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The map label for this gene is cvrA

Identifier: 146284191

GI number: 146284191

Start: 4201837

End: 4203582

Strand: Direct

Name: cvrA

Synonym: PST_3879

Alternate gene names: 146284191

Gene position: 4201837-4203582 (Clockwise)

Preceding gene: 146284190

Following gene: 146284192

Centisome position: 92.0

GC content: 66.32

Gene sequence:

>1746_bases
TTGGACGTCGGCAACATCAACCACCTGTTCTTCATCGGTGCCTTGTTGGTGGCTGCAAGCATCCTGATGAGTTCGCTGTC
GAATCGCCTCGGCGTACCCATCCTGGTCATCTTCCTTGCCGTCGGCATGCTCGCTGGCGTCGATGGCGTCGGCGGCATCG
TCTTCGAGGACTACCGCCTCGCCTTCGTCATCAGCAACCTGGCGCTGGCGGTGATCCTGCTCGACGGCGGCATGCGCACC
CGCACCGCCACCTTCCGCGTCGCGCTGAAACCGGCCTTTTCCCTGGCCACCCTCGGGGTCGCCATCACCTCGGGCCTGAC
CGGCCTGGCCGCCGCCTGGCTGTTCGACCTGCCGCTGCTGCAGGGCCTGCTGATCGGCGCCATCGTCGGCTCCACGGATG
CCGCGGTGGTGTTCAACCTGCTCAACGGCAAGGGCCTCAACGAGCGGGTCGGCTCGACCCTGGAAATCGAATCGGGCAGC
AACGACCCGATGGCGATGTTCCTGACCGTCGCACTGATCGAGATGCTGCTCGCCGGCCAGTCCACCTTTGGCTGGGATTT
CCTGCTCAGCCTGCTGCAGCAGTTCGGCATCGGCACCGTGCTCGGCCTGCTCGGCGGCTGGCTGCTGCTGCAGCTGATCA
ACCGTCTGTCGGTGGCCGACGGCCTCTATCCGCTGCTGGCGGTGGCCGGCGGCCTGATGATCTTCGCCCTGTCCGGCGCC
ATCGGCGGCAGCGGCATCCTGGCGATCTATGTCTGCGGCCTGCTGCTGGGCAACCGCCCGATCCGCAACCGCCACGGCAT
CCTGCACATGTTCGATGGCCTGGCCTGGCTCAGCCAGATCGGCATGTTCCTGGTGCTCGGCCTGCTGCTAACGCCCAGCG
AGCTGCTGCCCATTGCCATCCCGGCGCTGCTGCTGTCGCTGTGGATGATCCTCTTCGCCCGACCGCTGGCGGTGTTCGTC
AGCCTGCTGCCGTTTCGCAGCTTCCACCTGCGCGAGCGCCTGTTCATCTCCTGGATCGGCCTGCGCGGCGCGGTGCCGGT
GATCCTCGCGGTGTTCCCGCTGATGGCCGGGCTGGAAAATGCCCAGCTGTTCTTCAACGTGGCGTTCTTCATCGTCCTCG
TATCGCTGCTGCTGCAGGGCTCGACGCTGGCCTGGGCGGCGAAGAAGGCCAAGGTGGAAGTCCCGCCGTCGCCGATGCCG
GTCTCGCGCACCGGCCTGCAGGTGCACACCACCAGCCAGTGGGAGATGTTCGTCTACCGCCTGAGCGCCAGCAAATGGTG
CGTCGGCGCCGCGCTGCGCGAGCTGAAGATGCCACCGGGCACACGTATCGCCGCACTCTTCCGAGGCAAGGAACTGCTGC
ACCCCTCGGGCAGTACGCGGCTGCAGGTCGACGACATTCTCTGCGTGATCGGCCATGACGAAGACTTGCCGGCCCTTGGC
AAGCTGTTCAGCCAGGCGCCCACGCGCGGCCAGGACCTGCGTTTCTTCGGTGACTTCATCCTCGAAGGCGACGCTCGGCT
CAGCGACATCGCGGCGCTCTACGGCCTCAAGCTCGGCGAGGTGGATGGCAACCAGACGATCGGCGCCTTCATGGCCGAGC
AGGTCAGTGGCAATCCCGTGGTCGGCGACCAGGTCGAATGGAACGGCCTGACCTGGACCGTGGCGGCGATGGAGACCGGC
GAAGTGCGCAAGGTCGGCCTCAAATTCCCGGAGGGCGACAAGCCCGGTCCGCAGCTGATGTTCTAG

Upstream 100 bases:

>100_bases
ATGCGGGGCGTTTTTTGACAGCCCGTCAAATCATCAGGTTAGAATCGCTGGCATATCCCGTGCATGGGCGCGAGGCGGCT
TTCTCTAACGGAGTGTTCAT

Downstream 100 bases:

>100_bases
CGGCATCCCGCCCGCGAGCGGCGCCGACAACCGCCCGTCCGTCGGCCAGTTGCGCGGTACTCGCGCAGAACTGGCGCAGC
CCGTAGACTTTCGCCCTCTC

Product: potassium/proton antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 581; Mature: 581

Protein sequence:

>581_residues
MDVGNINHLFFIGALLVAASILMSSLSNRLGVPILVIFLAVGMLAGVDGVGGIVFEDYRLAFVISNLALAVILLDGGMRT
RTATFRVALKPAFSLATLGVAITSGLTGLAAAWLFDLPLLQGLLIGAIVGSTDAAVVFNLLNGKGLNERVGSTLEIESGS
NDPMAMFLTVALIEMLLAGQSTFGWDFLLSLLQQFGIGTVLGLLGGWLLLQLINRLSVADGLYPLLAVAGGLMIFALSGA
IGGSGILAIYVCGLLLGNRPIRNRHGILHMFDGLAWLSQIGMFLVLGLLLTPSELLPIAIPALLLSLWMILFARPLAVFV
SLLPFRSFHLRERLFISWIGLRGAVPVILAVFPLMAGLENAQLFFNVAFFIVLVSLLLQGSTLAWAAKKAKVEVPPSPMP
VSRTGLQVHTTSQWEMFVYRLSASKWCVGAALRELKMPPGTRIAALFRGKELLHPSGSTRLQVDDILCVIGHDEDLPALG
KLFSQAPTRGQDLRFFGDFILEGDARLSDIAALYGLKLGEVDGNQTIGAFMAEQVSGNPVVGDQVEWNGLTWTVAAMETG
EVRKVGLKFPEGDKPGPQLMF

Sequences:

>Translated_581_residues
MDVGNINHLFFIGALLVAASILMSSLSNRLGVPILVIFLAVGMLAGVDGVGGIVFEDYRLAFVISNLALAVILLDGGMRT
RTATFRVALKPAFSLATLGVAITSGLTGLAAAWLFDLPLLQGLLIGAIVGSTDAAVVFNLLNGKGLNERVGSTLEIESGS
NDPMAMFLTVALIEMLLAGQSTFGWDFLLSLLQQFGIGTVLGLLGGWLLLQLINRLSVADGLYPLLAVAGGLMIFALSGA
IGGSGILAIYVCGLLLGNRPIRNRHGILHMFDGLAWLSQIGMFLVLGLLLTPSELLPIAIPALLLSLWMILFARPLAVFV
SLLPFRSFHLRERLFISWIGLRGAVPVILAVFPLMAGLENAQLFFNVAFFIVLVSLLLQGSTLAWAAKKAKVEVPPSPMP
VSRTGLQVHTTSQWEMFVYRLSASKWCVGAALRELKMPPGTRIAALFRGKELLHPSGSTRLQVDDILCVIGHDEDLPALG
KLFSQAPTRGQDLRFFGDFILEGDARLSDIAALYGLKLGEVDGNQTIGAFMAEQVSGNPVVGDQVEWNGLTWTVAAMETG
EVRKVGLKFPEGDKPGPQLMF
>Mature_581_residues
MDVGNINHLFFIGALLVAASILMSSLSNRLGVPILVIFLAVGMLAGVDGVGGIVFEDYRLAFVISNLALAVILLDGGMRT
RTATFRVALKPAFSLATLGVAITSGLTGLAAAWLFDLPLLQGLLIGAIVGSTDAAVVFNLLNGKGLNERVGSTLEIESGS
NDPMAMFLTVALIEMLLAGQSTFGWDFLLSLLQQFGIGTVLGLLGGWLLLQLINRLSVADGLYPLLAVAGGLMIFALSGA
IGGSGILAIYVCGLLLGNRPIRNRHGILHMFDGLAWLSQIGMFLVLGLLLTPSELLPIAIPALLLSLWMILFARPLAVFV
SLLPFRSFHLRERLFISWIGLRGAVPVILAVFPLMAGLENAQLFFNVAFFIVLVSLLLQGSTLAWAAKKAKVEVPPSPMP
VSRTGLQVHTTSQWEMFVYRLSASKWCVGAALRELKMPPGTRIAALFRGKELLHPSGSTRLQVDDILCVIGHDEDLPALG
KLFSQAPTRGQDLRFFGDFILEGDARLSDIAALYGLKLGEVDGNQTIGAFMAEQVSGNPVVGDQVEWNGLTWTVAAMETG
EVRKVGLKFPEGDKPGPQLMF

Specific function: Participates in control of cell volume in low-osmolarity conditions

COG id: COG3263

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK C-terminal domain

Homologues:

Organism=Escherichia coli, GI87081854, Length=575, Percent_Identity=68, Blast_Score=728, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CVRA_PSEU5 (A4VRA1)

Other databases:

- EMBL:   CP000304
- RefSeq:   YP_001174344.1
- ProteinModelPortal:   A4VRA1
- STRING:   A4VRA1
- GeneID:   5096840
- GenomeReviews:   CP000304_GR
- KEGG:   psa:PST_3879
- eggNOG:   COG3263
- HOGENOM:   HBG359889
- OMA:   SEWELFV
- PhylomeDB:   A4VRA1
- ProtClustDB:   PRK05326
- BioCyc:   PSTU379731:PST_3879-MONOMER
- HAMAP:   MF_01075
- InterPro:   IPR006153
- InterPro:   IPR016169
- InterPro:   IPR006037
- InterPro:   IPR005170
- Gene3D:   G3DSA:3.30.465.10

