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The map label for this gene is sahH [H]

Identifier: 146284247

GI number: 146284247

Start: 4264630

End: 4266036

Strand: Direct

Name: sahH [H]

Synonym: PST_3935

Alternate gene names: 146284247

Gene position: 4264630-4266036 (Clockwise)

Preceding gene: 146284244

Following gene: 146284248

Centisome position: 93.37

GC content: 63.4

Gene sequence:

>1407_bases
ATGAGTGCTGTCATGACGCCTGCCGGTTTCACCGACTTCAAGGTCGCCGACATTTCCCTGGCCGCCTGGGGCCGCCGCGA
GATCATCATCGCCGAATCGGAAATGCCCGCCTTGATGGGCCTGCGCCGCAAGTACGCCGCCGAGCAACCGCTCAAGGGCG
CGAAGATCCTGGGCTGTATCCACATGACCATCCAGACCGCGGTGCTGATCGAGACGCTGATCGCCCTCGGCGCCGAGGTA
CGCTGGTCCTCCTGCAACATCTTCTCCACCCAGGACCAGGCCGCTGCCGCCATCGCCGCTGCCGGCATCCCGGTATTCGC
CTGGAAGGGCGAAACCGAGGAAGAATACGAGTGGTGCATCGAGCAGACCATCCTCAAGGACGGCCAGCCGTGGGACGCCA
ACATGGTGCTGGACGACGGCGGTGACCTGACCCAGATCCTGCACGACAAGTATCCGCAGGTGCTCGAGCGCGTGCACGGC
ATCACCGAGGAAACCACCACCGGTGTGCACCGCCTGCTCGACATGCTCAAGGGCGGCACCCTGAAAGTGCCGGCGATCAA
CGTCAACGACTCGGTCACCAAGAGCAAGAACGACAACAAGTACGGCTGCCGCCACAGCCTGAACGACGCCATCAAGCGCG
CCACCGATCACCTGCTCTCCGGCAAGCAGGCGCTGGTCATCGGCTACGGCGACGTAGGCAAGGGCTCGGCACAGTCGCTG
CGCCAGGAAGGCATGATCGTCAAGGTCTCCGAGGTCGATCCGATCTGCGCCATGCAGGCCTGCATGGACGGCTTCGAGCT
GGTTTCCCCCTACAAGAACGGCATCAACGACGGCACCGAAGCCAGCGTCGACGCCGCGCTGCTGGGCAAGATCGACCTGA
TCGTCACCACGACCGGTAACGTCAATGTGTGCGACGCCGGCATGCTCAAGGCGCTGAAGAAGCGCGCCGTGGTGTGCAAC
ATCGGTCACTTCGACAACGAGATCGACACCGCCTTCATGCGCCAGAACTGGGGCTGGGAAGAGGTCAAGCCGCAGGTGCA
CAAGATCCACCGCACCGGCAAGACCGTCGACCCGACCAACGATGACTACCTGATTCTCCTGGCCGAAGGCCGCTTGGTGA
ACCTGGGCAACGCCACCGGCCACCCGAGCCGGATCATGGACGGCTCCTTCGCCAACCAGGTGCTGGCGCAGATCCACCTC
TACAACGAGAAGTTCGCCGACCTGCCGGTGGCCGAGAAGACCCAGAACGTCACCGTCATGGTGCTGCCGAAGAAGCTCGA
CGAAGAAGTGGCGCTGGAGATGGTCAAGGGCTTCGGTGGCGTGGTCACCCAGCTGACCGCCAAGCAGGCCGAGTACATCG
GCGTTGCCGTCGAAGGTCCGTTCAAGCCGGACAGCTACCGCTACTAA

Upstream 100 bases:

>100_bases
GCGCTGCAGCAGGTTCCAGAACCTGTCAGGCTCGGATGGGGCGTTTCCTCGAACGCATCAACGGCGCCCATTCGCAACCA
TACGAATGGAGAACTCTTCG

Downstream 100 bases:

>100_bases
GCAGGTCACGTCACAGGCTGCGAGGCGCCAGGTGCGCTCGCGGCCTGCGGCTTGCAGCTCAAGGAATTTCTGTATGACCT
CTTCAAATCGCCCTTCCATC

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 468; Mature: 467

Protein sequence:

>468_residues
MSAVMTPAGFTDFKVADISLAAWGRREIIIAESEMPALMGLRRKYAAEQPLKGAKILGCIHMTIQTAVLIETLIALGAEV
RWSSCNIFSTQDQAAAAIAAAGIPVFAWKGETEEEYEWCIEQTILKDGQPWDANMVLDDGGDLTQILHDKYPQVLERVHG
ITEETTTGVHRLLDMLKGGTLKVPAINVNDSVTKSKNDNKYGCRHSLNDAIKRATDHLLSGKQALVIGYGDVGKGSAQSL
RQEGMIVKVSEVDPICAMQACMDGFELVSPYKNGINDGTEASVDAALLGKIDLIVTTTGNVNVCDAGMLKALKKRAVVCN
IGHFDNEIDTAFMRQNWGWEEVKPQVHKIHRTGKTVDPTNDDYLILLAEGRLVNLGNATGHPSRIMDGSFANQVLAQIHL
YNEKFADLPVAEKTQNVTVMVLPKKLDEEVALEMVKGFGGVVTQLTAKQAEYIGVAVEGPFKPDSYRY

Sequences:

>Translated_468_residues
MSAVMTPAGFTDFKVADISLAAWGRREIIIAESEMPALMGLRRKYAAEQPLKGAKILGCIHMTIQTAVLIETLIALGAEV
RWSSCNIFSTQDQAAAAIAAAGIPVFAWKGETEEEYEWCIEQTILKDGQPWDANMVLDDGGDLTQILHDKYPQVLERVHG
ITEETTTGVHRLLDMLKGGTLKVPAINVNDSVTKSKNDNKYGCRHSLNDAIKRATDHLLSGKQALVIGYGDVGKGSAQSL
RQEGMIVKVSEVDPICAMQACMDGFELVSPYKNGINDGTEASVDAALLGKIDLIVTTTGNVNVCDAGMLKALKKRAVVCN
IGHFDNEIDTAFMRQNWGWEEVKPQVHKIHRTGKTVDPTNDDYLILLAEGRLVNLGNATGHPSRIMDGSFANQVLAQIHL
YNEKFADLPVAEKTQNVTVMVLPKKLDEEVALEMVKGFGGVVTQLTAKQAEYIGVAVEGPFKPDSYRY
>Mature_467_residues
SAVMTPAGFTDFKVADISLAAWGRREIIIAESEMPALMGLRRKYAAEQPLKGAKILGCIHMTIQTAVLIETLIALGAEVR
WSSCNIFSTQDQAAAAIAAAGIPVFAWKGETEEEYEWCIEQTILKDGQPWDANMVLDDGGDLTQILHDKYPQVLERVHGI
TEETTTGVHRLLDMLKGGTLKVPAINVNDSVTKSKNDNKYGCRHSLNDAIKRATDHLLSGKQALVIGYGDVGKGSAQSLR
QEGMIVKVSEVDPICAMQACMDGFELVSPYKNGINDGTEASVDAALLGKIDLIVTTTGNVNVCDAGMLKALKKRAVVCNI
GHFDNEIDTAFMRQNWGWEEVKPQVHKIHRTGKTVDPTNDDYLILLAEGRLVNLGNATGHPSRIMDGSFANQVLAQIHLY
NEKFADLPVAEKTQNVTVMVLPKKLDEEVALEMVKGFGGVVTQLTAKQAEYIGVAVEGPFKPDSYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=458, Percent_Identity=55.6768558951965, Blast_Score=471, Evalue=1e-133,
Organism=Homo sapiens, GI239937451, Length=436, Percent_Identity=55.2752293577982, Blast_Score=441, Evalue=1e-124,
Organism=Homo sapiens, GI24308043, Length=462, Percent_Identity=48.7012987012987, Blast_Score=430, Evalue=1e-120,
Organism=Homo sapiens, GI298286489, Length=462, Percent_Identity=48.7012987012987, Blast_Score=429, Evalue=1e-120,
Organism=Homo sapiens, GI195539337, Length=462, Percent_Identity=48.7012987012987, Blast_Score=429, Evalue=1e-120,
Organism=Homo sapiens, GI195539349, Length=462, Percent_Identity=48.7012987012987, Blast_Score=429, Evalue=1e-120,
Organism=Homo sapiens, GI21361647, Length=462, Percent_Identity=48.7012987012987, Blast_Score=412, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI17506425, Length=458, Percent_Identity=57.8602620087336, Blast_Score=497, Evalue=1e-141,
Organism=Saccharomyces cerevisiae, GI6320882, Length=465, Percent_Identity=55.0537634408602, Blast_Score=462, Evalue=1e-131,
Organism=Drosophila melanogaster, GI24642172, Length=461, Percent_Identity=57.4837310195228, Blast_Score=480, Evalue=1e-136,
Organism=Drosophila melanogaster, GI24656245, Length=463, Percent_Identity=47.9481641468683, Blast_Score=419, Evalue=1e-117,
Organism=Drosophila melanogaster, GI45553387, Length=462, Percent_Identity=48.0519480519481, Blast_Score=403, Evalue=1e-112,
Organism=Drosophila melanogaster, GI45553385, Length=461, Percent_Identity=47.939262472885, Blast_Score=399, Evalue=1e-111,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 51058; Mature: 50927

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAVMTPAGFTDFKVADISLAAWGRREIIIAESEMPALMGLRRKYAAEQPLKGAKILGCI
CCCCCCCCCCCCEEEEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCHHHHHH
HMTIQTAVLIETLIALGAEVRWSSCNIFSTQDQAAAAIAAAGIPVFAWKGETEEEYEWCI
HHHHHHHHHHHHHHHCCCCEEECCCCEECCCHHHHHHHHHCCCEEEEECCCCHHHHHHHH
EQTILKDGQPWDANMVLDDGGDLTQILHDKYPQVLERVHGITEETTTGVHRLLDMLKGGT
HHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCC
LKVPAINVNDSVTKSKNDNKYGCRHSLNDAIKRATDHLLSGKQALVIGYGDVGKGSAQSL
EEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHH
RQEGMIVKVSEVDPICAMQACMDGFELVSPYKNGINDGTEASVDAALLGKIDLIVTTTGN
HHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHEECEEEEEEEECCC
VNVCDAGMLKALKKRAVVCNIGHFDNEIDTAFMRQNWGWEEVKPQVHKIHRTGKTVDPTN
CEECCHHHHHHHHHCEEEEECCCCCCHHHHHHHHCCCCHHHHCHHHHHHHHCCCCCCCCC
DDYLILLAEGRLVNLGNATGHPSRIMDGSFANQVLAQIHLYNEKFADLPVAEKTQNVTVM
CCEEEEEECCCEEECCCCCCCCCHHCCCHHHHHHHHHHHHHCCHHCCCCCCCCCCCEEEE
VLPKKLDEEVALEMVKGFGGVVTQLTAKQAEYIGVAVEGPFKPDSYRY
EECCCCCHHHHHHHHHHCCHHHHHHHHHHHHEEEEEEECCCCCCCCCC
>Mature Secondary Structure 
SAVMTPAGFTDFKVADISLAAWGRREIIIAESEMPALMGLRRKYAAEQPLKGAKILGCI
CCCCCCCCCCCEEEEEEEEECCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCHHHHHH
HMTIQTAVLIETLIALGAEVRWSSCNIFSTQDQAAAAIAAAGIPVFAWKGETEEEYEWCI
HHHHHHHHHHHHHHHCCCCEEECCCCEECCCHHHHHHHHHCCCEEEEECCCCHHHHHHHH
EQTILKDGQPWDANMVLDDGGDLTQILHDKYPQVLERVHGITEETTTGVHRLLDMLKGGT
HHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCC
LKVPAINVNDSVTKSKNDNKYGCRHSLNDAIKRATDHLLSGKQALVIGYGDVGKGSAQSL
EEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHH
RQEGMIVKVSEVDPICAMQACMDGFELVSPYKNGINDGTEASVDAALLGKIDLIVTTTGN
HHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHEECEEEEEEEECCC
VNVCDAGMLKALKKRAVVCNIGHFDNEIDTAFMRQNWGWEEVKPQVHKIHRTGKTVDPTN
CEECCHHHHHHHHHCEEEEECCCCCCHHHHHHHHCCCCHHHHCHHHHHHHHCCCCCCCCC
DDYLILLAEGRLVNLGNATGHPSRIMDGSFANQVLAQIHLYNEKFADLPVAEKTQNVTVM
CCEEEEEECCCEEECCCCCCCCCHHCCCHHHHHHHHHHHHHCCHHCCCCCCCCCCCEEEE
VLPKKLDEEVALEMVKGFGGVVTQLTAKQAEYIGVAVEGPFKPDSYRY
EECCCCCHHHHHHHHHHCCHHHHHHHHHHHHEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA