC
>Mature Secondary Structure 
PLTLRRAAALLLGALYLPLVAAADNQPTHEFFLDNGLKVIVREDHRAPVVVSQLWYKVG
CCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCEEEEECCCCCCHHHHHHHHHHC
SSYETAGQTGLSHALEHMMFKGSRKLDAGEASRILRELGAEENAFTSDDYTAYYQVLARD
CCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHC
RLAVAFELEADRLASLKLPPEEFAREIEVIKEERRLRTDDKPSSLAYERFKTIAYPASGY
CEEEEEEECHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCC
RNPTIGWMDDLNRMQADELRAWYEQWYAPNNATLVVVGDVTADEVRGLAERFFGGIERRE
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCCHHHC
VPTAKRPLELDEPGERRLRLHVRTQLPTLLMAFNAPSLATEENARQVHALRLISALLDGG
CCCCCCCCCCCCCCCCEEEEEEHHHCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCC
YSARLPERLERGEELVTSASAWYDAYARGDSLFVLSAAPNMQKGRTLEEVEAGLWRELDA
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHH
LKEAPPSADELERVRAQVIAGLVYERDSITQQAATIGKLETVGLSWRLMDEELAALEAVT
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHCCC
PEDIQQAARSYFTRSRLSVAHVLPEEARDE
HHHHHHHHHHHHHHHHHHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]