Pfam domain/function: PF03471 CorC_HlyC; PF00999 Na_H_Exchanger; PF02080 TrkA_C

EC number: NA

Molecular weight: Translated: 62142; Mature: 62142

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS51202 RCK_C

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1ec10e60)-; HASH(0x20515378)-; HASH(0x1fd641bc)-; HASH(0x20384acc)-; HASH(0x1ed498d8)-; HASH(0x204e7c98)-; HASH(0x1fe7fa04)-; HASH(0x200540c8)-; HASH(0x1f63253c)-; HASH(0x202cfab4)-; HASH(0x2050c184)-; HASH(0x200f6488)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVGNINHLFFIGALLVAASILMSSLSNRLGVPILVIFLAVGMLAGVDGVGGIVFEDYRL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCEEEECHHH
AFVISNLALAVILLDGGMRTRTATFRVALKPAFSLATLGVAITSGLTGLAAAWLFDLPLL
HHHHHHHHHEEEEECCCCCEEEEEEEEEECCHHHHHHHHHHHHHCHHHHHHHHHHHHHHH
QGLLIGAIVGSTDAAVVFNLLNGKGLNERVGSTLEIESGSNDPMAMFLTVALIEMLLAGQ
HHHHHHHHHCCCCHHHHHHHHCCCCCHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHCCC
STFGWDFLLSLLQQFGIGTVLGLLGGWLLLQLINRLSVADGLYPLLAVAGGLMIFALSGA
CCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
IGGSGILAIYVCGLLLGNRPIRNRHGILHMFDGLAWLSQIGMFLVLGLLLTPSELLPIAI
CCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
PALLLSLWMILFARPLAVFVSLLPFRSFHLRERLFISWIGLRGAVPVILAVFPLMAGLEN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC
AQLFFNVAFFIVLVSLLLQGSTLAWAAKKAKVEVPPSPMPVSRTGLQVHTTSQWEMFVYR
HHHHHHHHHHHHHHHHHHCCCCCEEECCCCEEECCCCCCCCCCCCEEEEECCHHEEEEEE
LSASKWCVGAALRELKMPPGTRIAALFRGKELLHPSGSTRLQVDDILCVIGHDEDLPALG
ECCCCHHHHHHHHHHCCCCCCEEHHHHCCCHHCCCCCCCEEEEEEEEEEECCCCCCHHHH
KLFSQAPTRGQDLRFFGDFILEGDARLSDIAALYGLKLGEVDGNQTIGAFMAEQVSGNPV
HHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCEEECCCCCCHHHHHHHHHCCCCCC
VGDQVEWNGLTWTVAAMETGEVRKVGLKFPEGDKPGPQLMF
CCCCEEECCEEEEEEEECCCCHHEECCCCCCCCCCCCCCCH
>Mature Secondary Structure
MDVGNINHLFFIGALLVAASILMSSLSNRLGVPILVIFLAVGMLAGVDGVGGIVFEDYRL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCEEEECHHH
AFVISNLALAVILLDGGMRTRTATFRVALKPAFSLATLGVAITSGLTGLAAAWLFDLPLL
HHHHHHHHHEEEEECCCCCEEEEEEEEEECCHHHHHHHHHHHHHCHHHHHHHHHHHHHHH
QGLLIGAIVGSTDAAVVFNLLNGKGLNERVGSTLEIESGSNDPMAMFLTVALIEMLLAGQ
HHHHHHHHHCCCCHHHHHHHHCCCCCHHHCCCEEEECCCCCCHHHHHHHHHHHHHHHCCC
STFGWDFLLSLLQQFGIGTVLGLLGGWLLLQLINRLSVADGLYPLLAVAGGLMIFALSGA
CCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCC
IGGSGILAIYVCGLLLGNRPIRNRHGILHMFDGLAWLSQIGMFLVLGLLLTPSELLPIAI
CCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
PALLLSLWMILFARPLAVFVSLLPFRSFHLRERLFISWIGLRGAVPVILAVFPLMAGLEN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC
AQLFFNVAFFIVLVSLLLQGSTLAWAAKKAKVEVPPSPMPVSRTGLQVHTTSQWEMFVYR
HHHHHHHHHHHHHHHHHHCCCCCEEECCCCEEECCCCCCCCCCCCEEEEECCHHEEEEEE
LSASKWCVGAALRELKMPPGTRIAALFRGKELLHPSGSTRLQVDDILCVIGHDEDLPALG
ECCCCHHHHHHHHHHCCCCCCEEHHHHCCCHHCCCCCCCEEEEEEEEEEECCCCCCHHHH
KLFSQAPTRGQDLRFFGDFILEGDARLSDIAALYGLKLGEVDGNQTIGAFMAEQVSGNPV
HHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCEEECCCCCCHHHHHHHHHCCCCCC
VGDQVEWNGLTWTVAAMETGEVRKVGLKFPEGDKPGPQLMF
CCCCEEECCEEEEEEEECCCCHHEECCCCCCCCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA